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| | skp1 | Suppressor of kinetochore protein 1; Required for cig2 degradation in the G2 and M phases of the cell cycle. Together with pof6, essential for septum processing and cell separation. Involved in mitotic progression, essential for the execution of anaphase B; required for coordinated structural alterations of mitotic spindles and segregation of nuclear membrane structures at anaphase. Involved in the DNA damage checkpoint pathway and maintenance of genome integrity. Component of the RAVE complex which is required for stable assembly of the vacuolar ATPase complex V- ATPase. Belongs to th [...] (161 aa) |
| | apc11 | Anaphase-promoting complex subunit 11; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. (94 aa) |
| | swd22 | Uncharacterized WD repeat-containing protein C824.04. (341 aa) |
| | paa1 | Protein phosphatase PP2A regulatory subunit A; Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates (By similarity). (590 aa) |
| | ppk22 | Serine/threonine-protein kinase ppk22. (526 aa) |
| | sfr1 | Swi5-dependent recombination DNA repair protein 1; Involved in DNA recombination repair and meiotic chromosome segregation; Belongs to the SFR1/MEI5 family. (299 aa) |
| | spc24 | Kinetochore protein spc24; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Belongs to the SPC24 family. (198 aa) |
| | tif512 | Eukaryotic translation initiation factor 5A-2; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis (By similarity); Belongs to the eIF-5A family. (169 aa) |
| | ppk29 | Serine/threonine-protein kinase ppk29. (872 aa) |
| | pre4 | Probable proteasome subunit beta type-7; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1B family. (262 aa) |
| | rmn1 | Uncharacterized RNA-binding protein C902.04. (589 aa) |
| | itt1 | E3 ubiquitin-protein ligase itt1. (435 aa) |
| | klf1 | Zinc finger protein klf1; Required for maintaining cell viability in nitrogen-deficient stationary phase (G0) cells. (781 aa) |
| | cut4 | Anaphase-promoting complex subunit 1; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Mutations to this protein prevent the exit from mitosis; Belongs to the APC1 family. (1458 aa) |
| | pam1 | Probable proteasome subunit beta type-6; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1B family. (225 aa) |
| | clp1 | Tyrosine-protein phosphatase CDC14 homolog; Protein phosphatase which antagonizes mitotic cyclin- dependent kinase cdc2, the inactivation of which is essential for exit from mitosis. To access its substrates, is released from nucleolar sequestration during mitosis. Plays an essential in coordinating the nuclear division cycle with cytokinesis through the cytokinesis checkpoint. Involved in chromosome segregation, where it is required for meiosis I spindle dissambly as well as for establishing two consecutive chromosome segregation phases. Allows damaged actomyosin rings to be maintaine [...] (537 aa) |
| | abp1 | Protein app1. (857 aa) |
| | ctr1 | Uncharacterized protein C140.04. (295 aa) |
| | atg2402 | Sorting nexin C1711.11; Belongs to the sorting nexin family. (390 aa) |
| | vrp1 | Verprolin; Involved in cytoskeletal organization and cellular growth. May exert its effects on the cytoskeleton directly, or indirectly via proline-binding proteins such as profilin or proteins possessing SH3 domains. Plays a role in actin patch assembly by enhancing the ability of myo1 to stimulate actin polymerization by the Arp2/3 complex. (309 aa) |
| | apc5 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome; Belongs to the APC5 family. (744 aa) |
| | acp2 | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Competes with formin cdc12 for attachment to the actin filaments barbed ends. Slowly replaces cdc12 on the barbed ends in preparation for filament disassembly during contractile ring constriction. (268 aa) |
| | pds5 | Sister chromatid cohesion protein pds5; Required for the establishment and maintenance of sister chromatid cohesion during S phase. Prevents their formation until eso1 is present. May also have a role during meiosis. (1205 aa) |
| | rho5 | GTP-binding protein rho5. (200 aa) |
| | ypt71 | GTP-binding protein ypt71. (208 aa) |
| | rap1 | DNA-binding protein rap1; Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE). Unlike yeast, exhibits no effect in transcription regulation. Belongs to the RAP1 family. (693 aa) |
| | ssb1 | Replication factor A protein 1; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism; Belongs to the replication factor A protein 1 family. (609 aa) |
| | arc4 | Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). (168 aa) |
| | apc2 | Anaphase-promoting complex subunit 2; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome; Belongs to the cullin family. (681 aa) |
| | rho4 | GTP-binding protein rho4; Required for cell separation. Involved in the regulation of the septum degradation during cytokinesis and in the organization of F- actin patches and cytoplasmic microtubules. Belongs to the small GTPase superfamily. Rho family. (203 aa) |
| | cti6 | Putative histone deacetylase complex subunit cti6; Could be a component of the RPD3C(L) histone deacetylase complex (HDAC). (424 aa) |
| | ppb1 | Serine/threonine-protein phosphatase 2B catalytic subunit; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Appears to be involved in cytokinesis, mating, transport, nuclear and spindle pole body positioning, and cell shape; Belongs to the PPP phosphatase family. PP-2B subfamily. (554 aa) |
| | pab1 | Protein phosphatase PP2A regulatory subunit B; Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates. (463 aa) |
| | ksg1 | Serine/threonine-protein kinase ksg1; Involved in the control of sexual development and cell growth under stressed conditions. Phosphorylates AGC kinase gad8 at 'Thr-387', activating gad8 kinase activity and promoting sexual development. Phosphorylates AGC kinase psk1 at 'Ser-248', activating psk1 kinase activity and promoting phosphorylation of ribosomal protein S6. (592 aa) |
| | ofd1 | Prolyl 3,4-dihydroxylase ofd1; Prolyl 3,4-dihydroxylase that catalyzes 3,4-dihydroxylation of 'Pro-62' of small ribosomal subunit uS12 (rps23 and rps2302), thereby regulating protein translation termination efficiency. Negative regulator of the stability of the N-terminal transcription factor domain (Sre1N) of sre1 which is released from the membrane and enters the nucleus to activate hypoxic gene expression. Belongs to the TPA1 family. (515 aa) |
| | byr4 | Protein byr4; Has an essential role in ensuring cytokinesis and septation occur only once during mitosis. It does so by interacting with the ras1 signaling pathways, thereby suppressing them; To yeast BFA1. (665 aa) |
| | fus1 | Cell fusion protein fus1; Required for cell fusion. It associates with the pre-zygotic projection tips in conjugating cells; Belongs to the formin homology family. BNI1 subfamily. (1372 aa) |
| | spo14 | Membrane glycoprotein spo14; Required for the formation of transport vesicles from the ER. This function involves the cytoplasmic domain of the protein, which is thought to interact with the small GTP-binding protein sar1. (395 aa) |
| | acp1 | F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Competes with formin cdc12 for attachment to the actin filaments barbed ends. Slowly replaces cdc12 on the barbed ends in preparation for filament disassembly during contractile ring constriction. (256 aa) |
| | ccq1 | Coiled-coil quantitatively-enriched protein 1; Component of the meiotic bouquet that facilitates meiotic nuclear reorganization of the telomeres to the centrosome. Links telomeres to the meiotic centrosome component pcp1. Essential for the formation of normal telomere clusters during meiotic prophase. Required for telomere length regulation and chromosome segregation. Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac- containing repressor complex (SHREC). (735 aa) |
| | spc25 | Kinetochore protein spc25; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. (238 aa) |
| | par1 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 1 isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Has a role in cell shape control and septum formation. (548 aa) |
| | pre6 | Probable proteasome subunit alpha type-4; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family. (259 aa) |
| | dma1 | Probable E3 ubiquitin-protein ligase dma1; Probable E3 ubiquitin-protein ligase which is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is compromised. Inhibits the septation initiation netwok (SIN) during spindle checkpoint activation. The effect appears to be mediated through preventing the SIN activator, plo1 kinase, from localizing to the SPB. Belongs to the DMA1 family. (267 aa) |
| | arc5 | Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (152 aa) |
| | ppa3 | Putative serine/threonine-protein phosphatase C22H10.04. (307 aa) |
| | mek1 | Meiosis-specific serine/threonine-protein kinase mek1; Probable protein kinase required for meiotic recombination. (445 aa) |
| | ndc80 | Kinetochore protein ndc80; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Belongs to the NDC80/HEC1 family. (624 aa) |
| | nuf2 | Kinetochore protein nuf2; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Belongs to the NUF2 family. (441 aa) |
| | rho2 | GTP-binding protein rho2; Involved in cell morphogenesis, the maintenance of growth direction, control of polarity and of cell wall integrity. Regulates the synthesis of alpha-D-glucan through activation of pck2. (200 aa) |
| | mal3 | Microtubule integrity protein mal3; May play a role in regulating the integrity of microtubules possibly by influencing their stability. Involved in an anchoring mechanism to maintain tea2 and tip1 at growing microtubule ends. Strongly stimulates the ATPase activity of tea2. Belongs to the MAPRE family. (308 aa) |
| | ppk13 | Serine/threonine-protein kinase ppk13. (344 aa) |
| | cdc12 | Cell division control protein 12; Plays a role in the cell cycle. Involved in cytokinesis. Component of the cell division ring. In the absence of profilin, caps the barbed end of actin filaments, thus preventing subunit addition and dissociation. In the presence of profilin, nucleates actin filaments that grow rapidly from their barbed ends. Belongs to the formin homology family. BNI1 subfamily. (1841 aa) |
| | stn1 | Protein stn1; Required for telomere maintenance. (325 aa) |
| | rho1 | GTP-binding protein rho1; Involved in the regulation of cell wall growth and actin cytoskeleton organization. Activates (1,3)-beta-D-glucan synthase. Belongs to the small GTPase superfamily. Rho family. (202 aa) |
| | sid2 | Serine/threonine-protein kinase sid2; Part of a signaling pathway. Required for initiation of medial ring constriction and septation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (607 aa) |
| | sty1 | Mitogen-activated protein kinase sty1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Involved in osmoregulation and stress response pathways leading to an efficient start of sexual differentiation. Supports translation initiation and facilitates adaptation to environmental stress in part through reducing eIF2-alpha phosphorylation. Links the cell-cycle G2/M control with changes in the extracellular environment that a [...] (349 aa) |
| | dcr1 | ATP-dependent helicase dcr1; Required for G1 arrest and mating in response to nitrogen starvation. Ago1 regulation of cytokinesis and cell cycle checkpoints occurs downstream of dcr1. Required, indirectly, for regulated hyperphosphorylation of cdc2. (1374 aa) |
| | pup1 | Probable proteasome subunit beta type-2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (Potential); Belongs to the peptidase T1B family. (267 aa) |
| | sds23 | Protein sds23/moc1; Required for normal DNA replication and for proper mitosis. Induces sexual development and ascus formation. Belongs to the SDS23 family. (408 aa) |
| | pom2 | Serine/threonine-protein kinase ppk5; Has a role in meiosis; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. (836 aa) |
| | gef1 | Rho guanine nucleotide exchange factor gef1; Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth, via modulation of cdc42-shk1-orb6 signaling, and septum formation. Stimulates guanine nucleotide exchange of cdc42. (753 aa) |
| | pre1 | Probable proteasome subunit beta type-4; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1B family. (194 aa) |
| | pom1 | DYRK-family kinase pom1; Polarity factor involved in localization of polarized growth and cytokinesis. Forms an intracellular gradient that serves to measure cell length and control mitotic entry. Controls the timing of mitotic commitment by regulating the inhibitory impact of cdr1/cdr2 on wee1 activity. Directly phosphorylates the tail of cdr2 which inhibits cdr2 activation by ssp1. Cdr2 phosphorylation by pom1 also modulates cdr2 association with membranes and inhibits cdr2 interaction with mid1, reducing its clustering ability, possibly via the down-regulation of cdr2 kinase activit [...] (1087 aa) |
| | pre9 | Probable proteasome subunit alpha type-3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family. (248 aa) |
| | eri1 | 3'-5' exonuclease eri1; RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Acts by degrading the 3'-overhangs of double- stranded short interfering RNAs (siRNAs). Represses the accumulation of heterochromatic siRNAs leading to negative regulation of the RNAi- mediated heterochromoatin assembly. Also involved in rRNA biogenesis, trimming the 5.8S ribosomal RNA (rRNA) from a slightly longer pre-5.8S RNA in the cytoplasm. (313 aa) |
| | rad3 | Protein kinase rad3; Serine/threonine kinase which activates checkpoint signaling upon genotoxic stresses. Involved in G2 arrest following DNA damage where it phosphorylates chk1. Phosphorylation of 'Thr-73' and 'Ser-80' of checkpoint mediator crb2 promotes its interaction with chk1. It is also involved in the dependence of mitosis on the completion of DNA replication ; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2386 aa) |
| | cdc8 | Tropomyosin; Forms part of the F-actin contractile ring during cytokinesis. (161 aa) |
| | sar1 | Small COPII coat GTPase sar1; Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. Sar1 controls the coat assembly in a stepwise manner. Activated sar1-GTP binds to membranes first and recruits the SEC23/24 complex. These sec23/24-sar1 prebudding intermediates are then collected by the sec13/31 complex as subunits polymerize to form coated trans [...] (190 aa) |
| | cdc42 | Cell division control protein 42 homolog; Involved in development of cell polarity during the cell division cycle; Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily. (192 aa) |
| | mad1 | Spindle assembly checkpoint component mad1; Central component of the spindle assembly checkpoint. Has a role in the correct positioning of the septum. Required for anchoring mad2 to the nuclear periphery. (689 aa) |
| | rbm10 | Uncharacterized RNA-binding protein C57A7.13. (565 aa) |
| | mip1 | Target of rapamycin complex 1 subunit mip1; Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Tor2 is essential for growth. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulating ribosomal protein gene expression. TORC1 negatively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Represses mating, meiosis and sporulation efficiency by interfering with the functions of the transcrip [...] (1313 aa) |
| | pas1 | G1/S-specific cyclin pas1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the pef1 protein kinase. The pef1/pas1 complex activates the res2/cdc10 complex. (411 aa) |
| | spg1 | Septum-promoting GTP-binding protein 1; GTP-binding protein essential for the induction of septum formation at G2 and pre-START stages of mitosis. Acts via the cdc7 protein kinase pathway. (198 aa) |
| | slp1 | WD repeat-containing protein slp1; Required for mad2-dependent spindle checkpoint activation. Promotes ubiquitin-dependent degradation of cdc13 by the anaphase promoting complex/cyclosome (APC/C). (488 aa) |
| | arc1 | Actin-related protein 2/3 complex subunit 1; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (377 aa) |
| | par2 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 2 isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Has a role in cell shape control and septum formation. (627 aa) |
| | clr3 | Histone deacetylase clr3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC). (687 aa) |
| | tif51 | Eukaryotic translation initiation factor 5A-1; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis (By similarity); Belongs to the eIF-5A family. (157 aa) |
| | atf1 | Transcription factor atf1; Transcription factor required for sexual development and entry into stationary phase. Binds and activates meiotic recombination hot spot ade6-M26. (566 aa) |
| | sck1 | Serine/threonine-protein kinase sck1; Protein kinase that is part of growth control pathway which is at least partially redundant with the cAMP pathway. Required for trehalase activation. (696 aa) |
| | plo1 | Serine/threonine-protein kinase plo1; Required to form a bipolar spindle, the actin ring and septum. Functions upstream of the whole septum formation pathway, including actin ring formation (regulated by late septation genes) and septal material deposition (regulated by early septation genes). Behaves as a 'septum-promoting factor', and could also be involved in inducing other late events of cell division. Together with moa1, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromer [...] (683 aa) |
| | shk1 | Serine/threonine-protein kinase shk1/pak1; MAP4K component of the MAPK pathway required for the mating pheromone response. Phosphorylates histone H2B to form H2BS10ph (By similarity). Phosphorylates tea1. Required for skb1-dependent mitotic inhibitory function. Regulates microtubule dynamics and cell polarity. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (658 aa) |
| | ssp1 | Serine/threonine-protein kinase ssp1; Involved in actin localization and thus in polarized cell growth; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (652 aa) |
| | tfs1 | Transcription elongation factor S-II; Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus (By similarity). Belongs to the TFS-II family. (293 aa) |
| | ubc4 | Ubiquitin-conjugating enzyme E2 4; Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Mediates ubiquitination of PEX5. (147 aa) |
| | rad24 | DNA damage checkpoint protein rad24; Required for the DNA damage checkpoint that ensures that DNA damage is repaired before mitosis is attempted. Acts as a negative regulator of meiosis by antagonizing the function of mei2. It inhibits the association of meiRNA (a non-coding RNA molecule required for the nuclear mei2 dot formation) to the phosphorylated but not to the unphosphorylated form of mei2 in vitro. (270 aa) |
| | cdc7 | Cell division control protein 7; Protein kinase essential for cell division. Plays a key role in initiation of septum formation and cytokinesis. (1062 aa) |
| | cut9 | Anaphase-promoting complex subunit cut9; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. May play a pivotal role in the control of anaphase. (671 aa) |
| | rpt6 | 26S proteasome regulatory subunit 8 homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (403 aa) |
| | mes1 | Protein mes1; Specifically required for meiosis II (MII). Binds to slp1, an activator of the anapahase promoting complex/cyclcosome (APC/C), and counteracts its function in promoting proteolysis of cdc13. By suppressing the degradation of cdc13 at anaphase I this protein may help maintain a sufficient level of cdc2 kinase activity to complete MII. (101 aa) |
| | scd2 | Protein scd2/ral3; Required for mating and morphogenesis. Interacts directly with scd1 and with cdc42. May bridge and facilitate scd1 and cdc42 interactions. (536 aa) |
| | scd1 | Rho guanine nucleotide exchange factor scd1; Required for mating and morphogenesis. May contain a cryptic binding site for cdc42 that is enhanced by binding Ras. Interacts directly with scd2. Promotes the exchange of cdc42-bound GDP by GTP. Involved in septation and stimulates the elongation of conjugation tubes. (872 aa) |
| | hus5 | SUMO-conjugating enzyme ubc9; Catalyzes the covalent attachment of ubiquitin-like protein SUMO/Smt3 to other proteins. Required for efficient recovery from DNA damage or S-phase arrest and normal mitosis. This may be as part of a checkpoint independent recovery process; Belongs to the ubiquitin-conjugating enzyme family. (157 aa) |
| | swi6 | Chromatin-associated protein swi6; Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Involved in the repression of the silent mating-type loci MAT2 and MAT3. May compact MAT2/3 into a heterochromatin-like conformation which represses the transcription of these silent cassettes. (328 aa) |
| | mcm2 | DNA replication licensing factor mcm2; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (830 aa) |
| | pka1 | cAMP-dependent protein kinase catalytic subunit. (512 aa) |
| | hhp2 | Casein kinase I homolog hhp2; Involved in DNA repair. May regulate the activity of protein(s) involved in double strand break repair caused by gamma rays; Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. (400 aa) |
| | hhp1 | Casein kinase I homolog hhp1; Involved in DNA repair. Has a probable role in repairing alkylated DNA and may regulate the activity of protein(s) involved in double strand break repair caused by gamma rays; Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. (365 aa) |
| | cki2 | Casein kinase I homolog 2; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. May contribute to the regulation of morphology. (435 aa) |
| | cki1 | Casein kinase I homolog 1; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. (446 aa) |
| | ckb1 | Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit. (231 aa) |
| | cdc3 | Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. In S.pombe, it is essential for cytokinesis. (127 aa) |
| | cek1 | Serine/threonine-protein kinase cek1; May facilitate the progression of anaphase through direct or indirect interaction with the cut8 protein. (1338 aa) |
| | cap1 | Adenylyl cyclase-associated protein; The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control. (551 aa) |
| | cdc16 | Cell division control protein 16; Has a dual role in the cell cycle. In mitosis, it is involved in maintenance of cdc2 kinase activity. It is subsequently required for regulation of septum formation. Could be involved in maintenance of cdc2 kinase activity by preventing, directly or indirectly, the degradation of cyclin or the dephosphorylation of 'Thr-167' of cdc2. (299 aa) |
| | dsk1 | Protein kinase dsk1; May play an important role in mitotic control by altering cellular location, degree of phosphorylation and kinase activity. Abundant expression accelerates the exit when cells are in M-phase and also delays the entry into mitosis when cells are in G2. Phosphorylates prp2 in vitro and so may have a role in co-ordinating pre-mRNA splicing with the progression of the cell division cycle. (544 aa) |
| | ppe1 | Serine/threonine-protein phosphatase ppe1; Has a role in chromosome segregation. May provide a dynamic connection between kinetochore microtubules and kinetochore chromatin. Negatively regulates mis12. (305 aa) |
| | rpt2 | 26S proteasome regulatory subunit 4 homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. (448 aa) |
| | chk1 | Serine/threonine-protein kinase chk1; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Binds to and phosphorylates CDC25. This leads to negative regulation of CDC25 and prevents mitotic entry. (496 aa) |
| | gap1 | GTPase-activating protein; Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase activity of Ras1. (766 aa) |
| | pts1 | Probable proteasome subunit beta type-5; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity; Belongs to the peptidase T1B family. (272 aa) |
| | pim1 | Protein pim1; Promotes the exchange of Ran(spi1)-bound GDP by GTP. Involved in the control of mitosis. Regulates a variety of nuclear events, including mitotic check-point, chromosome decondensation and mRNA processing/transport. (539 aa) |
| | kin1 | Protein kinase kin1; Has a role in establishing the characteristic rod cell shape. Important for cell polarity and is involved in directing growth to the cell ends; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (891 aa) |
| | sds22 | Protein phosphatase 1 regulatory subunit SDS22; Essential for the mitotic metaphase/anaphase transition. Positively modulates protein phosphatase-1, possibly by forming a repeating helical rod that is capable of enhancing a PP1-dependent dephosphorylation activity. (332 aa) |
| | cut2 | Securin; Regulatory protein, which plays a central role in chromosome stability. Probably acts by blocking the action of key proteins. During the mitosis, it blocks separase/cut1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of cut1. (301 aa) |
| | ypt3 | GTP-binding protein ypt3; Has a role in retrograde traffricking of proteins from the endosome to the Golgi. Involved in the secretory pathway where it has a role in acid phosphatase secretion; Belongs to the small GTPase superfamily. Rab family. (214 aa) |
| | dis2 | Serine/threonine-protein phosphatase PP1-1; Essential role in cell cycle control. PP1 is perhaps required for exit from mitosis. (327 aa) |
| | cdc13 | G2/mitotic-specific cyclin cdc13; Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the cdc2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Involved in the reorganization of the cytoskeleton on transition from G2 to mitosis. Association with rum1 promotes its proteolysis during G1. (482 aa) |
| | nuc2 | Anaphase-promoting complex subunit 3; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Interacts with spindle apparatus, chromosomes, or nuclear envelope, and interconnect nuclear and cytoskeletal functions in mitosis [...] (665 aa) |
| | mei2 | Meiosis protein mei2; Crucial for commitment to meiosis but it is not sufficient itself for the commitment. May be a splicing regulator. (750 aa) |
| | ras1 | Ras-like protein 1; Participates in the process of sexual differentiation and the determination of cell shape. Essential for mating and for recognition of the mating pheromone, but not for vegetative growth. Does not regulate the intracellular cAMP level. Regulates two downstream pathways, namely the byr2/byr1/spk1 mitogen-activated protein kinase cascade and the cdc42 small G protein pathway. The former is relevant to mating and sporulation, whereas the latter is relevant to mating, cell growth and cell morphology. (219 aa) |
| | cdc2 | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required for entry into S-phase and mitosis. When complexed with cig2, plays a role in G1-S phase transition. When activated and complexed with the cyclin cdc13, it leads to the onset of mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. Involved in cell cycle arrest induced by defective RNA splicing. Required for phosphorylation of dis1 to ensure accurate chromosome segregation and for the DNA damage checkpoint. (297 aa) |
| | bub1 | Checkpoint serine/threonine-protein kinase bub1; Involved in cell cycle checkpoint enforcement. Acts to stabilize the spindle during mitosis. Required for the correct localization of bub3 and mad3 to the kinetochore. Appears to have a role in chromosome segregation. Catalyzes the phosphorylation of bub3. (1044 aa) |
| | spt2 | Protein spt2; Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Global regulatory protein that plays positive as well as negative regulatory roles in transcription. Belongs to the SPT2 family. (406 aa) |
| | apc15 | Anaphase-promoting complex subunit 15; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. (136 aa) |
| | ypt7 | GTP-binding protein ypt7; Needed for homotypic vacuole fusion, the last step in the vacuole inheritance process; Belongs to the small GTPase superfamily. Rab family. (205 aa) |
| | gle1 | Nucleoporin gle1; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. It is specifically involved in a terminal step of poly(A)+ mRNA transport through the NPC (By similarity). (480 aa) |
| | epe1 | Putative JmjC domain-containing histone demethylation protein 1; May be a histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code (By similarity). Represses transcriptional silencing by negatively affecting heterochromatin stability. (948 aa) |
| | pre8 | Probable proteasome subunit alpha type-2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family. (245 aa) |
| | far8 | Uncharacterized WD repeat-containing protein C1773.01. (612 aa) |
| | les1 | Uncharacterized protein C23C4.05c; Belongs to the LEA type 1 family. (431 aa) |
| | cut23 | Anaphase-promoting complex subunit 8; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in promoting metaphase to anaphase transition via the ubiquitination of specific mitotic substrates. (565 aa) |
| | ire1 | Serine/threonine-protein kinase ppk4. (1072 aa) |
| | for3 | Formin-3; Involved in controlling polarized cell growth. Required for interphase actin cable formation and microtubule organization. Belongs to the formin homology family. (1461 aa) |
| | scl1 | Probable proteasome subunit alpha type-1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family. (244 aa) |
| | aim21 | Uncharacterized serine-rich protein C18E5.07. (615 aa) |
| | rga7 | Probable Rho-GTPase-activating protein 7. (695 aa) |
| | pli1 | E3 SUMO-protein ligase pli1; Acts as an E3 ligase mediating SUMO/Smt3 attachment to other proteins. Involved in the maintenance of the centromere and in telomere length. Regulates recombination, via extension sumoylation, particularly within the heterochromatin repeats. Belongs to the PIAS family. (727 aa) |
| | mst1 | Histone acetyltransferase mst1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. Recruitment to promoters depends on [...] (463 aa) |
| | mfr1 | Meiotic fizzy-related protein 1; Meiosis-specific activator of the anaphase promoting complex/cyclosome (APC/C). Involved in cdc13 degradation. (421 aa) |
| | twf1 | Twinfilin; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin. Prevents actin filament assembly by forming a 1:1 complex with actin monomers, and inhibits the nucleotide exchange reaction of actin monomers (By similarity). (328 aa) |
| | pku70 | ATP-dependent DNA helicase II subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. R [...] (607 aa) |
| | imp1 | Importin subunit alpha-2; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope. Involved in nuclear protein import. Required for efficient nuclera import of both an SV [...] (539 aa) |
| | wpl1 | Wings apart-like protein homolog 1; Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Belongs to the WAPL family. (602 aa) |
| | mob1 | Maintenance of ploidy protein mob1; Has a role in promoting the onset of septum formation during the latter stages of mitosis; Belongs to the MOB1/phocein family. (210 aa) |
| | rxt2 | Transcriptional regulatory protein rxt2; Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity); Belongs to the RXT2 family. (240 aa) |
| | cwf10 | Pre-mRNA-splicing factor cwf10; Component of the U5 snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (984 aa) |
| | mph1 | Serine/threonine-protein kinase mph1; Involved in the regulation of the onset of mitosis. Involved in a pathway that coordinates cell proliferation and differentiation. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (678 aa) |
| | mmi1 | YTH domain-containing protein mmi1; RNA-binding protein that recognizes and binds N6- methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs (By similarity). Required for elemination of certain meiosis-specific mRNAs in an early event following transcription. May bind to the cis-acting region (DSR) of the mRNA, activating the nuclear exosome which may lead to the degradation of the transcript from the 3' region. (488 aa) |
| | rpt3 | 26S proteasome regulatory subunit 6B homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (389 aa) |
| | est1 | Telomere elongation protein est1; Directly involved in telomere replication. Associates with telomerase and during its interaction with trt1, telomerase activity is promoted; Belongs to the EST1 family. (490 aa) |
| | pph3 | Putative serine/threonine-protein phosphatase C26H8.05c; Belongs to the PPP phosphatase family. PP-1 subfamily. (348 aa) |
| | dip1 | Protein dip1; May be involved in protein-linked oligosaccharide phosphorylation; Belongs to the LDB17 family. (374 aa) |
| | ekc1 | Extragenic suppressor of kinetochore protein 1; Has a role in chromosome segregation. May provide a dynamic connection between kinetochore microtubules and kinetochore chromatin. Belongs to the SAPS family. (838 aa) |
| | pef1 | Serine/threonine-protein kinase pef1. (288 aa) |
| | skb15 | Shk1 kinase-binding protein 15; Negatively regulates pak1/shk1 kinase activity leading to proper execution of cytoskeletal remodeling and cytokinetic functions. (341 aa) |
| | rpt4 | Probable 26S proteasome subunit rpt4; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (388 aa) |
| | asp1 | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis- diphosphoinositol tetrakisphosphate, (PP)2-InsP4. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP- InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (B [...] (920 aa) |
| | pxl1 | LIM domain-containing protein C4F6.12. (438 aa) |
| | far10 | Uncharacterized protein C3H7.13. (301 aa) |
| | SPBC32F12.07c | Uncharacterized RING finger protein C32F12.07c. (340 aa) |
| | rga4 | Probable Rho-type GTPase-activating protein 4; GTPase-activating protein for Rho-type proteins. (933 aa) |
| | dnt1 | Nucleolar protein dnt1; Negatively regulates the septation initiation network (SIN) pathway, independently of the cdc14 phosphatase clp1. May also have a role in silencing rDNA transcription. Required for maintaining the exclusive nucleolus localization of nuc1. (599 aa) |
| | ucp3 | UBA domain-containing protein 3. (601 aa) |
| | rga5 | Rho-GTPase-activating protein 5; GTPase-activating protein for Rho1. Has a role in the negative regulation of (1-3)beta-D-glucan synthase activity and cell integrity. (361 aa) |
| | pop3 | Target of rapamycin complex subunit wat1; component of both TORC1 and TORC2, which regulate multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulating ribosomal protein gene expression. TORC1 negatively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Represses mating, meiosis and sporulation efficiency by interfering with the functions of the transcription factor ste11 [...] (314 aa) |
| | cki3 | Casein kinase I homolog 3; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. (439 aa) |
| | sid4 | Septation initiation protein sid4; Required for activation of the spg1 GTPase signaling cascade which leads to the initiation of septation and the subsequent termination of mitosis. May act as a scaffold at the spindle pole body to which other components of the spg1 signaling cascade attach. (660 aa) |
| | tea4 | Tip elongation aberrant protein Tea4; Cell polarity factor essential for the bipolar localization and function of structures containing the cell-end marker tea1 during the normal cell cycle. Regulates cell polarity in complex with tea1 and together with the stress signaling MAPK cascade, contributes to cell polarity maintenance under stress conditions. Required for the localization of for3 at the cell tip specifically during initiation of bipolar growth. During the new end take off (NETO), formation of a protein complex that includes tea1, tea4 and for3 is necessary and sufficient for [...] (821 aa) |
| | psl1 | PHO85 cyclin-like protein psl1; Cyclin partner of the cyclin-dependent kinase (CDK) pef1 (PHO85 homolog). (243 aa) |
| | nrl1 | Protein NRDE2 homolog; Belongs to the NRDE2 family. (972 aa) |
| | SPBC20F10.02c | UPF0588 membrane protein C20F10.02c. (600 aa) |
| | rpt1 | 26S proteasome regulatory subunit 7 homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (438 aa) |
| | ssu72 | RNA polymerase II subunit A C-terminal domain phosphatase ssu72; Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (rpb1); Belongs to the SSU72 phosphatase family. (197 aa) |
| | bub3 | Mitotic checkpoint protein bub3; Involved in cell cycle checkpoint enforcement. Involved in recruitment of checkpoint proteins bub1 and mad3 to the kinetochores, ensuring correct spindle checkpoint function. Belongs to the WD repeat BUB3 family. (320 aa) |
| | cut20 | Anaphase-promoting complex subunit 4; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in promoting metaphase to anaphase transition via the ubiquitination of specific mitotic substrates. (719 aa) |
| | wsp1 | Wiskott-Aldrich syndrome protein homolog 1; Has a role in regulating actin assembly, so regulating polarized growth. (574 aa) |
| | mad2 | Mitotic spindle checkpoint component mad2; Feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. It interacts with the anaphase promoting complex/cyclosome (APC/C) thereby inhibiting APC/C-dependent proteolysis, a step required for exit from mitosis. Belongs to the MAD2 family. (203 aa) |
| | klp5 | Kinesin-like protein 5; Has a role in establishing metaphase during mitosis. Required for chromosome segregation where it generates tension during kinetochore capturing; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily. (883 aa) |
| | clg1 | Meiotically up-regulated gene 80 protein; Has a role in meiosis. (461 aa) |
| | aip1 | Uncharacterized WD repeat-containing protein C9G1.05; Belongs to the WD repeat AIP1 family. (595 aa) |
| | iss10 | Uncharacterized protein C7D4.14c. (551 aa) |
| | pre5 | Probable proteasome subunit alpha type-6; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family. (272 aa) |
| | tpz1 | Protection of telomeres protein tpz1; Telomeric DNA-binding protein that is required to protect the 3'-end telomeric overhang and involved in telomere length regulation. recruits poz1 and ccq1 to telomeres, regulating telomere length negatively and positivels respectively. (508 aa) |
| | atg24 | Sorting nexin-4; Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells. Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans- Golgi network, for cytoplasm to vacuole transport (Cvt), mitophagy, and pexophagy (By similarity). (401 aa) |
| | arc2 | Actin-related protein 2/3 complex subunit 2; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). (317 aa) |
| | fsv1 | Syntaxin-like protein fsv1; Involved in vesicle-mediated protein transport between the Golgi and the vacuole. (247 aa) |
| | SPAC6B12.13 | Type 1 phosphatases regulator ypi1; Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control; Belongs to the YPI1 family. (104 aa) |
| | rng2 | Ras GTPase-activating-like protein rng2; Required for cytokinesis. Component of the contractile F- actin ring; required for its construction following assembly of F-actin at the division site. (1489 aa) |
| | ptc4 | Protein phosphatase 2C homolog 4; Has a role in the regulation of vacuole fusion. (383 aa) |
| | pit1 | Sporulation protein kinase pit1; Protein kinase which is essential for spore formation. (650 aa) |
| | rpt5 | 26S proteasome regulatory subunit 6A; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (438 aa) |
| | csc4 | Uncharacterized protein C2C4.10c. (166 aa) |
| | pot1 | Protection of telomeres protein 1; Single-stranded telomeric DNA-binding protein that is required to protect the 3'-end telomeric overhang. It binds the consensus sequence 5'-GGTTAC-3'. Regulates telomerase and telomere length. (555 aa) |
| | jmj1 | JmjC domain-containing protein 1. (464 aa) |
| | rho3 | GTP-binding protein rho3; Involved in controlling cell shape and septation. Regulates cell separation by modulating the function of the exocyst complex. Involved in post-Golgi vesicle transport. (205 aa) |
| | hcn1 | Anaphase-promoting complex subunit hcn1; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in assembling cut9 in the 20S APC/cyclosome. (80 aa) |
| | poz1 | Protection of telomeres protein poz1; Telomeric DNA-binding protein that negatively regulates telomerase and telomere length. (249 aa) |
| | fin1 | G2-specific protein kinase fin1; Promotes chromosome condensation and nuclear envelope dynamics during mitosis. Activity appears at metaphase-anaphase transition; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. NIMA subfamily. (722 aa) |
| | gmf1 | Actin-depolymerizing factor gmf1; Actin depolymerizing factor involved in the control of the disassembly of actin patches. Binds and suppresses the arp2/3 complex functions such as the promotion of actin polymerisation and branching filaments. (141 aa) |
| | dri1 | Uncharacterized RNA-binding protein C17H9.04c. (604 aa) |
| | mtl1 | Uncharacterized helicase C17H9.02; Belongs to the helicase family. SKI2 subfamily. (1030 aa) |
| | nup132 | Nucleoporin nup132; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope. (1162 aa) |
| | etd1 | Septation protein etd1; Involved in septation. (391 aa) |
| | red1 | Protein red1; Required for elimination of meiosis-specific mRNAs from mitotic cells. Promotes the destabilization of mRNAs containing a degradation signal sequence called determinant of selective removal (DSR) to prevent ectopic expression of meiotic mRNAs in vegetative cells. (712 aa) |
| | ppk38 | Protein kinase domain-containing protein ppk38. (650 aa) |
| | swi5 | Mating-type switching protein swi5; Required for normal mating-type switching. Also involved in the rhp51-dependent recombination DNA repair pathway. (85 aa) |
| | bud6 | Actin-interacting protein 3 homolog; Involved in the organization and/or function of the actin cytoskeleton; To yeast BUD6. (1385 aa) |
| | arc3 | Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (174 aa) |
| | psy2 | Uncharacterized protein C216.01c. (836 aa) |
| | tor2 | Serine/threonine-protein kinase tor2; Phosphatidylinositol 3-kinase homolog, component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. TORC1 controls the switch between cell proliferation and differentiation by sensing nutrient availability. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulating ribosomal protein gene expression. In nutrient rich conditions, responsible for the phosphorylation of AGC S6 kinase ( [...] (2337 aa) |
| | pup3 | Probable proteasome subunit beta type-3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1B family. (204 aa) |
| | rgf3 | Rho1 guanine nucleotide exchange factor 3; Stimulates the exchange of Rho1 GDP-bound form into GTP-bound form. Regulates, via interaction and activation of Rho1, beta-1,3- glucan biosynthesis and cell wall integrity during septation. Involved in the regulation of contractile ring assembly. (1275 aa) |
| | bye1 | Transcription factor bye1; Negative regulator of transcription elongation. Belongs to the BYE1 family. (721 aa) |
| | arf6 | ADP-ribosylation factor 6; GTP-binding protein that functions as a molecular switch for the activation of 'new end take off' (NETO), a process in which the directions of cell growth change from a monopolar manner to a bipolar manner in fission yeast. Involved in supplying membrane to the growing new end; Belongs to the small GTPase superfamily. Arf family. (184 aa) |
| | myo1 | Myosin-1; Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Contributes to proper septation by transporting vesicles containing septal material to the division site and is involved in the formation of sterol-rich membrane domains at the cell division site. Required also for mating. (1217 aa) |
| | lsd1 | Lysine-specific histone demethylase 1; Catalytic component of the SWM histone demethylase complex that specifically demethylates H3K9me2, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Has a role in regulating heterochromatin propagation and euchromatic transcription. Also has a gene activating role; Belongs to the flavin monoamine oxidase family. (1000 aa) |
| | pek1 | MAP kinase kinase skh1/pek1; Involved in the mkh1 signal transduction pathway that plays a role in cell wall integrity. Activates spm1/pmk1 via phosphorylation. (363 aa) |
| | pup2 | Probable proteasome subunit alpha type-5; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family. (247 aa) |
| | rga1 | Rho-type GTPase-activating protein 1; GTPase-activating protein for Rho1. Involved in the F-actin patch localization, cell morphogenesis, regulation of septation, and cell wall synthesis. (1150 aa) |
| | pre3 | Probable proteasome subunit beta type-1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1B family. (226 aa) |
| | ppk30 | Serine/threonine-protein kinase ppk30. (953 aa) |
| | klp6 | Kinesin-like protein 6; Has a role in establishing metaphase during mitosis. Required for chromosome segregation where it generates tension during kinetochore capturing; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily. (784 aa) |
| | cut12 | Spindle pole body-associated protein cut12; Required for bipolar spindle formation. May act as a regulator of the p34cdc2/cyclin B kinase. Required for full activation of the plo1 kinase. However, in cut12.1 cells at restrictive temperature the H1 kinase does rise concomitant with entry into mitosis, indicating that cut12 is not required for activation of p34cdc2/cyclin B. The cut12.s11 allele may promote cdc2-independent phosphorylation of SPB proteins thereby overcoming the requirement for cdc25 in cell cycle progression. (548 aa) |
| | spc7 | Kinetochore protein spc7; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. (1364 aa) |
| | mad3 | Mitotic spindle checkpoint component mad3; Has a role in transducing the anaphase inhibitory signal to the anaphase promoting complex (APC). Forms part of the mad2 feedback control. (310 aa) |
| | pre10 | Probable proteasome subunit alpha type-7; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family. (253 aa) |
| | gem1 | Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. (630 aa) |
| | ark1 | Serine/threonine-protein kinase ark1; Required for the spindle checkpoint attachment response during spindle formation, kinetochore microtubule interactions and chromosome segregation during anaphase. Ark1 activity depends upon cut17 function and phosphorylation. Ark1 with bir1 is required for full-scale association with kinetochores and formation of a complex with mad3. Ark1 is also required for phosphorylation of histone H3 that accompanies chromosome condensation and condensin recruitment to mitotic chromatin. Ark1 with pic1 is required for the execution of cytokinesis. (355 aa) |
| | fim1 | Fimbrin; Binds to actin, and functionally associates with actin structures involved in the development and maintenance of cell polarity. Plays a role in cytokinesis. Plays important roles in mating and in spore formation. (614 aa) |
| | clr4 | Histone-lysine N-methyltransferase, H3 lysine-9 specific; Histone methyltransferase. Catalytic component of the rik1- associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransfer [...] (490 aa) |
| | erh1 | Enhancer of rudimentary homolog; May have a role in the cell cycle; Belongs to the E(R) family. (104 aa) |
| | ubc11 | Ubiquitin-conjugating enzyme E2-20 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins. (176 aa) |
| | trt1 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (988 aa) |
| | pmt3 | Ubiquitin-like protein pmt3/smt3; Required for chromosome segregation where it may be involved in microtubule assembly. Loss of smt3 leads to an increase in telomere length; Belongs to the ubiquitin family. SUMO subfamily. (117 aa) |
| | far11 | Factor arrest protein 11; Participates in the control of the reentry into the cell cycle following pheromone treatment; Belongs to the FAR11 family. (817 aa) |
| | syt22 | PH and SEC7 domain-containing protein C11E3.11c. (942 aa) |
