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pep7 pep7 sst4 sst4 its3 its3 vps28 vps28 did4 did4 arc2 arc2 atg24 atg24 vps24 vps24 pub3 pub3 wsp1 wsp1 vps36 vps36 ssa2 ssa2 did2 did2 ubp4 ubp4 hob1 hob1 vps60 vps60 ent1 ent1 ist1 ist1 vps35 vps35 hse1 hse1 vps25 vps25 snx3 snx3 vps20 vps20 SPCC622.14 SPCC622.14 ypt7 ypt7 dot2 dot2 cmp7 cmp7 ypt2 ypt2 ypt3 ypt3 arf1 arf1 ypt5 ypt5 arc1 arc1 ent3 ent3 cdc42 cdc42 pld1 pld1 apm4 apm4 vps4 vps4 vps45 vps45 alx1 alx1 rho1 rho1 chc1 chc1 vps26 vps26 ssa1 ssa1 sks2 sks2 arc5 arc5 glo3 glo3 acp1 acp1 arc4 arc4 pub1 pub1 vps5 vps5 apl3 apl3 ypt71 ypt71 rho5 rho5 ede1 ede1 acp2 acp2 sst2 sst2 vps32 vps32 gea1 gea1 sec72 sec72 sec71 sec71 SPAC824.09c SPAC824.09c pub2 pub2 vps29 vps29 cnt5 cnt5 arc3 arc3 aps2 aps2 arf6 arf6
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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pep7Vacuolar segregation protein pep7; Required for vacuole segregation and vacuole protein sorting. Possibly part of a complex which tethers the vacuole membrane to microtubules, either directly or via kinesin or dynein-like motor proteins. Probably functions in several interorganelle traffic pathways (By similarity). (536 aa)
sst4Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane. (610 aa)
its3Phosphatidylinositol 4-phosphate 5-kinase its3; Involved, together with the calcineurin ppb1, in cytokinesis. (742 aa)
vps28Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. (248 aa)
did4ESCRT-III complex subunit did4; Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Acts a component of the ESCRT-III complex, which appears to be critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruitment of late-acting components of the sorting machinery. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complex assemblies (By similarity); Belongs to the SNF7 family. (210 aa)
arc2Actin-related protein 2/3 complex subunit 2; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). (317 aa)
atg24Sorting nexin-4; Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells. Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans- Golgi network, for cytoplasm to vacuole transport (Cvt), mitophagy, and pexophagy (By similarity). (401 aa)
vps24Vacuolar protein sorting-associated protein 24; Class E VPS protein implicated in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins will be targeted into the vacuole after fusion of the endosome with the vacuole. (231 aa)
pub3E3 ubiquitin-protein ligase pub3; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (786 aa)
wsp1Wiskott-Aldrich syndrome protein homolog 1; Has a role in regulating actin assembly, so regulating polarized growth. (574 aa)
vps36Vacuolar protein-sorting-associated protein 36; Component of the ESCRT-II complex, which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin plays a central role in endosomal sorting of ubiquitinated cargo proteins by the ESCRT complexes (By similarity). Required for vacuolar sorting of carboxypeptidase S (CPS); Be [...] (467 aa)
ssa2Probable heat shock protein ssa2. (647 aa)
did2Vacuolar protein-sorting-associated protein 46; Class E VPS protein implicated in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins will be targeted into the vacuole after fusion of the endosome with the vacuole (By similarity). (200 aa)
ubp4Probable ubiquitin carboxyl-terminal hydrolase 4; Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Acts late in the proteolytic pathway in conjunction with the 26S proteasome. Plays a role in avoiding DNA overreplication (By similarity); Belongs to the peptidase C19 family. (593 aa)
hob1Protein hob1; Has a role in DNA damage signaling as a part of stress response processes. (466 aa)
vps60Uncharacterized protein C162.06c; Belongs to the SNF7 family. (210 aa)
ent1Epsin-1; Binds to membranes enriched in phosphatidylinositol 3,5- bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Required for endocytosis and localization of actin. Belongs to the epsin family. (702 aa)
ist1Vacuolar protein sorting-associated protein ist1; Involved in a late step in sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins are targeted into the vacuole after fusion of the endosome with the vacuole (By similarity). Belongs to the IST1 family. (271 aa)
vps35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. Required for the endosome-to-Golgi retrieval of the vacuolar protein sorting receptor vps10. Required to form proper forespore membranes. Belongs to the VPS35 family. (836 aa)
hse1Class E vacuolar protein-sorting machinery protein hse1; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB). (373 aa)
vps25Vacuolar protein-sorting-associated protein 25; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. (175 aa)
snx3Sorting nexin-3; Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity). (143 aa)
vps20Vacuolar protein sorting-associated protein 20; Class E VPS protein implicated in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins will be targeted into the vacuole after fusion of the endosome with the vacuole. (226 aa)
SPCC622.14Uncharacterized protein C622.14; GTPase-activating protein for the ADP ribosylation factor family. (321 aa)
ypt7GTP-binding protein ypt7; Needed for homotypic vacuole fusion, the last step in the vacuole inheritance process; Belongs to the small GTPase superfamily. Rab family. (205 aa)
dot2Vacuolar-sorting protein dot2; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Negatively regulates meiotic spindle pole body maturation via indirect regulation of the pcp1 gene. Required for efficient entry into pre-meiotic S phase. (252 aa)
cmp7Uncharacterized protein C1604.18c. (449 aa)
ypt2GTP-binding protein ypt2; Protein transport. Probably involved in vesicular traffic (By similarity). (200 aa)
ypt3GTP-binding protein ypt3; Has a role in retrograde traffricking of proteins from the endosome to the Golgi. Involved in the secretory pathway where it has a role in acid phosphatase secretion; Belongs to the small GTPase superfamily. Rab family. (214 aa)
arf1ADP-ribosylation factor 1; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus; Belongs to the small GTPase superfamily. Arf family. (180 aa)
ypt5GTP-binding protein ypt5; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (211 aa)
arc1Actin-related protein 2/3 complex subunit 1; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (377 aa)
ent3ENTH domain-containing protein C794.11c. (476 aa)
cdc42Cell division control protein 42 homolog; Involved in development of cell polarity during the cell division cycle; Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily. (192 aa)
pld1Phospholipase D1; Required for meiosis and spore formation. Seems to be involved in the coordinate induction of late meiotic events. (1369 aa)
apm4AP-2 complex subunit mu; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor (Potential). (446 aa)
vps4Suppressor protein of bem1/bed5 double mutants; Involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Involved in multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex (By similarity). (432 aa)
vps45Vacuolar protein sorting-associated protein 45; Vacuolar protein sorting-associated protein involved in Golgi-to-vacuole protein transport. (558 aa)
alx1pH-response regulator protein palA/rim20; Belongs to the palA/RIM20 family. (701 aa)
rho1GTP-binding protein rho1; Involved in the regulation of cell wall growth and actin cytoskeleton organization. Activates (1,3)-beta-D-glucan synthase. Belongs to the small GTPase superfamily. Rho family. (202 aa)
chc1Probable clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. (1666 aa)
vps26Vacuolar protein sorting-associated protein 26; Plays a role in vesicular protein sorting. Required for the endosome-to-Golgi retrieval of the vacuolar protein sorting receptor pep1/vps10. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The vps29- vps26-vps35 subcomplex may be involved in cargo selection. (298 aa)
ssa1Probable heat shock protein ssa1. (644 aa)
sks2Ribosome-associated molecular chaperone sks2; Ribosome-bound, Hsp70-type chaperone that assists in the cotranslational folding of newly synthesized proteins in the cytosol. Stimulates folding by interacting with nascent chains, binding to short, largely hydrophobic sequences exposed by unfolded proteins, thereby stabilizing longer, more slowly translated, and aggregation- prone nascent polypeptides and domains that cannot fold stably until fully synthesized. The Hsp70-protein substrate interaction depends on ATP-binding and on allosteric regulation between the NBD and the SBD. The ATP- [...] (613 aa)
arc5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (152 aa)
glo3ADP-ribosylation factor GTPase-activating protein glo3; GTPase-activating protein for the ADP ribosylation factor (ARF) family. Involved in retrograde vesicular transport from the Golgi to the endoplasmic reticulum (By similarity). (483 aa)
acp1F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Competes with formin cdc12 for attachment to the actin filaments barbed ends. Slowly replaces cdc12 on the barbed ends in preparation for filament disassembly during contractile ring constriction. (256 aa)
arc4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). (168 aa)
pub1E3 ubiquitin-protein ligase pub1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Regulates ubiquitination of cdc25. (767 aa)
vps5Vacuolar protein sorting-associated protein vps5; Required for efficient sporulation target of PtdIns(3)P in vesicle transport required for onset of the forespore membrane formation. (576 aa)
apl3AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Alpha adaptin is a subunit of the plasma membrane adaptor (By similarity). (878 aa)
ypt71GTP-binding protein ypt71. (208 aa)
rho5GTP-binding protein rho5. (200 aa)
ede1Uncharacterized calcium-binding protein C800.10c. (1116 aa)
acp2F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Competes with formin cdc12 for attachment to the actin filaments barbed ends. Slowly replaces cdc12 on the barbed ends in preparation for filament disassembly during contractile ring constriction. (268 aa)
sst2AMSH-like protease sst2; Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in the multivesicular body (MVB) sorting pathway. Required for ubiquitin- dependent sorting of proteins into the endosome and subsequent trafficking to the vacuole. May regulate MVB sorting through deubiquitination of ubiquitinated ESCRT proteins; Belongs to the peptidase M67C family. (435 aa)
vps32Vacuolar-sorting protein snf7; Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). (222 aa)
gea1Uncharacterized protein C211.03. (1462 aa)
sec72Protein transport protein sec72; May play a role in protein transport. (1822 aa)
sec71Protein transport protein sec71; May play a role in protein transport. (1811 aa)
SPAC824.09cUncharacterized protein C824.09c; GTPase-activating protein for the ADP ribosylation factor family. (320 aa)
pub2E3 ubiquitin-protein ligase pub2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Has a role in the G2/M transition. (671 aa)
vps29Vacuolar protein sorting-associated protein 29; Plays a role in vesicular protein sorting. Required for the endosome-to-Golgi retrieval of the vacuolar protein sorting receptor pep1/vps10. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The vps29- vps26-vps35 subcomplex may be involved in cargo selection. (187 aa)
cnt5Protein csx2. (870 aa)
arc3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (174 aa)
aps2AP-2 complex subunit sigma; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity). (143 aa)
arf6ADP-ribosylation factor 6; GTP-binding protein that functions as a molecular switch for the activation of 'new end take off' (NETO), a process in which the directions of cell growth change from a monopolar manner to a bipolar manner in fission yeast. Involved in supplying membrane to the growing new end; Belongs to the small GTPase superfamily. Arf family. (184 aa)
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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