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| | dcp2 | mRNA decapping complex subunit 2; Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense- mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body. (741 aa) |
| | ptr8 | General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ptr8, but not its helicase activity, is required f [...] (804 aa) |
| | dbr1 | Lariat debranching enzyme; Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover (By similarity); Belongs to the lariat debranching enzyme family. (478 aa) |
| | utp24 | rRNA-processing protein fcf1; Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly. Required for the early cleavage steps of 35S rRNA at the A(0), A(1), and A(2) sites (By similarity). Belongs to the UTP23/FCF1 family. FCF1 subfamily. (192 aa) |
| | pop6 | Uncharacterized protein new2. (95 aa) |
| | rna15 | Uncharacterized RNA-binding protein C644.16. (422 aa) |
| | rrp36 | rRNA biogenesis protein rrp36; Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity). (265 aa) |
| | eme1 | Crossover junction endonuclease eme1; Interacts with mus81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI). Belongs to the EME1/MMS4 family. (735 aa) |
| | nop9 | Nucleolar protein 9; RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit (By similarity); Belongs to the NOP9 family. (655 aa) |
| | sen2 | Probable tRNA-splicing endonuclease subunit sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant s [...] (380 aa) |
| | SPAC2F3.18c | Uncharacterized membrane protein C2F3.18c. (85 aa) |
| | pop8 | Probable ribonucleases P protein subunit pop8; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (108 aa) |
| | nhp2 | H/ACA ribonucleoprotein complex subunit nhp2; Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (By similarity). Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity). The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs (By similarity). The H/ACA snoRNP complex mediates pseudourid [...] (154 aa) |
| | rex3 | RNA exonuclease 3; 3' to 5' exoribonuclease required for proper 3' end maturation of MRP RNA and of the U5L snRNA; Belongs to the REXO1/REXO3 family. (540 aa) |
| | swt1 | Transcriptional protein swt1; Involved in transcription; Belongs to the SWT1 family. (465 aa) |
| | slx1 | Structure-specific endonuclease subunit slx1; Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for stem-loop (SL) and splayed arm Y structures. Introduces a single-strand cut in duplex DNA on the 3' side of a double-strand/single-strand junction with respect to the single-strand moving 3' to 5' away from the junction. Plays a critica [...] (271 aa) |
| | hop1 | Meiosis-specific protein hop1; Constituent of the linear elements (LE) during meiosis, the S.pombe equivalents of synaptonemal complexes. (528 aa) |
| | mtr3 | Exosome complex component mtr3; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm [...] (257 aa) |
| | pop4 | Probable ribonuclease P protein subunit 1; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (217 aa) |
| | dcp1 | mRNA-decapping enzyme subunit 1; Component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense- mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body; Belongs to the DCP1 family. (127 aa) |
| | Tf2-11 | Transposon Tf2-11 polyprotein. (1333 aa) |
| | dna2 | DNA replication ATP-dependent helicase/nuclease dna2; Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape fen1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit dna2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for fen1. Is a target of the intra-S phase checkpoint, associating with stalled replication forks when phosphorylated at Ser- 219 and preventing the stalled replication forks from reversing. Also involve [...] (1397 aa) |
| | tdp1 | Probable tyrosyl-DNA phosphodiesterase; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a sin [...] (536 aa) |
| | dom34 | Protein dom34; Involved in protein translation. Together with hbs1, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. The complex formed by dom34 and hbs1 has ribonuclease activity towards double-stranded RNA substrates, but does not cleave single-stranded RNA. Acts as endonuclease; has no exonuclease activity. Increases the affinity of hbs1 for GTP, but nor for GDP. Promotes G1 progression and differentiation and is involved in mitotic and meiotic cell divisions [...] (390 aa) |
| | utp13 | Probable U3 small nucleolar RNA-associated protein 13; Involved in nucleolar processing of pre-18S ribosomal RNA. (777 aa) |
| | rnh1 | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (264 aa) |
| | swd22 | Uncharacterized WD repeat-containing protein C824.04. (341 aa) |
| | SPAC824.03c | Uncharacterized protein C824.03c, mitochondrial. (247 aa) |
| | rmp1 | Ribonuclease MRP protein subunit rmp1; Functions as part of ribonuclease MRP (RNase MRP), which is involved in rRNA processing in mitochondria. (211 aa) |
| | pop100 | Ribonucleases P/MRP protein subunit pop1; Required for processing of 5.8S rRNA (short form) at site A3 and for 5' and 3' processing of pre-tRNA; Belongs to the POP1 family. (698 aa) |
| | yth1 | mRNA 3'-end-processing protein yth1; Component of the cleavage factor I (CF I) involved in pre- mRNA 3'-end processing; Belongs to the CPSF4/YTH1 family. (170 aa) |
| | rad50 | DNA repair protein rad50; Involved in DNA double-strand break (DSB) repair. Involved in mating type switching and has a role in choosing the sister chromatid for recombinational repair. Also has a role in telomere length maintenance. (1285 aa) |
| | nob1 | 20S-pre-rRNA D-site endonuclease nob1; Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm (By similarity). (388 aa) |
| | mkt1 | Uncharacterized protein C139.01c. (802 aa) |
| | pfs2 | Polyadenylation factor subunit 2; Required for 3'-end cleavage and polyadenylation of pre- mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle. (509 aa) |
| | SPAC11H11.03c | Smr domain-containing protein C11H11.03c. (206 aa) |
| | pop5 | Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences (By similarity). (139 aa) |
| | grc3 | Polynucleotide 5'-hydroxyl-kinase grc3; Polynucleotide 5'-kinase required for both rRNA processing and heterochromatic gene silencing. (736 aa) |
| | SPBC17A3.08 | Deoxyribonuclease Tat-D; Has both endo- and exonuclease activities. Incises double- stranded DNA without obvious specificity via its endonuclease activity and excises the DNA from the 3'-to 5'-end by its exonuclease activity. May have a role in apoptosis (By similarity). (312 aa) |
| | rec24 | Meiotic recombination protein rec24; Required for correct meiotic chromosome segregation and recombination. (350 aa) |
| | exo5 | Probable exonuclease V, mitochondrial; Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively (By similarity). (409 aa) |
| | SPBC9B6.11c | Probable RNA exonuclease C9B6.11c. (502 aa) |
| | snd1 | Staphylococcal nuclease domain-containing protein 1. (878 aa) |
| | mrp15 | 54S ribosomal protein L15, mitochondrial; Belongs to the ribonuclease III family. Mitochondrion- specific ribosomal protein mL57 subfamily. (210 aa) |
| | fan1 | Fanconi-associated nuclease 1 homolog; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions (By similarity). (703 aa) |
| | rpr2 | Ribonuclease P protein subunit rpr2; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 4 family. (107 aa) |
| | sen15 | Probable tRNA-splicing endonuclease subunit sen15; Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of th [...] (143 aa) |
| | rpm1 | Exoribonuclease II, mitochondrial; Required for intron-independent turnover and processing of mitochondrial RNA. Participates in 3'-mtRNA processing where it hydrolyzes single-stranded RNA or partially double-stranded RNA with 3'-single-stranded tails; Belongs to the RNR ribonuclease family. (957 aa) |
| | pog1 | DNA polymerase gamma; Involved in the replication of mitochondrial DNA. (1018 aa) |
| | uve1 | UV-damage endonuclease; Endonuclease for the repair of UV-irradiated DNA. Involved in the excision of cyclobutane pyrimidine dimers (CPD) and 6-4 pyrimidine pyrimidones (6-4PP) which forms the UV damage repair (UVDR) pathway. Functions also in oxidative damage repair in vivo. Provides back-up AP endonuclease activity to apn2 together with apn1. Belongs to the uve1/UvsE family. (599 aa) |
| | pnu1 | Nuclease 1, mitochondrial; This enzyme has both RNase and DNase activity. It degrades single-stranded DNA and RNA. (322 aa) |
| | rnh203 | Uncharacterized protein C12B10.15c. (147 aa) |
| | cce1 | Cruciform cutting endonuclease 1, mitochondrial; Capable of resolving Holliday junctions. Specific for 4-way junctions. Seems to be important for the maintenance of mitochondrial DNA. Cleaves fixed junctions at the point of strand exchange. Cleaves after 5'-CT-3' and 5'-TT-3' sequences. (258 aa) |
| | SPAC1F12.06c | Putative endonuclease C1F12.06c. (252 aa) |
| | rpp40 | Uncharacterized protein C6C3.09. (335 aa) |
| | SPAC22H10.05c | mRNA cleavage and polyadenylation factor clp1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation. (456 aa) |
| | pso2 | DNA cross-link repair protein pso2/snm1; Required for DNA interstrand cross-link repair. This requires cleavage of cross-linked DNA to generate DNA double strand breaks (DSBs). This protein may have 5' exonuclease activity on single- stranded and double-stranded DNA, which could be necessary for the processing of DNA double strand breaks prior to religation. (560 aa) |
| | pcf11 | Uncharacterized protein C4G9.04c. (638 aa) |
| | rnh201 | Ribonuclease H2 subunit A; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Participates in DNA replication. (326 aa) |
| | pta1 | mRNA cleavage and polyadenylation specificity factor complex subunit pta1; Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. (670 aa) |
| | rrp43 | Exosome complex component rrp43; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplas [...] (270 aa) |
| | trz1 | Ribonuclease Z 1; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. May be involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Belongs to the RNase Z family. (809 aa) |
| | rrp6 | Exosome complex exonuclease rrp6; Nuclear-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export t [...] (777 aa) |
| | nth1 | Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8- dihydroguanine (8-oxoG) DNA glycosylas [...] (355 aa) |
| | dcr1 | ATP-dependent helicase dcr1; Required for G1 arrest and mating in response to nitrogen starvation. Ago1 regulation of cytokinesis and cell cycle checkpoints occurs downstream of dcr1. Required, indirectly, for regulated hyperphosphorylation of cdc2. (1374 aa) |
| | rcl1 | Probable RNA 3'-terminal phosphate cyclase-like protein; Does not have cyclase activity. Plays a role in 40S- ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity); Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily. (363 aa) |
| | rec10 | Meiotic recombination protein rec10; Involved primarily in the early steps of meiotic recombination localized to chromosome III. (791 aa) |
| | iss1 | Pre-mRNA polyadenylation factor fip1; Pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase; Belongs to the FIP1 family. (344 aa) |
| | kri1 | Protein kri1; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity); Belongs to the KRI1 family. (598 aa) |
| | pan2 | PAN2-PAN3 deadenylation complex catalytic subunit pan2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent [...] (1088 aa) |
| | SPAC12G12.16c | Uncharacterized protein C12G12.16c. (496 aa) |
| | rrp4 | Exosome complex component rrp4; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm [...] (329 aa) |
| | mre11 | DNA repair protein rad32; Required for the repair of double strand breaks (DSB) caused by gamma and UV radiation. May work in conjunction with rhp51; Belongs to the MRE11/RAD32 family. (649 aa) |
| | cdb4 | Curved DNA-binding protein; A non-essential protein that preferentially binds curved DNA. Binds non-curved DNA with a much lower affinity; Belongs to the peptidase M24 family. (381 aa) |
| | eri1 | 3'-5' exonuclease eri1; RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Acts by degrading the 3'-overhangs of double- stranded short interfering RNAs (siRNAs). Represses the accumulation of heterochromatic siRNAs leading to negative regulation of the RNAi- mediated heterochromoatin assembly. Also involved in rRNA biogenesis, trimming the 5.8S ribosomal RNA (rRNA) from a slightly longer pre-5.8S RNA in the cytoplasm. (313 aa) |
| | swi10 | Mating-type switching protein swi10; Involved in termination of copy-synthesis during mating-type switching. Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Along with RAD16 forms an endonuclease that specifically degrades single-stranded DNA; Belongs to the ERCC1/RAD10/SWI10 family. (252 aa) |
| | mde2 | Mei4-dependent protein 2; Required for the formation of meiotic double-strand breaks and for the segregation of homologous centromeres during meiosis I. Interacts with the SFT and DSBC complexes, two subcomplexes involved in the formation of meiotic double-strand breaks. Stabilizes the SFT subcomplex on DSB sites and recruits the DSBC subcomplex onto DSB sites. (278 aa) |
| | mus81 | Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI). Belongs to the XPF family. (608 aa) |
| | apn2 | DNA-(apurinic or apyrimidinic site) lyase 2; DNA repair enzyme that cleaves apurinic/apyrimidinic (AP) sites and removes 3'-blocking groups present at single strand breaks of damaged DNA. Provides the majority of the AP-endonuclease (APE) activity. Repairs phleomycin D1-induced DNA damage. Plays a role in oxidative damage repair; Belongs to the DNA repair enzymes AP/ExoA family. (523 aa) |
| | trz2 | Ribonuclease Z 2, mitochondrial; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. May be involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Belongs to the RNase Z family. (678 aa) |
| | cdc20 | DNA polymerase epsilon catalytic subunit A; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2199 aa) |
| | rpp1 | Probable ribonuclease P protein subunit 3; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (235 aa) |
| | exo1 | Exodeoxyribonuclease 1; 5'->3' double-stranded DNA exonuclease that could act in a pathway that corrects mismatched base pairs. (571 aa) |
| | dhp1 | 5'-3' exoribonuclease 2; Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II (By similarity). Essential for vegetative cell growth and chromosome segregation. Possesses 5'->3' exoribonuclease activity. (991 aa) |
| | rec6 | Meiotic recombination protein rec6; Required for formation of the rec12-mediated double-strand breaks (DSBs) that initiate meiotic recombination. May be involved primarily in the early steps of meiotic recombination (Probable); Belongs to the TOP6B-like family. (260 aa) |
| | rec12 | Meiotic recombination protein rec12; Required for formation of the double-strand breaks (DSBs) that initiate meiotic recombination. Required for crossover recombination and chiasmatic segregation of chromosomes during meiosis I. Also involved in the faithful equational segregation of chromosomes during meiosis II. (345 aa) |
| | exo2 | 5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. Involved in the degradation of several hypomodified mature tRNA species and participates in the 5'-processing or the degradation of the snoRNA pr [...] (1328 aa) |
| | rad2 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | dis3 | Exosome complex exonuclease dis3; Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. [...] (970 aa) |
| | rad16 | DNA repair protein rad16; Endonuclease that specifically degrades single-stranded DNA and which is involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Required for double strand break-induced interchromosomal gene conversion. Belongs to the XPF family. (877 aa) |
| | cdc6 | DNA polymerase delta catalytic subunit; Catalytic component of DNA polymerase delta (DNA polymerase III) which participates in chromosomal DNA replication. Required during synthesis of the lagging DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork. Participates in leading strand synthesis during replication initiation and termination. Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Belongs to the DNA polymerase type-B family. (1086 aa) |
| | cdc27 | DNA polymerase delta subunit 3. (372 aa) |
| | rad13 | DNA repair protein rad13; Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair (Probable). (1112 aa) |
| | rad15 | General transcription and DNA repair factor IIH helicase subunit XPD; ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/rad15 is required for DNA opening. [...] (772 aa) |
| | pac1 | Double-strand-specific pac1 ribonuclease; Digests double-stranded RNA. Converts long double-stranded RNAs into short oligonucleotides, leaving 5'-phosphates on their cleavage products. Probably inhibits mating and meiosis by degrading a specific mRNA required for sexual development. (363 aa) |
| | cox1-I1b | Uncharacterized cox1 intron-1 45.6 kDa protein. (384 aa) |
| | cox1-I2b | Uncharacterized cox1 intron-2 37.2 kDa protein. (323 aa) |
| | rps2802 | 40S ribosomal protein S28-B. (68 aa) |
| | Tf2-8 | Transposon Tf2-8 polyprotein. (1333 aa) |
| | Tf2-7 | Transposon Tf2-7 polyprotein. (1333 aa) |
| | Tf2-12 | Transposon Tf2-12 polyprotein. (1333 aa) |
| | Tf2-9 | Transposon Tf2-9 polyprotein. (1333 aa) |
| | Tf2-6 | Transposon Tf2-6 polyprotein. (1333 aa) |
| | Tf2-5 | Transposon Tf2-5 polyprotein. (1333 aa) |
| | Tf2-4 | Transposon Tf2-4 polyprotein. (1333 aa) |
| | Tf2-3 | Transposon Tf2-3 polyprotein. (1333 aa) |
| | Tf2-2 | Transposon Tf2-2 polyprotein. (1333 aa) |
| | Tf2-1 | Transposon Tf2-1 polyprotein. (1333 aa) |
| | rps21 | 40S ribosomal protein S21; Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability. Belongs to the eukaryotic ribosomal protein eS21 family. (87 aa) |
| | SPMIT.06 | Uncharacterized 91 kDa protein in cob intron. (807 aa) |
| | edc3 | Enhancer of mRNA-decapping protein 3; Stimulates decapping of both stable and unstable mRNA during mRNA decay. Stimulates decapping presumably by preventing the DCP1-DCP2 decapping complex from adopting an inactive conformation. Belongs to the EDC3 family. (454 aa) |
| | rpa12 | DNA-directed RNA polymerase I subunit RPA12; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Required for growth at higher temperatures. Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (119 aa) |
| | bms1 | Ribosome biogenesis protein bms1; May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus; Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily. (1121 aa) |
| | rnh202 | Ribonuclease H2 subunit B; Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity). (293 aa) |
| | rex2 | Probable oligoribonuclease; 3'-to-5' exoribonuclease specific for small oligoribonucleotides; Belongs to the oligoribonuclease family. (252 aa) |
| | ire1 | Serine/threonine-protein kinase ppk4. (1072 aa) |
| | SPBC609.01 | Uncharacterized ribonuclease C609.01. (1157 aa) |
| | rex1 | Uncharacterized exonuclease C637.09. (631 aa) |
| | msi2 | Uncharacterized RNA-binding protein C660.15. (474 aa) |
| | tri1 | Uncharacterized protein C29A10.09c; Belongs to the CAF1 family. (427 aa) |
| | rex4 | RNA exonuclease 4; Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs (By similarity); Belongs to the REXO4 family. (260 aa) |
| | rpp21 | Uncharacterized protein C16C4.19. (184 aa) |
| | mpe1 | Uncharacterized RING finger protein P8B7.15c. (482 aa) |
| | pop7 | Ribonucleases P/MRP protein subunit POP7; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences (By similarity). Belongs to the histone-like Alba family. (102 aa) |
| | ctp1 | DNA endonuclease ctp1; Endonuclease that cooperates with the MRN complex in processing meiotic and mitotic double-strand breaks by allowing the endonucleolytic removal of rec12 from the break sites and ensuring both resection and intrachromosomal association of the broken ends. Required for the formation of RPA-coated single strand DNA adjacent to the DSBs where it functions together with the MRN complex in 5'- 3' resection. Required for the repair of programmed meiotic DSBs. Involved also in an rhp51 recombinase-dependent recombinational repair pathway. Belongs to the COM1/SAE2/CtIP family. (294 aa) |
| | ago1 | Protein argonaute; Required for G1 arrest and mating in response to nitrogen starvation. Ago1 regulation of cytokinesis and cell cycle checkpoints occurs downstream of dcr1. Required, indirectly, for regulated hyperphosphorylation of cdc2. Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation, accurate chromosome segregation, centromere cohesion and telomere function during mitosis and meiosis. Required for silencing at the centromeres and for initiation of transcriptionally silent heterochromatin at the mating type locus. Promotes histone H [...] (834 aa) |
| | tfx1 | Translin-associated protein X homolog; Belongs to the translin family. (231 aa) |
| | rrp45 | Exosome complex component rrp45; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplas [...] (291 aa) |
| | sen54 | Probable tRNA-splicing endonuclease subunit sen54; Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of th [...] (384 aa) |
| | ccr4 | Glucose-repressible alcohol dehydrogenase transcriptional effector; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA. Discovered because of its role in the control of ADH2 gene expression. It is required for the expression of genes involved in non-fermentative growth (By similarity); Belongs to [...] (690 aa) |
| | utp23 | rRNA-processing protein utp23; Involved in rRNA-processing and ribosome biogenesis. Belongs to the UTP23/FCF1 family. UTP23 subfamily. (260 aa) |
| | hnt3 | Aprataxin-like protein; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'- phosphate termini that can be efficiently rejoined. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, bu [...] (232 aa) |
| | caf1 | Poly(A) ribonuclease pop2; Acts as the catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. In vivo and in vitro, caf1 has 3'-exoribonuclease activity with a preference for poly(A) RNAs. (335 aa) |
| | cue2 | Smr domain-containing protein C1235.03. (502 aa) |
| | cft2 | Cleavage factor two protein 2; RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation- dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. May be involved in poly(A)-site recognition. May be involved in the association of the CPF, CPFIA and RNA polymerase II complexes (By similarity). (797 aa) |
| | cft1 | Protein cft1; RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation- dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation (By similarity); Belongs to the CFT1 family. (1441 aa) |
| | rpb9 | DNA-directed RNA polymerase II subunit RPB9; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity). Involved in the regulation o [...] (113 aa) |
| | ppn1 | Cleavage and polyadenylation factor complex subunit C74.02c; RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation- dependent pre-mRNA 3'-end formation. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation. (710 aa) |
| | cti1 | Exosome complex protein C1739.07; Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites (By similarity); Belongs to the C1D family. (133 aa) |
| | sts5 | Protein sts5; Required for the maintenance of cell shape during interphase. Required for localization of cortical actin to the growing tips before mitosis. (1066 aa) |
| | pop23 | Ribonucleases P/MRP protein subunit pop3; Required for processing of 5.8S rRNA (short form) at site A3 and for 5'- and 3'-processing of pre-tRNA. (201 aa) |
| | esf2 | Pre-rRNA-processing protein esf2; Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2 (By similarity); Belongs to the ESF2/ABP1 family. (334 aa) |
| | lcl3 | Probable endonuclease C19F8.04c. (230 aa) |
| | sen34 | Probable tRNA-splicing endonuclease subunit sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant [...] (284 aa) |
| | rpl701 | 60S ribosomal protein L7-C. (251 aa) |
| | rrp42 | Exosome complex component rrp42; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplas [...] (299 aa) |
| | enp1 | Uncharacterized protein C13G1.09; Belongs to the bystin family. (449 aa) |
| | cdm1 | DNA polymerase delta subunit 4; Appears to have a role in the stabilization of the DNA polymerase delta complex. (160 aa) |
| | csl4 | Exosome complex component csl4; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm [...] (181 aa) |
| | rhp14 | DNA repair protein rad14; Involved in nucleotide excision repair (NER). Functional in repair of ultraviolet radiation induced damages and in mitotic mutation avoidance. Binds damaged DNA. Binds specifically to base-base mismatches or small insertion/deletion loops with unpaired nucleotides. Maintains GT repeat stability. Functions as a part of the short-patch excision repair system. (289 aa) |
| | rrs1 | Ribosome biogenesis regulatory protein homolog; Involved in ribosomal large subunit assembly. (166 aa) |
| | mrpl3 | 54S ribosomal protein L3, mitochondrial; Belongs to the ribonuclease III family. Mitochondrion- specific ribosomal protein mL44 subfamily. (326 aa) |
| | ctf1 | Cleavage and termination factor 1; Component of the cleavage factor I (CF I) involved in pre- mRNA 3'-end processing. (363 aa) |
| | las1 | Pre-rRNA-processing protein las1; Required for both pre-rRNA processing and heterochromatic gene silencing. (470 aa) |
| | rrp46 | Exosome complex component rrp46; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplas [...] (226 aa) |
| | rrp41 | Exosome complex component ski6; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm [...] (242 aa) |
| | rna14 | mRNA 3'-end-processing protein rna14; Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation. (733 aa) |
| | mtr4 | ATP-dependent RNA helicase mtr4; Component of the TRAMP complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates (By similarity). Required for heterochromatic gene silencing at centromeric repeats by either exosome- or RNAi-mediated degradation of heterochromatic transcripts. (1117 aa) |
| | mpp6 | Uncharacterized protein UNK4.11c; Belongs to the MPP6 family. (188 aa) |
| | ast1 | Asteroid homolog 1. (519 aa) |
| | dis32 | DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. (927 aa) |
| | rrp17 | Ribosomal RNA-processing protein 17; Involved in ribosomal RNA processing; Belongs to the RRP17 family. (203 aa) |
| | tsr1 | Ribosome biogenesis protein tsr1; Required for 40S ribosomal subunit synthesis. Required for normal export of the pre-40S particles from the nucleus to the cytoplasm (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily. (783 aa) |
| | mpn1 | U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA; Belongs to the 2H phosphoesterase superfamily. USB1 family. (265 aa) |
| | rrp40 | Exosome complex component rrp40; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplas [...] (240 aa) |
| | rpc11 | DNA-directed RNA polymerase III subunit RPC10; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (109 aa) |
| | pdc1 | Uncharacterized protein C20G4.08. (1076 aa) |
| | din1 | Decapping nuclease din1; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA (By similarity). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates. Stimulates exoribonuclease activity of rat1, allowing it to degrade RNAs with stable secondary structure more [...] (352 aa) |
| | cid1 | Terminal uridylyltransferase cid1; Cytoplasmic uridylyltransferase that mediates the terminal uridylation of mRNAs with short poly(A) tails such as such as act1, hcn1 and urg1 mRNAs, hence facilitating global mRNA decay. Uridylates the 3' ends of actin mRNAs upon S-phase arrest. Has also a weak poly(A) polymerase (PAP) activity. Residue His-336 is responsible for the specificity for UTP. Involved in cell cycle arrest where in association with crb2/rhp9 and chk1 it inhibits unscheduled mitosis. (405 aa) |
| | ysh1 | Endoribonuclease ysh1; Component of the cleavage factor I (CF I) involved in pre- mRNA 3'-end processing; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily. (757 aa) |
