STRINGSTRING
arp5 arp5 pss1 pss1 ssa2 ssa2 arp10 arp10 ptk1 ptk1 arp6 arp6 arp1 arp1 kae1 kae1 pgp1 pgp1 act1 act1 ssc1 ssc1 arp3 arp3 bip1 bip1 hxk2 hxk2 ssz1 ssz1 hxk1 hxk1 arp42 arp42 lsh1 lsh1 ssa1 ssa1 sks2 sks2 xks1 xks1 alp5 alp5 arp8 arp8 arp9 arp9 arp2 arp2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
arp5Actin-like protein arp5; Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (721 aa)
pss1Heat shock protein homolog pss1; Required for normal growth at various temperatures. (720 aa)
ssa2Probable heat shock protein ssa2. (647 aa)
arp10Actin-like protein arp10. (380 aa)
ptk1Pantothenate kinase; Plays a role in the physiological regulation of the intracellular CoA concentration. (403 aa)
arp6Actin-like protein arp6; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity). (401 aa)
arp1Centractin; Core component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding. The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. Arp1 forms the backbone filament of the dynactin rod structure and serves as the scaffold for the remaining subunits. Required for proper orientation of the mitotic spindle (By similarity). (379 aa)
kae1tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Pgp2 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (346 aa)
pgp1tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. (412 aa)
act1Actin; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (375 aa)
ssc1Heat shock 70 kDa protein, mitochondrial; Belongs to the heat shock protein 70 family. (674 aa)
arp3Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). May be involved in cytokinesis. (427 aa)
bip1Endoplasmic reticulum chaperone BiP; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis. (663 aa)
hxk2Hexokinase-2; Catalyzes the phosphorylation of hexose (six-carbon sugars) to hexose 6-phosphate. Phosphorylates D-glucose, D-fructose and D-mannose. Compared to hxk1, has a much higher affinity for D-glucose. Constitutes the initial enzyme of glycolysis by catalyzing the phosphorylation of glucose to D-glucose 6- phosphate (Probable). (455 aa)
ssz1Heat shock protein 70 homolog C57A7.12; Belongs to the heat shock protein 70 family. (566 aa)
hxk1Hexokinase-1; Catalyzes the phosphorylation of hexose (six-carbon sugars) to hexose 6-phosphate. Phosphorylates D-fructose, D-mannose and, to a lower extent, D-glucose. Compared to hxk2, has low affinity for D-glucose. (484 aa)
arp42SWI/SNF and RSC complexes subunit arp42; Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing bindi [...] (424 aa)
lsh1Heat shock protein 70 homolog lhs1; Chaperone required for protein translocation and folding in the endoplasmic reticulum. (848 aa)
ssa1Probable heat shock protein ssa1. (644 aa)
sks2Ribosome-associated molecular chaperone sks2; Ribosome-bound, Hsp70-type chaperone that assists in the cotranslational folding of newly synthesized proteins in the cytosol. Stimulates folding by interacting with nascent chains, binding to short, largely hydrophobic sequences exposed by unfolded proteins, thereby stabilizing longer, more slowly translated, and aggregation- prone nascent polypeptides and domains that cannot fold stably until fully synthesized. The Hsp70-protein substrate interaction depends on ATP-binding and on allosteric regulation between the NBD and the SBD. The ATP- [...] (613 aa)
xks1Xylulose kinase; Belongs to the FGGY kinase family. (555 aa)
alp5Actin-related protein 4; Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes [...] (433 aa)
arp8Probable actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Exhibits low basal ATPase activity, and unable to polymerize. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex (By similarity). (662 aa)
arp9SWI/SNF and RSC complexes subunit arp9; Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing bindin [...] (523 aa)
arp2Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). During cytokinesis it colocalizes to the cortical actin patches until spetation is complete. Has a role in the mobility of these patches. Essential for viability. (390 aa)
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.