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| | atp18 | ATP synthase subunit J, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the centr [...] (60 aa) |
| | uge1 | UDP-glucose 4-epimerase uge1; Major UDP-glucose/-galactose 4-epimerase under glucose-rich conditions involved in protein galactosylation. (355 aa) |
| | sec59 | Dolichol kinase sec59; Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors. It is required for spore germination. Has an essential role in cellular metabolism (By similarity). Belongs to the polyprenol kinase family. (504 aa) |
| | SPCC1450.15 | Uncharacterized protein C1450.15; Acts in the GPI biosynthetic pathway between GlcNAc-PI synthesis and GPI transfer to protein. Required for the formation of complete GPI precursors CP1 and CP2 (By similarity). (494 aa) |
| | gpi15 | Phosphatidylinositol N-acetylglucosaminyltransferase subunit gpi15; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis; Belongs to the PIGH family. (160 aa) |
| | nus1 | Dehydrodolichyl diphosphate synthase complex subunit nus1; With SPAC4D7.04c, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). (258 aa) |
| | alg3 | Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol; Belongs to the glycosyltransferase 58 family. (406 aa) |
| | ade5 | Phosphoribosylglycinamide formyltransferase; Belongs to the GART family. (207 aa) |
| | pet1 | Uncharacterized transporter C22F8.04. (383 aa) |
| | SPAC630.12 | Uncharacterized protein C630.12. (422 aa) |
| | ade7 | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (299 aa) |
| | och1 | Initiation-specific alpha-1,6-mannosyltransferase; Mannosyltransferase involved in outer chain elongation of asparagine-linked oligosaccharides of the type Man(9)GlcNAc(2). May otherwise add the first alpha-1,6-mannose to the Man(8)GlcNAc(2) core oligosaccharide from the ER. Represents the first enzymatic event required for synthesis of outer chain mannose linkages on yeast secretory proteins. (396 aa) |
| | gwt1 | GPI-anchored wall transfer protein 1; Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor (By similarity). Has a role in meiosis. (459 aa) |
| | pmm1 | Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. (257 aa) |
| | hal3 | Probable thymidylate synthase; Required for both nuclear and mitochondrial DNA synthesis. In the N-terminal section; belongs to the HFCD (homo- oligomeric flavin containing Cys decarboxylase) superfamily. (625 aa) |
| | ura2 | Probable dihydroorotase. (337 aa) |
| | erd1 | Protein ERD1 homolog 1; Required for the retention of luminal endoplasmic reticulum proteins, affects glycoprotein processing in the Golgi apparatus. Belongs to the ERD1 family. (373 aa) |
| | yfh7 | Putative uridine kinase C227.14. (235 aa) |
| | tyw3 | tRNA wybutosine-synthesizing protein 3; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72 (By similarity). (237 aa) |
| | imt2 | Inositol phosphoceramide mannosyltransferase 2; With imt1 and imt3, is required for the synthesis of mannosyl phosphorylinositol ceramide (MIPC). Catalyzes the addition of mannosyl to phosphorylinositol ceramide (IPC). MIPC is essential for cell morphology, cell-surface distribution of ergosterol, localization for plasma-membrane transporters, and lipid-raft-mediated endocytosis of plasma membrane proteins to the vacuole; Belongs to the glycosyltransferase 32 family. (345 aa) |
| | gda1 | Guanosine-diphosphatase; After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol; Belongs to the GDA1/CD39 NTPase family. (556 aa) |
| | pvg3 | Beta-1,3-galactosyltransferase pvg3; Involved in cell wall biogenesis. Has a role in the addition of Gal-beta1,3 moeities to galactomannans and their subsequent pyruvylation. Has a role in meiosis. (378 aa) |
| | dpm2 | Dolichol phosphate-mannose biosynthesis regulatory protein; Regulates the biosynthesis of dolichol phosphate-mannose. Essential for the ER localization and stable expression of dpm1 (By similarity). (72 aa) |
| | gpi8 | GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity). (380 aa) |
| | ynd1 | Golgi apyrase; Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates. Required for Golgi glycosylation and cell wall integrity. Involved in N-mannosylation of proteins in Golgi. (572 aa) |
| | gpi10 | GPI mannosyltransferase 3; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly (By similarity). (506 aa) |
| | ppc1 | Uncharacterized protein C4B3.18. (316 aa) |
| | gbs1 | Glucosidase 2 subunit beta; Subunit of glucosidase 2, which cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins in the endoplasmic reticulum (ER). Specifically required for the cleavage of the final glucose. The subunit beta retains the catalytic subunit alpha in the ER. (506 aa) |
| | alg12 | Probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase; Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation; Belongs to the glycosyltransferase 22 family. (546 aa) |
| | gls2 | Glucosidase 2 subunit alpha; Catalytic subunit of glucosidase 2, which cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. (923 aa) |
| | gaa1 | GPI transamidase component gaa1; Component of the GPI transamidase complex. Required for a terminal step of GPI anchor attachment onto proteins (By similarity). (581 aa) |
| | urg2 | Putative uracil phosphoribosyltransferase urg2; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate; Belongs to the UPRTase family. (204 aa) |
| | tim11 | ATP synthase subunit e, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (92 aa) |
| | acl1 | Probable ATP-citrate synthase subunit 1; Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols. Belongs to the succinate/malate CoA ligase alpha subunit family. (615 aa) |
| | alg9 | Alpha-1,2-mannosyltransferase alg9; Catalyzes the transfer of mannose from Dol-P-Man to lipid- linked oligosaccharides. (577 aa) |
| | mns1 | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; Involved in glycoprotein quality control as it is important for the targeting of misfolded glycoproteins for degradation. It trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2) with low efficiency. (521 aa) |
| | gua2 | GMP synthase [glutamine-hydrolyzing]. (539 aa) |
| | atp16 | ATP synthase subunit delta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the c [...] (167 aa) |
| | gpi14 | GPI mannosyltransferase 1; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN- acyl-PI during GPI precursor assembly. Required for cell wall integrity (By similarity). (371 aa) |
| | dut1 | Probable deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (140 aa) |
| | pkp1 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial; Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism. (425 aa) |
| | pga3 | Protein PER1 homolog; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for efficient transport of GPI-anchor proteins (By similarity). Belongs to the PGAP3/PER1 family. (331 aa) |
| | guk1 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP; Belongs to the guanylate kinase family. (202 aa) |
| | omh6 | O-glycoside alpha-1,2-mannosyltransferase homolog 6; Probable mannosyltransferase involved in O-glycosylation of cell wall and secreted proteins; Belongs to the glycosyltransferase 15 family. (298 aa) |
| | uck2 | Uracil phosphoribosyltransferase 2; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (220 aa) |
| | cwh43 | Protein cwh43; Involved in the maintenance of cell wall integrity. Required for the replacement of the diacylglycerol moiety by ceramides during GPI-anchor maturation (By similarity); In the N-terminal section; belongs to the PGAP2 family. (971 aa) |
| | gpi12 | Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase; Involved in the second step of GPI biosynthesis. De-N- acetylation of N-acetylglucosaminyl-phosphatidylinositol (By similarity); Belongs to the PIGL family. (248 aa) |
| | gal7 | Galactose-1-phosphate uridylyltransferase; Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. (369 aa) |
| | gal10 | Bifunctional protein gal10; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity); In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. (713 aa) |
| | gal1 | Galactokinase; Belongs to the GHMP kinase family. GalK subfamily. (519 aa) |
| | ogm2 | Dolichyl-phosphate-mannose--protein mannosyltransferase 2; Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. (739 aa) |
| | alg2 | Alpha-1,3/1,6-mannosyltransferase alg2; Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. (506 aa) |
| | omh5 | O-glycoside alpha-1,2-mannosyltransferase homolog 5; Probable mannosyltransferase involved in O-glycosylation of cell wall and secreted proteins; Belongs to the glycosyltransferase 15 family. (421 aa) |
| | ost4 | Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase 4 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation [...] (32 aa) |
| | its8 | GPI ethanolamine phosphate transferase 1; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily. (935 aa) |
| | eos1 | N-glycosylation protein eos1; Involved in N-glycosylation; Belongs to the EOS1 family. (209 aa) |
| | ost3 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (309 aa) |
| | pda1 | Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (409 aa) |
| | alg8 | Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity). Belongs to the ALG6/ALG8 glucosyltransferase family. (501 aa) |
| | gmh3 | Alpha-1,2-galactosyltransferase gmh3; Involved in the galactosylation of the N-linked core oligosaccharide Man(9)GlcNAc(2); Belongs to the glycosyltransferase 34 family. (332 aa) |
| | gpi17 | GPI transamidase component PIG-S homolog; Component of the GPI transamidase complex. Involved in transfer of GPI to proteins (By similarity); Belongs to the PIGS family. (554 aa) |
| | cab4 | Uncharacterized protein C1F12.08; To yeast YGR277c. (316 aa) |
| | imt3 | Inositol phosphoceramide mannosyltransferase 3; With imt1 and imt2, is required for the synthesis of mannosylinositol phosphoceramide (MIPC). Catalyzes the addition of mannosyl to inositol phosphoceramide (IPC). MIPC is essential for cell morphology, cell-surface distribution of ergosterol, localization for plasma-membrane transporters, and lipid-raft-mediated endocytosis of plasma membrane proteins to the vacuole; Belongs to the glycosyltransferase 32 family. (356 aa) |
| | alg10 | Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol; Belongs to the ALG10 glucosyltransferase family. (445 aa) |
| | cmr2 | Uncharacterized protein C56F8.02. (1517 aa) |
| | ost1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (450 aa) |
| | smp3 | GPI mannosyltransferase 4; Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is essential in fungi (By similarity). (533 aa) |
| | trm12 | tRNA wybutosine-synthesizing protein 2; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86 (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family. (418 aa) |
| | mta1 | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (307 aa) |
| | ura1 | Glutamine-dependent carbamoyl-phosphate synthase; This protein is a 'fusion' protein encoding three enzymatic activities of the pyrimidine pathway (GATase, CPSase, and ATCase). In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily. (2244 aa) |
| | gpi7 | GPI ethanolamine phosphate transferase 2; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose (By similarity). (758 aa) |
| | atp20 | ATP synthase subunit g, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (118 aa) |
| | mug62 | Meiotically up-regulated gene 62 protein; Has a role in meiosis. (1487 aa) |
| | SPAC1296.01c | Phosphoacetylglucosamine mutase 2; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins. (542 aa) |
| | gup1 | Putative membrane-bound O-acyltransferase C24H6.01c. (583 aa) |
| | gfa1 | Probable glutamine--fructose-6-phosphate aminotransferase [isomerizing]; Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins). (696 aa) |
| | gpi18 | GPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Responsible for the transfer of the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity); Belongs to the PIGV family. (464 aa) |
| | SPAC13C5.05c | Phosphoacetylglucosamine mutase 1; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins. (518 aa) |
| | gmh2 | Probable alpha-1,2-galactosyltransferase gmh2. (346 aa) |
| | otg1 | Uncharacterized protein C5H10.12c. (371 aa) |
| | gmh1 | Probable alpha-1,2-galactosyltransferase gmh1. (329 aa) |
| | gma12 | Alpha-1,2-galactosyltransferase; Involved in the O- and N-linked oligosaccharide modification of proteins transported through the Golgi stack. This occurs in cis Golgi where the enzyme transfers galactose from UDP-galactose to a variety of mannose based acceptors. (375 aa) |
| | pdb1 | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (366 aa) |
| | gpt1 | UDP-glucose:glycoprotein glucosyltransferase; Selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER. Unfolded, denatured glycoproteins are substantially better substrates for glucosylation by this enzyme than are the corresponding native proteins. This protein and transient glucosylation may be involved in monitoring and/or assisting the folding and assembly of newly made glycoproteins, in order to identify glycoproteins that need assistance in folding from chaperones; Belongs to the glycosyltransferase 8 family. (1448 aa) |
| | ade2 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Belongs to the adenylosuccinate synthetase family. (434 aa) |
| | atp15 | Putative ATP synthase subunit epsilon, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechan [...] (67 aa) |
| | gpi3 | Phosphatidylinositol N-acetylglucosaminyltransferase gpi3 subunit; Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. (456 aa) |
| | prs5 | Ribose-phosphate pyrophosphokinase 5; 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (By similarity); Belongs to the ribose-phosphate pyrophosphokinase family. (341 aa) |
| | ado1 | Adenosine kinase. (340 aa) |
| | cut6 | Acetyl-CoA carboxylase; Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. (2280 aa) |
| | gmh5 | Uncharacterized alpha-1,2-galactosyltransferase C637.06. (347 aa) |
| | acs1 | Probable acetyl-coenzyme A synthetase. (662 aa) |
| | ada1 | AMP deaminase; AMP deaminase plays a critical role in energy metabolism; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (831 aa) |
| | ndk1 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (151 aa) |
| | gpt2 | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; Catalyzes the initial step in the synthesis of dolichol-P-P- oligosaccharides; Belongs to the glycosyltransferase 4 family. (446 aa) |
| | SPAC4A8.14 | Ribose-phosphate pyrophosphokinase 1; 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (By similarity); Belongs to the ribose-phosphate pyrophosphokinase family. (409 aa) |
| | ade4 | Amidophosphoribosyltransferase. (533 aa) |
| | suc22 | Ribonucleoside-diphosphate reductase small chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (391 aa) |
| | cdc22 | Ribonucleoside-diphosphate reductase large chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (811 aa) |
| | tmp1 | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP. (210 aa) |
| | adk1 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (220 aa) |
| | ura3 | Dihydroorotate dehydrogenase (quinone), mitochondrial; In the de novo pyrimidine biosynthesis pathway, catalyzes the stereospecific oxidation of (S)-dihydroorotate to orotate with reduction of flavin and the transfer of electrons to ubiquinone, which is part of the repiratory chain. Does not use fumarate and NAD as electron acceptors; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (443 aa) |
| | vma1 | V-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (619 aa) |
| | chs1 | Chitin synthase 1; Plays a major role in cell wall biogenesis. (859 aa) |
| | atp1 | ATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...] (536 aa) |
| | atp2 | ATP synthase subunit beta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the c [...] (525 aa) |
| | atp9 | ATP synthase subunit 9, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the centr [...] (74 aa) |
| | atp8 | ATP synthase protein 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] (48 aa) |
| | atp6 | ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] (257 aa) |
| | ade1 | Phosphoribosylformylglycinamidine cyclo-ligase; In the N-terminal section; belongs to the GARS family. (788 aa) |
| | ade6 | Phosphoribosylaminoimidazole carboxylase; In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily. (552 aa) |
| | ura4 | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (264 aa) |
| | cyr1 | Adenylate cyclase; Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP. (1692 aa) |
| | tpi1 | Triosephosphate isomerase; Belongs to the triosephosphate isomerase family. (249 aa) |
| | pdx1 | Probable pyruvate dehydrogenase protein X component, mitochondrial; Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex (By similarity). (456 aa) |
| | dpm3 | Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate-mannose synthase complex. (90 aa) |
| | gmh6 | Uncharacterized alpha-1,2-galactosyltransferase C1289.13c. (375 aa) |
| | uap1 | Probable UDP-N-acetylglucosamine pyrophosphorylase. (475 aa) |
| | omh4 | O-glycoside alpha-1,2-mannosyltransferase homolog 4; Probable mannosyltransferase involved in O-glycosylation of cell wall and secreted proteins. Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha- (1->2)-D-mannosyl-D-mannose linkage; Belongs to the glycosyltransferase 15 family. (440 aa) |
| | pbn1 | Protein pbn1; Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase gpi14 (By similarity). (332 aa) |
| | SPCC1620.06c | Ribose-phosphate pyrophosphokinase 2; 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (By similarity); Belongs to the ribose-phosphate pyrophosphokinase family. (321 aa) |
| | atp7 | ATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (175 aa) |
| | gpi16 | GPI transamidase component PIG-T homolog; Component of the GPI transamidase complex. Involved in transfer of GPI to proteins (By similarity). (545 aa) |
| | atp17 | ATP synthase subunit f, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the centr [...] (96 aa) |
| | atp4 | ATP synthase subunit 4, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (244 aa) |
| | stt3 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt3; Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation [...] (752 aa) |
| | ura5 | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP); Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. (215 aa) |
| | arg4 | Carbamoyl-phosphate synthase arginine-specific large chain; Belongs to the CarB family. (1160 aa) |
| | rft1 | Oligosaccharide translocation protein rft1; May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane; Belongs to the RFT1 family. (527 aa) |
| | ptk1 | Pantothenate kinase; Plays a role in the physiological regulation of the intracellular CoA concentration. (403 aa) |
| | swp1 | Uncharacterized protein C553.06. (271 aa) |
| | ade10 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Belongs to the PurH family. (585 aa) |
| | alg11 | GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. (471 aa) |
| | fmn1 | Riboflavin kinase; Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme. (163 aa) |
| | the4 | Uncharacterized protein C26H8.11c. (175 aa) |
| | chs2 | Chitin synthase-like protein 2; Plays a role in septum formation. Has no chitin synthase activity; Belongs to the chitin synthase family. (926 aa) |
| | atp3 | ATP synthase subunit gamma, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...] (301 aa) |
| | anp1 | Mannan polymerase II complex anp1 subunit; The M-Pol II complex possesses alpha-1,6-mannosyltransferase activity and is probably involved in the elongation of the mannan backbone of N-linked glycans on cell wall and periplasmic proteins. (430 aa) |
| | omh3 | O-glycoside alpha-1,2-mannosyltransferase homolog 3; Probable mannosyltransferase involved in O-glycosylation of cell wall and secreted proteins; Belongs to the glycosyltransferase 15 family. (378 aa) |
| | mpg1 | Mannose-1-phosphate guanyltransferase; Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint. Required for the correct assembly of the septum. Belongs to the transferase hexapeptide repeat family. (363 aa) |
| | atp5 | ATP synthase subunit 5, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the centr [...] (216 aa) |
| | pgm2 | Probable phosphoribomutase; Converts ribose 1-phosphate to ribose 5-phosphate. Involved in ribose salvage via the pentose phosphate pathway. Belongs to the phosphohexose mutase family. (587 aa) |
| | urk1 | Uridine kinase; Catalyzes the conversion of uridine into UMP and cytidine into CMP in the pyrimidine salvage pathway. (454 aa) |
| | cab5 | Uncharacterized protein C14G10.01. (236 aa) |
| | omh1 | O-glycoside alpha-1,2-mannosyltransferase omh1; Mannosyltransferase involved in O-glycosylation of cell wall and secreted proteins. Plays a major role in extending alpha-1,2-linked mannose in the O-glycan pathway; Belongs to the glycosyltransferase 15 family. (390 aa) |
| | ppm2 | tRNA wybutosine-synthesizing protein 4; Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues (By similarity); Belongs to the methyltransferase superfamily. LCMT family. (681 aa) |
| | ade8 | Adenylosuccinate lyase. (482 aa) |
| | mpg2 | Probable mannose-1-phosphate guanyltransferase; Involved in cell wall synthesis where it is required for glycosylation; Belongs to the transferase hexapeptide repeat family. (414 aa) |
| | alg5 | Dolichyl-phosphate beta-glucosyltransferase. (322 aa) |
| | wbp1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit wbp1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (437 aa) |
| | SPCC965.14c | Probable cytosine deaminase; Converts cytosine to uracil or 5-methylcytosine to thymine by deaminating carbon number 4; Belongs to the cytidine and deoxycytidylate deaminase family. (162 aa) |
| | lat1 | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (483 aa) |
| | gpi2 | Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis; Belongs to the PIGC family. (324 aa) |
| | ura6 | Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (191 aa) |
| | tyw1 | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase; Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity); Belongs to the TYW1 family. (688 aa) |
| | SPCC1020.07 | Putative uncharacterized hydrolase C1020.07. (236 aa) |
| | pdf1 | Palmitoyl-protein thioesterase-dolichyl pyrophosphate phosphatase fusion 1; Essential protein. Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during vacuolar degradation. Required for efficient N- glycosylation. Necessary for maintaining optimal levels of dolichol- linked oligosaccharides; In the N-terminal section; belongs to the palmitoyl-protein thioesterase family. (622 aa) |
| | atp14 | ATP synthase subunit H, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the centr [...] (103 aa) |
| | otg3 | Uncharacterized protein C4C3.09. (376 aa) |
| | otg2 | Meiotically up-regulated gene 136 protein; Has a role in meiosis. (372 aa) |
| | alg6 | Probable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol (By similarity); Belongs to the ALG6/ALG8 glucosyltransferase family. (506 aa) |
| | mpi1 | Mannose-6-phosphate isomerase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. (412 aa) |
| | dcd1 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. Belongs to the cytidine and deoxycytidylate deaminase family. (322 aa) |
| | omh2 | O-glycoside alpha-1,2-mannosyltransferase homolog 2; Probable mannosyltransferase involved in O-glycosylation of cell wall and secreted proteins; Belongs to the glycosyltransferase 15 family. (372 aa) |
| | ogm4 | Dolichyl-phosphate-mannose--protein mannosyltransferase 4; Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. Required for normal cell wall and septum formation. (778 aa) |
| | apt1 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. (188 aa) |
| | ted1 | Uncharacterized protein C23A1.02c. (430 aa) |
| | cts1 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (600 aa) |
| | mnn9 | Mannan polymerase complex subunit mnn9; Required for the addition of the long alpha 1,6-mannose backbone of N-linked glycans on cell wall and periplasmic proteins. (337 aa) |
| | dpm1 | Dolichol-phosphate mannosyltransferase; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; Belongs to the glycosyltransferase 2 family. (236 aa) |
| | gpi1 | N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein gpi1; Necessary for the synthesis of N-acetylglucosaminyl- phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis. (653 aa) |
| | isn1 | IMP-specific 5'-nucleotidase 1; IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation; Belongs to the ISN1 family. (405 aa) |
| | gua1 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (524 aa) |
| | dfg10 | Uncharacterized protein C7D4.09c. (274 aa) |
| | gls1 | Probable mannosyl-oligosaccharide glucosidase; Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor highly specifically. (808 aa) |
| | ost2 | Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit ost2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation a [...] (122 aa) |
| | ade3 | Probable phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity); In the N-terminal section; belongs to the FGAMS family. (1323 aa) |
| | alg14 | UDP-N-acetylglucosamine transferase subunit alg14; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit alg13 to the ER (By similarity). (210 aa) |
| | alg13 | UDP-N-acetylglucosamine transferase subunit alg13; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway (By similarity). Belongs to the glycosyltransferase 28 family. (162 aa) |
| | rer2 | Dehydrodolichyl diphosphate synthase complex subunit SPAC4D7.04c; With nus1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). (264 aa) |
| | pud1 | Uncharacterized protein C4C5.01; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (249 aa) |
| | imt1 | Inositol phosphoceramide mannosyltransferase 1; With imt2 and imt3, is required for the synthesis of mannosyl phosphorylinositol ceramide (MIPC). Catalyzes the addition of mannosyl to phosphorylinositol ceramide (IPC). MIPC is essential for cell morphology, cell-surface distribution of ergosterol, localization for plasma-membrane transporters, and lipid-raft-mediated endocytosis of plasma membrane proteins to the vacuole; Belongs to the glycosyltransferase 32 family. (319 aa) |
| | pvg2 | Pyruvylated Gal-beta-1,3-epitope synthesis protein 2; Involved in cell wall biogenesis. Has a role in the addition of Gal-beta1,3 moeities to galactomannans and their subsequent pyruvylation. Has a role in meiosis. (389 aa) |
| | alg1 | Chitobiosyldiphosphodolichol beta-mannosyltransferase; Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER (By similarity); Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 33 subfamily. (424 aa) |
| | hpt1 | Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity); Belongs to the purine/pyrimidine phosphoribosyltransferase family. (206 aa) |
| | acl2 | Probable ATP-citrate synthase subunit 2; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA. Has a central role in de novo lipid synthesis (By similarity); In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (492 aa) |
| | mug84 | Meiotically up-regulated gene 84 protein; Has a role in meiosis. (195 aa) |
| | ogm1 | Dolichyl-phosphate-mannose--protein mannosyltransferase 1; Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. Required for normal cell growth and septum formation. Shown to actively O-mannosylate wsc1. (893 aa) |
| | gab1 | GPI transamidase component GAB1 homolog; Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI (By similarity); Belongs to the PIGU family. (408 aa) |
| | SPAC1B3.01c | Uracil phosphoribosyltransferase 1; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (219 aa) |
| | gna1 | Glucosamine 6-phosphate N-acetyltransferase; Belongs to the acetyltransferase family. GNA1 subfamily. (111 aa) |
| | gpi13 | GPI ethanolamine phosphate transferase 3; Involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond. Involved in cell wall biosynthesis (By similarity); Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily. (918 aa) |
| | gmh4 | Uncharacterized alpha-1,2-galactosyltransferase C8D2.17. (328 aa) |
| | dld1 | Dihydrolipoyl dehydrogenase, mitochondrial; Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes (By similarity). Malfunction of this protein blocks the progression of cell cycle from G1 to S phase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (511 aa) |
| | ost5 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit ost5; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (94 aa) |
| | SPAC227.19c | Uncharacterized protein C227.19c. (83 aa) |
| | pga1 | GPI mannosyltransferase 2 subunit C167.09; Essential component of the GPI mannosyltransferase 2 complex. Responsible for the transfer of the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity). (178 aa) |
| | atp19 | ATP synthase subunit K, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the centr [...] (68 aa) |
