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| | sir1 | Sulfite reductase [NADPH] subunit beta; Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate. (1473 aa) |
| | fol1 | 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; Catalyzes three sequential steps of tetrahydrofolate biosynthesis; In the central section; belongs to the HPPK family. (733 aa) |
| | thf1 | C-1-tetrahydrofolate synthase, cytoplasmic; In the C-terminal section; belongs to the formate-- tetrahydrofolate ligase family. (937 aa) |
| | mtd1 | Methylenetetrahydrofolate dehydrogenase [NAD(+)]; Catalyzes oxidation of cytoplasmic one-carbon units for purine biosynthesis. (320 aa) |
| | met14 | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. Required for methionine synthesis. (202 aa) |
| | srx1 | Sulfiredoxin; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in a peroxiredoxin. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase. Belongs to the sulfiredoxin family. (124 aa) |
| | rpl31 | 60S ribosomal protein L31; Belongs to the eukaryotic ribosomal protein eL31 family. (113 aa) |
| | vps1 | Vacuolar protein sorting-associated protein 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (678 aa) |
| | sfh1 | Chromatin structure-remodeling complex subunit sfh1; Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. (418 aa) |
| | SPAC9.02c | Uncharacterized N-acetyltransferase C9.02c; Belongs to the acetyltransferase family. (165 aa) |
| | SPAC1805.14 | Uncharacterized protein C1805.14. (452 aa) |
| | SPCC63.13 | Uncharacterized J domain-containing protein C63.13. (208 aa) |
| | SPBC1604.12 | Uncharacterized protein C1604.12. (860 aa) |
| | SPBC887.12 | Probable phospholipid-transporting ATPase C887.12; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids. (1258 aa) |
| | hmt2 | Sulfide:quinone oxidoreductase, mitochondrial; Catalyzes the oxidation of hydrogen sulfide, with the help of a quinone. (459 aa) |
| | msn5 | Uncharacterized protein C328.01c. (1234 aa) |
| | gcs2 | Putative glutamate--cysteine ligase regulatory subunit. (287 aa) |
| | met11 | Methylenetetrahydrofolate reductase 2; Major methylenetetrahydrofolate reductase required to generate the methyl groups necessary for methionine synthetase to convert homocysteine to methionine. Performs 15 to 20 percent of the total methylenetetrahydrofolate reductase activity of the cells. (641 aa) |
| | ldb1 | Adhesion defective protein 1; Probable transcriptional regulator involved in cell adhesion. Belongs to the adn1/SEU family. (391 aa) |
| | win1 | MAP kinase kinase kinase win1; Involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the wis1 MAP kinase kinase by phosphorylation. (1436 aa) |
| | clr4 | Histone-lysine N-methyltransferase, H3 lysine-9 specific; Histone methyltransferase. Catalytic component of the rik1- associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransfer [...] (490 aa) |
| | gpx1 | Glutathione peroxidase-like peroxiredoxin gpx1; Glutathione peroxidase-like protein that protects cells during oxidative stress. Has peroxidase activity reducing hydrogen peroxide, alkyl and phospholipid hydroperoxides using preferentially thioredoxin as a reducing power. May act as a scavenger of H(2)O(2). Belongs to the glutathione peroxidase family. (158 aa) |
| | spo9 | Geranylgeranyl pyrophosphate synthase; Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Required for the membrane attachment of ypt7 and rhb1. May be involved in vesicle trafficking and protein sorting. Required for forespore membrane formation. Belongs to the FPP/GGPP synthase family. (351 aa) |
| | cys11 | Cysteine synthase 1; Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine ; Belongs to the cysteine synthase/cystathionine beta- synthase family. (351 aa) |
| | gid2 | LisH domain-containing protein C29A3.03c. (398 aa) |
| | peg1 | Protein peg1; Microtubule binding protein that regulates the stability of dynamic microtubules. Required for mitotic spindle formation. Belongs to the CLASP family. (1462 aa) |
| | ebs1 | Uncharacterized serine-rich protein C2F12.03c. (891 aa) |
| | wis4 | MAP kinase kinase kinase wis4; Involved in a signal transduction pathway that is activated in under conditions of heat shock, oxidative stress or limited nutrition. Unlike win1, it is not activated by changes in the osmolarity of the extracellular environment. Activates the wis1 MAP kinase kinase by phosphorylation. (1401 aa) |
| | stg1 | Transgelin; Has actin-binding and actin-bundling activity and is a component of the actin patch. Stabilizes actin filaments against disassembly. Cross-links F-actin and is required for the formation of the contractile F-actin ring. (174 aa) |
| | SPCC1827.07c | Protein SYG1 homolog; May function in G-protein coupled signal transduction. Belongs to the SYG1 (TC 2.A.94) family. (682 aa) |
| | ura4 | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (264 aa) |
| | ade6 | Phosphoribosylaminoimidazole carboxylase; In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily. (552 aa) |
| | leu1 | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (371 aa) |
| | wis1 | Protein kinase wis1; Dosage-dependent regulator of mitosis with serine/ threonine protein kinase activity. May play a role in the integration of nutritional sensing with the control over entry into mitosis. It may interact with cdc25, wee1 and win1. May activate sty1. (605 aa) |
| | dfr1 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). (461 aa) |
| | trk1 | Potassium transport protein 1; Together with TRK2, defines the major, high-affinity potassium influx transport system. Involved in maintenance of the proper sodium/potassium ratio in the cell and in regulating the plasma membrane potential. (841 aa) |
| | atf1 | Transcription factor atf1; Transcription factor required for sexual development and entry into stationary phase. Binds and activates meiotic recombination hot spot ade6-M26. (566 aa) |
| | tif223 | Probable translation initiation factor eIF-2B subunit gamma; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP. (458 aa) |
| | sua1 | Sulfate adenylyltransferase; Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids. Belongs to the sulfate adenylyltransferase family. (490 aa) |
| | erf1 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (433 aa) |
| | cys12 | Cysteine synthase 2; Putative cysteine synthase that catalyzes the conversion of O-acetyl-L-serine (OAS) into cysteine, the last step in the cysteine biosynthesis pathway. However, in contrast to cysteine synthase cys11, this CS-like protein seems not to function in cysteine biosynthesis, at least under normal growth conditions, although the transcript is produced. (395 aa) |
| | mcs4 | Response regulator mcs4; Response regulator that coordinately controls the stress activated wak1-wis1-sty1 MAP kinase pathway and fission yeast cell cycle. (522 aa) |
| | pap1 | AP-1-like transcription factor; Transcription activator involved in multidrug resistance, oxidative stress response, and redox homeostasis. Regulates the transcription of genes encoding antioxidant enzymes like catalase ctt1 and components of the cellular thiol-reducing pathways, including the thioredoxin system (trx2, trr1), ABC tansporters involved in multidrug resistance like bfr1/hba2 and pmd1 as well as the gene obr1/apt1. Preferentially binds to promoters with the core binding site 5'- TTA[CG]TAA-3'. Activity of the transcription factor is controlled through oxidation of specific [...] (552 aa) |
| | psr1 | Uncharacterized protein C2F7.02c. (325 aa) |
| | gcs1 | Glutamate--cysteine ligase. (669 aa) |
| | SPAC4G8.09 | Putative leucine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (874 aa) |
| | met10 | Probable sulfite reductase [NADPH] flavoprotein component; This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate (By similarity). (1006 aa) |
| | sty1 | Mitogen-activated protein kinase sty1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Involved in osmoregulation and stress response pathways leading to an efficient start of sexual differentiation. Supports translation initiation and facilitates adaptation to environmental stress in part through reducing eIF2-alpha phosphorylation. Links the cell-cycle G2/M control with changes in the extracellular environment that a [...] (349 aa) |
| | pcs2 | Glutathione gamma-glutamylcysteinyltransferase; Required for detoxification of heavy metals such as cadmium and arsenate. (414 aa) |
| | shm2 | Serine hydroxymethyltransferase, mitochondrial; Interconversion of serine and glycine; Belongs to the SHMT family. (488 aa) |
| | met9 | Methylenetetrahydrofolate reductase 1; Major methylenetetrahydrofolate reductase required to generate the methyl groups necessary for methionine synthetase to convert homocysteine to methionine. Performs 80 to 85 percent of the total methylenetetrahydrofolate reductase activity of the cells. (603 aa) |
| | sks2 | Ribosome-associated molecular chaperone sks2; Ribosome-bound, Hsp70-type chaperone that assists in the cotranslational folding of newly synthesized proteins in the cytosol. Stimulates folding by interacting with nascent chains, binding to short, largely hydrophobic sequences exposed by unfolded proteins, thereby stabilizing longer, more slowly translated, and aggregation- prone nascent polypeptides and domains that cannot fold stably until fully synthesized. The Hsp70-protein substrate interaction depends on ATP-binding and on allosteric regulation between the NBD and the SBD. The ATP- [...] (613 aa) |
| | byr1 | Protein kinase byr1; Serine/threonine protein kinase involved in conjugation and sporulation. It is thought that it is phosphorylated by the byr2 protein kinase and that it can phosphorylate the spk1 kinase. When bound to bob1, is involved in the regulation of sexual differentiation. (340 aa) |
