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map4 map4 myo1 myo1 hob3 hob3 eng1 eng1 dni2 dni2 exg1 exg1 prm1 prm1 acp2 acp2 fus1 fus1 exg2 exg2 dma1 dma1 arc5 arc5 bgs1 bgs1 cdc12 cdc12 eng2 eng2 cdc15 cdc15 cdc8 cdc8 cdc42 cdc42 scd2 scd2 scd1 scd1 cdc3 cdc3 ste6 ste6 gtb1 gtb1 act1 act1 ras1 ras1 cam1 cam1 for3 for3 agn2 agn2 myo52 myo52 twf1 twf1 rng9 rng9 myo51 myo51 exg3 exg3 dip1 dip1 bgs4 bgs4 hob1 hob1 wsp1 wsp1 exo84 exo84 dni1 dni1 cam2 cam2 crn1 crn1 agn1 agn1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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map4P cell-type agglutination protein map4; P cell-type specific protein which involved in agglutination during conjugation. (948 aa)
myo1Myosin-1; Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Contributes to proper septation by transporting vesicles containing septal material to the division site and is involved in the formation of sterol-rich membrane domains at the cell division site. Required also for mating. (1217 aa)
hob3Protein hob3; Involved in cytokinesis and septation where it has a role in the localization of F-actin. (264 aa)
eng1Endo-1,3(4)-beta-glucanase 1; Has a role in cell separation where it is required for the degradation of the primary septum after completion of cytokinesis. (1016 aa)
dni2Delayed minus-nitrogen induction protein 2; Belongs to the SUR7 family. (248 aa)
exg1Glucan 1,3-beta-glucosidase 1; Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. It could also function biosynthetically as a transglycosylase (By similarity). (407 aa)
prm1Plasma membrane fusion protein prm1; Involved in cell fusion during mating by stabilizing the plasma membrane fusion event; Belongs to the PRM1 family. (703 aa)
acp2F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Competes with formin cdc12 for attachment to the actin filaments barbed ends. Slowly replaces cdc12 on the barbed ends in preparation for filament disassembly during contractile ring constriction. (268 aa)
fus1Cell fusion protein fus1; Required for cell fusion. It associates with the pre-zygotic projection tips in conjugating cells; Belongs to the formin homology family. BNI1 subfamily. (1372 aa)
exg2Glucan 1,3-beta-glucosidase 2; Belongs to the glycosyl hydrolase 5 (cellulase A) family. (570 aa)
dma1Probable E3 ubiquitin-protein ligase dma1; Probable E3 ubiquitin-protein ligase which is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is compromised. Inhibits the septation initiation netwok (SIN) during spindle checkpoint activation. The effect appears to be mediated through preventing the SIN activator, plo1 kinase, from localizing to the SPB. Belongs to the DMA1 family. (267 aa)
arc5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (152 aa)
bgs11,3-beta-glucan synthase component bgs1; Required for the assembly of the division septum and maintenance of cell polarity. (1729 aa)
cdc12Cell division control protein 12; Plays a role in the cell cycle. Involved in cytokinesis. Component of the cell division ring. In the absence of profilin, caps the barbed end of actin filaments, thus preventing subunit addition and dissociation. In the presence of profilin, nucleates actin filaments that grow rapidly from their barbed ends. Belongs to the formin homology family. BNI1 subfamily. (1841 aa)
eng2Putative endo-1,3(4)-beta-glucanase 2; Belongs to the glycosyl hydrolase 81 family. (706 aa)
cdc15Cell division control protein 15; After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Appears to mediate cytoskeletal rearrangements required for cytokinesis. Essential for viability. (927 aa)
cdc8Tropomyosin; Forms part of the F-actin contractile ring during cytokinesis. (161 aa)
cdc42Cell division control protein 42 homolog; Involved in development of cell polarity during the cell division cycle; Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily. (192 aa)
scd2Protein scd2/ral3; Required for mating and morphogenesis. Interacts directly with scd1 and with cdc42. May bridge and facilitate scd1 and cdc42 interactions. (536 aa)
scd1Rho guanine nucleotide exchange factor scd1; Required for mating and morphogenesis. May contain a cryptic binding site for cdc42 that is enhanced by binding Ras. Interacts directly with scd2. Promotes the exchange of cdc42-bound GDP by GTP. Involved in septation and stimulates the elongation of conjugation tubes. (872 aa)
cdc3Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. In S.pombe, it is essential for cytokinesis. (127 aa)
ste6Protein ste6; Promotes the exchange of RAS-bound GDP by GTP. This protein is essential for mating. (911 aa)
gtb1Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly. (446 aa)
act1Actin; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (375 aa)
ras1Ras-like protein 1; Participates in the process of sexual differentiation and the determination of cell shape. Essential for mating and for recognition of the mating pheromone, but not for vegetative growth. Does not regulate the intracellular cAMP level. Regulates two downstream pathways, namely the byr2/byr1/spk1 mitogen-activated protein kinase cascade and the cdc42 small G protein pathway. The former is relevant to mating and sporulation, whereas the latter is relevant to mating, cell growth and cell morphology. (219 aa)
cam1Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (150 aa)
for3Formin-3; Involved in controlling polarized cell growth. Required for interphase actin cable formation and microtubule organization. Belongs to the formin homology family. (1461 aa)
agn2Glucan endo-1,3-alpha-glucosidase agn2; Involved in the endolysis of the ascus wall. (433 aa)
myo52Myosin-52; Involved in cell wall deposition where it has a role in the localization of mok1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1516 aa)
twf1Twinfilin; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin. Prevents actin filament assembly by forming a 1:1 complex with actin monomers, and inhibits the nucleotide exchange reaction of actin monomers (By similarity). (328 aa)
rng9Uncharacterized protein P8B7.02. (261 aa)
myo51Myosin-51; Involved in cytokinesis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1471 aa)
exg3Glucan 1,3-beta-glucosidase 3. (464 aa)
dip1Protein dip1; May be involved in protein-linked oligosaccharide phosphorylation; Belongs to the LDB17 family. (374 aa)
bgs41,3-beta-glucan synthase component bgs4; Belongs to the glycosyltransferase 48 family. (1955 aa)
hob1Protein hob1; Has a role in DNA damage signaling as a part of stress response processes. (466 aa)
wsp1Wiskott-Aldrich syndrome protein homolog 1; Has a role in regulating actin assembly, so regulating polarized growth. (574 aa)
exo84Exocyst complex component exo84; Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome (By similarity). (584 aa)
dni1Cell fusion protein dni1; Cell membrane protein which plays a relevant role in coordinating membrane organization and cell wall remodeling during mating; Belongs to the SUR7 family. (234 aa)
cam2Myosin 1 light chain cam2; Plays a role in meiosis and sporulation. (143 aa)
crn1Coronin-like protein crn1. (601 aa)
agn1Glucan endo-1,3-alpha-glucosidase agn1; Has a role in cell separation where it is required for the degradation of the cell wall material surrounding the septum (the septum edging) which must be hydrolyzed before full separation of the daughter cells can occur. Hydrolyzes 1,3-alpha-glucan predominantly into pentasaccharides. (424 aa)
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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