STRINGSTRING
rpl39 rpl39 rps601 rps601 utp22 utp22 rps20 rps20 rpp0 rpp0 rps3 rps3 ski2 ski2 not3 not3 zuo1 zuo1 tsr2 tsr2 sfp1 sfp1 nop58 nop58 rrb1 rrb1 btf3 btf3 ste13 ste13 not2 not2 egd2 egd2 rpl3001 rpl3001 rpl402 rpl402 rpl1101 rpl1101
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rpl3960S ribosomal protein L39. (51 aa)
rps60140S ribosomal protein S6-A; Belongs to the eukaryotic ribosomal protein eS6 family. (239 aa)
utp22U3 small nucleolar RNA-associated protein 22; Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. (1097 aa)
rps2040S ribosomal protein S20; Belongs to the universal ribosomal protein uS10 family. (118 aa)
rpp060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (312 aa)
rps340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (249 aa)
ski2Putative ATP-dependent RNA helicase C550.03c; RNA helicase component of the SKI complex involved in 3'-mRNA degradation pathway. (1213 aa)
not3General negative regulator of transcription subunit 3; Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery (By similarity). Belongs to the CNOT2/3/5 family. (640 aa)
zuo1Zuotin; Component of the ribosome-associated complex (RAC), a heterodimeric chaperone complex involved in regulation of accurate translation termination and in folding or maintaining nascent polypeptides in a folding-competent state. RAC stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones SSB1/SSB2 that bind to the nascent polypeptide chain (By similarity). (442 aa)
tsr2Pre-rRNA-processing protein tsr2; Required for 20S pre-rRNA processing; Belongs to the TSR2 family. (179 aa)
sfp1Zinc finger protein sfp1. (442 aa)
nop58Nucleolar protein 58; Required for pre-18S rRNA processing. May bind microtubules (By similarity); Belongs to the NOP5/NOP56 family. (508 aa)
rrb1Ribosome assembly protein rrb1; Involved in regulation of L3 expression and stability and plays a role in early 60S ribosomal subunit assembly. May be required for proper assembly of pre-ribosomal particles during early ribosome biogenesis, presumably by targeting L3 onto the 35S precursor rRNA (By similarity). (480 aa)
btf3Nascent polypeptide-associated complex subunit beta; Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the [...] (151 aa)
ste13Putative ATP-dependent RNA helicase ste13; ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity); Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. (485 aa)
not2General negative regulator of transcription subunit 2; Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. NOT2 is required for the integrity of the complex. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery (By similarity); Belongs to the CNOT2/3 [...] (306 aa)
egd2Nascent polypeptide-associated complex subunit alpha; Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of th [...] (173 aa)
rpl300160S ribosomal protein L30-1. (109 aa)
rpl40260S ribosomal protein L4-A. (363 aa)
rpl110160S ribosomal protein L11-A; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome throu [...] (174 aa)
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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