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ste13 ste13 lsm3 lsm3 rnh1 rnh1 lsm1 lsm1 lsm2 lsm2 caf1 caf1 rpt5 rpt5 SPAC23C11.06c SPAC23C11.06c cid1 cid1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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ste13Putative ATP-dependent RNA helicase ste13; ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity); Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. (485 aa)
lsm3Probable U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (93 aa)
rnh1Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (264 aa)
lsm1U6 snRNA-associated Sm-like protein LSm1; Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step. The LSM1-LSM7 complex binds RNA with a preference for poly-U ends. (140 aa)
lsm2U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (96 aa)
caf1Poly(A) ribonuclease pop2; Acts as the catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. In vivo and in vitro, caf1 has 3'-exoribonuclease activity with a preference for poly(A) RNAs. (335 aa)
rpt526S proteasome regulatory subunit 6A; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (438 aa)
SPAC23C11.06cUncharacterized protein C23C11.06c. (535 aa)
cid1Terminal uridylyltransferase cid1; Cytoplasmic uridylyltransferase that mediates the terminal uridylation of mRNAs with short poly(A) tails such as such as act1, hcn1 and urg1 mRNAs, hence facilitating global mRNA decay. Uridylates the 3' ends of actin mRNAs upon S-phase arrest. Has also a weak poly(A) polymerase (PAP) activity. Residue His-336 is responsible for the specificity for UTP. Involved in cell cycle arrest where in association with crb2/rhp9 and chk1 it inhibits unscheduled mitosis. (405 aa)
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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