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| | ppk30 | Serine/threonine-protein kinase ppk30. (953 aa) |
| | orb6 | Serine/threonine-protein kinase orb6; Interacts with pak1/shk1 and coordinates cell morphogenesis with the cell cycle. It is essential for maintenance of cell polarity and is involved in mitotic control. (469 aa) |
| | ppk3 | Protein kinase domain-containing protein ppk3. (637 aa) |
| | fin1 | G2-specific protein kinase fin1; Promotes chromosome condensation and nuclear envelope dynamics during mitosis. Activity appears at metaphase-anaphase transition; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. NIMA subfamily. (722 aa) |
| | pan3 | PAB-dependent poly(A)-specific ribonuclease subunit pan3-like; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex; Belongs to the protein kinase superfamily. PAN3 family. (681 aa) |
| | hri1 | Eukaryotic translation initiation factor 2-alpha kinase 1; Mediates down-regulation of protein synthesis in response to stress conditions by the phosphorylation of the alpha subunit of eIF-2 (tif211) on 'Ser-52'. Protein synthesis is inhibited at the level of initiation. Activity is inhibited in the presence of heme. (704 aa) |
| | hrk1 | Serine/threonine-protein kinase haspin homolog hrk1; Serine/threonine haspin-like protein kinase involved in cell cycle regulation. Acts in chromosomal passenger complex (CPC) targeting to centromeres by phosphorylating histone H3 at 'Thr3' (H3T3ph). (488 aa) |
| | ppk9 | Protein kinase domain-containing protein ppk9. (532 aa) |
| | srb10 | Serine/threonine-protein kinase srb10; Catalytic component of the Cdk8 module/Srb8-11 module which is a regulatory module of the Mediator complex that regulates basal RNA polymerase II transcription. The Cdk8 module may sterically hinder the interaction between Mediator and RNA polymerase II leading to transcriptional repression of a subset of genes regulated by Mediator. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (369 aa) |
| | mak2 | Peroxide stress-activated histidine kinase mak2; Involved in the control of the SAPK-dependent transcriptional response to peroxide stress. Regulates sty1 activity. (2310 aa) |
| | hal4 | Serine/threonine-protein kinase hal4; Promotes K(+) uptake, by the potassium transporter trk1-trk2, which leads to the subsequent cellular resistance to toxic cations such as Na(+), Li(+) and Ca(2+). (636 aa) |
| | ppk11 | Serine/threonine-protein kinase ppk11. (312 aa) |
| | lsk1 | CTD kinase subunit alpha; Catalytic subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. Involved in RNA polymerase II transcriptional elongation and pre-mRNA 3'-end processing (By similarity). Together with ctk2/lsc1, required for the regulation of cytokinesis by phosphorylating 'Ser-2' residues found in the heptad repeats of the CTD. Required for nuclear localization of ctk2/lsc1. Positively regulates the septation initiation network (SIN) and promotes successful completion of cytokinesis in [...] (593 aa) |
| | pit1 | Sporulation protein kinase pit1; Protein kinase which is essential for spore formation. (650 aa) |
| | wis4 | MAP kinase kinase kinase wis4; Involved in a signal transduction pathway that is activated in under conditions of heat shock, oxidative stress or limited nutrition. Unlike win1, it is not activated by changes in the osmolarity of the extracellular environment. Activates the wis1 MAP kinase kinase by phosphorylation. (1401 aa) |
| | sid1 | Serine/threonine-protein kinase sid1; Has a role in the septation initiation network (SIN) required for cytokinesis. (471 aa) |
| | ksp1 | Serine/threonine-protein kinase ksp1. (474 aa) |
| | tor1 | Serine/threonine-protein kinase tor1; Phosphatidylinositol 3-kinase homolog, component of TORC2, which regulates multiple cellular processes to control cell growth in response to environmental signals. TORC2 is required for cell survival under various stress conditions. TORC2 positively controls G1 cell- cycle arrest, sexual development and amino acid uptake. Positively regulates amino acid uptake through the control of expression of amino acid permeases. Responsible for the phosphorylation of AGC kinase gad8 at 'Ser-527' and 'Ser-546', activating gad8 kinase activity and promoting sex [...] (2335 aa) |
| | rio1 | Serine/threonine-protein kinase rio1; Required for the final endonucleolytic cleavage at site D converting 20S pre-rRNA into the mature 18S rRNA. Required for the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). (497 aa) |
| | SPAC10F6.14c | ABC1 family protein C10F6.14c; Belongs to the protein kinase superfamily. ADCK protein kinase family. (535 aa) |
| | cmk2 | Calcium/calmodulin-dependent protein kinase type II; Has a role in the regulation of G2/M transition during mitosis; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. (504 aa) |
| | vps15 | Serine/threonine-protein kinase ppk19; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (1706 aa) |
| | mde3 | Sporulation protein kinase mde3; Protein kinase which is essential for spore formation. (559 aa) |
| | ppk25 | Serine/threonine-protein kinase ppk25. (423 aa) |
| | oca2 | Serine/threonine-protein kinase oca2; Overexpression causes cell cycle arrest. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (650 aa) |
| | ark1 | Serine/threonine-protein kinase ark1; Required for the spindle checkpoint attachment response during spindle formation, kinetochore microtubule interactions and chromosome segregation during anaphase. Ark1 activity depends upon cut17 function and phosphorylation. Ark1 with bir1 is required for full-scale association with kinetochores and formation of a complex with mad3. Ark1 is also required for phosphorylation of histone H3 that accompanies chromosome condensation and condensin recruitment to mitotic chromatin. Ark1 with pic1 is required for the execution of cytokinesis. (355 aa) |
| | SPBC15C4.02 | ABC1 family protein MCP2 homolog; Involved in mitochondrial lipid homeostasis. Belongs to the protein kinase superfamily. ADCK protein kinase family. (557 aa) |
| | cdk11 | Serine/threonine-protein kinase ppk23. (398 aa) |
| | cki3 | Casein kinase I homolog 3; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. (439 aa) |
| | win1 | MAP kinase kinase kinase win1; Involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the wis1 MAP kinase kinase by phosphorylation. (1436 aa) |
| | ppk33 | Serine/threonine-protein kinase ppk33; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (338 aa) |
| | pef1 | Serine/threonine-protein kinase pef1. (288 aa) |
| | nnk1 | Probable serine/threonine-protein kinase C70.05c. (781 aa) |
| | ssp2 | SNF1-like protein kinase ssp2; Serine/threonine protein kinase essential for release from glucose repression via the phosphorylation of scr1 upon glucose deprivation. Catalytic subunit of the AMP-activated protein kinase complex also known as the SNF1 kinase complex (Snf1c), a central regulator of cellular energy homeostasis, which, in response to a fall in intracellular ATP levels, activates energy-producing pathways and inhibits energy-consuming processes. The complex phosphorylates histone H3 to form H3S10ph, which promotes H3K14ac formation, leading to transcriptional activation th [...] (576 aa) |
| | mak3 | Peroxide stress-activated histidine kinase mak3; Involved in the control of the SAPK-dependent transcriptional response to peroxide stress. Regulates sty1 activity. (2344 aa) |
| | tel1 | Serine/threonine-protein kinase tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Undirectly involved in the phosphorylation of rad32 which is necessary for its telomere function. Required for the control of telomere length [...] (2812 aa) |
| | ppk27 | Serine/threonine-protein kinase ppk27. (413 aa) |
| | nak1 | Serine/threonine-protein kinase nak1; Has a role in the regulation of cell polarity, growth and division. (652 aa) |
| | mph1 | Serine/threonine-protein kinase mph1; Involved in the regulation of the onset of mitosis. Involved in a pathway that coordinates cell proliferation and differentiation. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (678 aa) |
| | ppk31 | Serine/threonine-protein kinase ppk31; Has a role in meiosis; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (1032 aa) |
| | mug27 | Serine/threonine-protein kinase ppk35; Has a role in meiosis; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (624 aa) |
| | ire1 | Serine/threonine-protein kinase ppk4. (1072 aa) |
| | srk1 | Serine/threonine-protein kinase srk1; Has a role in the regulation of meiosis via the sty1 stress- activated MAPK pathway. Inhibits nitrogen-limitation induced arrest at G1; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. (580 aa) |
| | ppk24 | Serine/threonine-protein kinase ppk24, mitochondrial; Has a role late in meiosis; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (461 aa) |
| | bub1 | Checkpoint serine/threonine-protein kinase bub1; Involved in cell cycle checkpoint enforcement. Acts to stabilize the spindle during mitosis. Required for the correct localization of bub3 and mad3 to the kinetochore. Appears to have a role in chromosome segregation. Catalyzes the phosphorylation of bub3. (1044 aa) |
| | cdc2 | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required for entry into S-phase and mitosis. When complexed with cig2, plays a role in G1-S phase transition. When activated and complexed with the cyclin cdc13, it leads to the onset of mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. Involved in cell cycle arrest induced by defective RNA splicing. Required for phosphorylation of dis1 to ensure accurate chromosome segregation and for the DNA damage checkpoint. (297 aa) |
| | cdr1 | Mitosis inducer protein kinase cdr1; This protein, a dose-dependent mitotic inducer, appears to function as a negative regulator of mitosis inhibitor wee1 by phosphorylating and inactivating it. (593 aa) |
| | wee1 | Mitosis inhibitor protein kinase wee1; Protein kinase that acts both on serines and on tyrosines. It acts as a dosage-dependent negative regulator of entry into mitosis (G2 to M transition). Phosphorylates and inhibits cdc2. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. (877 aa) |
| | pat1 | Negative regulator of sexual conjugation and meiosis; This protein is a negative regulator of both sexual conjugation and meiosis. It phosphorylates mei2. It blocks the onset of meiosis until conjugation takes place. (470 aa) |
| | byr1 | Protein kinase byr1; Serine/threonine protein kinase involved in conjugation and sporulation. It is thought that it is phosphorylated by the byr2 protein kinase and that it can phosphorylate the spk1 kinase. When bound to bob1, is involved in the regulation of sexual differentiation. (340 aa) |
| | kin1 | Protein kinase kin1; Has a role in establishing the characteristic rod cell shape. Important for cell polarity and is involved in directing growth to the cell ends; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (891 aa) |
| | spk1 | Mitogen-activated protein kinase spk1; Involved in mating signal transduction pathway. (372 aa) |
| | byr2 | Protein kinase byr2; Serine/threonine protein kinase involved in conjugation and sporulation. It is thought that it phosphorylates the byr1 protein kinase which itself phosphorylate the spk1 kinase. (659 aa) |
| | mik1 | Mitosis inhibitor protein kinase mik1; Protein kinase that acts both on serines and on tyrosines. It acts as a negative regulator of entry into mitosis (G2 to M transition). Phosphorylates and inhibits cdc2. (581 aa) |
| | wis1 | Protein kinase wis1; Dosage-dependent regulator of mitosis with serine/ threonine protein kinase activity. May play a role in the integration of nutritional sensing with the control over entry into mitosis. It may interact with cdc25, wee1 and win1. May activate sty1. (605 aa) |
| | chk1 | Serine/threonine-protein kinase chk1; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Binds to and phosphorylates CDC25. This leads to negative regulation of CDC25 and prevents mitotic entry. (496 aa) |
| | pck1 | Protein kinase C-like 1; Involved in the control of the cell shape. Target of the inhibitor staurosporine; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (988 aa) |
| | pck2 | Protein kinase C-like 2; Involved in the control of the cell shape. Target of the inhibitor staurosporine; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (1016 aa) |
| | csk1 | Serine/threonine-protein kinase csk1; Acts as a CAK-activating kinase that specifically activates crk1 of the crk1-mcs2 CAK complex. (306 aa) |
| | dsk1 | Protein kinase dsk1; May play an important role in mitotic control by altering cellular location, degree of phosphorylation and kinase activity. Abundant expression accelerates the exit when cells are in M-phase and also delays the entry into mitosis when cells are in G2. Phosphorylates prp2 in vitro and so may have a role in co-ordinating pre-mRNA splicing with the progression of the cell division cycle. (544 aa) |
| | cek1 | Serine/threonine-protein kinase cek1; May facilitate the progression of anaphase through direct or indirect interaction with the cut8 protein. (1338 aa) |
| | cka1 | Casein kinase II subunit alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Plays a role in the translation of cell polarity into polarized growth. The alpha and alpha' chains contain the catalytic site. (332 aa) |
| | cki1 | Casein kinase I homolog 1; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. (446 aa) |
| | cki2 | Casein kinase I homolog 2; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. May contribute to the regulation of morphology. (435 aa) |
| | hhp1 | Casein kinase I homolog hhp1; Involved in DNA repair. Has a probable role in repairing alkylated DNA and may regulate the activity of protein(s) involved in double strand break repair caused by gamma rays; Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. (365 aa) |
| | hhp2 | Casein kinase I homolog hhp2; Involved in DNA repair. May regulate the activity of protein(s) involved in double strand break repair caused by gamma rays; Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. (400 aa) |
| | pka1 | cAMP-dependent protein kinase catalytic subunit. (512 aa) |
| | cdc7 | Cell division control protein 7; Protein kinase essential for cell division. Plays a key role in initiation of septum formation and cytokinesis. (1062 aa) |
| | pik3 | Phosphatidylinositol 3-kinase vps34; Phosphatidylinositol 3-kinase homolog required for vacuolar sorting and segregation; Belongs to the PI3/PI4-kinase family. (801 aa) |
| | ssp1 | Serine/threonine-protein kinase ssp1; Involved in actin localization and thus in polarized cell growth; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (652 aa) |
| | shk1 | Serine/threonine-protein kinase shk1/pak1; MAP4K component of the MAPK pathway required for the mating pheromone response. Phosphorylates histone H2B to form H2BS10ph (By similarity). Phosphorylates tea1. Required for skb1-dependent mitotic inhibitory function. Regulates microtubule dynamics and cell polarity. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (658 aa) |
| | plo1 | Serine/threonine-protein kinase plo1; Required to form a bipolar spindle, the actin ring and septum. Functions upstream of the whole septum formation pathway, including actin ring formation (regulated by late septation genes) and septal material deposition (regulated by early septation genes). Behaves as a 'septum-promoting factor', and could also be involved in inducing other late events of cell division. Together with moa1, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromer [...] (683 aa) |
| | sck1 | Serine/threonine-protein kinase sck1; Protein kinase that is part of growth control pathway which is at least partially redundant with the cAMP pathway. Required for trehalase activation. (696 aa) |
| | hsk1 | Cell cycle serine/threonine-protein kinase hsk1; Required for G1/S transition. Plays a role in DNA replication checkpoint signaling through regulating rad3 and cds1. Involved in the maintenance of mitotic chromosome structures during S phase through regulating the function of rad21. Required for initiation of mitotic DNA replication through phosphorylating mcm2/cdc19. Required for genome integrity; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily. (507 aa) |
| | cdr2 | Mitosis inducer protein kinase cdr2; Acts as a mitotic inducer. In G2 it negatively regulates wee1, a mitotic inhibitor. Also has a role in cytokinesis where it required for proper septum formation; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily. (775 aa) |
| | rad3 | Protein kinase rad3; Serine/threonine kinase which activates checkpoint signaling upon genotoxic stresses. Involved in G2 arrest following DNA damage where it phosphorylates chk1. Phosphorylation of 'Thr-73' and 'Ser-80' of checkpoint mediator crb2 promotes its interaction with chk1. It is also involved in the dependence of mitosis on the completion of DNA replication ; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2386 aa) |
| | prp4 | Serine/threonine-protein kinase prp4; Has a role in pre-mRNA splicing and is essential for growth. Phosphorylates srp1. (477 aa) |
| | cds1 | Serine/threonine-protein kinase cds1; Has a role in the DNA replication-monitoring S/G2 checkpoint system. It is responsible for blocking mitosis in the S phase. It monitors DNA synthesis by interacting with DNA polymerase alpha and sends a signal to block the onset of mitosis while DNA synthesis is in progress. Phosphorylates rad60 and dna2. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily. (460 aa) |
| | pom1 | DYRK-family kinase pom1; Polarity factor involved in localization of polarized growth and cytokinesis. Forms an intracellular gradient that serves to measure cell length and control mitotic entry. Controls the timing of mitotic commitment by regulating the inhibitory impact of cdr1/cdr2 on wee1 activity. Directly phosphorylates the tail of cdr2 which inhibits cdr2 activation by ssp1. Cdr2 phosphorylation by pom1 also modulates cdr2 association with membranes and inhibits cdr2 interaction with mid1, reducing its clustering ability, possibly via the down-regulation of cdr2 kinase activit [...] (1087 aa) |
| | ppk8 | Serine/threonine-protein kinase ppk8. (513 aa) |
| | pom2 | Serine/threonine-protein kinase ppk5; Has a role in meiosis; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. (836 aa) |
| | ppk14 | Serine/threonine-protein kinase ppk14; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. KIN82 subfamily. (566 aa) |
| | sty1 | Mitogen-activated protein kinase sty1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Involved in osmoregulation and stress response pathways leading to an efficient start of sexual differentiation. Supports translation initiation and facilitates adaptation to environmental stress in part through reducing eIF2-alpha phosphorylation. Links the cell-cycle G2/M control with changes in the extracellular environment that a [...] (349 aa) |
| | sid2 | Serine/threonine-protein kinase sid2; Part of a signaling pathway. Required for initiation of medial ring constriction and septation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (607 aa) |
| | shk2 | Serine/threonine-protein kinase shk2; Forms an activated complex with GTP-bound Ras-like cdc42. Participates in Ras-dependent morphological control and mating response pathways. (589 aa) |
| | tra2 | Uncharacterized PI3/PI4-kinase family protein C1F5.11c; Belongs to the PI3/PI4-kinase family. (3655 aa) |
| | ppk13 | Serine/threonine-protein kinase ppk13. (344 aa) |
| | lkh1 | Dual specificity protein kinase lkh1; Protein kinase that may act as a negative regulator of filamentous growth and flocculation. Appears to have a role in normal cell wall and septum formation and in cell separation. May have antagonistic function in the regulation of beta-glucan distribution between the sites for cell wall and septum assembly. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. (690 aa) |
| | eki1 | Putative choline kinase; Belongs to the choline/ethanolamine kinase family. (456 aa) |
| | mek1 | Meiosis-specific serine/threonine-protein kinase mek1; Probable protein kinase required for meiotic recombination. (445 aa) |
| | sck2 | Serine/threonine-protein kinase sck2; Protein kinase that is part of growth control pathway which is at least partially redundant with the cAMP pathway. (646 aa) |
| | pik1 | Phosphatidylinositol 4-kinase pik1; Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,- trisphosphate. PIK1 is part of a nuclear phosphoinositide cycle and could control cytokinesis through the actin cytoskeleton (By similarity); Belongs to the PI3/PI4-kinase family. (851 aa) |
| | mkh1 | MAP kinase kinase kinase mkh1; May regulate cell morphology, cell wall integrity, salt resistance, cell cycle reentry from stationary-phase arrest, and filamentous growth in response to stress. Activates the MAP kinase kinase skh1/pek1 by phosphorylation. (1116 aa) |
| | tea5 | Protein kinase domain-containing protein ppk2. (665 aa) |
| | gsk3 | Protein kinase gsk3; Interacts with cdc14 which is thought to play a role in the initiation and completion of mitosis. Involved in the positive regulation of mis12. (387 aa) |
| | mcs6 | Serine/threonine-protein kinase crk1; Protein kinase essential for cell proliferation, where it is required for completion of cytokinesis. Phosphorylates the C-terminal repeat domain (CTD) of RNA polymerase II; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (335 aa) |
| | ksg1 | Serine/threonine-protein kinase ksg1; Involved in the control of sexual development and cell growth under stressed conditions. Phosphorylates AGC kinase gad8 at 'Thr-387', activating gad8 kinase activity and promoting sexual development. Phosphorylates AGC kinase psk1 at 'Ser-248', activating psk1 kinase activity and promoting phosphorylation of ribosomal protein S6. (592 aa) |
| | psk1 | Serine/threonine-protein kinase psk1; AGC kinase which plays a role in TOR complex 1 (TORC1) signaling pathway which mediates temporal control of cell growth in response to nutrients. Required for phosphorylation of ribosomal protein S6 (rps601/rps602) at 'Ser-235' and 'Ser-236'. (436 aa) |
| | ppk18 | Serine/threonine-protein kinase ppk18. (1318 aa) |
| | coq8 | Protein ABC1 homolog, mitochondrial. (610 aa) |
| | pmk1 | Mitogen-activated protein kinase spm1; Regulates cell integrity and functions coordinately with the protein kinase C pathway (pck1 and pck2). Involved the regulation of wall architecture, cell shape, cytokinesis in exponential and stationary phase, and metabolism of ions. (422 aa) |
| | cdk9 | Probable cyclin-dependent kinase 9; Component of the positive transcription elongation factor b (P-TEFb) which consists of cdk9 and pch1, and which phosphorylates the C-terminal domain (CTD) of RNA polymerase II and spt5. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (591 aa) |
| | tra1 | Transcription-associated protein 1; Essential component of histone acetyltransferase (HAT) complexes, which serves as a target for activators during recruitment of HAT complexes. Essential for vegetative growth. Functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activator [...] (3699 aa) |
| | ppk1 | Serine/threonine-protein kinase ppk1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (1023 aa) |
| | gcn2 | eIF-2-alpha kinase GCN2; Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2- alpha/tif211) on 'Ser-52' in response to low amino acid availability. Plays a role as an activator of the general amino acid control (GAAC) pathway required for adapatation to amino acid starvation. Converts phosphorylated eIF-2-alpha/tif211 either to a competitive inhibitor of translation initiation factor eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a tr [...] (1576 aa) |
| | ppk15 | Serine/threonine-protein kinase ppk15. (534 aa) |
| | cmk1 | Calcium/calmodulin-dependent protein kinase type I; Important in cell cycle regulation; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. (335 aa) |
| | gad8 | Serine/threonine-protein kinase gad8; Involved in a signaling module for sexual development and cell growth under stressed conditions. Required for G1 arrest under nitrogen starvation and for growth at high temperature and osmolarity. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (569 aa) |
| | SPBC21C3.03 | ABC1 family protein C21C3.03, mitochondrial. (692 aa) |
| | bud32 | EKC/KEOPS complex subunit SPAP27G11.07c; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The comp [...] (238 aa) |
| | rio2 | Serine/threonine-protein kinase rio2; Required for the final endonucleolytic cleavage of 20S pre- rRNA at site D in the cytoplasm, converting it into the mature 18S rRNA. Involved in normal export of the pre-40S particles from the nucleus to the cytoplasm (By similarity); Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (344 aa) |
| | ppk32 | Protein kinase domain-containing protein ppk32. (749 aa) |
| | spo4 | Cell cycle protein kinase spo4; Required for the initiation of meiosis II and progression through anaphase II. (429 aa) |
| | gsk31 | Protein kinase gsk31; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. (381 aa) |
| | ppk16 | Serine/threonine-protein kinase ppk16; Has a role in meiosis; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (672 aa) |
| | stt4 | Phosphatidylinositol 4-kinase stt4; Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,- trisphosphate. (1877 aa) |
| | ppk29 | Serine/threonine-protein kinase ppk29. (872 aa) |
| | ppk26 | PAN2-PAN3 deadenylation complex subunit pan3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exo [...] (589 aa) |
| | ppk22 | Serine/threonine-protein kinase ppk22. (526 aa) |
| | hri2 | Eukaryotic translation initiation factor 2-alpha kinase 2; Mediates down-regulation of protein synthesis in response to stress conditions by the phosphorylation of the alpha subunit of eIF-2 (tif211) on 'Ser-52'. Protein synthesis is inhibited at the level of initiation. Activity is inhibited in the presence of heme. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. (639 aa) |
| | ppk6 | Serine/threonine-protein kinase ppk6. (775 aa) |
| | ppk38 | Protein kinase domain-containing protein ppk38. (650 aa) |
| | ckk2 | Serine/threonine-protein kinase ppk34. (354 aa) |
| | pdk1 | Serine/threonine-protein kinase ppk21; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. (551 aa) |
| | tor2 | Serine/threonine-protein kinase tor2; Phosphatidylinositol 3-kinase homolog, component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. TORC1 controls the switch between cell proliferation and differentiation by sensing nutrient availability. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulating ribosomal protein gene expression. In nutrient rich conditions, responsible for the phosphorylation of AGC S6 kinase ( [...] (2337 aa) |
| | atg1 | Serine/threonine-protein kinase atg1; Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing [...] (830 aa) |
| | pek1 | MAP kinase kinase skh1/pek1; Involved in the mkh1 signal transduction pathway that plays a role in cell wall integrity. Activates spm1/pmk1 via phosphorylation. (363 aa) |
