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| | polX_2 | DNA polymerase/3'-5' exonuclease PolX. (577 aa) |
| | mug | G/U mismatch-specific DNA glycosylase. (187 aa) |
| | ung_2 | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (227 aa) |
| | dinB_1 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (541 aa) |
| | priA_1 | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (714 aa) |
| | AOT57983.1 | DNA polymerase III subunit epsilon. (242 aa) |
| | ypcP | 5'-3' exonuclease. (310 aa) |
| | dinB_2 | DNA polymerase IV. (324 aa) |
| | dnaE2 | Error-prone DNA polymerase; Belongs to the DNA polymerase type-C family. DnaE2 subfamily. (1194 aa) |
| | dnaQ | DNA polymerase III subunit epsilon. (326 aa) |
| | uvrC | UvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (695 aa) |
| | uvrA_1 | UvrABC system protein A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (964 aa) |
| | uvrB | UvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...] (722 aa) |
| | polA_1 | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (884 aa) |
| | dnaE | DNA polymerase III subunit alpha. (1179 aa) |
| | nfo | Putative endonuclease 4; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (358 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (634 aa) |
| | recO | DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (251 aa) |
| | AOT58807.1 | Hypothetical protein. (327 aa) |
| | ssb1 | Single-stranded DNA-binding protein 1. (149 aa) |
| | mfd | Transcription-repair-coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1176 aa) |
| | exoA | Exodeoxyribonuclease. (281 aa) |
| | dnaN_1 | DNA polymerase III subunit beta. (543 aa) |
| | dnaX_1 | DNA polymerase III subunit tau. (823 aa) |
| | gyrA_1 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (886 aa) |
| | gyrBR | DNA gyrase subunit B, novobiocin-resistant; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-de [...] (710 aa) |
| | recF | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (376 aa) |
| | dnaN_2 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (376 aa) |
| | dnaA | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (600 aa) |
| | ssb2 | Single-stranded DNA-binding protein 2. (191 aa) |
| | dnaB | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (500 aa) |
| | recR | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (199 aa) |
| | dnaX_2 | DNA polymerase III subunit tau. (403 aa) |
| | radA | Hypothetical protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (481 aa) |
| | uvrD1 | ATP-dependent DNA helicase UvrD1. (821 aa) |
| | xseA | Exodeoxyribonuclease 7 large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (411 aa) |
| | xseB | Exodeoxyribonuclease 7 small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (116 aa) |
| | rutE | Putative malonic semialdehyde reductase RutE. (196 aa) |
| | pcrA_2 | ATP-dependent DNA helicase PcrA; Belongs to the helicase family. UvrD subfamily. (1222 aa) |
| | uvrD2 | ATP-dependent DNA helicase UvrD2. (727 aa) |
| | AOT61050.1 | Putative DNA ligase-like protein. (306 aa) |
| | AOT61051.1 | Putative DNA ligase-like protein. (328 aa) |
| | ykoV | Putative DNA repair protein YkoV; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (419 aa) |
| | ligA | DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (734 aa) |
| | fpg1 | Formamidopyrimidine-DNA glycosylase 1; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (290 aa) |
| | recA | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (376 aa) |
| | recX | Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. (189 aa) |
| | lexA | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (268 aa) |
| | gyrB | DNA gyrase subunit B. (705 aa) |
| | gyrA_2 | DNA gyrase subunit A. (817 aa) |
| | polC | DNA polymerase III PolC-type. (252 aa) |
| | xthA | Exodeoxyribonuclease III. (259 aa) |
| | AOT62104.1 | Putative DNA ligase-like protein. (362 aa) |
| | ykoU | Putative ATP-dependent DNA ligase YkoU. (331 aa) |
| | fpg2 | Putative formamidopyrimidine-DNA glycosylase-like protein; Belongs to the FPG family. (286 aa) |
| | uvrA_2 | UvrABC system protein A. (797 aa) |
| | lig | Putative DNA ligase-like protein; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (518 aa) |
