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ste6 ste6 gpa1 gpa1 spk1 spk1 map3 map3 wis1 wis1 mfm1 mfm1 mug24 mug24 ste4 ste4 ste11 ste11 pka1 pka1 atf1 atf1 rst2 rst2 tht1 tht1 sty1 sty1 pcr1 pcr1 fep1 fep1 mug133 mug133 gaf1 gaf1 mug8 mug8 mug14 mug14 ams2 ams2 bqt2 bqt2 moa1 moa1 rec24 rec24 tor2 tor2 cgs2 cgs2 ala1 ala1 wis4 wis4 win1 win1 ppk33 ppk33 mug112 mug112 fzr3 fzr3 pat1 pat1 mei2 mei2 act1 act1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ste6Protein ste6; Promotes the exchange of RAS-bound GDP by GTP. This protein is essential for mating. (911 aa)
gpa1Guanine nucleotide-binding protein alpha-1 subunit; Implicated in the mating and sporulation pathway. Probably coupled to mating-factor receptors. May act in concert with Ras1; Belongs to the G-alpha family. G(q) subfamily. (407 aa)
spk1Mitogen-activated protein kinase spk1; Involved in mating signal transduction pathway. (372 aa)
map3Pheromone M-factor receptor; Receptor for the peptide pheromone M-factor, a mating factor of S.pombe. Pheromone signaling is essential for initiation of meiosis in S.pombe; M-factor signaling alone may be sufficient. (365 aa)
wis1Protein kinase wis1; Dosage-dependent regulator of mitosis with serine/ threonine protein kinase activity. May play a role in the integration of nutritional sensing with the control over entry into mitosis. It may interact with cdc25, wee1 and win1. May activate sty1. (605 aa)
mfm1M-factor; M-factor is a mating pheromone produced by M-type mating cells. All three mfm genes contribute to the production of M-factor. (42 aa)
mug24Meiotically up-regulated gene 24 protein; Has a role in meiosis. (654 aa)
ste4Sexual differentiation protein ste4; Essential for mating and meiosis. (264 aa)
ste11Transcription factor ste11; Key transcription factor for sexual development. Activates the transcription of the matp, matm, mei2, mfm, ste6 and rgs1 genes. Binds specifically to a DNA fragment carrying a 10-base motif 5'- TTCTTTGTTY-3'. (468 aa)
pka1cAMP-dependent protein kinase catalytic subunit. (512 aa)
atf1Transcription factor atf1; Transcription factor required for sexual development and entry into stationary phase. Binds and activates meiotic recombination hot spot ade6-M26. (566 aa)
rst2Zinc finger protein rst2; Key transcription factor for sexual development. Activates the transcription of ste11. Binds to a stress response element-like (SRE) region in the ste11 promoter. (567 aa)
tht1Nuclear fusion protein tht1; Required for nuclear membrane fusion during karyogamy. Belongs to the KAR5 family. (577 aa)
sty1Mitogen-activated protein kinase sty1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Involved in osmoregulation and stress response pathways leading to an efficient start of sexual differentiation. Supports translation initiation and facilitates adaptation to environmental stress in part through reducing eIF2-alpha phosphorylation. Links the cell-cycle G2/M control with changes in the extracellular environment that a [...] (349 aa)
pcr1Transcription factor pcr1; Involved in regulation of gene expression for sexual development. Binds and activates meiotic recombination hot spot ade6- M26. (171 aa)
fep1Iron-sensing transcription factor 1; Represses the expression of the iron transporter fio1 in response to high iron concentrations. Binds to the consensus sequence 5'-[AT]GATAA-3'. Also represses the expression of str1, str2 and str3. (564 aa)
mug133Meiotically up-regulated gene 133 protein; Has a role in meiosis; Belongs to the UPF0300 family. (513 aa)
gaf1Transcription factor gaf1; Transcriptional activator. (855 aa)
mug8Meiotically up-regulated gene 8 protein; Has a role in meiosis and septation. (720 aa)
mug14Meiotically up-regulated gene 14 protein; Has a role in meiosis. (257 aa)
ams2CENP-A multicopy suppressor protein 2; Required for proper chromosome segregation via regulation of CENP-A localization to the centromere. (697 aa)
bqt2Telomere bouquet protein 2; Involved in chromosome segregation. During meiotic prophase, connects telomeres to the spindle pole body by forming a bridge between the telomere protein rap1 and the spindle pole body protein sad1. (118 aa)
moa1Monopolar attachment protein 1; Plays an important role in chromosome segregation during meiosis I by allowing meiotic rec8 to establish cohesion at the centromeric central core and thereby promote the side-by-side structure of kinetochores at meiosis I. Enables monopolar attachment during meiosis I. Required to facilitate kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Acts in collaboration with plo1. (172 aa)
rec24Meiotic recombination protein rec24; Required for correct meiotic chromosome segregation and recombination. (350 aa)
tor2Serine/threonine-protein kinase tor2; Phosphatidylinositol 3-kinase homolog, component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. TORC1 controls the switch between cell proliferation and differentiation by sensing nutrient availability. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulating ribosomal protein gene expression. In nutrient rich conditions, responsible for the phosphorylation of AGC S6 kinase ( [...] (2337 aa)
cgs23',5'-cyclic-nucleotide phosphodiesterase. (346 aa)
ala1Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (959 aa)
wis4MAP kinase kinase kinase wis4; Involved in a signal transduction pathway that is activated in under conditions of heat shock, oxidative stress or limited nutrition. Unlike win1, it is not activated by changes in the osmolarity of the extracellular environment. Activates the wis1 MAP kinase kinase by phosphorylation. (1401 aa)
win1MAP kinase kinase kinase win1; Involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the wis1 MAP kinase kinase by phosphorylation. (1436 aa)
ppk33Serine/threonine-protein kinase ppk33; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (338 aa)
mug112Meiotically up-regulated gene 112 protein; Has a role in meiosis. (125 aa)
fzr3Meiotic fizzy-related protein 2; Has a role in meiosis; Belongs to the WD repeat CDC20/Fizzy family. (509 aa)
pat1Negative regulator of sexual conjugation and meiosis; This protein is a negative regulator of both sexual conjugation and meiosis. It phosphorylates mei2. It blocks the onset of meiosis until conjugation takes place. (470 aa)
mei2Meiosis protein mei2; Crucial for commitment to meiosis but it is not sufficient itself for the commitment. May be a splicing regulator. (750 aa)
act1Actin; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (375 aa)
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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