9 items (Schizosaccharomyces pombe) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	lsm3	Probable U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (93 aa)
	dcp2	mRNA decapping complex subunit 2; Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense- mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body. (741 aa)
	lsm4	Probable U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (121 aa)
	prp31	Pre-mRNA-processing factor 31; Required for spliceosome assembly where it is needed to link the U4/U6XU5 tri-snRNP to the prespliceosome complexes. Belongs to the PRP31 family. (518 aa)
	lsm8	U6 snRNA-associated Sm-like protein LSm8; Probable component of the spliceosome; Belongs to the snRNP Sm proteins family. (94 aa)
	top2	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1485 aa)
	pka1	cAMP-dependent protein kinase catalytic subunit. (512 aa)
	ste13	Putative ATP-dependent RNA helicase ste13; ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity); Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. (485 aa)
	prp24	Uncharacterized RNA-binding protein C1861.04c. (1014 aa)

Your Current Organism:

Schizosaccharomyces pombe

NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
dcp2	lsm3	O13828	Q9Y7M4	mRNA decapping complex subunit 2; Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense- mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.	Probable U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.755
dcp2	lsm4	O13828	O14352	mRNA decapping complex subunit 2; Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense- mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.	Probable U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.936
dcp2	lsm8	O13828	O74483	mRNA decapping complex subunit 2; Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense- mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.	U6 snRNA-associated Sm-like protein LSm8; Probable component of the spliceosome; Belongs to the snRNP Sm proteins family.	0.691
dcp2	ste13	O13828	Q09181	mRNA decapping complex subunit 2; Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense- mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.	Putative ATP-dependent RNA helicase ste13; ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity); Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.	0.996
lsm3	dcp2	Q9Y7M4	O13828	Probable U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	mRNA decapping complex subunit 2; Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense- mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.	0.755
lsm3	lsm4	Q9Y7M4	O14352	Probable U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	Probable U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.999
lsm3	lsm8	Q9Y7M4	O74483	Probable U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	U6 snRNA-associated Sm-like protein LSm8; Probable component of the spliceosome; Belongs to the snRNP Sm proteins family.	0.999
lsm3	prp24	Q9Y7M4	Q9USY2	Probable U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	Uncharacterized RNA-binding protein C1861.04c.	0.997
lsm3	prp31	Q9Y7M4	O42904	Probable U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	Pre-mRNA-processing factor 31; Required for spliceosome assembly where it is needed to link the U4/U6XU5 tri-snRNP to the prespliceosome complexes. Belongs to the PRP31 family.	0.995
lsm3	ste13	Q9Y7M4	Q09181	Probable U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	Putative ATP-dependent RNA helicase ste13; ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity); Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.	0.548
lsm4	dcp2	O14352	O13828	Probable U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	mRNA decapping complex subunit 2; Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense- mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.	0.936
lsm4	lsm3	O14352	Q9Y7M4	Probable U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	Probable U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.999
lsm4	lsm8	O14352	O74483	Probable U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	U6 snRNA-associated Sm-like protein LSm8; Probable component of the spliceosome; Belongs to the snRNP Sm proteins family.	0.999
lsm4	prp24	O14352	Q9USY2	Probable U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	Uncharacterized RNA-binding protein C1861.04c.	0.998
lsm4	prp31	O14352	O42904	Probable U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	Pre-mRNA-processing factor 31; Required for spliceosome assembly where it is needed to link the U4/U6XU5 tri-snRNP to the prespliceosome complexes. Belongs to the PRP31 family.	0.991
lsm4	ste13	O14352	Q09181	Probable U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	Putative ATP-dependent RNA helicase ste13; ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity); Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.	0.956
lsm8	dcp2	O74483	O13828	U6 snRNA-associated Sm-like protein LSm8; Probable component of the spliceosome; Belongs to the snRNP Sm proteins family.	mRNA decapping complex subunit 2; Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense- mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.	0.691
lsm8	lsm3	O74483	Q9Y7M4	U6 snRNA-associated Sm-like protein LSm8; Probable component of the spliceosome; Belongs to the snRNP Sm proteins family.	Probable U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.999
lsm8	lsm4	O74483	O14352	U6 snRNA-associated Sm-like protein LSm8; Probable component of the spliceosome; Belongs to the snRNP Sm proteins family.	Probable U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.999
lsm8	prp24	O74483	Q9USY2	U6 snRNA-associated Sm-like protein LSm8; Probable component of the spliceosome; Belongs to the snRNP Sm proteins family.	Uncharacterized RNA-binding protein C1861.04c.	0.998