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hisG hisG hisE hisE AOT58186.1 AOT58186.1 cobD cobD hisI hisI hisF_1 hisF_1 priA_2 priA_2 hisH hisH hisB hisB hisC hisC hisD hisD pat pat pheA pheA AOT60162.1 AOT60162.1 AOT60438.1 AOT60438.1 hisF_2 hisF_2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (282 aa)
hisEPhosphoribosyl-ATP pyrophosphatase. (90 aa)
AOT58186.1Prephenate dehydrogenase. (361 aa)
cobDThreonine-phosphate decarboxylase. (367 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (116 aa)
hisF_1Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (256 aa)
priA_2Phosphoribosyl isomerase A; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. (241 aa)
hisHImidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (216 aa)
hisBImidazoleglycerol-phosphate dehydratase. (197 aa)
hisCHistidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (370 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (445 aa)
patPutative phenylalanine aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (361 aa)
pheAPrephenate dehydratase. (312 aa)
AOT60162.1Haloacid dehalogenase-like hydrolase. (299 aa)
AOT60438.1Aspartate aminotransferase. (408 aa)
hisF_2Imidazole glycerol phosphate synthase subunit HisF; Belongs to the HisA/HisF family. (266 aa)
Your Current Organism:
Streptomyces rubrolavendulae
NCBI taxonomy Id: 285473
Other names: S. rubrolavendulae
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