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| | sro7 | Uncharacterized protein C1F3.03. (1004 aa) |
| | bun62 | UBP9-binding protein bun62; Required for the ubp9 recruitment to septa and cell tips but also for its enzymatic activity at these specific locations. (543 aa) |
| | exg2 | Glucan 1,3-beta-glucosidase 2; Belongs to the glycosyl hydrolase 5 (cellulase A) family. (570 aa) |
| | tea5 | Protein kinase domain-containing protein ppk2. (665 aa) |
| | sec74 | Arf guanine nucleotide exchange factor sec74; Guanine nucleotide exchange factor for Arf GTPases, stimulating the nucleotide exchange from the GDP-bound to the GTP-bound form. Involved in vesicular transport (By similarity). (928 aa) |
| | fus1 | Cell fusion protein fus1; Required for cell fusion. It associates with the pre-zygotic projection tips in conjugating cells; Belongs to the formin homology family. BNI1 subfamily. (1372 aa) |
| | SPCC330.07c | Uncharacterized MFS-type transporter C330.07c. (500 aa) |
| | tea2 | Kinesin-like protein tea2; Promotes microtubule growth, possibly through interactions with the microtubule end, and is important for establishing and maintaining polarized growth along the long axis of the cell. Acts as a kinesin motor protein that moves along microtubules and is required for proper localization of tea1 and tip1 to the cell tips and microtubules, respectively. ATPase activity stimulated via interaction with mal3. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (628 aa) |
| | SPBC15C4.06c | Uncharacterized RING finger membrane protein C15C4.06c. (556 aa) |
| | SPAPB17E12.09 | Meiotically up-regulated protein PB17E12.09; Has a role in meiosis and sporulation. (203 aa) |
| | ght3 | High-affinity gluconate transporter ght3; High-affinity gluconate transporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (555 aa) |
| | syb1 | Synaptobrevin homolog 1; Involved in membrane trafficking during cytokinesis and cell elongation; Belongs to the synaptobrevin family. (121 aa) |
| | opy1 | Uncharacterized PH domain-containing protein PB16A4.02c. (339 aa) |
| | apl3 | AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Alpha adaptin is a subunit of the plasma membrane adaptor (By similarity). (878 aa) |
| | mor2 | Cell polarity protein mor2; Required for the maintenance of cell polarity. Has a role in localizing F-actin at the cell tips; To yeast TAO3/PAG1. (2196 aa) |
| | SPAPB1A10.13 | Uncharacterized protein PB1A10.13. (529 aa) |
| | rho5 | GTP-binding protein rho5. (200 aa) |
| | fet4 | Low-affinity iron/zinc ion transport protein fet4; Required for Fe(2+) ion low affinity uptake (By similarity). Has a role in zinc uptake under conditions of zinc limitation. (584 aa) |
| | apm1 | AP-1 complex subunit mu-1; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity). (426 aa) |
| | ede1 | Uncharacterized calcium-binding protein C800.10c. (1116 aa) |
| | acp2 | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Competes with formin cdc12 for attachment to the actin filaments barbed ends. Slowly replaces cdc12 on the barbed ends in preparation for filament disassembly during contractile ring constriction. (268 aa) |
| | bgs3 | 1,3-beta-glucan synthase component bgs3; Required for cell wall biosynthesis and cell elongation. (1826 aa) |
| | gas1 | 1,3-beta-glucanosyltransferase gas1; Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. (542 aa) |
| | ptr2 | Probable peptide transporter ptr2; Uptake of small peptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. (618 aa) |
| | ght1 | High-affinity glucose transporter ght1; High-affinity glucose transporter. (557 aa) |
| | aat1 | Amino acid transporter 1; Probable amino acid transporter that may play a role in function in microtubule organization since it causes microtubule defects when overexpressed; Belongs to the amino acid-polyamine-organocation (APC) superfamily. (579 aa) |
| | SPBC1198.03c | Uncharacterized protein C1198.03c. (249 aa) |
| | end4 | Endocytosis protein end4; Required for cellular morphogenesis and polarization of the cortical cytoskeleton. Required for establishment of new polarized growth zones where it acts in actin organization. Involved plasma membrane internalization and is essential for fluid-phase endocytosis. Belongs to the SLA2 family. (1102 aa) |
| | rng10 | Uncharacterized protein C688.07c. (1038 aa) |
| | ppk15 | Serine/threonine-protein kinase ppk15. (534 aa) |
| | vrp1 | Verprolin; Involved in cytoskeletal organization and cellular growth. May exert its effects on the cytoskeleton directly, or indirectly via proline-binding proteins such as profilin or proteins possessing SH3 domains. Plays a role in actin patch assembly by enhancing the ability of myo1 to stimulate actin polymerization by the Arp2/3 complex. (309 aa) |
| | uds1 | Up-regulated during septation protein 1; Involved in septation. (1052 aa) |
| | per1 | Uncharacterized amino-acid permease P7G5.06. (583 aa) |
| | prm1 | Plasma membrane fusion protein prm1; Involved in cell fusion during mating by stabilizing the plasma membrane fusion event; Belongs to the PRM1 family. (703 aa) |
| | SPBP4H10.14c | Uncharacterized protein P4H10.14c. (308 aa) |
| | abp1 | Protein app1. (857 aa) |
| | mak1 | Peroxide stress-activated histidine kinase mak1; Involved in the control of the SAPK-dependent transcriptional response to peroxide stress. Also has a role in G2/M regulation. (1639 aa) |
| | pmo25 | Mo25-like protein; Belongs to the Mo25 family. (329 aa) |
| | ubp9 | Probable ubiquitin carboxyl-terminal hydrolase 9; Ubiquitin C-terminal hydrolase involved in regulating actin dynamics and/or endocytosis at cell tips and septa. Belongs to the peptidase C19 family. (585 aa) |
| | par2 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 2 isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Has a role in cell shape control and septum formation. (627 aa) |
| | shk1 | Serine/threonine-protein kinase shk1/pak1; MAP4K component of the MAPK pathway required for the mating pheromone response. Phosphorylates histone H2B to form H2BS10ph (By similarity). Phosphorylates tea1. Required for skb1-dependent mitotic inhibitory function. Regulates microtubule dynamics and cell polarity. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (658 aa) |
| | ssp1 | Serine/threonine-protein kinase ssp1; Involved in actin localization and thus in polarized cell growth; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (652 aa) |
| | trk1 | Potassium transport protein 1; Together with TRK2, defines the major, high-affinity potassium influx transport system. Involved in maintenance of the proper sodium/potassium ratio in the cell and in regulating the plasma membrane potential. (841 aa) |
| | rad25 | DNA damage checkpoint protein rad25; Required for the DNA damage checkpoint that ensures that DNA damage is repaired before mitosis is attempted. (270 aa) |
| | scd2 | Protein scd2/ral3; Required for mating and morphogenesis. Interacts directly with scd1 and with cdc42. May bridge and facilitate scd1 and cdc42 interactions. (536 aa) |
| | scd1 | Rho guanine nucleotide exchange factor scd1; Required for mating and morphogenesis. May contain a cryptic binding site for cdc42 that is enhanced by binding Ras. Interacts directly with scd2. Promotes the exchange of cdc42-bound GDP by GTP. Involved in septation and stimulates the elongation of conjugation tubes. (872 aa) |
| | uvi15 | UV-induced protein uvi15; Required for the maintenance of viability of cells in stationary phase and in starvation conditions. (87 aa) |
| | hhp2 | Casein kinase I homolog hhp2; Involved in DNA repair. May regulate the activity of protein(s) involved in double strand break repair caused by gamma rays; Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. (400 aa) |
| | cka1 | Casein kinase II subunit alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Plays a role in the translation of cell polarity into polarized growth. The alpha and alpha' chains contain the catalytic site. (332 aa) |
| | cdc3 | Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. In S.pombe, it is essential for cytokinesis. (127 aa) |
| | cap1 | Adenylyl cyclase-associated protein; The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control. (551 aa) |
| | nhe1 | Na(+)/H(+) antiporter; Sodium export from cell, takes up external protons in exchange for internal sodium ions. Involved in regulation of pH; Belongs to the fungal Na(+)/H(+) exchanger family. (468 aa) |
| | sec10 | Exocyst complex component sec10; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane; Belongs to the SEC10 family. (811 aa) |
| | syt22 | PH and SEC7 domain-containing protein C11E3.11c. (942 aa) |
| | ync13 | Uncharacterized protein C11E3.02c. (1237 aa) |
| | sbg1 | Uncharacterized protein P22H7.03. (181 aa) |
| | orb6 | Serine/threonine-protein kinase orb6; Interacts with pak1/shk1 and coordinates cell morphogenesis with the cell cycle. It is essential for maintenance of cell polarity and is involved in mitotic control. (469 aa) |
| | spo13 | Sporulation-specific protein 13; Involved in sporulation. Plays a significant role in modification of the spindle pole body prior to spore formation and is required for initiating forespore membrane formation. (138 aa) |
| | SPBC36.11 | Uncharacterized protein C36.11. (343 aa) |
| | knk1 | ATPase-like fidgetin. (660 aa) |
| | pal2 | Uncharacterized protein C6B1.03c. (272 aa) |
| | rga1 | Rho-type GTPase-activating protein 1; GTPase-activating protein for Rho1. Involved in the F-actin patch localization, cell morphogenesis, regulation of septation, and cell wall synthesis. (1150 aa) |
| | rga6 | Probable Rho-GTPase-activating protein 6. (733 aa) |
| | rsn1 | Uncharacterized protein C354.08c; Acts as an osmosensitive calcium-permeable cation channel. Belongs to the CSC1 (TC 1.A.17) family. (865 aa) |
| | mug110 | Meiotically up-regulated gene 110 protein; Has a role in meiosis. (248 aa) |
| | apl1 | AP-2 complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Beta adaptin is a subunit of the plasma membrane adaptor (By similarity). (677 aa) |
| | syj1 | Inositol-1,4,5-trisphosphate 5-phosphatase 1; Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5- bisphosphate. Involved in distinct membrane trafficking and signal transduction pathways. Highly active against a range of soluble and lipid inositol phosphates. Active in dephosphorylating the 5-position of Ins(1,4,5)P3 and Ins(1,3,4,5)P4 and to a lesser extent Ins(1,4,5,6)P4. The enzyme is also active against PI(4,5)P2 presented in sonicated vesicles and Triton mixed micelles, and somewhat less active against PI(3,5) [...] (1076 aa) |
| | spa2 | Uncharacterized protein C3G9.05. (659 aa) |
| | bbc1 | SH3 domain-containing protein C23A1.17. (1611 aa) |
| | cmk2 | Calcium/calmodulin-dependent protein kinase type II; Has a role in the regulation of G2/M transition during mitosis; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. (504 aa) |
| | ssm4 | Microtubule-associated protein ssm4; Binds to nuclear microtubules with the effect of either modifying their structure or function. This then promotes meiotic nuclear division. (670 aa) |
| | wsp1 | Wiskott-Aldrich syndrome protein homolog 1; Has a role in regulating actin assembly, so regulating polarized growth. (574 aa) |
| | inp53 | Probable inositol polyphosphate 5-phosphatase C9G1.10c. (1191 aa) |
| | cyk3 | Cytokinesis protein 3; Involved in cytokinesis; Belongs to the CYK3 family. (886 aa) |
| | aip1 | Uncharacterized WD repeat-containing protein C9G1.05; Belongs to the WD repeat AIP1 family. (595 aa) |
| | pck2 | Protein kinase C-like 2; Involved in the control of the cell shape. Target of the inhibitor staurosporine; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (1016 aa) |
| | trs120 | Transport protein particle subunit trs120; Component of the TRAPP II complex. TRAPP II seems to play a role in intra-Golgi transport (By similarity). (1210 aa) |
| | tea3 | Tip elongation aberrant protein 3; Acts as a cell end marker required for efficient new end take-off (NETO), whereby growth is activated at the cell end to generate bipolarity in extending cells. Also required for proper placement of the septum. (1125 aa) |
| | arc2 | Actin-related protein 2/3 complex subunit 2; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). (317 aa) |
| | rax2 | Polarized growth protein rax2; Controls cell polarity, through the G1 phase of mitosis, via regulation of for3 localization. Required for actin cable formation where it directs the spatial distribution of the actin cables. (1155 aa) |
| | exo84 | Exocyst complex component exo84; Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome (By similarity). (584 aa) |
| | mug170 | Meiotically up-regulated gene 170 protein; Has a role in meiosis; Belongs to the arrestin family. (426 aa) |
| | csr103 | CRAL-TRIO domain-containing protein C365.01. (355 aa) |
| | klp8 | Kinesin-like protein 8. (511 aa) |
| | pub2 | E3 ubiquitin-protein ligase pub2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Has a role in the G2/M transition. (671 aa) |
| | eng1 | Endo-1,3(4)-beta-glucanase 1; Has a role in cell separation where it is required for the degradation of the primary septum after completion of cytokinesis. (1016 aa) |
| | thi9 | Thiamine transporter thi9; Thiamine transporter involved in the cellular uptake of thiamine. Pyrithiamine, oxythiamine, amprolium, and the thiazole part of thiamine have been shown to be also substrates of thi9. (591 aa) |
| | tcb3 | Uncharacterized protein PYUK71.03c. (1225 aa) |
| | inp2 | Inheritance of peroxisomes protein 2; Required for peroxisome inheritance. Acts as the peroxisome- specific receptor for the myosin V motor myo2 (By similarity). Belongs to the INP2 family. (470 aa) |
| | gas2 | 1,3-beta-glucanosyltransferase gas2; Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall; Belongs to the glycosyl hydrolase 72 family. (459 aa) |
| | dni2 | Delayed minus-nitrogen induction protein 2; Belongs to the SUR7 family. (248 aa) |
| | ags1 | Cell wall alpha-1,3-glucan synthase ags1; Required for alpha-1,3-glucan and alpha-1,4-glucan production which are required for cell wall synthesis. (2410 aa) |
| | psy1 | Syntaxin-like protein psy1. (284 aa) |
| | tna1 | Uncharacterized transporter C1002.16c. (499 aa) |
| | btn1 | Protein btn1; Involved in vacuolar transport and vacuole pH homeostasis. Also required for cytokinesis; Belongs to the battenin family. (396 aa) |
| | cat1 | Cationic amino acid transporter 1; Major permease specifically involved in arginine and lysine uptake. (587 aa) |
| | ppk16 | Serine/threonine-protein kinase ppk16; Has a role in meiosis; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (672 aa) |
| | exg1 | Glucan 1,3-beta-glucosidase 1; Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. It could also function biosynthetically as a transglycosylase (By similarity). (407 aa) |
| | pal1 | Protein pal1; Involved in cellular morphogenesis and cell wall integrity. Important for the maintenance of a cylindrical cell shape. (425 aa) |
| | gap1 | GTPase-activating protein; Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase activity of Ras1. (766 aa) |
| | arp3 | Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). May be involved in cytokinesis. (427 aa) |
| | gtp1 | GTP-binding protein 1; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (364 aa) |
| | map3 | Pheromone M-factor receptor; Receptor for the peptide pheromone M-factor, a mating factor of S.pombe. Pheromone signaling is essential for initiation of meiosis in S.pombe; M-factor signaling alone may be sufficient. (365 aa) |
| | pma2 | Plasma membrane ATPase 2; The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. (1010 aa) |
| | byr2 | Protein kinase byr2; Serine/threonine protein kinase involved in conjugation and sporulation. It is thought that it phosphorylates the byr1 protein kinase which itself phosphorylate the spk1 kinase. (659 aa) |
| | ste6 | Protein ste6; Promotes the exchange of RAS-bound GDP by GTP. This protein is essential for mating. (911 aa) |
| | gtb1 | Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly. (446 aa) |
| | kin1 | Protein kinase kin1; Has a role in establishing the characteristic rod cell shape. Important for cell polarity and is involved in directing growth to the cell ends; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (891 aa) |
| | ypt3 | GTP-binding protein ypt3; Has a role in retrograde traffricking of proteins from the endosome to the Golgi. Involved in the secretory pathway where it has a role in acid phosphatase secretion; Belongs to the small GTPase superfamily. Rab family. (214 aa) |
| | dis2 | Serine/threonine-protein phosphatase PP1-1; Essential role in cell cycle control. PP1 is perhaps required for exit from mitosis. (327 aa) |
| | act1 | Actin; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (375 aa) |
| | byr1 | Protein kinase byr1; Serine/threonine protein kinase involved in conjugation and sporulation. It is thought that it is phosphorylated by the byr2 protein kinase and that it can phosphorylate the spk1 kinase. When bound to bob1, is involved in the regulation of sexual differentiation. (340 aa) |
| | ras1 | Ras-like protein 1; Participates in the process of sexual differentiation and the determination of cell shape. Essential for mating and for recognition of the mating pheromone, but not for vegetative growth. Does not regulate the intracellular cAMP level. Regulates two downstream pathways, namely the byr2/byr1/spk1 mitogen-activated protein kinase cascade and the cdc42 small G protein pathway. The former is relevant to mating and sporulation, whereas the latter is relevant to mating, cell growth and cell morphology. (219 aa) |
| | cam1 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (150 aa) |
| | fic1 | Ingression protein fic1; Involved in the ingression of the plasma membrane during cytokinesis, leading to the separation of the daughter cells. Unlike its S.cerevisiae ortholog INN1, it does not play an essential role, probably because the actinomyosin ring is connected to the cell cortex by many more proteins. (272 aa) |
| | apm3 | AP-3 complex subunit mu; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole (By similarity); Belongs to the adaptor complexes medium subunit family. (425 aa) |
| | mug166 | Meiotically up-regulated gene 166 protein; Has a role in meiosis. (234 aa) |
| | arp1 | Centractin; Core component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding. The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. Arp1 forms the backbone filament of the dynactin rod structure and serves as the scaffold for the remaining subunits. Required for proper orientation of the mitotic spindle (By similarity). (379 aa) |
| | chr4 | Chitin synthase regulatory factor 4; Involved in septum formation. Required for the proper localization of chs2 at the septum. (633 aa) |
| | sec5 | Exocyst complex component sec5; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (815 aa) |
| | sec1 | Protein transport protein sec1; Involved in the final stage of protein secretion. Belongs to the STXBP/unc-18/SEC1 family. (693 aa) |
| | dal52 | Uncharacterized transporter C1773.15. (497 aa) |
| | for3 | Formin-3; Involved in controlling polarized cell growth. Required for interphase actin cable formation and microtubule organization. Belongs to the formin homology family. (1461 aa) |
| | agn2 | Glucan endo-1,3-alpha-glucosidase agn2; Involved in the endolysis of the ascus wall. (433 aa) |
| | dal51 | Uncharacterized transporter C417.10. (508 aa) |
| | myo52 | Myosin-52; Involved in cell wall deposition where it has a role in the localization of mok1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1516 aa) |
| | rga7 | Probable Rho-GTPase-activating protein 7. (695 aa) |
| | slm1 | Cytoskeletal signaling protein slm1; Effector of the TORC2- and calcineurin-signaling pathways. Mediates actin polarization via inhibition of calcineurin-dependent transcription (By similarity). (498 aa) |
| | ypp1 | Putative cargo-transport protein ypp1; Involved in endocytosis; Belongs to the YPP1 family. (862 aa) |
| | twf1 | Twinfilin; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin. Prevents actin filament assembly by forming a 1:1 complex with actin monomers, and inhibits the nucleotide exchange reaction of actin monomers (By similarity). (328 aa) |
| | pfd5 | Probable prefoldin subunit 5; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Required for normal cytoskeletal function and when bound to byr1, is involved in the regulation of sexual differentiation; Belongs to the prefoldin subunit alpha family. (154 aa) |
| | sog2 | Leucine-rich repeat-containing protein sog2. (886 aa) |
| | mug30 | Probable E3 ubiquitin-protein ligase mug30; Probable E3 ubiquitin-protein ligase. Has a role in meiosis. (807 aa) |
| | SPBP8B7.26 | Uncharacterized protein P8B7.26. (262 aa) |
| | rng9 | Uncharacterized protein P8B7.02. (261 aa) |
| | cog4 | Conserved oligomeric Golgi complex subunit 4; Component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis- Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity). (738 aa) |
| | SPCC757.11c | Uncharacterized MFS-type transporter C757.11c. (471 aa) |
| | pof6 | F-box protein pof6; Together with skp1, essential for septum processing and cell separation. (872 aa) |
| | ght6 | High-affinity fructose transporter ght6; High-affinity fructose transporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (535 aa) |
| | sec6 | Exocyst complex component sec6; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (752 aa) |
| | arp2 | Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). During cytokinesis it colocalizes to the cortical actin patches until spetation is complete. Has a role in the mobility of these patches. Essential for viability. (390 aa) |
| | hob3 | Protein hob3; Involved in cytokinesis and septation where it has a role in the localization of F-actin. (264 aa) |
| | arc3 | Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (174 aa) |
| | pdk1 | Serine/threonine-protein kinase ppk21; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. (551 aa) |
| | num1 | Meiotic coiled-coil protein 5; Involved in chromosome segregation. Facilitates nuclear oscillation during meiotic prophase I, the 'horsetail' phase, by acting as a dynein anchor. Essential for anchoring dhc1 to the cortex. Required for proper sliding of the microtubules along the cell cortex, which leads to the proper U-turn movement of the nucleus. (968 aa) |
| | rgf2 | Rho1 guanine nucleotide exchange factor 2; Stimulates the exchange of Rho1 and Rho5 GDP-bound form into GTP-bound form. Controls septum formation, cell wall synthesis and localization of F-actin patches. (1158 aa) |
| | etd1 | Septation protein etd1; Involved in septation. (391 aa) |
| | dma1 | Probable E3 ubiquitin-protein ligase dma1; Probable E3 ubiquitin-protein ligase which is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is compromised. Inhibits the septation initiation netwok (SIN) during spindle checkpoint activation. The effect appears to be mediated through preventing the SIN activator, plo1 kinase, from localizing to the SPB. Belongs to the DMA1 family. (267 aa) |
| | stg1 | Transgelin; Has actin-binding and actin-bundling activity and is a component of the actin patch. Stabilizes actin filaments against disassembly. Cross-links F-actin and is required for the formation of the contractile F-actin ring. (174 aa) |
| | dni1 | Cell fusion protein dni1; Cell membrane protein which plays a relevant role in coordinating membrane organization and cell wall remodeling during mating; Belongs to the SUR7 family. (234 aa) |
| | irs4 | Increased rDNA silencing protein 4 homolog; Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity). (1379 aa) |
| | pgt1 | Glutathione transporter 1; High-affinity glutathione transporter which plays a role in scavenging glutathione from the extracellular environment for the maintenance of sulfur homeostasis; Belongs to the oligopeptide OPT transporter family. (851 aa) |
| | rga3 | Probable Rho-type GTPase-activating protein 3; GTPase-activating protein for Rho-type proteins. (969 aa) |
| | cam2 | Myosin 1 light chain cam2; Plays a role in meiosis and sporulation. (143 aa) |
| | pvg2 | Pyruvylated Gal-beta-1,3-epitope synthesis protein 2; Involved in cell wall biogenesis. Has a role in the addition of Gal-beta1,3 moeities to galactomannans and their subsequent pyruvylation. Has a role in meiosis. (389 aa) |
| | sec2 | Rab guanine nucleotide exchange factor sec2; Guanyl-nucleotide exchange factor for ypt2. Catalyzing the dissociation of GDP from ypt2 and promotes the binding of GTP (By similarity). (527 aa) |
| | crn1 | Coronin-like protein crn1. (601 aa) |
| | fsh2 | Uncharacterized hydrolase C22A12.06c. (429 aa) |
| | sle1 | Eisosome protein sle1; Important for the biogenesis of filamentous eisosomes, large cytoplasmic protein assemblies that localize to specialized domains on the plasma membrane to cluster specific proteins at sites of membrane invaginations. (636 aa) |
| | sec73 | Protein transport protein sec73; May play a role in protein transport. (1082 aa) |
| | tco1 | Uncharacterized protein C17G6.02c. (324 aa) |
| | pos1 | Uncharacterized protein C16E8.08. (269 aa) |
| | shd1 | Actin cytoskeleton-regulatory complex protein sla1; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity). (1420 aa) |
| | bud6 | Actin-interacting protein 3 homolog; Involved in the organization and/or function of the actin cytoskeleton; To yeast BUD6. (1385 aa) |
| | pun1 | SUR7 family protein pun1; Contributes to the wild-type cellular response to nitrogen stress through signaling pathways that regulate the expression of genes involved in amino acid biosynthesis. Required for wild-type filamentous growth, cell growth, and cell-cell adhesion (By similarity). Belongs to the SUR7 family. (288 aa) |
| | agn1 | Glucan endo-1,3-alpha-glucosidase agn1; Has a role in cell separation where it is required for the degradation of the cell wall material surrounding the septum (the septum edging) which must be hydrolyzed before full separation of the daughter cells can occur. Hydrolyzes 1,3-alpha-glucan predominantly into pentasaccharides. (424 aa) |
| | sec3 | Uncharacterized protein C17G8.12. (608 aa) |
| | tip1 | Tip elongation protein 1; Has a role in stabilizing and targeting the growing tips of the microtubules along the long axis of the cell, directing them to the ends of the cell. Acts as a cargo for tea2. (461 aa) |
| | mam1 | Mating factor M secretion protein mam1; Required in S.pombe M (minus) cells for production of M- factor pheromone. Involved in the transport of the farnesyl-derivation of the M-factor pheromone; Belongs to the ABC transporter superfamily. Alpha-factor sex pheromone exporter (TC 3.A.1.206) family. (1336 aa) |
| | skb1 | Protein arginine N-methyltransferase skb1; S-adenosyl-L-methionine-dependent protein-arginine N- methyltransferase that can catalyze both the mono- and symmetric (type II) dimethylation of the guanidino nitrogens of arginine residues in target proteins (By similarity). Positively modulates the shk1 kinase function. May be a mediator of hyperosmotic stress response. (645 aa) |
| | adf1 | Cofilin; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. Binding to F-actin is regulated by tropomyosin. It is the major component of intranuclear and cytoplasmic actin rods. Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends. In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments. Involved in the maintenance of the contractile ring once formed. In association with [...] (137 aa) |
| | ght5 | High-affinity glucose transporter ght5; High-affinity glucose transporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (546 aa) |
| | arc1 | Actin-related protein 2/3 complex subunit 1; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (377 aa) |
| | exo70 | Exocyst complex component exo70; Required for exocytosis; Belongs to the EXO70 family. (615 aa) |
| | mkh1 | MAP kinase kinase kinase mkh1; May regulate cell morphology, cell wall integrity, salt resistance, cell cycle reentry from stationary-phase arrest, and filamentous growth in response to stress. Activates the MAP kinase kinase skh1/pek1 by phosphorylation. (1116 aa) |
| | acp1 | F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Competes with formin cdc12 for attachment to the actin filaments barbed ends. Slowly replaces cdc12 on the barbed ends in preparation for filament disassembly during contractile ring constriction. (256 aa) |
| | mug72 | Meiotically up-regulated gene 72 protein; Has a role in meiosis. (574 aa) |
| | myo1 | Myosin-1; Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Contributes to proper septation by transporting vesicles containing septal material to the division site and is involved in the formation of sterol-rich membrane domains at the cell division site. Required also for mating. (1217 aa) |
| | arf6 | ADP-ribosylation factor 6; GTP-binding protein that functions as a molecular switch for the activation of 'new end take off' (NETO), a process in which the directions of cell growth change from a monopolar manner to a bipolar manner in fission yeast. Involved in supplying membrane to the growing new end; Belongs to the small GTPase superfamily. Arf family. (184 aa) |
| | rgf1 | Rho1 guanine nucleotide exchange factor 1; Stimulates the exchange of Rho1 and Rho5 GDP-bound form into GTP-bound form. Controls septum formation, cell wall synthesis and localization of F-actin patches. Coordinates actin deposition with cell wall biosynthesis during bipolar growth. (1334 aa) |
| | myo51 | Myosin-51; Involved in cytokinesis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1471 aa) |
| | exg3 | Glucan 1,3-beta-glucosidase 3. (464 aa) |
| | aly2 | Putative arrestin-related trafficking adapter C2D10.04; May regulate endocytosis in response to extracellular stimuli; Belongs to the ALY1 family. (658 aa) |
| | SPBC25B2.10 | Universal stress protein A family protein C25B2.10. (307 aa) |
| | dip1 | Protein dip1; May be involved in protein-linked oligosaccharide phosphorylation; Belongs to the LDB17 family. (374 aa) |
| | yea4 | UDP-N-acetylglucosamine transporter yea4; Sugar transporter that specifically mediates the transport of UDP-N-acetylglucosamine (UDP-GlcNAc) and is required for cell wall chitin synthesis; Belongs to the nucleotide-sugar transporter family. SLC35B subfamily. (316 aa) |
| | rid1 | GTPase-binding protein rid1. (400 aa) |
| | pob1 | Protein pob1; Has a role in cell elongation and separation. (871 aa) |
| | sec8 | Exocyst complex component sec8; Component of the exocyst complex involved in the delivery of secretory vesicles to the plasma membrane. Also required for polarized cell growth and division septum assembly. The exocyst complex plays an important role in the targeting of rho3, as well as the two main hydrolases required for cell separation, eng1 and agn1, to the cell wall surrounding the septum before cell separation begins. (1073 aa) |
| | mob2 | Maintenance of ploidy protein mob2; Required for coordinating polarized cell growth during interphase with the onset of mitosis; Belongs to the MOB1/phocein family. (244 aa) |
| | bgs4 | 1,3-beta-glucan synthase component bgs4; Belongs to the glycosyltransferase 48 family. (1955 aa) |
| | mug33 | Meiotically up-regulated gene 33 protein; Has a role in meiosis. (336 aa) |
| | far10 | Uncharacterized protein C3H7.13. (301 aa) |
| | hob1 | Protein hob1; Has a role in DNA damage signaling as a part of stress response processes. (466 aa) |
| | map4 | P cell-type agglutination protein map4; P cell-type specific protein which involved in agglutination during conjugation. (948 aa) |
| | ucp3 | UBA domain-containing protein 3. (601 aa) |
| | rga5 | Rho-GTPase-activating protein 5; GTPase-activating protein for Rho1. Has a role in the negative regulation of (1-3)beta-D-glucan synthase activity and cell integrity. (361 aa) |
| | fhn1 | Non-classical export protein 2 homolog; Involved in membrane organization and might act as a sensor of sphingolipids that regulates plasma membrane function. Involved in a novel pathway of export of proteins that lack a cleavable signal sequence; Belongs to the NCE102 family. (183 aa) |
| | cki3 | Casein kinase I homolog 3; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. (439 aa) |
| | SPBC18H10.05 | Uncharacterized WD repeat-containing protein C18H10.05. (586 aa) |
| | tea4 | Tip elongation aberrant protein Tea4; Cell polarity factor essential for the bipolar localization and function of structures containing the cell-end marker tea1 during the normal cell cycle. Regulates cell polarity in complex with tea1 and together with the stress signaling MAPK cascade, contributes to cell polarity maintenance under stress conditions. Required for the localization of for3 at the cell tip specifically during initiation of bipolar growth. During the new end take off (NETO), formation of a protein complex that includes tea1, tea4 and for3 is necessary and sufficient for [...] (821 aa) |
| | SPBC15C4.04c | Uncharacterized amino-acid permease C15C4.04c. (542 aa) |
| | ght4 | High-affinity hexose transporter ght4. (557 aa) |
| | SPCC965.13 | Uncharacterized transporter C965.13. (537 aa) |
| | oca2 | Serine/threonine-protein kinase oca2; Overexpression causes cell cycle arrest. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (650 aa) |
| | mod5 | Cell polarity protein mod5; With tea1, acts in a positive-feedback loop in the microtubule-mediated regulation of cell polarity. Involved in the anchoring of tea1 at the cortex as well as the correct localization of tea3. (522 aa) |
| | tea1 | Tip elongation aberrant protein 1; Cell polarity protein. Acts as an end marker, directing the growth machinery to the cell poles. Involved in the regulation of microtubular organization, affecting the maintenance of a single central axis. Prevents the curling of microtubule tips around the cell ends and is required for the retention of polarity factors such as pom1, tip1 and tea2 at the cell ends, necessary for the cell to grow in a straight line. Links tip1 and tea4 in a common complex. (1147 aa) |
| | nif1 | Mitosis inhibitor nif1; Functions as a negative regulator of mitosis. It interacts with the C-terminal of nim1, thereby inhibiting its kinase activity which phosphorylates wee1. (681 aa) |
| | SPAC16A10.01 | Uncharacterized UPF0442 protein C16A10.01. (830 aa) |
| | mam2 | Pheromone P-factor receptor; Receptor for the peptide pheromone P-factor, a mating factor of S.pombe. Pheromone signaling is essential for initiation of meiosis in S.pombe; P-factor signaling alone may be sufficient; Belongs to the G-protein coupled receptor 4 family. (348 aa) |
| | cdc42 | Cell division control protein 42 homolog; Involved in development of cell polarity during the cell division cycle; Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily. (192 aa) |
| | cdc8 | Tropomyosin; Forms part of the F-actin contractile ring during cytokinesis. (161 aa) |
| | pom1 | DYRK-family kinase pom1; Polarity factor involved in localization of polarized growth and cytokinesis. Forms an intracellular gradient that serves to measure cell length and control mitotic entry. Controls the timing of mitotic commitment by regulating the inhibitory impact of cdr1/cdr2 on wee1 activity. Directly phosphorylates the tail of cdr2 which inhibits cdr2 activation by ssp1. Cdr2 phosphorylation by pom1 also modulates cdr2 association with membranes and inhibits cdr2 interaction with mid1, reducing its clustering ability, possibly via the down-regulation of cdr2 kinase activit [...] (1087 aa) |
| | rga8 | Rho-GTPase-activating protein 8; Acts in signal transduction. Negatively regulates the pak1/shk1 control pathway. (777 aa) |
| | apm4 | AP-2 complex subunit mu; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor (Potential). (446 aa) |
| | bun107 | UBP9-binding protein bun107; Required for the ubp9 recruitment to septa and cell tips but also for its enzymatic activity at these specific locations. (962 aa) |
| | bzz1 | Protein BZZ1; Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress (By similarity); Belongs to the BZZ1 family. (642 aa) |
| | gef1 | Rho guanine nucleotide exchange factor gef1; Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth, via modulation of cdc42-shk1-orb6 signaling, and septum formation. Stimulates guanine nucleotide exchange of cdc42. (753 aa) |
| | cdc15 | Cell division control protein 15; After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Appears to mediate cytoskeletal rearrangements required for cytokinesis. Essential for viability. (927 aa) |
| | sds23 | Protein sds23/moc1; Required for normal DNA replication and for proper mitosis. Induces sexual development and ascus formation. Belongs to the SDS23 family. (408 aa) |
| | eng2 | Putative endo-1,3(4)-beta-glucanase 2; Belongs to the glycosyl hydrolase 81 family. (706 aa) |
| | SPAC24B11.07c | Uncharacterized protein C24B11.07c. (561 aa) |
| | cfh1 | Chitin synthase regulatory factor 3. (932 aa) |
| | rho1 | GTP-binding protein rho1; Involved in the regulation of cell wall growth and actin cytoskeleton organization. Activates (1,3)-beta-D-glucan synthase. Belongs to the small GTPase superfamily. Rho family. (202 aa) |
| | pkd2 | TRP-like ion channel pkd2; Acts as a key signaling component in the regulation of cell shape and cell wall synthesis through interaction with GTPase Rho1. (710 aa) |
| | cdc12 | Cell division control protein 12; Plays a role in the cell cycle. Involved in cytokinesis. Component of the cell division ring. In the absence of profilin, caps the barbed end of actin filaments, thus preventing subunit addition and dissociation. In the presence of profilin, nucleates actin filaments that grow rapidly from their barbed ends. Belongs to the formin homology family. BNI1 subfamily. (1841 aa) |
| | mso1 | Uncharacterized protein C1F5.05c. (151 aa) |
| | glm1 | Uncharacterized protein C15F9.01c. (227 aa) |
| | mal3 | Microtubule integrity protein mal3; May play a role in regulating the integrity of microtubules possibly by influencing their stability. Involved in an anchoring mechanism to maintain tea2 and tip1 at growing microtubule ends. Strongly stimulates the ATPase activity of tea2. Belongs to the MAPRE family. (308 aa) |
| | rho2 | GTP-binding protein rho2; Involved in cell morphogenesis, the maintenance of growth direction, control of polarity and of cell wall integrity. Regulates the synthesis of alpha-D-glucan through activation of pck2. (200 aa) |
| | spo20 | Sec14 cytosolic factor; Required for transport of secretory proteins from the Golgi complex. Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro. Essential for viability and secretion. (286 aa) |
| | grh1 | Uncharacterized protein C1D4.02c. (345 aa) |
| | rga2 | Probable Rho-type GTPase-activating protein 2; GTPase-activating protein for Rho-type proteins. (1275 aa) |
| | cnt6 | Probable ribosylation factor GTPase-activating protein cnt6; GTPase-activating protein for the ADP ribosylation factor family. (923 aa) |
| | mug113 | Meiotically up-regulated gene 113 protein; Has a role in meiosis. (326 aa) |
| | SPAC4H3.01 | Uncharacterized J domain-containing protein C4H3.01. (392 aa) |
| | SPAC2E12.03c | Uncharacterized protein C2E12.03c. (283 aa) |
| | mac1 | Membrane-anchored protein 1; Required for correct cell separation at high temperatures; To yeast YOL019W and YMR063W. (756 aa) |
| | bgs1 | 1,3-beta-glucan synthase component bgs1; Required for the assembly of the division septum and maintenance of cell polarity. (1729 aa) |
| | arc5 | Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (152 aa) |
