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SPAC4H3.09 SPAC4H3.09 atf1 atf1 atf21 atf21 mug143 mug143 mlo2 mlo2 atf31 atf31 rgs1 rgs1 pcr1 pcr1 pyk1 pyk1 SPAC4H3.08 SPAC4H3.08 mcm2 mcm2 sks2 sks2 rap1 rap1 reb1 reb1 rsv1 rsv1 SPAC922.04 SPAC922.04 med6 med6 itt1 itt1 dni2 dni2 SPAC22F8.05 SPAC22F8.05 SPCC306.11 SPCC306.11 meu31 meu31 ura4 ura4 mei2 mei2 pat1 pat1 srk1 srk1 erg27 erg27 dus2 dus2 meu17 meu17 leu3 leu3 omt2 omt2 php4 php4 ace2 ace2 mei4 mei4 leu1 leu1 mik1 mik1 cdc22 cdc22 ste11 ste11
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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SPAC4H3.09Putative acyl carrier protein, mitochondrial; Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). May be involved in the synthesis of very- long-chain fatty acids; Belongs to the acyl carrier protein (ACP) family. (112 aa)
atf1Transcription factor atf1; Transcription factor required for sexual development and entry into stationary phase. Binds and activates meiotic recombination hot spot ade6-M26. (566 aa)
atf21Transcription factor atf21. (355 aa)
mug143Meiotically up-regulated gene 143 protein; Has a role in meiosis. (121 aa)
mlo2Protein mlo2; Not known, interfere with mitotic chromosome segregation when overexpressed. (329 aa)
atf31Transcription factor atf31. (209 aa)
rgs1Regulator of G-protein signaling 1; Negatively regulates pheromone signaling during mating. Acts in a negative feedback loop that is essential for the mating process. This loop acts to down-regulate cellular sensitivity to pheromone. Activated by ste11. (481 aa)
pcr1Transcription factor pcr1; Involved in regulation of gene expression for sexual development. Binds and activates meiotic recombination hot spot ade6- M26. (171 aa)
pyk1Pyruvate kinase. (509 aa)
SPAC4H3.08Uncharacterized oxidoreductase C4H3.08; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (286 aa)
mcm2DNA replication licensing factor mcm2; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (830 aa)
sks2Ribosome-associated molecular chaperone sks2; Ribosome-bound, Hsp70-type chaperone that assists in the cotranslational folding of newly synthesized proteins in the cytosol. Stimulates folding by interacting with nascent chains, binding to short, largely hydrophobic sequences exposed by unfolded proteins, thereby stabilizing longer, more slowly translated, and aggregation- prone nascent polypeptides and domains that cannot fold stably until fully synthesized. The Hsp70-protein substrate interaction depends on ATP-binding and on allosteric regulation between the NBD and the SBD. The ATP- [...] (613 aa)
rap1DNA-binding protein rap1; Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE). Unlike yeast, exhibits no effect in transcription regulation. Belongs to the RAP1 family. (693 aa)
reb1DNA-binding protein reb1; DNA-binding protein that recognizes sites within both the enhancer and the promoter of rRNA transcription, as well as upstream of many genes transcribed by RNA polymerase II. Has a role in the termination of RNA polymerase I catalyzed transcription. (504 aa)
rsv1Zinc finger protein rsv1; Involved in maintaining cell viability under glucose starvation conditions. May have a role in regulating genes involved in gluconeogenesis. (428 aa)
SPAC922.04Uncharacterized protein C922.04. (117 aa)
med6Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (216 aa)
itt1E3 ubiquitin-protein ligase itt1. (435 aa)
dni2Delayed minus-nitrogen induction protein 2; Belongs to the SUR7 family. (248 aa)
SPAC22F8.05Putative alpha,alpha-trehalose-phosphate synthase [UDP-forming] 100 kDa subunit. (891 aa)
SPCC306.11Uncharacterized protein C306.11. (283 aa)
meu31Meiotic expression up-regulated protein 31. (185 aa)
ura4Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (264 aa)
mei2Meiosis protein mei2; Crucial for commitment to meiosis but it is not sufficient itself for the commitment. May be a splicing regulator. (750 aa)
pat1Negative regulator of sexual conjugation and meiosis; This protein is a negative regulator of both sexual conjugation and meiosis. It phosphorylates mei2. It blocks the onset of meiosis until conjugation takes place. (470 aa)
srk1Serine/threonine-protein kinase srk1; Has a role in the regulation of meiosis via the sty1 stress- activated MAPK pathway. Inhibits nitrogen-limitation induced arrest at G1; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. (580 aa)
erg273-keto-steroid reductase; Responsible for the reduction of the keto group on the C-3 of sterols. (338 aa)
dus2tRNA-dihydrouridine(20) synthase [NAD(P)+]; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. (479 aa)
meu17Probable glucoamylase. (450 aa)
leu32-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). (584 aa)
omt2Pterin-4-alpha-carbinolamine dehydratase; Has a role in spore wall formation. (96 aa)
php4CCAAT-binding factor complex subunit php4; Component of the transcription regulatory CCAAT-binding complex. Required for the reprogramming of the cell for iron use. Downregulates pcl1, sdh4, and isa1 underlow-iron conditions. (295 aa)
ace2Metallothionein expression activator; Regulates the transcription of genes required for cell separation. (533 aa)
mei4Meiosis-specific transcription factor mei4; Functions as a meiosis-specific transcription factor. Binds to the 5'-GTAAAYA-3' consensus sequence of the promoter of the spo6 gene. (517 aa)
leu13-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (371 aa)
mik1Mitosis inhibitor protein kinase mik1; Protein kinase that acts both on serines and on tyrosines. It acts as a negative regulator of entry into mitosis (G2 to M transition). Phosphorylates and inhibits cdc2. (581 aa)
cdc22Ribonucleoside-diphosphate reductase large chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (811 aa)
ste11Transcription factor ste11; Key transcription factor for sexual development. Activates the transcription of the matp, matm, mei2, mfm, ste6 and rgs1 genes. Binds specifically to a DNA fragment carrying a 10-base motif 5'- TTCTTTGTTY-3'. (468 aa)
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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