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ilvE_1 ilvE_1 leuA_1 leuA_1 ilvB ilvB ilvD ilvD ilvB1 ilvB1 ilvH ilvH ilvC ilvC leuB leuB ilvE_2 ilvE_2 leuA_2 leuA_2 leuC_1 leuC_1 leuD_1 leuD_1 leuC_2 leuC_2 leuD_2 leuD_2 leuA_3 leuA_3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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gene co-occurrence
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ilvE_1Branched-chain-amino-acid aminotransferase. (270 aa)
leuA_12-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (589 aa)
ilvBAcetolactate synthase large subunit; Belongs to the TPP enzyme family. (562 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (617 aa)
ilvB1Acetolactate synthase large subunit IlvB1. (617 aa)
ilvHAcetolactate synthase small subunit. (174 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (347 aa)
ilvE_2Branched-chain-amino-acid aminotransferase. (363 aa)
leuA_22-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (535 aa)
leuC_13-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (476 aa)
leuD_13-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa)
leuC_23-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (464 aa)
leuD_23-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (198 aa)
leuA_32-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (391 aa)
Your Current Organism:
Streptomyces rubrolavendulae
NCBI taxonomy Id: 285473
Other names: S. rubrolavendulae
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