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pac1 pac1 agn1 agn1 crn1 crn1 cam2 cam2 wsp1 wsp1 spa2 spa2 bgs4 bgs4 dip1 dip1 exg3 exg3 myo51 myo51 myo52 myo52 agn2 agn2 for3 for3 cam1 cam1 act1 act1 ura4 ura4 map3 map3 cdc3 cdc3 cdc8 cdc8 pst1 pst1 cdc15 cdc15 eng2 eng2 cdc12 cdc12 bgs1 bgs1 arc5 arc5 exg2 exg2 fus1 fus1 exg1 exg1 myo2 myo2 eng1 eng1 rlc1 rlc1 myo1 myo1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pac1Double-strand-specific pac1 ribonuclease; Digests double-stranded RNA. Converts long double-stranded RNAs into short oligonucleotides, leaving 5'-phosphates on their cleavage products. Probably inhibits mating and meiosis by degrading a specific mRNA required for sexual development. (363 aa)
agn1Glucan endo-1,3-alpha-glucosidase agn1; Has a role in cell separation where it is required for the degradation of the cell wall material surrounding the septum (the septum edging) which must be hydrolyzed before full separation of the daughter cells can occur. Hydrolyzes 1,3-alpha-glucan predominantly into pentasaccharides. (424 aa)
crn1Coronin-like protein crn1. (601 aa)
cam2Myosin 1 light chain cam2; Plays a role in meiosis and sporulation. (143 aa)
wsp1Wiskott-Aldrich syndrome protein homolog 1; Has a role in regulating actin assembly, so regulating polarized growth. (574 aa)
spa2Uncharacterized protein C3G9.05. (659 aa)
bgs41,3-beta-glucan synthase component bgs4; Belongs to the glycosyltransferase 48 family. (1955 aa)
dip1Protein dip1; May be involved in protein-linked oligosaccharide phosphorylation; Belongs to the LDB17 family. (374 aa)
exg3Glucan 1,3-beta-glucosidase 3. (464 aa)
myo51Myosin-51; Involved in cytokinesis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1471 aa)
myo52Myosin-52; Involved in cell wall deposition where it has a role in the localization of mok1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1516 aa)
agn2Glucan endo-1,3-alpha-glucosidase agn2; Involved in the endolysis of the ascus wall. (433 aa)
for3Formin-3; Involved in controlling polarized cell growth. Required for interphase actin cable formation and microtubule organization. Belongs to the formin homology family. (1461 aa)
cam1Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (150 aa)
act1Actin; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (375 aa)
ura4Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (264 aa)
map3Pheromone M-factor receptor; Receptor for the peptide pheromone M-factor, a mating factor of S.pombe. Pheromone signaling is essential for initiation of meiosis in S.pombe; M-factor signaling alone may be sufficient. (365 aa)
cdc3Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. In S.pombe, it is essential for cytokinesis. (127 aa)
cdc8Tropomyosin; Forms part of the F-actin contractile ring during cytokinesis. (161 aa)
pst1Paired amphipathic helix protein pst1; Has a role in modulating the nuclear import of TF1 virus-like particles. Essential for viability. (1522 aa)
cdc15Cell division control protein 15; After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Appears to mediate cytoskeletal rearrangements required for cytokinesis. Essential for viability. (927 aa)
eng2Putative endo-1,3(4)-beta-glucanase 2; Belongs to the glycosyl hydrolase 81 family. (706 aa)
cdc12Cell division control protein 12; Plays a role in the cell cycle. Involved in cytokinesis. Component of the cell division ring. In the absence of profilin, caps the barbed end of actin filaments, thus preventing subunit addition and dissociation. In the presence of profilin, nucleates actin filaments that grow rapidly from their barbed ends. Belongs to the formin homology family. BNI1 subfamily. (1841 aa)
bgs11,3-beta-glucan synthase component bgs1; Required for the assembly of the division septum and maintenance of cell polarity. (1729 aa)
arc5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (152 aa)
exg2Glucan 1,3-beta-glucosidase 2; Belongs to the glycosyl hydrolase 5 (cellulase A) family. (570 aa)
fus1Cell fusion protein fus1; Required for cell fusion. It associates with the pre-zygotic projection tips in conjugating cells; Belongs to the formin homology family. BNI1 subfamily. (1372 aa)
exg1Glucan 1,3-beta-glucosidase 1; Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. It could also function biosynthetically as a transglycosylase (By similarity). (407 aa)
myo2Myosin type-2 heavy chain 1; Required for cell division. It is a component of the cdc12 'spot', a structure thought to mark the site of septation. May work in conjunction with myo3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1526 aa)
eng1Endo-1,3(4)-beta-glucanase 1; Has a role in cell separation where it is required for the degradation of the primary septum after completion of cytokinesis. (1016 aa)
rlc1Myosin regulatory light chain 1. (184 aa)
myo1Myosin-1; Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Contributes to proper septation by transporting vesicles containing septal material to the division site and is involved in the formation of sterol-rich membrane domains at the cell division site. Required also for mating. (1217 aa)
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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