STRINGSTRING
zwf1 zwf1 SPAC3C7.13c SPAC3C7.13c ggt2 ggt2 idp1 idp1 gcd1 gcd1 gst2 gst2 gcs2 gcs2 gsa1 gsa1 cdc22 cdc22 suc22 suc22 gnd1 gnd1 pgr1 pgr1 ggg1 ggg1 ysp2 ysp2 srm1 srm1 gcs1 gcs1 SPAC11D3.14c SPAC11D3.14c SPAC11D3.15 SPAC11D3.15 dug1 dug1 gst3 gst3 spe1 spe1 ggt1 ggt1 gst1 gst1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
Predicted Interactions
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zwf1Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity). (500 aa)
SPAC3C7.13cProbable glucose-6-phosphate 1-dehydrogenase C7.13c; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity); Belongs to the glucose-6-phosphate dehydrogenase family. (473 aa)
ggt2Glutathione hydrolase 2 heavy chain; Catalyzes the transfer of the gamma-glutamyl moiety of glutathione (GSH) and other gamma-glutamyl compounds to amino acids and peptides. Major GSH-degrading enzyme, catalyzing the hydrolytic release of L-glutamate from GSH. Plays a role in the turnover of the vacuolar GSH, serving as an alternative nitrogen source during nitrogen starvation (By similarity). (611 aa)
idp1Probable isocitrate dehydrogenase [NADP], mitochondrial. (439 aa)
gcd1Probable glucose-6-phosphate 1-dehydrogenase C794.01c; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity); Belongs to the glucose-6-phosphate dehydrogenase family. (475 aa)
gst2Glutathione S-transferase 2; Involved in the oxidative stress response and detoxification. (230 aa)
gcs2Putative glutamate--cysteine ligase regulatory subunit. (287 aa)
gsa1Glutathione synthetase large chain; Belongs to the eukaryotic GSH synthase family. (498 aa)
cdc22Ribonucleoside-diphosphate reductase large chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (811 aa)
suc22Ribonucleoside-diphosphate reductase small chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (391 aa)
gnd16-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (492 aa)
pgr1Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. (464 aa)
ggg1Glutathione-specific gamma-glutamylcyclotransferase; Gamma-glutamylcyclotransferase acting specifically on glutathione, but not on other gamma-glutamyl peptides. Allows utilization of gluthathione through subsequent cleavage of the Cys-Gly dipeptide by Cys-Gly metallodipeptidase dug1. (203 aa)
ysp2Putative aminopeptidase C13A11.05; Belongs to the peptidase M17 family. (513 aa)
srm1Spermidine synthase; Belongs to the spermidine/spermine synthase family. (298 aa)
gcs1Glutamate--cysteine ligase. (669 aa)
SPAC11D3.14cUncharacterized protein C11D3.14c; Belongs to the oxoprolinase family. (1260 aa)
SPAC11D3.15Uncharacterized protein C11D3.15; Belongs to the oxoprolinase family. (1317 aa)
dug1Cys-Gly metallodipeptidase dug1; Catalytic component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond. Has a Gly-Cys dipeptidase activity. Belongs to the peptidase M20A family. (476 aa)
gst3Glutathione S-transferase 3; May have a role in the detoxification of various heavy metals. (242 aa)
spe1Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. (432 aa)
ggt1Glutathione hydrolase 1 heavy chain; Catalyzes the transfer of the gamma-glutamyl moiety of glutathione (GSH) and other gamma-glutamyl compounds to amino acids and peptides. Major GSH-degrading enzyme, catalyzing the hydrolytic release of L-glutamate from GSH. (630 aa)
gst1Glutathione S-transferase 1; Involved in the oxidative stress response and detoxification. (229 aa)
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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