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tfb2 tfb2 rad55 rad55 vps54 vps54 sgd1 sgd1 yos1 yos1 tfb1 tfb1 smc5 smc5 sed5 sed5 sec31 sec31 vps24 vps24 sec20 sec20 vps68 vps68 rhp14 rhp14 tfb4 tfb4 ssl1 ssl1 gpi16 gpi16 ski3 ski3 rad51 rad51 dad3 dad3 vtc4 vtc4 vps53 vps53 hrf1 hrf1 lcp5 lcp5 uso1 uso1 grh1 grh1 ksh1 ksh1 rmt2 rmt2 gpi17 gpi17 spc19 spc19 dad4 dad4 nse4 nse4 sft2 sft2 nrf1 nrf1 gaa1 gaa1 gpi8 gpi8 vps52 vps52 dad2 dad2 vps55 vps55 sec24 sec24 rad57 rad57 sec22 sec22 nse3 nse3 did4 did4
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
tfb2General transcription and DNA repair factor IIH subunit tfb2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has be [...] (447 aa)
rad55DNA repair protein rhp55; Required for radiation resistance and meiotic viability and acts in recombination and recombinational DNA repair pathways. (350 aa)
vps54Vacuolar protein sorting-associated protein 54; Involved in retrograde transport from early and late endosomes to late Golgi by linking the vesicle through the t-SNARE TGL1 to the Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles. Seems also to be involved in protein transport from Golgi to the plasma membrane and is required for the integrity of the actin cytoskeleton (By similarity). (949 aa)
sgd1Suppressor of glycerol defect protein 1; Involved in osmoregulatory glycerol response; Belongs to the CWC22 family. (775 aa)
yos1Protein transport protein yos1; Required for protein transport between endoplasmic reticulum and Golgi apparatus. (81 aa)
tfb1General transcription and DNA repair factor IIH subunit tfb1; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has be [...] (533 aa)
smc5Structural maintenance of chromosomes protein 5; Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis. (1076 aa)
sed5Integral membrane protein sed5; Required for vesicular transport between the endoplasmic reticulum and the Golgi complex. Acts as a target organelle soluble NSF attachment protein receptor (t-SNARE) (By similarity); Belongs to the syntaxin family. (309 aa)
sec31Protein transport protein sec31; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (1224 aa)
vps24Vacuolar protein sorting-associated protein 24; Class E VPS protein implicated in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins will be targeted into the vacuole after fusion of the endosome with the vacuole. (231 aa)
sec20Protein transport protein sec20; SNARE required for targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. (226 aa)
vps68UPF0220 protein C8D2.02c. (170 aa)
rhp14DNA repair protein rad14; Involved in nucleotide excision repair (NER). Functional in repair of ultraviolet radiation induced damages and in mitotic mutation avoidance. Binds damaged DNA. Binds specifically to base-base mismatches or small insertion/deletion loops with unpaired nucleotides. Maintains GT repeat stability. Functions as a part of the short-patch excision repair system. (289 aa)
tfb4General transcription and DNA repair factor IIH subunit tfb4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has be [...] (297 aa)
ssl1General transcription and DNA repair factor IIH subunit ssl1; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has be [...] (421 aa)
gpi16GPI transamidase component PIG-T homolog; Component of the GPI transamidase complex. Involved in transfer of GPI to proteins (By similarity). (545 aa)
ski3Superkiller protein 3; Component of the SKI complex involved in 3'-mRNA degradation pathway. (1389 aa)
rad51DNA repair protein rhp51; Required both for recombination and for the repair of DNA damage caused by X-rays. Binds to single and double-stranded DNA, in the presence of magnesium, and exhibits DNA-dependent ATPase activity. Promotes DNA strand annealing and strand exchange via DNA recombinase activity and forms helical nucleoprotein filaments. Belongs to the RecA family. RAD51 subfamily. (365 aa)
dad3DASH complex subunit dad3; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity). (86 aa)
vtc4Vacuolar transporter chaperone 4; Component of the vacuolar transporter chaperone (VTC) complex, which plays a role in vacuolar membrane fusion. (721 aa)
vps53Vacuolar protein sorting-associated protein 53; Involved in retrograde transport from early and late endosomes to late Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles. (756 aa)
hrf1Protein transport protein yif1; Required for fusion of ER-derived vesicles with the Golgi during ER-to-Golgi protein transport. May be involved in proper membrane localization of Rab GTPases (By similarity). (293 aa)
lcp5Uncharacterized protein C18B11.06. (327 aa)
uso1Intracellular protein transport protein uso1; Required for protein transport from the ER to the Golgi complex; Belongs to the VDP/USO1/EDE1 family. (1067 aa)
grh1Uncharacterized protein C1D4.02c. (345 aa)
ksh1Protein kish; Involved in the early part of the secretory pathway. (73 aa)
rmt2Protein arginine N-methyltransferase 2; S-adenosyl-L-methionine-dependent protein-arginine N- methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12. (357 aa)
gpi17GPI transamidase component PIG-S homolog; Component of the GPI transamidase complex. Involved in transfer of GPI to proteins (By similarity); Belongs to the PIGS family. (554 aa)
spc19DASH complex subunit spc19; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. May be necessary for growth under high osmotic stress. (152 aa)
dad4DASH complex subunit dad4; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. May be necessary for growth under high osmotic stress. (72 aa)
nse4Non-structural maintenance of chromosome element 4; Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis. Belongs to the NSE4 family. (300 aa)
sft2Protein transport protein sft2; Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex. Can be replaced by got1 (By similarity); Belongs to the SFT2 family. (201 aa)
nrf1Vacuolar transporter chaperone 1; Component of the vacuolar transporter chaperone (VTC) complex, which plays a role in vacuolar membrane fusion (By similarity). Involved in the control of cell polarity. (122 aa)
gaa1GPI transamidase component gaa1; Component of the GPI transamidase complex. Required for a terminal step of GPI anchor attachment onto proteins (By similarity). (581 aa)
gpi8GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity). (380 aa)
vps52Vacuolar protein sorting-associated protein 52; Involved in retrograde transport from early and late endosomes to late Golgi by linking the vesicle through the t-SNARE TGL1 to the Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles. (508 aa)
dad2DASH complex subunit dad2; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. May be necessary for growth under high osmotic stress. (94 aa)
vps55Vacuolar protein sorting-associated protein 55; Involved in protein transport from endosomes to the vacuole. Belongs to the OB-RGRP/VPS55 family. (128 aa)
sec24Protein transport protein sec24; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (926 aa)
rad57DNA repair protein rhp57; Involved in recombination DNA repair and in the repair of gamma-ray-induced damage. (354 aa)
sec22Protein transport protein sec22; Nonessential SNARE involved in targeting and fusion of ER- derived transport vesicles with the Golgi complex as well as Golgi- derived retrograde transport vesicles with the ER; Belongs to the synaptobrevin family. (215 aa)
nse3Non-structural maintenance of chromosome element 3; Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis. (328 aa)
did4ESCRT-III complex subunit did4; Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Acts a component of the ESCRT-III complex, which appears to be critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruitment of late-acting components of the sorting machinery. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complex assemblies (By similarity); Belongs to the SNF7 family. (210 aa)
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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