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xpkA xpkA gabD1 gabD1 ppdK_1 ppdK_1 gap gap nanK nanK pfp_1 pfp_1 rpe rpe AOT58145.1 AOT58145.1 AOT58146.1 AOT58146.1 tkt_1 tkt_1 tal_1 tal_1 pgi pgi tpiA tpiA pgk pgk gap2 gap2 pyk_1 pyk_1 rbsK_2 rbsK_2 pdhD pdhD aceE_1 aceE_1 aceE_2 aceE_2 ppdK_2 ppdK_2 rpiB rpiB lpd lpd mmsA mmsA gltA2 gltA2 AOT59142.1 AOT59142.1 eno eno prs_1 prs_1 ppc ppc AOT59482.1 AOT59482.1 citA citA nagC_6 nagC_6 fbaA fbaA pdhC pdhC bkdB_1 bkdB_1 bkdA_1 bkdA_1 bkdB_2 bkdB_2 bkdB_3 bkdB_3 bkdA_2 bkdA_2 lpdC lpdC fba fba davT davT acsA_2 acsA_2 yfmT yfmT korB korB korA korA gabD2 gabD2 sucC sucC sucD sucD mdh mdh sdhB sdhB sdhA sdhA AOT60647.1 AOT60647.1 AOT60648.1 AOT60648.1 betB_2 betB_2 aldA aldA deoC deoC lpdA lpdA pckG pckG fumC fumC fumB fumB glpX glpX ppgK ppgK AOT61003.1 AOT61003.1 kgd kgd pyk_2 pyk_2 ackA ackA pta pta pfp_2 pfp_2 acyP acyP bioK_3 bioK_3 gabT gabT acnA acnA poxB poxB prs_2 prs_2 acsA_3 acsA_3 argD_2 argD_2 tkt_2 tkt_2 icd icd AOT62258.1 AOT62258.1 AOT62337.1 AOT62337.1 frdA frdA frdB frdB thcA thcA garR garR
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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xpkAXylulose-5-phosphate phosphoketolase. (824 aa)
gabD1Succinate-semialdehyde dehydrogenase [NADP(+)] 1. (463 aa)
ppdK_1Pyruvate, phosphate dikinase. (349 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (481 aa)
nanKN-acetylmannosamine kinase. (401 aa)
pfp_1Pyrophosphate--fructose 6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa)
rpeRibulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (227 aa)
AOT58145.1S-(hydroxymethyl)mycothiol dehydrogenase. (360 aa)
AOT58146.1Putative aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (463 aa)
tkt_1Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (695 aa)
tal_1Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (372 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (539 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (258 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (403 aa)
gap2Glyceraldehyde-3-phosphate dehydrogenase 2; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
pyk_1Pyruvate kinase; Belongs to the pyruvate kinase family. (475 aa)
rbsK_2Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (308 aa)
pdhDDihydrolipoyl dehydrogenase. (462 aa)
aceE_1Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (897 aa)
aceE_2Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (915 aa)
ppdK_2Pyruvate, phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (903 aa)
rpiBRibose-5-phosphate isomerase B. (160 aa)
lpdDihydrolipoyl dehydrogenase. (459 aa)
mmsAMethylmalonate-semialdehyde dehydrogenase. (500 aa)
gltA2Citrate synthase 1; Belongs to the citrate synthase family. (433 aa)
AOT59142.1NAD-dependent malic enzyme. (474 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
prs_1Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (325 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (909 aa)
AOT59482.1Hypothetical protein. (656 aa)
citACitrate synthase 1; Belongs to the citrate synthase family. (367 aa)
nagC_6N-acetylglucosamine repressor. (299 aa)
fbaAPutative fructose-bisphosphate aldolase. (287 aa)
pdhCDihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex. (488 aa)
bkdB_13-methyl-2-oxobutanoate dehydrogenase subunit beta. (326 aa)
bkdA_13-methyl-2-oxobutanoate dehydrogenase subunit alpha. (398 aa)
bkdB_2Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex. (457 aa)
bkdB_33-methyl-2-oxobutanoate dehydrogenase subunit beta. (342 aa)
bkdA_23-methyl-2-oxobutanoate dehydrogenase subunit alpha. (380 aa)
lpdCDihydrolipoyl dehydrogenase. (467 aa)
fbaFructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (340 aa)
davT5-aminovalerate aminotransferase DavT; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (502 aa)
acsA_2Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa)
yfmTPutative aldehyde dehydrogenase YfmT; Belongs to the aldehyde dehydrogenase family. (485 aa)
korB2-oxoglutarate oxidoreductase subunit KorB. (350 aa)
korA2-oxoglutarate oxidoreductase subunit KorA. (741 aa)
gabD2Putative succinate-semialdehyde dehydrogenase [NADP(+)] 2; Belongs to the aldehyde dehydrogenase family. (589 aa)
sucCSuccinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (392 aa)
sucDSuccinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (296 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
sdhBSuccinate dehydrogenase iron-sulfur subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (252 aa)
sdhASuccinate dehydrogenase flavoprotein subunit. (584 aa)
AOT60647.1Succinate dehydrogenase cytochrome b556 small membrane subunit. (159 aa)
AOT60648.1Succinate dehydrogenase/Fumarate reductase transmembrane subunit. (126 aa)
betB_2NAD/NADP-dependent betaine aldehyde dehydrogenase. (303 aa)
aldAPutative aldehyde dehydrogenase AldA. (498 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. (316 aa)
lpdANAD(P)H dehydrogenase (quinone). (479 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (607 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)
fumBFumarate hydratase class I, anaerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (555 aa)
glpXFructose-1,6-bisphosphatase class 2. (343 aa)
ppgKPolyphosphate glucokinase. (246 aa)
AOT61003.1NAD-dependent malic enzyme. (407 aa)
kgdMultifunctional 2-oxoglutarate metabolism enzyme. (1294 aa)
pyk_2Pyruvate kinase; Belongs to the pyruvate kinase family. (476 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa)
ptaPhosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (696 aa)
pfp_2Pyrophosphate--fructose 6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa)
acyPAcylphosphatase. (93 aa)
bioK_3L-Lysine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (445 aa)
gabT4-aminobutyrate aminotransferase GabT; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (449 aa)
acnAAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (905 aa)
poxBPyruvate dehydrogenase; Belongs to the TPP enzyme family. (670 aa)
prs_2Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (324 aa)
acsA_3Acetyl-coenzyme A synthetase. (591 aa)
argD_2Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (436 aa)
tkt_2Transketolase. (618 aa)
icdIsocitrate dehydrogenase [NADP]; Belongs to the monomeric-type IDH family. (739 aa)
AOT62258.1D-arabitol-phosphate dehydrogenase. (352 aa)
AOT62337.1Succinate dehydrogenase/Fumarate reductase transmembrane subunit. (207 aa)
frdAFumarate reductase flavoprotein subunit. (649 aa)
frdBFumarate reductase iron-sulfur subunit. (248 aa)
thcAEPTC-inducible aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (507 aa)
garR2-hydroxy-3-oxopropionate reductase. (297 aa)
Your Current Organism:
Streptomyces rubrolavendulae
NCBI taxonomy Id: 285473
Other names: S. rubrolavendulae
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