Your Input: | |
| | ubc11 | Ubiquitin-conjugating enzyme E2-20 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins. (176 aa) |
| | sum3 | ATP-dependent RNA helicase ded1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Inactivation of ded1 blocks mitotic cell cycle progression at G1 and G2/M. Induces sexual development and ascus formation. (636 aa) |
| | rsp1 | DnaJ-related protein rsp1; Has a role in the proper organization of the interphase microtubule cytoskeleton. Required for equatorial microtubule organizing center (eMTOC) disassembly into satellites, contributing to the dynamic redistribution of MTOC components for organization of interphase microtubules. (494 aa) |
| | sbg1 | Uncharacterized protein P22H7.03. (181 aa) |
| | sfi1 | Protein sfi1; Component of the spindle pole body (SPB) half-bridge involved in the initial steps of SPB duplication; Belongs to the SFI1 family. (840 aa) |
| | csm1 | Monopolin complex subunit pcs1; The monopolin-like pcs1/mde4 complex is essential for accurate chromosome segregation during mitosis and meiosis II. May clamp together microtubule binding sites on the same kinetochore, preventing merotelic attachment of microtubules. In contrast to its S.cerevisiae ortholog CSM1, is not required ofr mono-orientation during meiosis I. (261 aa) |
| | agn1 | Glucan endo-1,3-alpha-glucosidase agn1; Has a role in cell separation where it is required for the degradation of the cell wall material surrounding the septum (the septum edging) which must be hydrolyzed before full separation of the daughter cells can occur. Hydrolyzes 1,3-alpha-glucan predominantly into pentasaccharides. (424 aa) |
| | ain1 | Alpha-actinin-like protein 1; Binds to actin and is involved in actin-ring formation and organization. Plays a role in cytokinesis and is involved in septation. Belongs to the alpha-actinin family. (621 aa) |
| | sgo2 | Shugoshin-2; Involved in chromosome cohesion during mitosis and meiosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. Required for faithful mitotic chromosome segregation and proper kinetochore orientation during meiosis I. In contrast to sgo1, it is dispensable for centromeric protection of rec8 during meiosis I as well as protection of rad21 during mitosis. Required to sense the lack of tension at centromeres during mitosis. (647 aa) |
| | pos1 | Uncharacterized protein C16E8.08. (269 aa) |
| | cul1 | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(pop1-pop2) is required for the maintenance of ploidy and directs ubiquitination of cig2; Belongs to the cullin family. (767 aa) |
| | psc3 | Cohesin subunit psc3; Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the rad21 subunit of the cohesin complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Belongs to the SCC3 family. (962 aa) |
| | fin1 | G2-specific protein kinase fin1; Promotes chromosome condensation and nuclear envelope dynamics during mitosis. Activity appears at metaphase-anaphase transition; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. NIMA subfamily. (722 aa) |
| | its3 | Phosphatidylinositol 4-phosphate 5-kinase its3; Involved, together with the calcineurin ppb1, in cytokinesis. (742 aa) |
| | rho3 | GTP-binding protein rho3; Involved in controlling cell shape and septation. Regulates cell separation by modulating the function of the exocyst complex. Involved in post-Golgi vesicle transport. (205 aa) |
| | cnl2 | Inner kinetochore subunit cnl2; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. (188 aa) |
| | cam2 | Myosin 1 light chain cam2; Plays a role in meiosis and sporulation. (143 aa) |
| | bir1 | Protein bir1; Seems to act in the pleiotropic control of cell division. Has a role in chromosome segregation by recruiting condensin and ark1 kinase to appropriate sites as the cell progresses through mitosis. Ark1 activity depends upon bir1 function and phosphorylation. Ark1 with bir1 function is required for full-scale association with kinetochores and formation of a complex with mad3. (997 aa) |
| | cta4 | Manganese-transporting ATPase 4; Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis (By similarity). Involved in controlling nuclear calcium ion levels. Required for cytokinesis and stabilizing microtubules. (1211 aa) |
| | myp2 | Myosin type-2 heavy chain 2; Stabilizes the F-actin cables forming the F-actin ring that surrounds the nucleus during interphase. May work in conjunction with myo2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2104 aa) |
| | stg1 | Transgelin; Has actin-binding and actin-bundling activity and is a component of the actin patch. Stabilizes actin filaments against disassembly. Cross-links F-actin and is required for the formation of the contractile F-actin ring. (174 aa) |
| | rng2 | Ras GTPase-activating-like protein rng2; Required for cytokinesis. Component of the contractile F- actin ring; required for its construction following assembly of F-actin at the division site. (1489 aa) |
| | rax2 | Polarized growth protein rax2; Controls cell polarity, through the G1 phase of mitosis, via regulation of for3 localization. Required for actin cable formation where it directs the spatial distribution of the actin cables. (1155 aa) |
| | tea3 | Tip elongation aberrant protein 3; Acts as a cell end marker required for efficient new end take-off (NETO), whereby growth is activated at the cell end to generate bipolarity in extending cells. Also required for proper placement of the septum. (1125 aa) |
| | trs120 | Transport protein particle subunit trs120; Component of the TRAPP II complex. TRAPP II seems to play a role in intra-Golgi transport (By similarity). (1210 aa) |
| | fhl1 | Fork head transcription factor 1; Acts as a transcriptional activator with a role in the regulation of mitosis. Required for the correct timing, positioning and contraction of the division septum. (743 aa) |
| | spc34 | DASH complex subunit spc34; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. (164 aa) |
| | cyk3 | Cytokinesis protein 3; Involved in cytokinesis; Belongs to the CYK3 family. (886 aa) |
| | sid1 | Serine/threonine-protein kinase sid1; Has a role in the septation initiation network (SIN) required for cytokinesis. (471 aa) |
| | rem1 | Meiosis-specific cyclin rem1; Required for pre-meiotic DNA synthesis and S phase progression. Regulates levels of meiotic intragenic recombination. (402 aa) |
| | klp5 | Kinesin-like protein 5; Has a role in establishing metaphase during mitosis. Required for chromosome segregation where it generates tension during kinetochore capturing; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily. (883 aa) |
| | smi1 | Cell wall biosynthesis/cell cycle regulator smi1; Protein involved in the regulation of cell wall assembly and 1,3-beta-glucan synthesis, possibly through the transcriptional regulation of cell wall glucan and chitin synthesis (By similarity). Involved in cellular response to nitrogen starvation and required for quiescence-maintenance by regulating negatively G0 to G1 transition. Belongs to the KNR4/SMI1 family. (504 aa) |
| | mad2 | Mitotic spindle checkpoint component mad2; Feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. It interacts with the anaphase promoting complex/cyclosome (APC/C) thereby inhibiting APC/C-dependent proteolysis, a step required for exit from mitosis. Belongs to the MAD2 family. (203 aa) |
| | spn1 | Septin homolog spn1; Plays a role in the cell cycle. Involved in a late stage of septum formation leading to the separation of the daughter cells. (469 aa) |
| | fta1 | Inner kinetochore subunit fta1; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. (280 aa) |
| | wsp1 | Wiskott-Aldrich syndrome protein homolog 1; Has a role in regulating actin assembly, so regulating polarized growth. (574 aa) |
| | psm3 | Structural maintenance of chromosomes protein 3; Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate; Belongs to the SMC family. SMC3 subfamily. (1194 aa) |
| | apc14 | Anaphase-promoting complex subunit 14; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Appears to have some sort of role in spore wall formation. (107 aa) |
| | cdc23 | DNA replication licensing factor mcm10; Required for DNA synthesis. Required for entry into or completion of S phase. Involved in DNA replication and seems to participate in the activation of the pre-replication complex (pre-RC) and in transcription elongation. May play a role as key coordinator in assembling the replication fork. Proposed to function at replication origins following the binding of the mcm2-7 complex prior to the recruitment of sna41. Probably is required to stimulate phosphorylation of the mcm2-7 complex by the dfp1-hsk1 kinase complex. May recruit the DNA polymerase [...] (593 aa) |
| | cut20 | Anaphase-promoting complex subunit 4; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in promoting metaphase to anaphase transition via the ubiquitination of specific mitotic substrates. (719 aa) |
| | bub3 | Mitotic checkpoint protein bub3; Involved in cell cycle checkpoint enforcement. Involved in recruitment of checkpoint proteins bub1 and mad3 to the kinetochores, ensuring correct spindle checkpoint function. Belongs to the WD repeat BUB3 family. (320 aa) |
| | peg1 | Protein peg1; Microtubule binding protein that regulates the stability of dynamic microtubules. Required for mitotic spindle formation. Belongs to the CLASP family. (1462 aa) |
| | mbx1 | MADS-box transcription factor 1; Acts as a transcriptional activator with a role in the regulation of mitosis. Regulates septation and the periodic transcription of cdc15. (457 aa) |
| | art1 | Arrestin family protein 1; Involved in cytokinesis; Belongs to the arrestin family. (483 aa) |
| | apc10 | Anaphase-promoting complex subunit 10; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Acts as a positive regulator of the anaphase promoting complex (APC)-cyclosome. Involved in G1 cell cycle arrest in response to n [...] (189 aa) |
| | mis19 | CENP-A recruiting complex protein mis19; Component of the CENP-A recruiting complex that ensures the integrity of mitotic spindles through maintenance of kinetochore factors mis6/CENP-I and cnp1/CENP-A. Links mis16 and mis18 to recruit CENP-A through interacting with non-sense-mediated mRNA decay (NMD) factors and the SWI/SNF complex. Links also mis18 with the CCAN/mis6/ctf19 complex to promote CENP-A assembly. (112 aa) |
| | crs1 | Meiosis-specific cyclin crs1; Has a role in meiotic chromosome segregation. Belongs to the cyclin family. Cyclin AB subfamily. (300 aa) |
| | sep1 | Forkhead protein sep1; Required for promoter sequence element PCB-driven, M-phase- specific transcription. Acts as a transcriptional activator with a role in the regulation of mitosis. Regulates septation and the periodic transcription of cdc15. (663 aa) |
| | mde4 | Monopolin complex subunit mde4; The monopolin-like pcs1/mde4 complex is essential for accurate chromosome segregation during mitosis and meiosis II. May clamp together microtubule binding sites on the same kinetochore, preventing merotelic attachment of microtubules. (421 aa) |
| | kms2 | Karyogamy meiotic segregation protein 2. (457 aa) |
| | gef3 | Rho guanine nucleotide exchange factor gef3; Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth and septum formation. (525 aa) |
| | klp6 | Kinesin-like protein 6; Has a role in establishing metaphase during mitosis. Required for chromosome segregation where it generates tension during kinetochore capturing; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily. (784 aa) |
| | cut12 | Spindle pole body-associated protein cut12; Required for bipolar spindle formation. May act as a regulator of the p34cdc2/cyclin B kinase. Required for full activation of the plo1 kinase. However, in cut12.1 cells at restrictive temperature the H1 kinase does rise concomitant with entry into mitosis, indicating that cut12 is not required for activation of p34cdc2/cyclin B. The cut12.s11 allele may promote cdc2-independent phosphorylation of SPB proteins thereby overcoming the requirement for cdc25 in cell cycle progression. (548 aa) |
| | spc7 | Kinetochore protein spc7; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. (1364 aa) |
| | mad3 | Mitotic spindle checkpoint component mad3; Has a role in transducing the anaphase inhibitory signal to the anaphase promoting complex (APC). Forms part of the mad2 feedback control. (310 aa) |
| | efr3 | Protein efr3; Belongs to the EFR3 family. (798 aa) |
| | fim1 | Fimbrin; Binds to actin, and functionally associates with actin structures involved in the development and maintenance of cell polarity. Plays a role in cytokinesis. Plays important roles in mating and in spore formation. (614 aa) |
| | fkh2 | Fork head protein homolog 2; Required for promoter sequence element PCB-driven, M-phase- specific transcription. Acts as a transcriptional activator with a role in the regulation of mitosis. Binds, cooperatively with mcm1, the CLB cluster regulatory elements throughout the cell cycle. Regulates the periodic transcription of cdc15 and spo12. Required for the correct timing, positioning and contraction of the division septum. (642 aa) |
| | bqt4 | Bouquet formation protein 4; Connects telomeres to the nuclear envelop (NE) during both vegetative growth and meiosis. This connection ensures clustering of telomeres to the spindle pole body (SPB) when cells enter meiotic prophase. (432 aa) |
| | spn7 | Septin homolog spn7; Septin-like protein involved in the correct orientation of forespore membrane extension during sporulation. Binds phosphatidylinositol 4-phosphate. (428 aa) |
| | nud3 | Nuclear movement protein nudc; Required for nuclear movement. May interact between microtubules and nuclei and/or may be involved in the generation of force used to move nuclei during interphase (By similarity). Belongs to the nudC family. (166 aa) |
| | rfc1 | Replication factor C subunit 1; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. Subunit 1 is essential for cell cycle progression. It may associate with components of the DNA replication machinery and serve to enhance the efficiency of DNA replication. (934 aa) |
| | sid4 | Septation initiation protein sid4; Required for activation of the spg1 GTPase signaling cascade which leads to the initiation of septation and the subsequent termination of mitosis. May act as a scaffold at the spindle pole body to which other components of the spg1 signaling cascade attach. (660 aa) |
| | amo1 | Nucleoporin-like protein amo1; Involved in the cell polarity process where it is required for the correct termination of microtubule growth at the cell ends during interphase. (475 aa) |
| | blt1 | Mitosis inducer protein blt1; At the onset of mitosis, forms a medial ring structure before the arrangement of the medial actin ring. Essential for the central positioning of the division septum before the cell divides. (700 aa) |
| | dnt1 | Nucleolar protein dnt1; Negatively regulates the septation initiation network (SIN) pathway, independently of the cdc14 phosphatase clp1. May also have a role in silencing rDNA transcription. Required for maintaining the exclusive nucleolus localization of nuc1. (599 aa) |
| | apc13 | Anaphase-promoting complex subunit 13; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. (135 aa) |
| | duo1 | DASH complex subunit duo1; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity). (282 aa) |
| | pxl1 | LIM domain-containing protein C4F6.12. (438 aa) |
| | cdc31 | Cell division control protein 31; Required for the proper coordination between exit from mitosis and the initiation of septation. Has a role in bipolar spindle formation during spindle pole body (SPB) duplication. Required for the localization of sad1 to the SPB. (176 aa) |
| | pin1 | Peptidyl-prolyl cis-trans isomerase pin1; Has a role in the G1/S stage transition of mitosis where it is involved in the dephosphorylation of cdc25 and wee1. (175 aa) |
| | cdc11 | Septation initiation network scaffold protein cdc11; Essential for the onset of septum formation. Involved in the organization of astral microtubules during mitosis. Acts as a bridge between sid4 and the other SIN proteins mediating their association with the spindle pole body (SPB). The sid4-cdc11 complex organizes a signaling hub on the SPB which coordinates cell and nuclear division. (1045 aa) |
| | bgs4 | 1,3-beta-glucan synthase component bgs4; Belongs to the glycosyltransferase 48 family. (1955 aa) |
| | mpg1 | Mannose-1-phosphate guanyltransferase; Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint. Required for the correct assembly of the septum. Belongs to the transferase hexapeptide repeat family. (363 aa) |
| | bqt3 | Bouquet formation protein 3; Connects telomeres to the nuclear envelop (NE) during both vegetative growth and meiosis. This connection ensures clustering of telomeres to the spindle pole body (SPB) when cells enter meiotic prophase. (255 aa) |
| | ekc1 | Extragenic suppressor of kinetochore protein 1; Has a role in chromosome segregation. May provide a dynamic connection between kinetochore microtubules and kinetochore chromatin. Belongs to the SAPS family. (838 aa) |
| | mob2 | Maintenance of ploidy protein mob2; Required for coordinating polarized cell growth during interphase with the onset of mitosis; Belongs to the MOB1/phocein family. (244 aa) |
| | sec8 | Exocyst complex component sec8; Component of the exocyst complex involved in the delivery of secretory vesicles to the plasma membrane. Also required for polarized cell growth and division septum assembly. The exocyst complex plays an important role in the targeting of rho3, as well as the two main hydrolases required for cell separation, eng1 and agn1, to the cell wall surrounding the septum before cell separation begins. (1073 aa) |
| | pch1 | Cyclin pch1; Essential for progression through the whole cell cycle. Belongs to the cyclin family. Cyclin C subfamily. (342 aa) |
| | chs2 | Chitin synthase-like protein 2; Plays a role in septum formation. Has no chitin synthase activity; Belongs to the chitin synthase family. (926 aa) |
| | myo51 | Myosin-51; Involved in cytokinesis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1471 aa) |
| | fta7 | Inner kinetochore subunit fta7; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere- associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. (244 aa) |
| | pof6 | F-box protein pof6; Together with skp1, essential for septum processing and cell separation. (872 aa) |
| | vps25 | Vacuolar protein-sorting-associated protein 25; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. (175 aa) |
| | rng3 | Ring assembly protein 3; Essential for actinomyosin ring assembly during cytokinesis. Has a role, in conjunction with F-actin, in assembling myosin II- containing proteins, such as myo2, at the division site. (746 aa) |
| | mog1 | Nuclear import protein mog1; Involved in the Ran-GTPase system for nuclear protein import and poly(A)+ mRNA export. Required for mitosis-to-interphase transition; Belongs to the MOG1 family. (190 aa) |
| | mph1 | Serine/threonine-protein kinase mph1; Involved in the regulation of the onset of mitosis. Involved in a pathway that coordinates cell proliferation and differentiation. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (678 aa) |
| | rng9 | Uncharacterized protein P8B7.02. (261 aa) |
| | fta3 | Inner kinetochore subunit fta3; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly (By similarity). Fta2, fta3 and fta4 associate with the central core (cnt) and inner repeat (inr) region of the centromere. (220 aa) |
| | mob1 | Maintenance of ploidy protein mob1; Has a role in promoting the onset of septum formation during the latter stages of mitosis; Belongs to the MOB1/phocein family. (210 aa) |
| | wpl1 | Wings apart-like protein homolog 1; Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Belongs to the WAPL family. (602 aa) |
| | imp1 | Importin subunit alpha-2; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope. Involved in nuclear protein import. Required for efficient nuclera import of both an SV [...] (539 aa) |
| | psm1 | Structural maintenance of chromosomes protein 1; Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. (1228 aa) |
| | ssl3 | MAU2 chromatid cohesion factor homolog; Involved in sister chromatid cohesion. Forms a complex with mis4, which is required for the association of the cohesin complex with chromosomes. (559 aa) |
| | rga7 | Probable Rho-GTPase-activating protein 7. (695 aa) |
| | myo52 | Myosin-52; Involved in cell wall deposition where it has a role in the localization of mok1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1516 aa) |
| | dad5 | High osmolarity sensitivity protein 3; May play a role in the progression of mitosis in an environment of high osmotic stress. (94 aa) |
| | sim4 | Inner kinetochore subunit sim4; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. Belongs to the CENP-K/MCM22 family. (277 aa) |
| | agn2 | Glucan endo-1,3-alpha-glucosidase agn2; Involved in the endolysis of the ascus wall. (433 aa) |
| | for3 | Formin-3; Involved in controlling polarized cell growth. Required for interphase actin cable formation and microtubule organization. Belongs to the formin homology family. (1461 aa) |
| | alp14 | Spindle pole body component alp14; Required for bipolar spindle formation and proper chromosome segregation. Has a role in connecting the kinetochores and the plus end of pole to chromosome microtubules. Also required for the activation of the spindle checkpoint pathway; Belongs to the TOG/XMAP215 family. (809 aa) |
| | cut23 | Anaphase-promoting complex subunit 8; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in promoting metaphase to anaphase transition via the ubiquitination of specific mitotic substrates. (565 aa) |
| | les1 | Uncharacterized protein C23C4.05c; Belongs to the LEA type 1 family. (431 aa) |
| | chr4 | Chitin synthase regulatory factor 4; Involved in septum formation. Required for the proper localization of chs2 at the septum. (633 aa) |
| | mis17 | Inner kinetochore subunit mis17; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere- associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. (441 aa) |
| | gyp10 | GTPase-activating protein gyp10; Has a role in vesicular trafficking and septation during cytokinesis. (373 aa) |
| | cnd1 | Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase. (1158 aa) |
| | mis20 | CENP-A recruiting complex protein mis20; Component of the CENP-A recruiting complex that ensures the integrity of mitotic spindles through maintenance of kinetochore factors mis6/CENP-I and cnp1/CENP-A. Seems dispensable for proper chromosome segregation. (253 aa) |
| | apc15 | Anaphase-promoting complex subunit 15; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. (136 aa) |
| | fic1 | Ingression protein fic1; Involved in the ingression of the plasma membrane during cytokinesis, leading to the separation of the daughter cells. Unlike its S.cerevisiae ortholog INN1, it does not play an essential role, probably because the actinomyosin ring is connected to the cell cortex by many more proteins. (272 aa) |
| | fta4 | Inner kinetochore subunit fta4; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. Fta2, fta3 and fta4 associate with the central core (cnt) and inner repeat (inr) region of the centromere. (233 aa) |
| | cdc37 | Hsp90 co-chaperone Cdc37; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. (466 aa) |
| | bub1 | Checkpoint serine/threonine-protein kinase bub1; Involved in cell cycle checkpoint enforcement. Acts to stabilize the spindle during mitosis. Required for the correct localization of bub3 and mad3 to the kinetochore. Appears to have a role in chromosome segregation. Catalyzes the phosphorylation of bub3. (1044 aa) |
| | cdc10 | Start control protein cdc10; Major component of the cell cycle transcription factor complex MBF (MCB binding factor, also known as DSC1), that controls G1- S phase specific gene expression. Involved in the control of rRNA production, via interaction with pol5. May be involved in the transcriptional regulation of the cdc22 and cdt1 genes. In fission yeast, two genes, cdc10 and cdc2, are required for the cell cycle control called start, the point early in the G1 phase at which cells become committed to the mitotic cycle. (767 aa) |
| | cdc2 | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required for entry into S-phase and mitosis. When complexed with cig2, plays a role in G1-S phase transition. When activated and complexed with the cyclin cdc13, it leads to the onset of mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. Involved in cell cycle arrest induced by defective RNA splicing. Required for phosphorylation of dis1 to ensure accurate chromosome segregation and for the DNA damage checkpoint. (297 aa) |
| | cdc25 | M-phase inducer phosphatase; This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity. (596 aa) |
| | cdr1 | Mitosis inducer protein kinase cdr1; This protein, a dose-dependent mitotic inducer, appears to function as a negative regulator of mitosis inhibitor wee1 by phosphorylating and inactivating it. (593 aa) |
| | wee1 | Mitosis inhibitor protein kinase wee1; Protein kinase that acts both on serines and on tyrosines. It acts as a dosage-dependent negative regulator of entry into mitosis (G2 to M transition). Phosphorylates and inhibits cdc2. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. (877 aa) |
| | suc1 | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinase (cdc2) and is essential for its biological function; Belongs to the CKS family. (113 aa) |
| | nuc2 | Anaphase-promoting complex subunit 3; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Interacts with spindle apparatus, chromosomes, or nuclear envelope, and interconnect nuclear and cytoskeletal functions in mitosis [...] (665 aa) |
| | cdc13 | G2/mitotic-specific cyclin cdc13; Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the cdc2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Involved in the reorganization of the cytoskeleton on transition from G2 to mitosis. Association with rum1 promotes its proteolysis during G1. (482 aa) |
| | act1 | Actin; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (375 aa) |
| | cdc17 | DNA ligase 1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family. (768 aa) |
| | dis2 | Serine/threonine-protein phosphatase PP1-1; Essential role in cell cycle control. PP1 is perhaps required for exit from mitosis. (327 aa) |
| | ypt3 | GTP-binding protein ypt3; Has a role in retrograde traffricking of proteins from the endosome to the Golgi. Involved in the secretory pathway where it has a role in acid phosphatase secretion; Belongs to the small GTPase superfamily. Rab family. (214 aa) |
| | cut1 | Separin; Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the rad21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by securin/cut2 protein. It is also required for pointed nuclear formation. (1828 aa) |
| | cut2 | Securin; Regulatory protein, which plays a central role in chromosome stability. Probably acts by blocking the action of key proteins. During the mitosis, it blocks separase/cut1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of cut1. (301 aa) |
| | sds22 | Protein phosphatase 1 regulatory subunit SDS22; Essential for the mitotic metaphase/anaphase transition. Positively modulates protein phosphatase-1, possibly by forming a repeating helical rod that is capable of enhancing a PP1-dependent dephosphorylation activity. (332 aa) |
| | kin1 | Protein kinase kin1; Has a role in establishing the characteristic rod cell shape. Important for cell polarity and is involved in directing growth to the cell ends; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (891 aa) |
| | ppa1 | Minor serine/threonine-protein phosphatase PP2A-1 catalytic subunit; Essential role in cell cycle control. PP2A may be involved in controlling the entry into mitosis, possibly acting as an inhibitor; Belongs to the PPP phosphatase family. PP-2A subfamily. (309 aa) |
| | ppa2 | Major serine/threonine-protein phosphatase PP2A-2 catalytic subunit; Essential role in cell cycle control. PP2A may be involved in controlling the entry into mitosis, possibly acting as an inhibitor. (322 aa) |
| | sds21 | Serine/threonine-protein phosphatase PP1-2; Essential role in cell cycle control. PP1 is perhaps required for exit from mitosis; Belongs to the PPP phosphatase family. PP-1 subfamily. (322 aa) |
| | cut7 | Kinesin-like protein cut7; Could be a spindle pole body motor. On transition from G2 to M phase of the cell cycle, the spindle pole body duplicates; the daughter pole bodies seed microtubules which interdigitate to form a short spindle that elongates to span the nucleus at metaphase. Mutations at cut7 block spindle formation. (1085 aa) |
| | cig1 | G2/mitotic-specific cyclin cig1; Required for efficient passage of the G1/S transition. (415 aa) |
| | puc1 | Cyclin puc1; Function in exit from the mitotic cycle. Contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. Interacts with protein kinase A. (359 aa) |
| | gtb1 | Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly. (446 aa) |
| | pyp1 | Tyrosine-protein phosphatase 1; Plays a role in inhibiting the onset of mitosis. Dephosphorylates sty1/spc1 and wis1/spc2/sty2. (550 aa) |
| | pim1 | Protein pim1; Promotes the exchange of Ran(spi1)-bound GDP by GTP. Involved in the control of mitosis. Regulates a variety of nuclear events, including mitotic check-point, chromosome decondensation and mRNA processing/transport. (539 aa) |
| | cdc27 | DNA polymerase delta subunit 3. (372 aa) |
| | mik1 | Mitosis inhibitor protein kinase mik1; Protein kinase that acts both on serines and on tyrosines. It acts as a negative regulator of entry into mitosis (G2 to M transition). Phosphorylates and inhibits cdc2. (581 aa) |
| | rad21 | Cohesin subunit rad21; Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by cut1 and dissociates from chromatin, allowing sister chromatids to segregate. Also involved in the DNA double-strand-break (DSB) repair system. (628 aa) |
| | arp3 | Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). May be involved in cytokinesis. (427 aa) |
| | pyp2 | Tyrosine-protein phosphatase 2; Plays a role in inhibiting the onset of mitosis. Dephosphorylates sty1/spc1 and wis1/spc2/sty2. (711 aa) |
| | pyp3 | Tyrosine-protein phosphatase 3; Contributes to dephosphorylation of tyrosine 15 of cdc2. (303 aa) |
| | wis1 | Protein kinase wis1; Dosage-dependent regulator of mitosis with serine/ threonine protein kinase activity. May play a role in the integration of nutritional sensing with the control over entry into mitosis. It may interact with cdc25, wee1 and win1. May activate sty1. (605 aa) |
| | cdc14 | Cell division control protein 14; Has a role in the septation initiation network (SIN) required for cytokinesis. (240 aa) |
| | mcs2 | Cyclin mcs2; Essential for progression through the cell cycle. Posseses kinase activity that can be detected when myelin basic protein (MBP) is provided as an exogenous substrate; Belongs to the cyclin family. Cyclin C subfamily. (322 aa) |
| | ppe1 | Serine/threonine-protein phosphatase ppe1; Has a role in chromosome segregation. May provide a dynamic connection between kinetochore microtubules and kinetochore chromatin. Negatively regulates mis12. (305 aa) |
| | dsk1 | Protein kinase dsk1; May play an important role in mitotic control by altering cellular location, degree of phosphorylation and kinase activity. Abundant expression accelerates the exit when cells are in M-phase and also delays the entry into mitosis when cells are in G2. Phosphorylates prp2 in vitro and so may have a role in co-ordinating pre-mRNA splicing with the progression of the cell division cycle. (544 aa) |
| | cig2 | G2/mitotic-specific cyclin cig2; Essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. Interacts with the cdc2 protein kinase to form MPF. Interaction with res2 promotes the phosphorylation of res1 and inhibits MBF-dependent gene transcription. Forms an autoregulating feedback-inhibition loop with MBF which is important for normal regulation of the cell cycle. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Negatively regulates conjugation via interacting with cell cycle 'start' genes. Degraded by skp1, pop1 and pop2 in [...] (411 aa) |
| | cdc3 | Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. In S.pombe, it is essential for cytokinesis. (127 aa) |
| | cdt1 | Cell division cycle protein cdt1; DNA replication licensing factor, required for pre- replication complex assembly. Faithful duplication of the genetic material requires 'once per cell cycle' DNA replication initiation and elongation. Central to this control is the tightly regulated formation of prereplicative complexes (preRCs) at future origins of DNA replication. Required for the recruitment of the MCM helicase complex to the replication origins; Belongs to the Cdt1 family. (444 aa) |
| | scd1 | Rho guanine nucleotide exchange factor scd1; Required for mating and morphogenesis. May contain a cryptic binding site for cdc42 that is enhanced by binding Ras. Interacts directly with scd2. Promotes the exchange of cdc42-bound GDP by GTP. Involved in septation and stimulates the elongation of conjugation tubes. (872 aa) |
| | scd2 | Protein scd2/ral3; Required for mating and morphogenesis. Interacts directly with scd1 and with cdc42. May bridge and facilitate scd1 and cdc42 interactions. (536 aa) |
| | cut14 | Structural maintenance of chromosomes protein 2; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1172 aa) |
| | cut3 | Structural maintenance of chromosomes protein 4; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases; Belongs to the SMC family. SMC4 subfamily. (1324 aa) |
| | cdc18 | Cell division control protein 18; Part of the checkpoint control that prevents mitosis from occurring until S phase is completed. Plays a key role in coupling S phase to start and mitosis. Acts at the initiation of DNA replication and plays a major role in controlling the onset of S-phase. Together with orp1, involved in the maintenance of replication forks and activation of cds1-dependent S-phase checkpoint. Belongs to the CDC6/cdc18 family. (577 aa) |
| | cut9 | Anaphase-promoting complex subunit cut9; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. May play a pivotal role in the control of anaphase. (671 aa) |
| | cdc7 | Cell division control protein 7; Protein kinase essential for cell division. Plays a key role in initiation of septum formation and cytokinesis. (1062 aa) |
| | zfs1 | Zinc finger protein zfs1; Binds to specific AU-rich elements (ARE) in the 3'- untranslated region of target mRNAs and promotes their degradation. Binds to ARE present in the arz1 mRNA and stimulates the rate of arz1 mRNA decay. Required for coordination of septum formation with exit from mitosis. Involved in the mating response pathway. Induces sexual development and ascus formation. (404 aa) |
| | spn3 | Septin homolog spn3; Plays a role in the cell cycle. Involved in a late stage of septum formation leading to the separation of the daughter cells. (412 aa) |
| | spn4 | Septin homolog spn4; Plays a role in the cell cycle. Involved in a late stage of septum formation leading to the separation of the daughter cells. (380 aa) |
| | spn5 | Septin homolog spn5; Septin-like protein involved in the correct orientation of forespore membrane extension during sporulation. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (464 aa) |
| | shk1 | Serine/threonine-protein kinase shk1/pak1; MAP4K component of the MAPK pathway required for the mating pheromone response. Phosphorylates histone H2B to form H2BS10ph (By similarity). Phosphorylates tea1. Required for skb1-dependent mitotic inhibitory function. Regulates microtubule dynamics and cell polarity. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (658 aa) |
| | plo1 | Serine/threonine-protein kinase plo1; Required to form a bipolar spindle, the actin ring and septum. Functions upstream of the whole septum formation pathway, including actin ring formation (regulated by late septation genes) and septal material deposition (regulated by early septation genes). Behaves as a 'septum-promoting factor', and could also be involved in inducing other late events of cell division. Together with moa1, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromer [...] (683 aa) |
| | hsk1 | Cell cycle serine/threonine-protein kinase hsk1; Required for G1/S transition. Plays a role in DNA replication checkpoint signaling through regulating rad3 and cds1. Involved in the maintenance of mitotic chromosome structures during S phase through regulating the function of rad21. Required for initiation of mitotic DNA replication through phosphorylating mcm2/cdc19. Required for genome integrity; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily. (507 aa) |
| | rtn1 | Reticulon-like protein 1; Required for the correct positioning of the cellular division plane by delimiting the actomyosin ring assembly at the cell equator. Overexpression causes cell lysis. (308 aa) |
| | dad3 | DASH complex subunit dad3; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity). (86 aa) |
| | adf1 | Cofilin; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. Binding to F-actin is regulated by tropomyosin. It is the major component of intranuclear and cytoplasmic actin rods. Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends. In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments. Involved in the maintenance of the contractile ring once formed. In association with [...] (137 aa) |
| | mid1 | Division mal foutue 1 protein; At the onset of mitosis, forms a medial ring structure before the arrangement of the medial actin ring. Essential for the central positioning of the division septum before the cell divides. (920 aa) |
| | hus1 | Checkpoint protein hus1; Essential in controlling the S-M checkpoint that couples mitosis to the completion of DNA replication. It is also required for the response to DNA damage. (287 aa) |
| | slp1 | WD repeat-containing protein slp1; Required for mad2-dependent spindle checkpoint activation. Promotes ubiquitin-dependent degradation of cdc13 by the anaphase promoting complex/cyclosome (APC/C). (488 aa) |
| | spg1 | Septum-promoting GTP-binding protein 1; GTP-binding protein essential for the induction of septum formation at G2 and pre-START stages of mitosis. Acts via the cdc7 protein kinase pathway. (198 aa) |
| | pas1 | G1/S-specific cyclin pas1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the pef1 protein kinase. The pef1/pas1 complex activates the res2/cdc10 complex. (411 aa) |
| | cdr2 | Mitosis inducer protein kinase cdr2; Acts as a mitotic inducer. In G2 it negatively regulates wee1, a mitotic inhibitor. Also has a role in cytokinesis where it required for proper septum formation; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily. (775 aa) |
| | nif1 | Mitosis inhibitor nif1; Functions as a negative regulator of mitosis. It interacts with the C-terminal of nim1, thereby inhibiting its kinase activity which phosphorylates wee1. (681 aa) |
| | mad1 | Spindle assembly checkpoint component mad1; Central component of the spindle assembly checkpoint. Has a role in the correct positioning of the septum. Required for anchoring mad2 to the nuclear periphery. (689 aa) |
| | mis6 | Inner kinetochore subunit mis6; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. Required for the localization of cnp1 to the centromere ; Belongs to the CENP-I/CTF3 family. (672 aa) |
| | alp16 | Spindle pole body component alp16; Component of the gamma tubule complex that is required for the regulation of both interphase microtubules and mitotic bipolar spindles. (759 aa) |
| | kms1 | Karyogamy meiotic segregation protein 1; Has a role in karyogamy, recombination and segregation during meiosis. Although it has been shown to associate with the spindle pole body it is unlikely to be involved in its formation or maintenance. (607 aa) |
| | dad1 | DASH complex subunit dad1; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. Mediates interaction between the DASH and sim4 complexes leading to loading of DASH onto the kinetochore. (90 aa) |
| | cdc1 | DNA polymerase subunit delta-2; Required for replication of the leading DNA strand and for completion of lagging strand synthesis. It is essential for cell cycle progression. (462 aa) |
| | cdc42 | Cell division control protein 42 homolog; Involved in development of cell polarity during the cell division cycle; Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily. (192 aa) |
| | cdc8 | Tropomyosin; Forms part of the F-actin contractile ring during cytokinesis. (161 aa) |
| | spn2 | Septin homolog spn2; Plays a role in the cell cycle. Involved in a late stage of septum formation leading to the separation of the daughter cells. Involved in the correct orientation of forespore membrane extension during sporulation. Binds phosphatidylinositol 4-phosphate. (331 aa) |
| | cdc4 | Myosin regulatory light chain cdc4; Involved in cytokinesis. Required for the formation and function of the contractile ring. (141 aa) |
| | gef2 | Rho guanine nucleotide exchange factor gef2; Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth and septum formation. (1101 aa) |
| | pst1 | Paired amphipathic helix protein pst1; Has a role in modulating the nuclear import of TF1 virus-like particles. Essential for viability. (1522 aa) |
| | gef1 | Rho guanine nucleotide exchange factor gef1; Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth, via modulation of cdc42-shk1-orb6 signaling, and septum formation. Stimulates guanine nucleotide exchange of cdc42. (753 aa) |
| | cdc15 | Cell division control protein 15; After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Appears to mediate cytoskeletal rearrangements required for cytokinesis. Essential for viability. (927 aa) |
| | rep2 | Transcriptional activator protein rep2; Transcriptional activator which interacts with the mcb binding subunit complex formed by res2 and cdc10. Rep2 is required for the mitotic cell cycle start. (219 aa) |
| | sad1 | Spindle pole body-associated protein sad1; Associates with the spindle pole body and maintains a functional interface between the nuclear membrane and the microtubule motor proteins. Involved in chromosome segregation during meiosis where it associates with the telomeres. (514 aa) |
| | nnf1 | Kinetochore protein nnf1; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. (145 aa) |
| | spn6 | Septin homolog spn6; Septin-like protein involved in the correct orientation of forespore membrane extension during sporulation. (380 aa) |
| | sid2 | Serine/threonine-protein kinase sid2; Part of a signaling pathway. Required for initiation of medial ring constriction and septation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (607 aa) |
| | rho1 | GTP-binding protein rho1; Involved in the regulation of cell wall growth and actin cytoskeleton organization. Activates (1,3)-beta-D-glucan synthase. Belongs to the small GTPase superfamily. Rho family. (202 aa) |
| | cdc12 | Cell division control protein 12; Plays a role in the cell cycle. Involved in cytokinesis. Component of the cell division ring. In the absence of profilin, caps the barbed end of actin filaments, thus preventing subunit addition and dissociation. In the presence of profilin, nucleates actin filaments that grow rapidly from their barbed ends. Belongs to the formin homology family. BNI1 subfamily. (1841 aa) |
| | mal3 | Microtubule integrity protein mal3; May play a role in regulating the integrity of microtubules possibly by influencing their stability. Involved in an anchoring mechanism to maintain tea2 and tip1 at growing microtubule ends. Strongly stimulates the ATPase activity of tea2. Belongs to the MAPRE family. (308 aa) |
| | lkh1 | Dual specificity protein kinase lkh1; Protein kinase that may act as a negative regulator of filamentous growth and flocculation. Appears to have a role in normal cell wall and septum formation and in cell separation. May have antagonistic function in the regulation of beta-glucan distribution between the sites for cell wall and septum assembly. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. (690 aa) |
| | rmi1 | RecQ-mediated genome instability protein 1; Structure-specific DNA-binding protein with a preference for cruciform structures. Also binds single-stranded DNA (ssDNA). Functions together with top3 to maintain genome integrity. Essential for proper meiotic cell division. Required for normal S-phase progression and DNA damage response; Belongs to the RMI1 family. (235 aa) |
| | nsp1 | Nucleoporin nsp1; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope. Appears to have a role in the formation of the septum. (598 aa) |
| | nuf2 | Kinetochore protein nuf2; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Belongs to the NUF2 family. (441 aa) |
| | spo12 | Mitosis-specific protein spo12; Has a role in controlling mitotic cell cycle progression at the G2/M transition phase. (90 aa) |
| | ndc80 | Kinetochore protein ndc80; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Belongs to the NDC80/HEC1 family. (624 aa) |
| | imp2 | Septation protein imp2; Required for normal septation. Involved in the disassembly of the medial ring during septation. (670 aa) |
| | rng8 | Uncharacterized protein C4H3.14c. (345 aa) |
| | mac1 | Membrane-anchored protein 1; Required for correct cell separation at high temperatures; To yeast YOL019W and YMR063W. (756 aa) |
| | bgs1 | 1,3-beta-glucan synthase component bgs1; Required for the assembly of the division septum and maintenance of cell polarity. (1729 aa) |
| | mal2 | Inner kinetochore subunit mal2; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere- associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. (303 aa) |
| | mug8 | Meiotically up-regulated gene 8 protein; Has a role in meiosis and septation. (720 aa) |
| | cnd3 | Condensin complex subunit 3; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase; Belongs to the CND3 (condensin subunit 3) family. (875 aa) |
| | spc25 | Kinetochore protein spc25; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. (238 aa) |
| | acp1 | F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Competes with formin cdc12 for attachment to the actin filaments barbed ends. Slowly replaces cdc12 on the barbed ends in preparation for filament disassembly during contractile ring constriction. (256 aa) |
| | nod1 | Uncharacterized protein C12B10.10. (419 aa) |
| | gsk3 | Protein kinase gsk3; Interacts with cdc14 which is thought to play a role in the initiation and completion of mitosis. Involved in the positive regulation of mis12. (387 aa) |
| | spd1 | S-phase delaying protein 1; Regulates the ribonucleotide reductase activity through its mediation of the nuclear localization of suc22, the small subunit of the ribonucleotide reductase. Delays the progression of the G1-S phase transition, thereby ensuring the G1 phase is complete. Interacts with both p34 and the p34-p56 complex, although no direct inhibitory effect on the bound proteins has been demonstrated. The action of p14 may happen coincidentally with the cdc10 function or may happen downstream of this. (124 aa) |
| | byr4 | Protein byr4; Has an essential role in ensuring cytokinesis and septation occur only once during mitosis. It does so by interacting with the ras1 signaling pathways, thereby suppressing them; To yeast BFA1. (665 aa) |
| | cdt2 | Cell division cycle protein cdt2; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for DNA replication during mitosis and meiosis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of cdt1 and spd1. Involved in the regulation of mitotic and pre-meiotic S- phase progression. (490 aa) |
| | mcs6 | Serine/threonine-protein kinase crk1; Protein kinase essential for cell proliferation, where it is required for completion of cytokinesis. Phosphorylates the C-terminal repeat domain (CTD) of RNA polymerase II; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (335 aa) |
| | uvi31 | UV-induced protein uvi31; May be involved in control of cell division, especially during the resumption from cell cycle arrest; Belongs to the BolA/IbaG family. (102 aa) |
| | ppb1 | Serine/threonine-protein phosphatase 2B catalytic subunit; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Appears to be involved in cytokinesis, mating, transport, nuclear and spindle pole body positioning, and cell shape; Belongs to the PPP phosphatase family. PP-2B subfamily. (554 aa) |
| | spc19 | DASH complex subunit spc19; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. May be necessary for growth under high osmotic stress. (152 aa) |
| | dad4 | DASH complex subunit dad4; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. May be necessary for growth under high osmotic stress. (72 aa) |
| | rho4 | GTP-binding protein rho4; Required for cell separation. Involved in the regulation of the septum degradation during cytokinesis and in the organization of F- actin patches and cytoplasmic microtubules. Belongs to the small GTPase superfamily. Rho family. (203 aa) |
| | apc2 | Anaphase-promoting complex subunit 2; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome; Belongs to the cullin family. (681 aa) |
| | ibp1 | Dual specificity phosphatase ibp1; May play a role in DNA replication checkpoint via regulation of hsk1 or may act downstream of hsk1 in an S phase regulatory pathway. (138 aa) |
| | bqt1 | Telomere bouquet protein 1; Involved in chromosome segregation. During meiotic prophase, connects telomeres to the spindle pole body by forming a bridge between the telomere protein rap1 and the spindle pole body protein sad1. (132 aa) |
| | opy1 | Uncharacterized PH domain-containing protein PB16A4.02c. (339 aa) |
| | mis15 | Inner kinetochore subunit mis15; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. Has a role in the formation and/or maintenance of specialized chromatin at the centromere. (409 aa) |
| | ase1 | Anaphase spindle elongation protein 1; Required for anaphase spindle elongation and microtubule bundling in both interphase and mitosis. Has a role in spatial and temporal regulation of septation and cytokinesis and ensures equal partition of segregating sister chromatids. Ensures correct midzone positioning of protein kinase ark1. Acts as a regulatory component at cytokinesis checkpoint where it inhibits nuclear division when actomyosin ring formation is impaired. (731 aa) |
| | dam1 | DASH complex subunit dam1; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. (155 aa) |
| | pds5 | Sister chromatid cohesion protein pds5; Required for the establishment and maintenance of sister chromatid cohesion during S phase. Prevents their formation until eso1 is present. May also have a role during meiosis. (1205 aa) |
| | acp2 | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Competes with formin cdc12 for attachment to the actin filaments barbed ends. Slowly replaces cdc12 on the barbed ends in preparation for filament disassembly during contractile ring constriction. (268 aa) |
| | gas1 | 1,3-beta-glucanosyltransferase gas1; Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. (542 aa) |
| | apc5 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome; Belongs to the APC5 family. (744 aa) |
| | rng10 | Uncharacterized protein C688.07c. (1038 aa) |
| | mis14 | Kinetochore protein mis14; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Required for correct chromosome segregation where it has a role in the formation and/or maintenance of specialized chromatin at the centromere. (210 aa) |
| | uds1 | Up-regulated during septation protein 1; Involved in septation. (1052 aa) |
| | ask1 | DASH complex subunit ask1; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. Plays a role in meiosis. (307 aa) |
| | sgo1 | Shugoshin-1; Plays a central role in chromosome cohesion during meiosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by protecting centromeric rec8 from separase degradation during anaphase I. (319 aa) |
| | clp1 | Tyrosine-protein phosphatase CDC14 homolog; Protein phosphatase which antagonizes mitotic cyclin- dependent kinase cdc2, the inactivation of which is essential for exit from mitosis. To access its substrates, is released from nucleolar sequestration during mitosis. Plays an essential in coordinating the nuclear division cycle with cytokinesis through the cytokinesis checkpoint. Involved in chromosome segregation, where it is required for meiosis I spindle dissambly as well as for establishing two consecutive chromosome segregation phases. Allows damaged actomyosin rings to be maintaine [...] (537 aa) |
| | cdc123 | Cell division cycle protein 123; Regulates the cell cycle in a nutrient dependent manner. (319 aa) |
| | SPAC23G3.05c | Protein rax1; May be involved in cell polarization and division. (343 aa) |
| | mid2 | Septin ring organizing protein mid2; Responsible for the proper stability and function of septins during cytokinesis. Required for the correct formation of the medial septin ring structure in mitosis and for the proper localization of endo-glucanases agn1 and eng1, which are needed for efficient cell separation. May act as a landmark for the localization of hydrolytic proteins to the medial region. (706 aa) |
| | mis18 | Kinetochore protein mis18; Component of the CENP-A recruiting complex that ensures the integrity of mitotic spindles through maintenance of kinetochore factors mis6/CENP-I and cnp1/CENP-A. Maintains the deacetylated state of histones specifically in the central core of the centromeres. Belongs to the mis18 family. (194 aa) |
| | spo4 | Cell cycle protein kinase spo4; Required for the initiation of meiosis II and progression through anaphase II. (429 aa) |
| | cut4 | Anaphase-promoting complex subunit 1; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Mutations to this protein prevent the exit from mitosis; Belongs to the APC1 family. (1458 aa) |
| | fta2 | Inner kinetochore subunit fta2; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere- associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. Ft [...] (351 aa) |
| | bqt2 | Telomere bouquet protein 2; Involved in chromosome segregation. During meiotic prophase, connects telomeres to the spindle pole body by forming a bridge between the telomere protein rap1 and the spindle pole body protein sad1. (118 aa) |
| | myo2 | Myosin type-2 heavy chain 1; Required for cell division. It is a component of the cdc12 'spot', a structure thought to mark the site of septation. May work in conjunction with myo3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1526 aa) |
| | ags1 | Cell wall alpha-1,3-glucan synthase ags1; Required for alpha-1,3-glucan and alpha-1,4-glucan production which are required for cell wall synthesis. (2410 aa) |
| | dom34 | Protein dom34; Involved in protein translation. Together with hbs1, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. The complex formed by dom34 and hbs1 has ribonuclease activity towards double-stranded RNA substrates, but does not cleave single-stranded RNA. Acts as endonuclease; has no exonuclease activity. Increases the affinity of hbs1 for GTP, but nor for GDP. Promotes G1 progression and differentiation and is involved in mitotic and meiotic cell divisions [...] (390 aa) |
| | mto2 | Uncharacterized protein C902.06. (397 aa) |
| | alp6 | Spindle pole body component alp6; Component of the gamma tubule complex that is required for the regulation of both interphase microtubules and mitotic bipolar spindles; Belongs to the TUBGCP family. (832 aa) |
| | spc24 | Kinetochore protein spc24; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Belongs to the SPC24 family. (198 aa) |
| | eng1 | Endo-1,3(4)-beta-glucanase 1; Has a role in cell separation where it is required for the degradation of the primary septum after completion of cytokinesis. (1016 aa) |
| | mod21 | Gamma-tubulin complex subunit mod21; Component of the gamma-tubulin complex that is required for the regulation of both interphase microtubule organization and nucleation, and mitotic bipolar spindles. Required for correct septation. (677 aa) |
| | apc11 | Anaphase-promoting complex subunit 11; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. (94 aa) |
| | dad2 | DASH complex subunit dad2; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. May be necessary for growth under high osmotic stress. (94 aa) |
| | moa1 | Monopolar attachment protein 1; Plays an important role in chromosome segregation during meiosis I by allowing meiotic rec8 to establish cohesion at the centromeric central core and thereby promote the side-by-side structure of kinetochores at meiosis I. Enables monopolar attachment during meiosis I. Required to facilitate kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Acts in collaboration with plo1. (172 aa) |
| | fta6 | Inner kinetochore subunit fta6; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. (59 aa) |
| | etd1 | Septation protein etd1; Involved in septation. (391 aa) |
| | rgf2 | Rho1 guanine nucleotide exchange factor 2; Stimulates the exchange of Rho1 and Rho5 GDP-bound form into GTP-bound form. Controls septum formation, cell wall synthesis and localization of F-actin patches. (1158 aa) |
| | yop1 | Protein yop1; Required for the correct positioning of the cellular division plane by delimiting the actomyosin ring assembly at the cell equator. (182 aa) |
| | mis13 | Kinetochore protein mis13; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Required for correct segregation of chromosomes and for maintaining the inner centromere structure. (329 aa) |
| | rlc1 | Myosin regulatory light chain 1. (184 aa) |
| | hob3 | Protein hob3; Involved in cytokinesis and septation where it has a role in the localization of F-actin. (264 aa) |
| | alp4 | Spindle pole body component alp4; Component of the gamma tubule complex that is required for the regulation of both interphase microtubules and mitotic bipolar spindles. Required for correct septation; Belongs to the TUBGCP family. (784 aa) |
| | skp1 | Suppressor of kinetochore protein 1; Required for cig2 degradation in the G2 and M phases of the cell cycle. Together with pof6, essential for septum processing and cell separation. Involved in mitotic progression, essential for the execution of anaphase B; required for coordinated structural alterations of mitotic spindles and segregation of nuclear membrane structures at anaphase. Involved in the DNA damage checkpoint pathway and maintenance of genome integrity. Component of the RAVE complex which is required for stable assembly of the vacuolar ATPase complex V- ATPase. Belongs to th [...] (161 aa) |
| | mis12 | Centromere protein mis12; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Required for correct segregation of chromosomes and for maintaining the inner centromere structure; Belongs to the mis12 family. (259 aa) |
| | cnd2 | Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase in processes such as DNA repair. Belongs to the CND2 (condensin subunit 2) family. (742 aa) |
| | rgf3 | Rho1 guanine nucleotide exchange factor 3; Stimulates the exchange of Rho1 GDP-bound form into GTP-bound form. Regulates, via interaction and activation of Rho1, beta-1,3- glucan biosynthesis and cell wall integrity during septation. Involved in the regulation of contractile ring assembly. (1275 aa) |
| | rgf1 | Rho1 guanine nucleotide exchange factor 1; Stimulates the exchange of Rho1 and Rho5 GDP-bound form into GTP-bound form. Controls septum formation, cell wall synthesis and localization of F-actin patches. Coordinates actin deposition with cell wall biosynthesis during bipolar growth. (1334 aa) |
| | tts1 | Tetra-spanning protein 1; Required for the correct positioning of the cellular division plane by delimiting the actomyosin ring assembly at the cell equator. (279 aa) |
| | myo1 | Myosin-1; Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Contributes to proper septation by transporting vesicles containing septal material to the division site and is involved in the formation of sterol-rich membrane domains at the cell division site. Required also for mating. (1217 aa) |
| | naa25 | N-terminal acetyltransferase B complex subunit arm1; Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met. (811 aa) |
| | sos7 | Kinetochore protein Sos7; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Essential for chromosome segregation and bipolar sister chromatid association. Required for kinetochore targeting of MIND, but not Ndc80 complex components. (264 aa) |
