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bub1 bub1 mis16 mis16 bub3 bub3 spc19 spc19 ndc80 ndc80 dad3 dad3 mis17 mis17 mis18 mis18 cnp20 cnp20 scm3 scm3 mis15 mis15 dad4 dad4
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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experimentally determined
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bub1Checkpoint serine/threonine-protein kinase bub1; Involved in cell cycle checkpoint enforcement. Acts to stabilize the spindle during mitosis. Required for the correct localization of bub3 and mad3 to the kinetochore. Appears to have a role in chromosome segregation. Catalyzes the phosphorylation of bub3. (1044 aa)
mis16Histone acetyltransferase type B subunit 2; Regulatory subunit of the histone acetylase B (HAT-B) complex (By similarity). The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing (By similarity). Component of the CENP-A recruiting complex that ensures the integrity of mitotic spindles through maintenance of kinetochore factors mis6/CENP-I and cnp1/CENP-A. Maintains the deacetylated state of histones specifically in the central core of the centromeres. Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. (430 aa)
bub3Mitotic checkpoint protein bub3; Involved in cell cycle checkpoint enforcement. Involved in recruitment of checkpoint proteins bub1 and mad3 to the kinetochores, ensuring correct spindle checkpoint function. Belongs to the WD repeat BUB3 family. (320 aa)
spc19DASH complex subunit spc19; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. May be necessary for growth under high osmotic stress. (152 aa)
ndc80Kinetochore protein ndc80; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Belongs to the NDC80/HEC1 family. (624 aa)
dad3DASH complex subunit dad3; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity). (86 aa)
mis17Inner kinetochore subunit mis17; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere- associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. (441 aa)
mis18Kinetochore protein mis18; Component of the CENP-A recruiting complex that ensures the integrity of mitotic spindles through maintenance of kinetochore factors mis6/CENP-I and cnp1/CENP-A. Maintains the deacetylated state of histones specifically in the central core of the centromeres. Belongs to the mis18 family. (194 aa)
cnp20Inner kinetochore subunit cnp20; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. (479 aa)
scm3Uncharacterized protein PB1A10.02. (336 aa)
mis15Inner kinetochore subunit mis15; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. Has a role in the formation and/or maintenance of specialized chromatin at the centromere. (409 aa)
dad4DASH complex subunit dad4; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. May be necessary for growth under high osmotic stress. (72 aa)
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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