node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
act1 | crm1 | P10989 | P14068 | Actin; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Belongs to the exportin family. | 0.522 |
cbc2 | crm1 | Q9P383 | P14068 | Nuclear cap-binding protein subunit 2; Component of the CBC complex, which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs. | Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Belongs to the exportin family. | 0.777 |
cbc2 | lsm2 | Q9P383 | O94408 | Nuclear cap-binding protein subunit 2; Component of the CBC complex, which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs. | U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. | 0.618 |
cbc2 | rpb7 | Q9P383 | O14459 | Nuclear cap-binding protein subunit 2; Component of the CBC complex, which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs. | DNA-directed RNA polymerase II subunit rpb7; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems [...] | 0.553 |
cbc2 | ste13 | Q9P383 | Q09181 | Nuclear cap-binding protein subunit 2; Component of the CBC complex, which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs. | Putative ATP-dependent RNA helicase ste13; ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity); Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. | 0.410 |
cbc2 | tif471 | Q9P383 | Q10475 | Nuclear cap-binding protein subunit 2; Component of the CBC complex, which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs. | Eukaryotic translation initiation factor 4 gamma; Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Belongs to the eukaryotic initiation factor 4G family. | 0.971 |
crm1 | act1 | P14068 | P10989 | Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Belongs to the exportin family. | Actin; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | 0.522 |
crm1 | cbc2 | P14068 | Q9P383 | Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Belongs to the exportin family. | Nuclear cap-binding protein subunit 2; Component of the CBC complex, which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs. | 0.777 |
crm1 | fib1 | P14068 | P35551 | Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Belongs to the exportin family. | rRNA 2'-O-methyltransferase fibrillarin; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification [...] | 0.465 |
crm1 | pdc2 | P14068 | O42958 | Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Belongs to the exportin family. | DNA topoisomerase 2-associated protein pat1; Activator of decapping that functions as a general and active mechanism of translational repression and required for P-body formation. Stabilizes the 3' terminus of mRNAs and modulates the rates of mRNA-decapping that occur following deadenylation. Might be required for promoting the formation or the stabilization of the preinitiation translation complexes. Necessary for accurate chromosome transmission during cell division (By similarity); Belongs to the PAT1 family. | 0.580 |
crm1 | ste13 | P14068 | Q09181 | Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Belongs to the exportin family. | Putative ATP-dependent RNA helicase ste13; ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity); Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. | 0.658 |
crm1 | tif471 | P14068 | Q10475 | Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Belongs to the exportin family. | Eukaryotic translation initiation factor 4 gamma; Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Belongs to the eukaryotic initiation factor 4G family. | 0.486 |
edc3 | lsm2 | O94752 | O94408 | Enhancer of mRNA-decapping protein 3; Stimulates decapping of both stable and unstable mRNA during mRNA decay. Stimulates decapping presumably by preventing the DCP1-DCP2 decapping complex from adopting an inactive conformation. Belongs to the EDC3 family. | U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. | 0.877 |
edc3 | pdc2 | O94752 | O42958 | Enhancer of mRNA-decapping protein 3; Stimulates decapping of both stable and unstable mRNA during mRNA decay. Stimulates decapping presumably by preventing the DCP1-DCP2 decapping complex from adopting an inactive conformation. Belongs to the EDC3 family. | DNA topoisomerase 2-associated protein pat1; Activator of decapping that functions as a general and active mechanism of translational repression and required for P-body formation. Stabilizes the 3' terminus of mRNAs and modulates the rates of mRNA-decapping that occur following deadenylation. Might be required for promoting the formation or the stabilization of the preinitiation translation complexes. Necessary for accurate chromosome transmission during cell division (By similarity); Belongs to the PAT1 family. | 0.954 |
edc3 | ste13 | O94752 | Q09181 | Enhancer of mRNA-decapping protein 3; Stimulates decapping of both stable and unstable mRNA during mRNA decay. Stimulates decapping presumably by preventing the DCP1-DCP2 decapping complex from adopting an inactive conformation. Belongs to the EDC3 family. | Putative ATP-dependent RNA helicase ste13; ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity); Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. | 0.999 |
edc3 | sum2 | O94752 | Q9HGL3 | Enhancer of mRNA-decapping protein 3; Stimulates decapping of both stable and unstable mRNA during mRNA decay. Stimulates decapping presumably by preventing the DCP1-DCP2 decapping complex from adopting an inactive conformation. Belongs to the EDC3 family. | Protein sum2; Required for G2/M phase checkpoint control. | 0.960 |
edc3 | tif471 | O94752 | Q10475 | Enhancer of mRNA-decapping protein 3; Stimulates decapping of both stable and unstable mRNA during mRNA decay. Stimulates decapping presumably by preventing the DCP1-DCP2 decapping complex from adopting an inactive conformation. Belongs to the EDC3 family. | Eukaryotic translation initiation factor 4 gamma; Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Belongs to the eukaryotic initiation factor 4G family. | 0.833 |
fib1 | crm1 | P35551 | P14068 | rRNA 2'-O-methyltransferase fibrillarin; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification [...] | Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Belongs to the exportin family. | 0.465 |
fib1 | sce3 | P35551 | O14369 | rRNA 2'-O-methyltransferase fibrillarin; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification [...] | Probable RNA-binding protein sce3. | 0.498 |
fib1 | tif471 | P35551 | Q10475 | rRNA 2'-O-methyltransferase fibrillarin; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification [...] | Eukaryotic translation initiation factor 4 gamma; Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Belongs to the eukaryotic initiation factor 4G family. | 0.607 |