STRINGSTRING
rds1 rds1 rpb11 rpb11 cuf1 cuf1 SPAC11D3.06 SPAC11D3.06 SPAC11D3.09 SPAC11D3.09 spc19 spc19 SPAPB24D3.03 SPAPB24D3.03 uck2 uck2 toe1 toe1 aat1 aat1 alr2 alr2 urh1 urh1 ask1 ask1 car2 car2 urg1 urg1 urg3 urg3 urg2 urg2 toe2 toe2 dad5 dad5 urk1 urk1 SPBC3H7.05c SPBC3H7.05c duo1 duo1 ura6 ura6 spc34 spc34 SPACUNK4.15 SPACUNK4.15 osh3 osh3 toe3 toe3 car1 car1 hsk1 hsk1 SPBC1773.13 SPBC1773.13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rds1Protein rds1; May have a function in stress-related responses of the cell. (402 aa)
rpb11DNA-directed RNA polymerase II subunit RPB11; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity). (123 aa)
cuf1Metal-binding regulatory protein cuf1; Copper-sensing transcription factor that regulates iron uptake genes. Under copper starvation conditions activates the transcription of the copper transport genes, ctr4, ctr5 and ctr6. (411 aa)
SPAC11D3.06Uncharacterized transporter C11D3.06. (455 aa)
SPAC11D3.09Putative agmatinase 1; Belongs to the arginase family. (394 aa)
spc19DASH complex subunit spc19; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. May be necessary for growth under high osmotic stress. (152 aa)
SPAPB24D3.03Putative agmatinase 3; Belongs to the arginase family. (408 aa)
uck2Uracil phosphoribosyltransferase 2; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (220 aa)
toe1Uncharacterized transcriptional regulatory protein C1399.05c. (529 aa)
aat1Amino acid transporter 1; Probable amino acid transporter that may play a role in function in microtubule organization since it causes microtubule defects when overexpressed; Belongs to the amino acid-polyamine-organocation (APC) superfamily. (579 aa)
alr2Putative alanine racemase 2; Belongs to the alanine racemase family. (370 aa)
urh1Uncharacterized protein C1683.06c. (310 aa)
ask1DASH complex subunit ask1; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. Plays a role in meiosis. (307 aa)
car2Ornithine aminotransferase car2. (438 aa)
urg1Uracil-regulated protein 1; Belongs to the GTP cyclohydrolase II family. (439 aa)
urg3Protein urg3; Belongs to the URC4/urg3 family. (399 aa)
urg2Putative uracil phosphoribosyltransferase urg2; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate; Belongs to the UPRTase family. (204 aa)
toe2Uncharacterized transcriptional regulatory protein C139.03. (625 aa)
dad5High osmolarity sensitivity protein 3; May play a role in the progression of mitosis in an environment of high osmotic stress. (94 aa)
urk1Uridine kinase; Catalyzes the conversion of uridine into UMP and cytidine into CMP in the pyrimidine salvage pathway. (454 aa)
SPBC3H7.05cUncharacterized membrane protein C3H7.05c. (357 aa)
duo1DASH complex subunit duo1; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity). (282 aa)
ura6Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (191 aa)
spc34DASH complex subunit spc34; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. (164 aa)
SPACUNK4.15Uncharacterized protein UNK4,15. (208 aa)
osh3Oxysterol-binding protein homolog C23H4.01c. (945 aa)
toe3Uncharacterized transcriptional regulatory protein PB24D3.01. (594 aa)
car1Arginase; Belongs to the arginase family. (323 aa)
hsk1Cell cycle serine/threonine-protein kinase hsk1; Required for G1/S transition. Plays a role in DNA replication checkpoint signaling through regulating rad3 and cds1. Involved in the maintenance of mitotic chromosome structures during S phase through regulating the function of rad21. Required for initiation of mitotic DNA replication through phosphorylating mcm2/cdc19. Required for genome integrity; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily. (507 aa)
SPBC1773.13Aromatic amino acid aminotransferase C1773.13; Has aromatic amino acid transaminase activity. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (481 aa)
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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