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spk1 spk1 byr2 byr2 wis1 wis1 rec8 rec8 ste11 ste11 rad24 rad24 atf1 atf1 map2 map2 sty1 sty1 pcr1 pcr1 rrp6 rrp6 pla1 pla1 spo5 spo5 tor2 tor2 cdc2 cdc2 mei4 mei4 wis4 wis4 pab2 pab2 tor1 tor1 win1 win1 mmi1 mmi1 mei3 mei3 pat1 pat1 mei2 mei2 byr1 byr1 gpa1 gpa1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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spk1Mitogen-activated protein kinase spk1; Involved in mating signal transduction pathway. (372 aa)
byr2Protein kinase byr2; Serine/threonine protein kinase involved in conjugation and sporulation. It is thought that it phosphorylates the byr1 protein kinase which itself phosphorylate the spk1 kinase. (659 aa)
wis1Protein kinase wis1; Dosage-dependent regulator of mitosis with serine/ threonine protein kinase activity. May play a role in the integration of nutritional sensing with the control over entry into mitosis. It may interact with cdc25, wee1 and win1. May activate sty1. (605 aa)
rec8Meiotic recombination protein rec8; Involved primarily in the early steps of meiotic recombination. Required to ensure reductional chromosome segregation. Belongs to the rad21 family. (561 aa)
ste11Transcription factor ste11; Key transcription factor for sexual development. Activates the transcription of the matp, matm, mei2, mfm, ste6 and rgs1 genes. Binds specifically to a DNA fragment carrying a 10-base motif 5'- TTCTTTGTTY-3'. (468 aa)
rad24DNA damage checkpoint protein rad24; Required for the DNA damage checkpoint that ensures that DNA damage is repaired before mitosis is attempted. Acts as a negative regulator of meiosis by antagonizing the function of mei2. It inhibits the association of meiRNA (a non-coding RNA molecule required for the nuclear mei2 dot formation) to the phosphorylated but not to the unphosphorylated form of mei2 in vitro. (270 aa)
atf1Transcription factor atf1; Transcription factor required for sexual development and entry into stationary phase. Binds and activates meiotic recombination hot spot ade6-M26. (566 aa)
map2P-factor-like 1; In h- cells under nutritional starvation, P-factor induces alteration of cell morphology toward mating, arrest of the cell cycle at the G1 phase prior to the initiation of DNA synthesis and indirect transcriptional activation of the sxa2 gene which down-regulates the signaling pathway. (201 aa)
sty1Mitogen-activated protein kinase sty1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Involved in osmoregulation and stress response pathways leading to an efficient start of sexual differentiation. Supports translation initiation and facilitates adaptation to environmental stress in part through reducing eIF2-alpha phosphorylation. Links the cell-cycle G2/M control with changes in the extracellular environment that a [...] (349 aa)
pcr1Transcription factor pcr1; Involved in regulation of gene expression for sexual development. Binds and activates meiotic recombination hot spot ade6- M26. (171 aa)
rrp6Exosome complex exonuclease rrp6; Nuclear-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export t [...] (777 aa)
pla1Poly(A) polymerase pla1; Polymerase that creates the 3'-poly(A) tail of mRNA's. May acquire specificity through interaction with a cleavage and polyadenylation factor (CF I). (566 aa)
spo5Sporulation-specific protein 5; RNA-binding protein which plays a role in sporulation. Regulates the progression of meiosis I and may function in the vicinity of the Mei2 dot. (567 aa)
tor2Serine/threonine-protein kinase tor2; Phosphatidylinositol 3-kinase homolog, component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. TORC1 controls the switch between cell proliferation and differentiation by sensing nutrient availability. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulating ribosomal protein gene expression. In nutrient rich conditions, responsible for the phosphorylation of AGC S6 kinase ( [...] (2337 aa)
cdc2Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required for entry into S-phase and mitosis. When complexed with cig2, plays a role in G1-S phase transition. When activated and complexed with the cyclin cdc13, it leads to the onset of mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. Involved in cell cycle arrest induced by defective RNA splicing. Required for phosphorylation of dis1 to ensure accurate chromosome segregation and for the DNA damage checkpoint. (297 aa)
mei4Meiosis-specific transcription factor mei4; Functions as a meiosis-specific transcription factor. Binds to the 5'-GTAAAYA-3' consensus sequence of the promoter of the spo6 gene. (517 aa)
wis4MAP kinase kinase kinase wis4; Involved in a signal transduction pathway that is activated in under conditions of heat shock, oxidative stress or limited nutrition. Unlike win1, it is not activated by changes in the osmolarity of the extracellular environment. Activates the wis1 MAP kinase kinase by phosphorylation. (1401 aa)
pab2Polyadenylate-binding protein 2. (166 aa)
tor1Serine/threonine-protein kinase tor1; Phosphatidylinositol 3-kinase homolog, component of TORC2, which regulates multiple cellular processes to control cell growth in response to environmental signals. TORC2 is required for cell survival under various stress conditions. TORC2 positively controls G1 cell- cycle arrest, sexual development and amino acid uptake. Positively regulates amino acid uptake through the control of expression of amino acid permeases. Responsible for the phosphorylation of AGC kinase gad8 at 'Ser-527' and 'Ser-546', activating gad8 kinase activity and promoting sex [...] (2335 aa)
win1MAP kinase kinase kinase win1; Involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the wis1 MAP kinase kinase by phosphorylation. (1436 aa)
mmi1YTH domain-containing protein mmi1; RNA-binding protein that recognizes and binds N6- methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs (By similarity). Required for elemination of certain meiosis-specific mRNAs in an early event following transcription. May bind to the cis-acting region (DSR) of the mRNA, activating the nuclear exosome which may lead to the degradation of the transcript from the 3' region. (488 aa)
mei321 kDa protein inducing meiosis and sporulation; This protein, expressed under control of the mating-type locus, induces meiosis and sporulation in fission yeast. It down regulates the ran1/pat1 gene product. (148 aa)
pat1Negative regulator of sexual conjugation and meiosis; This protein is a negative regulator of both sexual conjugation and meiosis. It phosphorylates mei2. It blocks the onset of meiosis until conjugation takes place. (470 aa)
mei2Meiosis protein mei2; Crucial for commitment to meiosis but it is not sufficient itself for the commitment. May be a splicing regulator. (750 aa)
byr1Protein kinase byr1; Serine/threonine protein kinase involved in conjugation and sporulation. It is thought that it is phosphorylated by the byr2 protein kinase and that it can phosphorylate the spk1 kinase. When bound to bob1, is involved in the regulation of sexual differentiation. (340 aa)
gpa1Guanine nucleotide-binding protein alpha-1 subunit; Implicated in the mating and sporulation pathway. Probably coupled to mating-factor receptors. May act in concert with Ras1; Belongs to the G-alpha family. G(q) subfamily. (407 aa)
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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