STRINGSTRING
skb5 skb5 lsb4 lsb4 abp1 abp1 imp2 imp2 shd1 shd1 pex13 pex13 sfp47 sfp47 cyk3 cyk3 bbc1 bbc1 lsb1 lsb1 tea4 tea4 hob1 hob1 pob1 pob1 hse1 hse1 mug137 mug137 ste6 ste6 scd2 scd2 myo1 myo1 SPBC19C2.10 SPBC19C2.10 bzz1 bzz1 cdc15 cdc15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
skb5Shk1 kinase-binding protein 5; Stimulates catalytic function of the p21-activated kinase homolog shk1. (140 aa)
lsb4SH3 domain-containing protein PJ696.02; Belongs to the SH3YL1 family. (430 aa)
abp1Protein app1. (857 aa)
imp2Septation protein imp2; Required for normal septation. Involved in the disassembly of the medial ring during septation. (670 aa)
shd1Actin cytoskeleton-regulatory complex protein sla1; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity). (1420 aa)
pex13Peroxisomal membrane protein pex13; Component of the peroxisomal translocation machinery with pex14 and pex17; Belongs to the peroxin-13 family. (288 aa)
sfp47Ubp4-interactor sfp47; Required for the regulation of activity and recruitment of ubp4 to endosomes. (415 aa)
cyk3Cytokinesis protein 3; Involved in cytokinesis; Belongs to the CYK3 family. (886 aa)
bbc1SH3 domain-containing protein C23A1.17. (1611 aa)
lsb1Protein csh3. (296 aa)
tea4Tip elongation aberrant protein Tea4; Cell polarity factor essential for the bipolar localization and function of structures containing the cell-end marker tea1 during the normal cell cycle. Regulates cell polarity in complex with tea1 and together with the stress signaling MAPK cascade, contributes to cell polarity maintenance under stress conditions. Required for the localization of for3 at the cell tip specifically during initiation of bipolar growth. During the new end take off (NETO), formation of a protein complex that includes tea1, tea4 and for3 is necessary and sufficient for [...] (821 aa)
hob1Protein hob1; Has a role in DNA damage signaling as a part of stress response processes. (466 aa)
pob1Protein pob1; Has a role in cell elongation and separation. (871 aa)
hse1Class E vacuolar protein-sorting machinery protein hse1; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB). (373 aa)
mug137Meiotically up-regulated gene 137 protein; Has a role in meiosis and sporulation. (420 aa)
ste6Protein ste6; Promotes the exchange of RAS-bound GDP by GTP. This protein is essential for mating. (911 aa)
scd2Protein scd2/ral3; Required for mating and morphogenesis. Interacts directly with scd1 and with cdc42. May bridge and facilitate scd1 and cdc42 interactions. (536 aa)
myo1Myosin-1; Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Contributes to proper septation by transporting vesicles containing septal material to the division site and is involved in the formation of sterol-rich membrane domains at the cell division site. Required also for mating. (1217 aa)
SPBC19C2.10Uncharacterized protein C19C2.10. (501 aa)
bzz1Protein BZZ1; Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress (By similarity); Belongs to the BZZ1 family. (642 aa)
cdc15Cell division control protein 15; After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Appears to mediate cytoskeletal rearrangements required for cytokinesis. Essential for viability. (927 aa)
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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