STRINGSTRING
spo5 spo5 srw1 srw1 cut11 cut11 cdc25 cdc25 mei2 mei2 cdc13 cdc13 crm1 crm1 ura4 ura4 ade6 ade6 leu1 leu1 rae1 rae1 atf1 atf1 atf21 atf21 atf31 atf31 pcr1 pcr1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
spo5Sporulation-specific protein 5; RNA-binding protein which plays a role in sporulation. Regulates the progression of meiosis I and may function in the vicinity of the Mei2 dot. (567 aa)
srw1WD repeat-containing protein srw1; Has a role in cell differentiation and cell cycling by negatively regulating cig2 and cdc12-associated cdc2. Down-regulates the level of cdc13, particularly in a nitrogen deprived environment. Regulator of cell cycle G1 phase progression. Prevents onset of mitosis during the pre-Start G1 period. Required for degradation of cdc13 mitotic cyclin B during G1 arrest but not during mitotic exit. (556 aa)
cut11Nuclear envelope protein ndc1; Component of the nuclear pore complex (NPC) and the spindle pole body (SPB), which plays a key role in de novo assembly and insertion of both structures in the nuclear envelope. Involved in the formation of the bipolar mitotic spindle. Anchors the spindle pole body in the nuclear envelope; Belongs to the NDC1 family. (601 aa)
cdc25M-phase inducer phosphatase; This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity. (596 aa)
mei2Meiosis protein mei2; Crucial for commitment to meiosis but it is not sufficient itself for the commitment. May be a splicing regulator. (750 aa)
cdc13G2/mitotic-specific cyclin cdc13; Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the cdc2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Involved in the reorganization of the cytoskeleton on transition from G2 to mitosis. Association with rum1 promotes its proteolysis during G1. (482 aa)
crm1Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Belongs to the exportin family. (1078 aa)
ura4Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (264 aa)
ade6Phosphoribosylaminoimidazole carboxylase; In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily. (552 aa)
leu13-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (371 aa)
rae1Poly(A)+ RNA export protein; Required for mitotic cell growth as well as for spore germination. Functions in cell cycle progression through trafficking of proteins required for mitosis. Has a role in the mRNA export process. (352 aa)
atf1Transcription factor atf1; Transcription factor required for sexual development and entry into stationary phase. Binds and activates meiotic recombination hot spot ade6-M26. (566 aa)
atf21Transcription factor atf21. (355 aa)
atf31Transcription factor atf31. (209 aa)
pcr1Transcription factor pcr1; Involved in regulation of gene expression for sexual development. Binds and activates meiotic recombination hot spot ade6- M26. (171 aa)
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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