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mcs2 | Cyclin mcs2; Essential for progression through the cell cycle. Posseses kinase activity that can be detected when myelin basic protein (MBP) is provided as an exogenous substrate; Belongs to the cyclin family. Cyclin C subfamily. (322 aa) | ||||
cdc2 | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required for entry into S-phase and mitosis. When complexed with cig2, plays a role in G1-S phase transition. When activated and complexed with the cyclin cdc13, it leads to the onset of mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. Involved in cell cycle arrest induced by defective RNA splicing. Required for phosphorylation of dis1 to ensure accurate chromosome segregation and for the DNA damage checkpoint. (297 aa) | ||||
wee1 | Mitosis inhibitor protein kinase wee1; Protein kinase that acts both on serines and on tyrosines. It acts as a dosage-dependent negative regulator of entry into mitosis (G2 to M transition). Phosphorylates and inhibits cdc2. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. (877 aa) | ||||
csk1 | Serine/threonine-protein kinase csk1; Acts as a CAK-activating kinase that specifically activates crk1 of the crk1-mcs2 CAK complex. (306 aa) |