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puf3 puf3 dis3 dis3 tdh1 tdh1 ste13 ste13 upf3 upf3 cbc2 cbc2 brr2 brr2 gpd3 gpd3 uap56 uap56 lsm4 lsm4 rrp40 rrp40 spt5 spt5 usp101 usp101 ski2 ski2 aco1 aco1 mtr4 mtr4 rna14 rna14 sup35 sup35 cft1 cft1 hbs1 hbs1 mpe1 mpe1 cwf29 cwf29 cwf10 cwf10
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
puf3mRNA-binding protein puf3; RNA-binding protein involved in post-transcriptional regulation. Predominantly binds to mRNAs encoding mitochondrial proteins and localizes them to the vicinity of mitochondria for translation. Regulates mitochondrial biogenesis, motility and morphology (By similarity); Belongs to the PUF3 family. (732 aa)
dis3Exosome complex exonuclease dis3; Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. [...] (970 aa)
tdh1Glyceraldehyde-3-phosphate dehydrogenase 1; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
ste13Putative ATP-dependent RNA helicase ste13; ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity); Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. (485 aa)
upf3Nonsense-mediated mRNA decay protein 3; Involved in nonsense-mediated decay of mRNAs containing premature stop codons; Belongs to the RENT3 family. (278 aa)
cbc2Nuclear cap-binding protein subunit 2; Component of the CBC complex, which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs. (182 aa)
brr2Pre-mRNA-splicing factor brr2; Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures (By similarity). Required for pre- spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'- exon region. (2176 aa)
gpd3Glyceraldehyde-3-phosphate dehydrogenase 2; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
uap56ATP-dependent RNA helicase uap56; ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity. Links the mRNA adapter mlo3 to rae1 for targeting mRNA-protein complex to the proteins of the nucleoporin complex (NPC). (434 aa)
lsm4Probable U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (121 aa)
rrp40Exosome complex component rrp40; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplas [...] (240 aa)
spt5Transcription elongation factor spt5; The spt4-spt5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). (990 aa)
usp101U1 small nuclear ribonucleoprotein 70 kDa homolog; Involved in nuclear mRNA splicing (By similarity). Essential for growth. (261 aa)
ski2Putative ATP-dependent RNA helicase C550.03c; RNA helicase component of the SKI complex involved in 3'-mRNA degradation pathway. (1213 aa)
aco1Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate, a step in the citric acid cycle; Belongs to the aconitase/IPM isomerase family. (789 aa)
mtr4ATP-dependent RNA helicase mtr4; Component of the TRAMP complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates (By similarity). Required for heterochromatic gene silencing at centromeric repeats by either exosome- or RNAi-mediated degradation of heterochromatic transcripts. (1117 aa)
rna14mRNA 3'-end-processing protein rna14; Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation. (733 aa)
sup35Eukaryotic peptide chain release factor GTP-binding subunit; Involved in translation termination. Stimulates the activity of ERF1. Binds guanine nucleotides; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. ERF3 subfamily. (662 aa)
cft1Protein cft1; RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation- dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation (By similarity); Belongs to the CFT1 family. (1441 aa)
hbs1Elongation factor 1 alpha-like protein; Involved in protein translation. Together with dom34, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs (By similarity). (592 aa)
mpe1Uncharacterized RING finger protein P8B7.15c. (482 aa)
cwf29U2 snRNP component ist3; Required for pre-mRNA splicing and spliceosome assembly. (217 aa)
cwf10Pre-mRNA-splicing factor cwf10; Component of the U5 snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (984 aa)
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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