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ura4 ura4 hri1 hri1 mak2 mak2 gor1 gor1 atm1 atm1 wis4 wis4 tor1 tor1 mmf1 mmf1 his7 his7 win1 win1 tif301 tif301 grx4 grx4 hnt3 hnt3 moe1 moe1 mpr1 mpr1 int6 int6 mbf1 mbf1 byr1 byr1 ade6 ade6 leu1 leu1 cta3 cta3 wis1 wis1 his5 his5 atf1 atf1 ctt1 ctt1 mcs4 mcs4 pap1 pap1 sty1 sty1 pcr1 pcr1 SPAC1F12.06c SPAC1F12.06c pmk1 pmk1 gcn2 gcn2 mak1 mak1 tif308 tif308 hri2 hri2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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ura4Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (264 aa)
hri1Eukaryotic translation initiation factor 2-alpha kinase 1; Mediates down-regulation of protein synthesis in response to stress conditions by the phosphorylation of the alpha subunit of eIF-2 (tif211) on 'Ser-52'. Protein synthesis is inhibited at the level of initiation. Activity is inhibited in the presence of heme. (704 aa)
mak2Peroxide stress-activated histidine kinase mak2; Involved in the control of the SAPK-dependent transcriptional response to peroxide stress. Regulates sty1 activity. (2310 aa)
gor1Putative 2-hydroxyacid dehydrogenase UNK4.10; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (334 aa)
atm1Iron-sulfur clusters transporter atm1, mitochondrial; Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Hydrolyzes ATP. Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound. Also has an indirect role in vacuolar function where it is required for fluid-phase endocytosis. (693 aa)
wis4MAP kinase kinase kinase wis4; Involved in a signal transduction pathway that is activated in under conditions of heat shock, oxidative stress or limited nutrition. Unlike win1, it is not activated by changes in the osmolarity of the extracellular environment. Activates the wis1 MAP kinase kinase by phosphorylation. (1401 aa)
tor1Serine/threonine-protein kinase tor1; Phosphatidylinositol 3-kinase homolog, component of TORC2, which regulates multiple cellular processes to control cell growth in response to environmental signals. TORC2 is required for cell survival under various stress conditions. TORC2 positively controls G1 cell- cycle arrest, sexual development and amino acid uptake. Positively regulates amino acid uptake through the control of expression of amino acid permeases. Responsible for the phosphorylation of AGC kinase gad8 at 'Ser-527' and 'Ser-546', activating gad8 kinase activity and promoting sex [...] (2335 aa)
mmf1Protein mmf1, mitochondrial; Plays a role in the maintenance of mitochondrial DNA. Belongs to the RutC family. (162 aa)
his7Histidine biosynthesis bifunctional protein his7. (417 aa)
win1MAP kinase kinase kinase win1; Involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the wis1 MAP kinase kinase by phosphorylation. (1436 aa)
tif301Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (932 aa)
grx4Monothiol glutaredoxin-4; Monothiol glutaredoxin involved in the biogenesis of iron- sulfur clusters (By similarity). Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit (By similarity). (244 aa)
hnt3Aprataxin-like protein; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'- phosphate termini that can be efficiently rejoined. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, bu [...] (232 aa)
moe1Eukaryotic translation initiation factor 3 subunit D; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7- methylguanosine cap of a subset of mRNAs. (567 aa)
mpr1Multistep phosphorelay regulator 1; Binds to the msc4 response regulator which is part of a multistep phosphorelay system that transmits oxidative stress signals to the spc1 MAPK cascade. (295 aa)
int6Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (Potential). Required for maintaining the basal level of atf1 and for transcriptional activation of core environmental stress response genes (CESR genes) i [...] (501 aa)
mbf1Multiprotein-bridging factor 1; Transcriptional coactivator that stimulates transcriptional activity by bridging regulatory proteins and TBP, thereby recruiting TBP to promoters occupied by DNA-binding regulators. (148 aa)
byr1Protein kinase byr1; Serine/threonine protein kinase involved in conjugation and sporulation. It is thought that it is phosphorylated by the byr2 protein kinase and that it can phosphorylate the spk1 kinase. When bound to bob1, is involved in the regulation of sexual differentiation. (340 aa)
ade6Phosphoribosylaminoimidazole carboxylase; In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily. (552 aa)
leu13-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (371 aa)
cta3Calcium-transporting ATPase 3; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. (1037 aa)
wis1Protein kinase wis1; Dosage-dependent regulator of mitosis with serine/ threonine protein kinase activity. May play a role in the integration of nutritional sensing with the control over entry into mitosis. It may interact with cdc25, wee1 and win1. May activate sty1. (605 aa)
his5Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family. (216 aa)
atf1Transcription factor atf1; Transcription factor required for sexual development and entry into stationary phase. Binds and activates meiotic recombination hot spot ade6-M26. (566 aa)
ctt1Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (512 aa)
mcs4Response regulator mcs4; Response regulator that coordinately controls the stress activated wak1-wis1-sty1 MAP kinase pathway and fission yeast cell cycle. (522 aa)
pap1AP-1-like transcription factor; Transcription activator involved in multidrug resistance, oxidative stress response, and redox homeostasis. Regulates the transcription of genes encoding antioxidant enzymes like catalase ctt1 and components of the cellular thiol-reducing pathways, including the thioredoxin system (trx2, trr1), ABC tansporters involved in multidrug resistance like bfr1/hba2 and pmd1 as well as the gene obr1/apt1. Preferentially binds to promoters with the core binding site 5'- TTA[CG]TAA-3'. Activity of the transcription factor is controlled through oxidation of specific [...] (552 aa)
sty1Mitogen-activated protein kinase sty1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Involved in osmoregulation and stress response pathways leading to an efficient start of sexual differentiation. Supports translation initiation and facilitates adaptation to environmental stress in part through reducing eIF2-alpha phosphorylation. Links the cell-cycle G2/M control with changes in the extracellular environment that a [...] (349 aa)
pcr1Transcription factor pcr1; Involved in regulation of gene expression for sexual development. Binds and activates meiotic recombination hot spot ade6- M26. (171 aa)
SPAC1F12.06cPutative endonuclease C1F12.06c. (252 aa)
pmk1Mitogen-activated protein kinase spm1; Regulates cell integrity and functions coordinately with the protein kinase C pathway (pck1 and pck2). Involved the regulation of wall architecture, cell shape, cytokinesis in exponential and stationary phase, and metabolism of ions. (422 aa)
gcn2eIF-2-alpha kinase GCN2; Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2- alpha/tif211) on 'Ser-52' in response to low amino acid availability. Plays a role as an activator of the general amino acid control (GAAC) pathway required for adapatation to amino acid starvation. Converts phosphorylated eIF-2-alpha/tif211 either to a competitive inhibitor of translation initiation factor eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a tr [...] (1576 aa)
mak1Peroxide stress-activated histidine kinase mak1; Involved in the control of the SAPK-dependent transcriptional response to peroxide stress. Also has a role in G2/M regulation. (1639 aa)
tif308Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (357 aa)
hri2Eukaryotic translation initiation factor 2-alpha kinase 2; Mediates down-regulation of protein synthesis in response to stress conditions by the phosphorylation of the alpha subunit of eIF-2 (tif211) on 'Ser-52'. Protein synthesis is inhibited at the level of initiation. Activity is inhibited in the presence of heme. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. (639 aa)
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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