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| | csn5 | COP9 signalosome complex subunit 5; Catalytic Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes; Belongs to the peptidase M67A family. CSN5 subfamily. (299 aa) |
| | ubc15 | Ubiquitin-conjugating enzyme E2 15; Catalyzes the covalent attachment of ubiquitin to other proteins. Has a role in the formation of chromatin structures that influence the localization of transcriptional silencing factors. (167 aa) |
| | bye1 | Transcription factor bye1; Negative regulator of transcription elongation. Belongs to the BYE1 family. (721 aa) |
| | pib2 | FYVE-type zinc finger-containing protein C9B6.03. (293 aa) |
| | san1 | Uncharacterized RING finger protein C2A9.04c. (741 aa) |
| | skp1 | Suppressor of kinetochore protein 1; Required for cig2 degradation in the G2 and M phases of the cell cycle. Together with pof6, essential for septum processing and cell separation. Involved in mitotic progression, essential for the execution of anaphase B; required for coordinated structural alterations of mitotic spindles and segregation of nuclear membrane structures at anaphase. Involved in the DNA damage checkpoint pathway and maintenance of genome integrity. Component of the RAVE complex which is required for stable assembly of the vacuolar ATPase complex V- ATPase. Belongs to th [...] (161 aa) |
| | otu2 | Ubiquitin thioesterase otu2; Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. (324 aa) |
| | csn71 | COP9 signalosome complex subunit 7; Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin- protein ligase complexes; Belongs to the CSN7/EIF3M family. CSN7 subfamily. (205 aa) |
| | pas4 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. Belongs to the pex2/pex10/pex12 family. (306 aa) |
| | ubp11 | Ubiquitin carboxyl-terminal hydrolase 11. (350 aa) |
| | ctu2 | Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ctu1 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. Belongs to the CTU2/NCS2 family. (366 aa) |
| | uch2 | Ubiquitin carboxyl-terminal hydrolase 2; Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Belongs to the peptidase C12 family. (300 aa) |
| | ubp15 | Ubiquitin carboxyl-terminal hydrolase 21; Involved in regulating the steady-state levels of proteins including prp4. (1129 aa) |
| | ubc14 | Ubiquitin-conjugating enzyme E2 14; Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. (155 aa) |
| | SPAC144.05 | Uncharacterized ATP-dependent helicase C144.05. (1375 aa) |
| | dsc2 | DSC E3 ubiquitin ligase complex subunit 2; Component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post- endoplasmic reticulum pathway for protein degradation. (372 aa) |
| | pub2 | E3 ubiquitin-protein ligase pub2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Has a role in the G2/M transition. (671 aa) |
| | atg10 | Ubiquitin-like-conjugating enzyme ATG10; E2-like enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy and nucleophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for proper localization of ATG8 to the preautophagosomal structure (PAS). Likely serves as an ATG5-recognition molecule. (179 aa) |
| | uba5 | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric uba3-ula1 E1 enzyme. E1 activates NEDD8/ubl1 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of ubc12 (By similarity). (517 aa) |
| | apc11 | Anaphase-promoting complex subunit 11; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. (94 aa) |
| | msc1 | Multicopy suppressor of chk1 protein 1; Has a role in regulating chromatin structure via global deacetylation of histone H3. This function is associated with the activity of a histone deacetylase. (1588 aa) |
| | rfp2 | E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp2; Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Involved in maintaining genome stability where it acts in the cellular response to DNA damage. (205 aa) |
| | csn3 | COP9 signalosome complex subunit 3; Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin- protein ligase complexes. (338 aa) |
| | tif308 | Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (357 aa) |
| | fbh1 | F-box DNA helicase protein 1; Involved in ATP-dependent DNA-unwinding in a 3' to 5' direction, and ATP-ase activities stimulated by the single-stranded DNA-binding protein ssb1. Essential for viability and normal growth of stationary phase cells and in the absence of either srs2 or rqh1 DNA helicase. Involved in DNA recombination repair of strand breaks and stalled or collapsed replication forks, on the rhp51-dependent pathway: promotes rhp51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Ubiquitination and D [...] (878 aa) |
| | ubp10 | Probable mRNA-splicing protein ubp10; May play a role in mRNA splicing. It is unsure if the protein really exhibits hydrolase activity. Could be a competitor of ubiquitin C-terminal hydrolases (UCHs) (By similarity); Belongs to the peptidase C19 family. (502 aa) |
| | ckn1 | DNA excision repair protein ckn1; Adapter protein for ddb1/cullin 4 ubiquitin ligases involved in transcription-coupled nucleotide excision repair. (404 aa) |
| | ubp1 | Probable ubiquitin carboxyl-terminal hydrolase 1. (849 aa) |
| | itt1 | E3 ubiquitin-protein ligase itt1. (435 aa) |
| | cut4 | Anaphase-promoting complex subunit 1; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Mutations to this protein prevent the exit from mitosis; Belongs to the APC1 family. (1458 aa) |
| | gid9 | Protein fyv10; Involved in the proteasome-dependent degradation of fructose- 1,6-bisphosphatase; Belongs to the FYV10 family. (404 aa) |
| | ubp9 | Probable ubiquitin carboxyl-terminal hydrolase 9; Ubiquitin C-terminal hydrolase involved in regulating actin dynamics and/or endocytosis at cell tips and septa. Belongs to the peptidase C19 family. (585 aa) |
| | ubp7 | Probable ubiquitin carboxyl-terminal hydrolase 7. (875 aa) |
| | ubc8 | Ubiquitin-conjugating enzyme E2 8; Catalyzes the covalent attachment of ubiquitin to other proteins; Belongs to the ubiquitin-conjugating enzyme family. (184 aa) |
| | hop1 | Meiosis-specific protein hop1; Constituent of the linear elements (LE) during meiosis, the S.pombe equivalents of synaptonemal complexes. (528 aa) |
| | SPBP4H10.07 | Uncharacterized RING finger protein P4H10.07. (583 aa) |
| | mit1 | Chromatin remodeling factor mit1; Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC). (1418 aa) |
| | cwf24 | Pre-mRNA-splicing factor cwf24; Involved in mRNA splicing. (533 aa) |
| | vps11 | E3 ubiquitin-protein ligase pep5; Required for vacuolar biogenesis and for trafficking of hydrolase precursors to the vacuole. Mediates transport at the vacuolar membrane where it may be responsible for tethering transport vesicles on the target membranes. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase ypt7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion. Acts as component of the CORVET complex that is required for transport between [...] (906 aa) |
| | ubc16 | Ubiquitin-conjugating enzyme E2 16; Catalyzes the covalent attachment of ubiquitin to other proteins. (160 aa) |
| | apc5 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome; Belongs to the APC5 family. (744 aa) |
| | urm1 | Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target pr [...] (97 aa) |
| | dbl5 | Uncharacterized RING finger protein C548.05c. (468 aa) |
| | dbl4 | E3 ubiquitin-protein ligase dbl4; Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation. (504 aa) |
| | ubp2 | Probable ubiquitin carboxyl-terminal hydrolase 2. (1141 aa) |
| | knd1 | Cullin-associated NEDD8-dissociated protein 1; Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate- recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (Probable); Belongs to the CAND family. (1220 aa) |
| | atg4 | Probable cysteine protease atg4; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Cleaves the C-terminal amino acid of atg8 to reveal a C-terminal glycine. Atg8 ubiquitin-like activity requires the exposure of the glycine at the C- terminus for its conjugation t [...] (320 aa) |
| | sst2 | AMSH-like protease sst2; Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in the multivesicular body (MVB) sorting pathway. Required for ubiquitin- dependent sorting of proteins into the endosome and subsequent trafficking to the vacuole. May regulate MVB sorting through deubiquitination of ubiquitinated ESCRT proteins; Belongs to the peptidase M67C family. (435 aa) |
| | pib1 | Putative E3 ubiquitin-protein ligase C36B7.05c; Functions as an E3 ubiquitin-protein ligase. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate. (279 aa) |
| | SPBC800.12c | Uncharacterized ubiquitin-like protein C800.12c. (137 aa) |
| | csn2 | COP9 signalosome complex subunit 2; Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin- protein ligase complexes (By similarity). Required, indirectly, for activation of ribonucleotide reductase through the degradation of the protein spd1, thereby supplying deoxyribonucleotides for DNA replication and repair. (437 aa) |
| | dsc3 | DSC E3 ubiquitin ligase complex subunit 3; Component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post- endoplasmic reticulum pathway for protein degradation. Belongs to the dsc3 family. (250 aa) |
| | ufd2 | Ubiquitin conjugation factor E4; E4 ubiquitin chain-elongation enzyme specifically involved in polyubiquitin chain assembly. Binds to cdc48 and elongates mono- and diubiquitinated ERAD substrates presented by the ufd1-npl4-cdc48 (UNC) AAA ATPase complex to a chain length of 4 to 6 ubiquitin moieties. Delivers these polyubiquitinated substrates to downstream ERAD components, which target them to the proteasome. Enhances ubiquitination at 'Lys-48', but not at 'Lys-29' of the Ub moiety. (1010 aa) |
| | pof15 | F-box protein pof15; Probable substrate recognition component of a SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (243 aa) |
| | lid2 | Lid2 complex component lid2. (1513 aa) |
| | bop1 | Uncharacterized RING finger protein P32A8.03c. (513 aa) |
| | pub1 | E3 ubiquitin-protein ligase pub1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Regulates ubiquitination of cdc25. (767 aa) |
| | ubp6 | Ubiquitin carboxyl-terminal hydrolase 6; Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Belongs to the peptidase C19 family. USP14/UBP6 subfamily. (468 aa) |
| | sdu1 | DeSI-like protein sdu1; Has a role in meiosis; Belongs to the DeSI family. (201 aa) |
| | dcn1 | Defective in cullin neddylation protein 1; May contribute to neddylation of cullin components of SCF- type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity). (251 aa) |
| | pex12 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. (343 aa) |
| | apc2 | Anaphase-promoting complex subunit 2; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome; Belongs to the cullin family. (681 aa) |
| | sus1 | Transcription and mRNA export factor sus1; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex required for deubiquitination of [...] (108 aa) |
| | SPCC1223.01 | E3 ubiquitin-protein ligase hel2; Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation. (732 aa) |
| | sgf11 | SAGA-associated factor 11; Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA [...] (117 aa) |
| | nse1 | Non-structural maintenance of chromosomes element 1; Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis. (232 aa) |
| | nse2 | E3 SUMO-protein ligase nse2; Acts as an E3 ligase mediating SUMO/Smt3 attachment to other proteins. Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis. Belongs to the NSE2 family. (250 aa) |
| | SPBC15C4.06c | Uncharacterized RING finger membrane protein C15C4.06c. (556 aa) |
| | cti6 | Putative histone deacetylase complex subunit cti6; Could be a component of the RPD3C(L) histone deacetylase complex (HDAC). (424 aa) |
| | brl1 | E3 ubiquitin-protein ligase brl1; E3 ubiquitin-protein ligase which belongs to the histone H2B ubiquitin ligase complex (HULC) which mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. (692 aa) |
| | hul5 | Probable E3 ubiquitin protein ligase C167.07c; Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. (1029 aa) |
| | ubp14 | Ubiquitin carboxyl-terminal hydrolase 14. (775 aa) |
| | cdt2 | Cell division cycle protein cdt2; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for DNA replication during mitosis and meiosis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of cdt1 and spd1. Involved in the regulation of mitotic and pre-meiotic S- phase progression. (490 aa) |
| | SPAC12B10.01c | Probable ubiquitin fusion degradation protein C12B10.01c; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (1647 aa) |
| | set3 | SET domain-containing protein 3; Transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. Required for both gene activation and repression. Part of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis. Required for the transcriptional activation of genes with high activity (By similarity); Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET3 subfamily. (859 aa) |
| | dma1 | Probable E3 ubiquitin-protein ligase dma1; Probable E3 ubiquitin-protein ligase which is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is compromised. Inhibits the septation initiation netwok (SIN) during spindle checkpoint activation. The effect appears to be mediated through preventing the SIN activator, plo1 kinase, from localizing to the SPB. Belongs to the DMA1 family. (267 aa) |
| | btb3 | BTB/POZ domain-containing protein 3; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (523 aa) |
| | ucp6 | UBA domain-containing protein 6. (612 aa) |
| | uch1 | Probable ubiquitin carboxyl-terminal hydrolase 1; Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (By similarity). Belongs to the peptidase C12 family. (222 aa) |
| | snt2 | Lid2 complex component snt2. (1131 aa) |
| | cyp8 | Peptidyl-prolyl cis-trans isomerase cyp8; May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins; Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily. (516 aa) |
| | phf2 | SWM histone demethylase complex subunit phf2; Component of the SWM histone demethylase complex that specifically demethylates H3K9me2, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Has a role in regulating heterochromatin propagation and euchromatic transcription. (538 aa) |
| | ubp5 | Probable ubiquitin carboxyl-terminal hydrolase 5. (1108 aa) |
| | miy1 | Uncharacterized protein C12G12.11c; To yeast YGL082w. (365 aa) |
| | sea4 | Uncharacterized WD repeat-containing protein C12G12.01c; Belongs to the WD repeat mio family. (905 aa) |
| | pof11 | F-box/WD repeat-containing protein pof11; Has a role in meiosis. (506 aa) |
| | cph1 | Uncharacterized protein C16C9.05. (404 aa) |
| | mot2 | Putative general negative regulator of transcription C16C9.04c; May negatively regulate the basal and activated transcription of many genes. (489 aa) |
| | uba42 | Adenylyltransferase and sulfurtransferase uba4; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subseque [...] (401 aa) |
| | pan2 | PAN2-PAN3 deadenylation complex catalytic subunit pan2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent [...] (1088 aa) |
| | uba3 | NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric uba3-ula1 E1 enzyme. E1 activates NEDD8/ubl1 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-uba3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of ubc12 (By similarity). (444 aa) |
| | cul3 | Cullin-3; Probable core component of multiple cullin-RING-based BC3B (BTB-CUL3-BTB) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the BC3B complex depends on the substrate recognition component (By similarity). Involved in ubiquitin-mediated degradation of btb3. (785 aa) |
| | ubp8 | Probable ubiquitin carboxyl-terminal hydrolase 8. (449 aa) |
| | bun107 | UBP9-binding protein bun107; Required for the ubp9 recruitment to septa and cell tips but also for its enzymatic activity at these specific locations. (962 aa) |
| | cph2 | Uncharacterized protein C2F7.07c. (607 aa) |
| | mlo2 | Protein mlo2; Not known, interfere with mitotic chromosome segregation when overexpressed. (329 aa) |
| | SPAC16A10.03c | Pep5-like zinc finger protein C16A10.03c. (847 aa) |
| | SPCC4G3.12c | Uncharacterized RING finger protein C4G3.12c. (821 aa) |
| | phf1 | SWM histone demethylase complex subunit phf1; Component of the SWM histone demethylase complex that specifically demethylates H3K9me2, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Has a role in regulating heterochromatin propagation and euchromatic transcription. (461 aa) |
| | slx8 | E3 ubiquitin-protein ligase complex slx8-rfp subunit slx8; Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Acts as a critical suppressor of gross chromosomal rearrangements (GCRs) during normal cell cycle progression. Involved in stabilizing, restarting or resolving transiently stalled replication forks. Prevents accumulation of DNA damage during cell cycle progression (By similarity). (269 aa) |
| | SPAC57A7.09 | Uncharacterized RING finger protein C57A7.09. (372 aa) |
| | meu34 | RING finger protein mug145; Has a role in meiosis. (309 aa) |
| | pop1 | WD repeat-containing protein pop1; Involved in maintenance of ploidy through proteasome dependent degradation of CDK inhibitor rum1 and S-phase initiator cdc18. Functions as a recognition factor for rum1 and cdc18, which are subsequently ubiquitinated and targeted to the 26S proteasome for degradation. Together with pop2, required for cig2 instability during G2 and M phase and cig2 degradation in exponentially growing cells. Regulates cell-cycle progression under starvation through the rum1 protein. (775 aa) |
| | rad31 | DNA damage tolerance protein rad31; Could be involved in a ubiquitin-related process important for DNA damage tolerance. Acts in a process which is defective in the checkpoint rad mutants and which involves hus5. (307 aa) |
| | rhp16 | ATP-dependent helicase rhp16; Involved in global genome repair (GGR) via nucleotide excision repair (NER), in conjunction with rhp7, after UV irradiation. Belongs to the SNF2/RAD54 helicase family. (861 aa) |
| | ubc4 | Ubiquitin-conjugating enzyme E2 4; Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Mediates ubiquitination of PEX5. (147 aa) |
| | cut9 | Anaphase-promoting complex subunit cut9; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. May play a pivotal role in the control of anaphase. (671 aa) |
| | rpn11 | 26S proteasome regulatory subunit rpn11; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (308 aa) |
| | cps3 | Protein cps3; Responsible for supersensitivity to the spindle poison, isopropyl N-3-chlorophenyl carbamate. Has a role in meiosis. (583 aa) |
| | hus5 | SUMO-conjugating enzyme ubc9; Catalyzes the covalent attachment of ubiquitin-like protein SUMO/Smt3 to other proteins. Required for efficient recovery from DNA damage or S-phase arrest and normal mitosis. This may be as part of a checkpoint independent recovery process; Belongs to the ubiquitin-conjugating enzyme family. (157 aa) |
| | rad8 | DNA repair protein rad8; Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein rad18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats (By similarity). Plays a role in surviving topoisomerase-mediated DNA damage. (1133 aa) |
| | rhp6 | Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Component of the histone H2B ubiquitin ligase complex (HULC) which plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation (By similarity). Required for obr1 ubiquitination, whi [...] (151 aa) |
| | nuc2 | Anaphase-promoting complex subunit 3; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Interacts with spindle apparatus, chromosomes, or nuclear envelope, and interconnect nuclear and cytoskeletal functions in mitosis [...] (665 aa) |
| | ubi2 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa) |
| | ubi1 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa) |
| | ubi4 | Polyubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys [...] (382 aa) |
| | ubi5 | Ubiquitin-40S ribosomal protein S27b; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (150 aa) |
| | ubi3 | Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (150 aa) |
| | pmh1 | RNA polymerase II transcription factor B subunit 3; Acts as component of the general transcription and DNA repair factor IIH (TFIIH or factor B), which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase activity and DNA-dependent ATPase activity, and is essential for polymerase II transcription (By similarity). (318 aa) |
| | ptr3 | Ubiquitin-activating enzyme E1 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. (1012 aa) |
| | wss2 | Ubiquitin and WLM domain-containing metalloprotease SPCC1442.07c. (282 aa) |
| | cut23 | Anaphase-promoting complex subunit 8; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in promoting metaphase to anaphase transition via the ubiquitination of specific mitotic substrates. (565 aa) |
| | pli1 | E3 SUMO-protein ligase pli1; Acts as an E3 ligase mediating SUMO/Smt3 attachment to other proteins. Involved in the maintenance of the centromere and in telomere length. Regulates recombination, via extension sumoylation, particularly within the heterochromatin repeats. Belongs to the PIAS family. (727 aa) |
| | asr1 | PHD and RING finger domain-containing protein C126.07c. (571 aa) |
| | pof13 | F-box protein pof13. (396 aa) |
| | csn1 | COP9 signalosome complex subunit 1; Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin- protein ligase complexes (By similarity). Required, indirectly, for activation of ribonucleotide reductase through the degradation of the protein spd1, thereby supplying deoxyribonucleotides for DNA replication and repair; Belongs to the CSN1 family. (422 aa) |
| | lub1 | Ubiquitin homeostasis protein lub1; Acts as a negative regulator of vacuole-dependent ubiquitin degradation. (718 aa) |
| | ctu1 | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation; Belongs to the TtcA family. CTU1/NCS6/A [...] (335 aa) |
| | mug30 | Probable E3 ubiquitin-protein ligase mug30; Probable E3 ubiquitin-protein ligase. Has a role in meiosis. (807 aa) |
| | rnf10 | Uncharacterized RING finger protein P8B7.23. (673 aa) |
| | ubp3 | Probable ubiquitin carboxyl-terminal hydrolase 3. (512 aa) |
| | mpe1 | Uncharacterized RING finger protein P8B7.15c. (482 aa) |
| | nxt3 | Putative G3BP-like protein; Probable scaffold protein that may be involved in mRNA transport. (434 aa) |
| | mms2 | Ubiquitin-conjugating enzyme spm2; Has a role in the DNA error-free postreplication repair (PRR) pathway. Lacks catalytic activity by itself. The ubc13/spm2 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'; Belongs to the ubiquitin-conjugating enzyme family. (139 aa) |
| | pep3 | Vacuolar membrane protein pep3; Required for vacuolar biogenesis; Belongs to the VPS18 family. (900 aa) |
| | btb1 | BTB/POZ domain-containing protein 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (1347 aa) |
| | ubc1 | Ubiquitin-conjugating enzyme E2 1; Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER- membrane proteins with misfolded transmembrane domains (ERAD-M). (217 aa) |
| | btb2 | BTB/POZ domain-containing protein 2; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (284 aa) |
| | SPBC25B2.03 | Protein sip5; May negatively regulate the snf1 kinase; Belongs to the SIP5 family. (554 aa) |
| | nto1 | Mst2 complex subunit nto1; Component of the mst2 complex which is a highly specific H3 lysine 14 (H3K14) acetyltransferase that functions together with gcn5 to regulate global levels of H3K14 acetylation (H3K14ac), critical for DNA damage checkpoint activation. (767 aa) |
| | hrd1 | ERAD-associated E3 ubiquitin-protein ligase hrd1; E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of endoplasmic reticulum proteins (ERQC), also called ER- associated degradation (ERAD). Component of the hrd1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolde [...] (677 aa) |
| | ipa1 | Uncharacterized protein C1734.10c. (332 aa) |
| | rhp18 | Postreplication repair E3 ubiquitin-protein ligase rad18; E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme ubc2/rad6 to form the ubc2-rad18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA (By similarity). (387 aa) |
| | png2 | Chromatin modification-related protein png2; Component of the clr6 histone deacetylase complex I' responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Has a role in silencing of mating type genes. (305 aa) |
| | brl2 | E3 ubiquitin-protein ligase brl2; E3 ubiquitin-protein ligase which belongs to the histone H2B ubiquitin ligase complex (HULC) which mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. (680 aa) |
| | ubc12 | NEDD8-conjugating enzyme ubc12; Accepts the ubiquitin-like protein NEDD8/RUB1 from the UBA3- ULA1 E1 complex and catalyzes its covalent attachment to other proteins; Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily. (177 aa) |
| | SPCC1739.01 | Uncharacterized protein C1739.01. (547 aa) |
| | ubp16 | Probable ubiquitin carboxyl-terminal hydrolase 16. (457 aa) |
| | SPBC32F12.07c | Uncharacterized RING finger protein C32F12.07c. (340 aa) |
| | rkr1 | E3 ubiquitin-protein ligase listerin; E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to cdc48 recruitment for extraction and degradation of the incomplete translation product. (1610 aa) |
| | rrp2 | Uncharacterized ATP-dependent helicase C23E6.02. (1040 aa) |
| | ubr1 | E3 ubiquitin-protein ligase ubr1; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Belongs to the UBR1 family. (1958 aa) |
| | SPBC18H10.09 | Uncharacterized protein C18H10.09. (495 aa) |
| | ubp4 | Probable ubiquitin carboxyl-terminal hydrolase 4; Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Acts late in the proteolytic pathway in conjunction with the 26S proteasome. Plays a role in avoiding DNA overreplication (By similarity); Belongs to the peptidase C19 family. (593 aa) |
| | mrz1 | Uncharacterized RING finger protein C16G5.03. (268 aa) |
| | SPBC14F5.10c | LON peptidase N-terminal domain and RING finger protein C14F5.10c. (486 aa) |
| | doa10 | ERAD-associated E3 ubiquitin-protein ligase doa10; E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of a broad range of substrates, including endoplasmic reticulum membrane proteins (ERQC), soluble nuclear proteins and soluble cytoplasmic proteins (CytoQC). Component of the doa10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains. Als [...] (1242 aa) |
| | ubp12 | Probable ubiquitin carboxyl-terminal hydrolase 12. (979 aa) |
| | fab1 | 1-phosphatidylinositol 3-phosphate 5-kinase fab1; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. The product of the reaction it catalyzes functions as an important regulator of vacuole homeostasis perhaps by controlling membrane flux to and/or from the vacuole (By s [...] (1932 aa) |
| | gid2 | LisH domain-containing protein C29A3.03c. (398 aa) |
| | dsc1 | DSC E3 ubiquitin ligase complex subunit 1; Catalytic component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post- endoplasmic reticulum pathway for protein degradation. (695 aa) |
| | atg7 | Ubiquitin-like modifier-activating enzyme atg7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates atg12 for its conjugation with atg5 and atg8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the atg8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...] (649 aa) |
| | tif306 | Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (302 aa) |
| | nep1 | NEDD8-specific protease 1; Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as the pcu1, pcu2 and pcu4 cullins and other proteins. (420 aa) |
| | apc10 | Anaphase-promoting complex subunit 10; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Acts as a positive regulator of the anaphase promoting complex (APC)-cyclosome. Involved in G1 cell cycle arrest in response to n [...] (189 aa) |
| | SPBC1E8.02 | Uncharacterized ubiquitin-like protein C1E8.02. (603 aa) |
| | ulp1 | Ubiquitin-like-specific protease 1; A cysteine protease that proteolytically removes the C- terminus of pmt3. (568 aa) |
| | uba2 | Ubiquitin-activating enzyme E1-like; The dimeric enzyme acts as a SUMO/pmt3 E1 ligase. It mediates ATP-dependent activation of pmt3 and formation of a thioester with a conserved cysteine residue on aos1 (By similarity). (628 aa) |
| | png1 | Chromatin modification-related protein png1; Component of a histone deacetylase complex responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Has a role in silencing of mating type genes. (283 aa) |
| | rnf170 | Uncharacterized RING finger protein C23A1.07. (251 aa) |
| | cut20 | Anaphase-promoting complex subunit 4; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in promoting metaphase to anaphase transition via the ubiquitination of specific mitotic substrates. (719 aa) |
| | ubc6 | Ubiquitin-conjugating enzyme E2 6; Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the doa10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains. (227 aa) |
| | ats1 | RCC1 repeat-containing protein C10F6.04. (351 aa) |
| | ned8 | Ubiquitin-like protein 1; Belongs to the ubiquitin family. (78 aa) |
| | pub3 | E3 ubiquitin-protein ligase pub3; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (786 aa) |
| | pqr1 | Uncharacterized RING finger protein C6B12.07c. (470 aa) |
| | spp42 | Pre-mRNA-splicing factor spp42; Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures (By similarity). Required for pre- spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'- exon region. (2363 aa) |
| | sea2 | Uncharacterized WD repeat-containing protein C4F8.11. (846 aa) |
| | dsc4 | DSC E3 ubiquitin ligase complex subunit 4; Component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post- endoplasmic reticulum pathway for protein degradation. (281 aa) |
| | pop2 | WD repeat-containing protein pop2; Involved in maintenance of ploidy through proteasome dependent degradation of CDK inhibitor rum1 and S-phase initiator cdc18. Functions as a recognition factor for rum1 and cdc18, which are subsequently ubiquitinated and targeted to the 26S proteasome for degradation. Together with pop1, required for cig2 instability during G2 and M phase and cig2 degradation in exponentially growing cells. (703 aa) |
| | cul4 | Cullin-4; Required, indirectly, for activation of ribonucleotide reductase through the degradation of the protein spd1, thereby supplying deoxyribonucleotides for DNA replication and repair. Also has a role as a scaffold for assembling ubiquitin ligases. Component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochroma [...] (734 aa) |
| | SPAC2F3.16 | Uncharacterized RING finger protein C2F3.16. (425 aa) |
| | prp19 | Pre-mRNA-processing factor 19; Probable ubiquitin-protein ligase involved in pre-mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome. May also function in DNA repair. Belongs to the WD repeat PRP19 family. (488 aa) |
| | mug105 | Ubiquitin carboxyl-terminal hydrolase mug105; Deubiquitinase with endodeubiquitinase activity that preferentially cleaves 'Lys-48'-linked polyubiquitin chains. Shows only weak activity against 'Lys-63' and 'Lys-11'-linked chains. Has a role in meiosis ; Belongs to the peptidase C78 family. ZUFSP subfamily. (244 aa) |
| | otu1 | Putative ubiquitin thioesterase otu1; Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation (By similarity). Has a role in meiosis. (329 aa) |
| | rbx1 | RING-box protein pip1; Component of E3 ubiquitin ligase SCF complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recruit the E2 ubiquitination enzyme, like UBC3/CDC34, to the complex and brings it into close proximity to the substrate. Component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional s [...] (107 aa) |
| | csn4 | COP9 signalosome complex subunit 4; Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin- protein ligase complexes. (377 aa) |
| | ptr1 | E3 ubiquitin-protein ligase ptr1; Probable ubiquitin ligase protein involved in mRNA export. E3 ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Probably participates in mRNA export from the nucleus by regulating the transport of hnRNP proteins such as rae1; Belongs to the UPL family. TOM1/PTR1 subfamily. (3227 aa) |
| | rfp1 | E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp1; Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Involved in maintaining genome stability where it acts in the cellular response to DNA damage. Has a role in meiosis. (254 aa) |
| | sst4 | Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane. (610 aa) |
| | ddb1 | DNA damage-binding protein 1; Component of an E3 ubiquitin-protein ligase that includes cul4 (By similarity). Required for ubiquitination and the subsequent degradation of the DNA replication licensing factor cdt1 and of the ribonucleotide reductase inhibitor spd1. Also required for transcription-coupled nucleotide excision repair. (1072 aa) |
| | cul1 | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(pop1-pop2) is required for the maintenance of ploidy and directs ubiquitination of cig2; Belongs to the cullin family. (767 aa) |
| | ulp2 | Ubiquitin-like-specific protease 2. (638 aa) |
| | rrp1 | Uncharacterized ATP-dependent helicase C17A2.12. (897 aa) |
| | SPAC16E8.13 | RING finger protein ETP1 homolog; May act as a cytoplasmic retention protein with a role in regulating nuclear transport. (547 aa) |
| | ubr11 | E3 ubiquitin-protein ligase ubr11; Belongs to the UBR1 family. (2052 aa) |
| | sea3 | Uncharacterized RWD, RING finger and WD repeat-containing protein C11E3.05; May be involved in telomere capping. (1323 aa) |
| | ubc13 | Ubiquitin-conjugating enzyme E2 13; Has a role in the DNA error-free postreplication repair (PRR) pathway. The ubc13/spm2 heterodimer catalyzes the synthesis of non- canonical poly-ubiquitin chains that are linked through 'Lys-63'. Belongs to the ubiquitin-conjugating enzyme family. (148 aa) |
| | nep2 | NEDD8-specific protease 2; Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as the pcu1, pcu2 and pcu4 cullins and other proteins (By similarity). Has a role in meiosis; Belongs to the peptidase C48 family. (415 aa) |
| | pmt3 | Ubiquitin-like protein pmt3/smt3; Required for chromosome segregation where it may be involved in microtubule assembly. Loss of smt3 leads to an increase in telomere length; Belongs to the ubiquitin family. SUMO subfamily. (117 aa) |
| | ubc11 | Ubiquitin-conjugating enzyme E2-20 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins. (176 aa) |
| | ubc7 | Ubiquitin-conjugating enzyme E2-18 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the doa10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and of the hrd1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradatio [...] (166 aa) |
