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gas2 gas2 gef2 gef2 asl1 asl1 cdc15 cdc15 mok11 mok11 sty1 sty1 rho1 rho1 yam8 yam8 rho2 rho2 rga2 rga2 knh1 knh1 bgs1 bgs1 mkh1 mkh1 nod1 nod1 ksg1 ksg1 rho4 rho4 pmk1 pmk1 rho5 rho5 bgs3 bgs3 gas1 gas1 mid2 mid2 myo2 myo2 ags1 ags1 clc1 clc1 nrd1 nrd1 eng1 eng1 rgf2 rgf2 mok12 mok12 mok14 mok14 mok13 mok13 rgf3 rgf3 rgf1 rgf1 gas4 gas4 pek1 pek1 rga8 rga8 cdc42 cdc42 wsc1 wsc1 atf1 atf1 shk1 shk1 ptc1 ptc1 pck2 pck2 pck1 pck1 pyp2 pyp2 spk1 spk1 pyp1 pyp1 rga7 rga7 rnc1 rnc1 bgs4 bgs4 rga4 rga4 map4 map4 rga5 rga5 rga1 rga1 rga6 rga6 mbx1 mbx1 cch1 cch1 bgs2 bgs2 mtl1 mtl1 agn1 agn1 mtl2 mtl2 gas5 gas5 sbg1 sbg1 pmp1 pmp1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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gas21,3-beta-glucanosyltransferase gas2; Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall; Belongs to the glycosyl hydrolase 72 family. (459 aa)
gef2Rho guanine nucleotide exchange factor gef2; Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth and septum formation. (1101 aa)
asl1Alkali-sensitive linkage protein 1. (530 aa)
cdc15Cell division control protein 15; After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Appears to mediate cytoskeletal rearrangements required for cytokinesis. Essential for viability. (927 aa)
mok11Cell wall alpha-1,3-glucan synthase mok11. (2397 aa)
sty1Mitogen-activated protein kinase sty1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Involved in osmoregulation and stress response pathways leading to an efficient start of sexual differentiation. Supports translation initiation and facilitates adaptation to environmental stress in part through reducing eIF2-alpha phosphorylation. Links the cell-cycle G2/M control with changes in the extracellular environment that a [...] (349 aa)
rho1GTP-binding protein rho1; Involved in the regulation of cell wall growth and actin cytoskeleton organization. Activates (1,3)-beta-D-glucan synthase. Belongs to the small GTPase superfamily. Rho family. (202 aa)
yam8Calcium influx-promoting protein ehs1; Required for Ca(2+) influx and for vitality of cells in a late, pheromone-induced event of the mating process requiring calcium- induced signaling; To yeast MID1. (486 aa)
rho2GTP-binding protein rho2; Involved in cell morphogenesis, the maintenance of growth direction, control of polarity and of cell wall integrity. Regulates the synthesis of alpha-D-glucan through activation of pck2. (200 aa)
rga2Probable Rho-type GTPase-activating protein 2; GTPase-activating protein for Rho-type proteins. (1275 aa)
knh1Uncharacterized protein C11C11.05. (284 aa)
bgs11,3-beta-glucan synthase component bgs1; Required for the assembly of the division septum and maintenance of cell polarity. (1729 aa)
mkh1MAP kinase kinase kinase mkh1; May regulate cell morphology, cell wall integrity, salt resistance, cell cycle reentry from stationary-phase arrest, and filamentous growth in response to stress. Activates the MAP kinase kinase skh1/pek1 by phosphorylation. (1116 aa)
nod1Uncharacterized protein C12B10.10. (419 aa)
ksg1Serine/threonine-protein kinase ksg1; Involved in the control of sexual development and cell growth under stressed conditions. Phosphorylates AGC kinase gad8 at 'Thr-387', activating gad8 kinase activity and promoting sexual development. Phosphorylates AGC kinase psk1 at 'Ser-248', activating psk1 kinase activity and promoting phosphorylation of ribosomal protein S6. (592 aa)
rho4GTP-binding protein rho4; Required for cell separation. Involved in the regulation of the septum degradation during cytokinesis and in the organization of F- actin patches and cytoplasmic microtubules. Belongs to the small GTPase superfamily. Rho family. (203 aa)
pmk1Mitogen-activated protein kinase spm1; Regulates cell integrity and functions coordinately with the protein kinase C pathway (pck1 and pck2). Involved the regulation of wall architecture, cell shape, cytokinesis in exponential and stationary phase, and metabolism of ions. (422 aa)
rho5GTP-binding protein rho5. (200 aa)
bgs31,3-beta-glucan synthase component bgs3; Required for cell wall biosynthesis and cell elongation. (1826 aa)
gas11,3-beta-glucanosyltransferase gas1; Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. (542 aa)
mid2Septin ring organizing protein mid2; Responsible for the proper stability and function of septins during cytokinesis. Required for the correct formation of the medial septin ring structure in mitosis and for the proper localization of endo-glucanases agn1 and eng1, which are needed for efficient cell separation. May act as a landmark for the localization of hydrolytic proteins to the medial region. (706 aa)
myo2Myosin type-2 heavy chain 1; Required for cell division. It is a component of the cdc12 'spot', a structure thought to mark the site of septation. May work in conjunction with myo3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1526 aa)
ags1Cell wall alpha-1,3-glucan synthase ags1; Required for alpha-1,3-glucan and alpha-1,4-glucan production which are required for cell wall synthesis. (2410 aa)
clc1Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. (229 aa)
nrd1Negative regulator of differentiation 1; Negative regulator of sexual differentiation. Acts by repressing the transcription of meiosis-inducing, ste11-regulated genes until cells reach a critical level of starvation. RNA-binding protein that preferentially binds poly(U). (529 aa)
eng1Endo-1,3(4)-beta-glucanase 1; Has a role in cell separation where it is required for the degradation of the primary septum after completion of cytokinesis. (1016 aa)
rgf2Rho1 guanine nucleotide exchange factor 2; Stimulates the exchange of Rho1 and Rho5 GDP-bound form into GTP-bound form. Controls septum formation, cell wall synthesis and localization of F-actin patches. (1158 aa)
mok12Cell wall alpha-1,3-glucan synthase mok12. (2352 aa)
mok14Cell wall alpha-1,3-glucan synthase mok14. (1369 aa)
mok13Cell wall alpha-1,3-glucan synthase mok13. (2358 aa)
rgf3Rho1 guanine nucleotide exchange factor 3; Stimulates the exchange of Rho1 GDP-bound form into GTP-bound form. Regulates, via interaction and activation of Rho1, beta-1,3- glucan biosynthesis and cell wall integrity during septation. Involved in the regulation of contractile ring assembly. (1275 aa)
rgf1Rho1 guanine nucleotide exchange factor 1; Stimulates the exchange of Rho1 and Rho5 GDP-bound form into GTP-bound form. Controls septum formation, cell wall synthesis and localization of F-actin patches. Coordinates actin deposition with cell wall biosynthesis during bipolar growth. (1334 aa)
gas41,3-beta-glucanosyltransferase gas4; Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in spore wall assembly. (456 aa)
pek1MAP kinase kinase skh1/pek1; Involved in the mkh1 signal transduction pathway that plays a role in cell wall integrity. Activates spm1/pmk1 via phosphorylation. (363 aa)
rga8Rho-GTPase-activating protein 8; Acts in signal transduction. Negatively regulates the pak1/shk1 control pathway. (777 aa)
cdc42Cell division control protein 42 homolog; Involved in development of cell polarity during the cell division cycle; Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily. (192 aa)
wsc1Cell wall integrity and stress response component 1. (374 aa)
atf1Transcription factor atf1; Transcription factor required for sexual development and entry into stationary phase. Binds and activates meiotic recombination hot spot ade6-M26. (566 aa)
shk1Serine/threonine-protein kinase shk1/pak1; MAP4K component of the MAPK pathway required for the mating pheromone response. Phosphorylates histone H2B to form H2BS10ph (By similarity). Phosphorylates tea1. Required for skb1-dependent mitotic inhibitory function. Regulates microtubule dynamics and cell polarity. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (658 aa)
ptc1Protein phosphatase 2C homolog 1; It has a serine and threonine phosphatase activity. Has a specialized role in the heat shock response. May be responsible for the dephosphorylation of hsp90. Also has a role in maintaining osmotic stability. (347 aa)
pck2Protein kinase C-like 2; Involved in the control of the cell shape. Target of the inhibitor staurosporine; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (1016 aa)
pck1Protein kinase C-like 1; Involved in the control of the cell shape. Target of the inhibitor staurosporine; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (988 aa)
pyp2Tyrosine-protein phosphatase 2; Plays a role in inhibiting the onset of mitosis. Dephosphorylates sty1/spc1 and wis1/spc2/sty2. (711 aa)
spk1Mitogen-activated protein kinase spk1; Involved in mating signal transduction pathway. (372 aa)
pyp1Tyrosine-protein phosphatase 1; Plays a role in inhibiting the onset of mitosis. Dephosphorylates sty1/spc1 and wis1/spc2/sty2. (550 aa)
rga7Probable Rho-GTPase-activating protein 7. (695 aa)
rnc1RNA-binding protein rnc1; Binds and stabilizes pmp1 mRNA and hence acts as a negative regulator of pmk1 signaling. Overexpression suppresses the Cl(-) sensitivity of calcineurin deletion. (398 aa)
bgs41,3-beta-glucan synthase component bgs4; Belongs to the glycosyltransferase 48 family. (1955 aa)
rga4Probable Rho-type GTPase-activating protein 4; GTPase-activating protein for Rho-type proteins. (933 aa)
map4P cell-type agglutination protein map4; P cell-type specific protein which involved in agglutination during conjugation. (948 aa)
rga5Rho-GTPase-activating protein 5; GTPase-activating protein for Rho1. Has a role in the negative regulation of (1-3)beta-D-glucan synthase activity and cell integrity. (361 aa)
rga1Rho-type GTPase-activating protein 1; GTPase-activating protein for Rho1. Involved in the F-actin patch localization, cell morphogenesis, regulation of septation, and cell wall synthesis. (1150 aa)
rga6Probable Rho-GTPase-activating protein 6. (733 aa)
mbx1MADS-box transcription factor 1; Acts as a transcriptional activator with a role in the regulation of mitosis. Regulates septation and the periodic transcription of cdc15. (457 aa)
cch1Calcium-channel protein cch1; Voltage-gated, high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones. Functions together with yam8 to ensure that adequate levels of Ca(2+) are supplied to pmr1 to sustain secretion and growth. Required for growth in low-calcium environments (By similarity). (1854 aa)
bgs21,3-beta-glucan synthase component bgs2; Has a role in ascospore development where it is required for the assembly of a functional spore wall; Belongs to the glycosyltransferase 48 family. (1894 aa)
mtl1Uncharacterized helicase C17H9.02; Belongs to the helicase family. SKI2 subfamily. (1030 aa)
agn1Glucan endo-1,3-alpha-glucosidase agn1; Has a role in cell separation where it is required for the degradation of the cell wall material surrounding the septum (the septum edging) which must be hydrolyzed before full separation of the daughter cells can occur. Hydrolyzes 1,3-alpha-glucan predominantly into pentasaccharides. (424 aa)
mtl2Uncharacterized serine-rich protein C11G7.01. (536 aa)
gas51,3-beta-glucanosyltransferase gas5; Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. (510 aa)
sbg1Uncharacterized protein P22H7.03. (181 aa)
pmp1Tyrosine-protein phosphatase pmp1; Dual specificity phosphatase that dephosphorylates MAP kinase pmk1 on a Tyr. Has a role in chloride ion homeostasis by inactivating this pmk1 MAP kinase pathway; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (278 aa)
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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