Your Input: | |
| | leuA_3 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (391 aa) |
| | pqsD_1 | PQB biosynthetic 3-oxoacyl-[acyl-carrier-protein] synthase III. (342 aa) |
| | asnB | Asparagine synthetase [glutamine-hydrolyzing] 1. (597 aa) |
| | AOT57442.1 | Hypothetical protein. (95 aa) |
| | iolD | 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase; Belongs to the TPP enzyme family. (628 aa) |
| | sbnA_1 | Putative siderophore biosynthesis protein SbnA. (403 aa) |
| | dapE_1 | Succinyl-diaminopimelate desuccinylase. (458 aa) |
| | AOT57598.1 | Hypothetical protein; RibD C-terminal domain. (250 aa) |
| | dapA_1 | 4-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (325 aa) |
| | panD_1 | Aspartate 1-decarboxylase precursor; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (139 aa) |
| | btrK | L-glutamyl-[BtrI acyl-carrier protein] decarboxylase. (422 aa) |
| | acpM | Meromycolate extension acyl carrier protein. (88 aa) |
| | bioF1 | 8-amino-7-oxononanoate synthase 1. (390 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (423 aa) |
| | bioA | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (431 aa) |
| | bioD | ATP-dependent dethiobiotin synthetase BioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (240 aa) |
| | AOT57785.1 | Acetyltransferase (GNAT) family protein. (498 aa) |
| | AOT57883.1 | Hypothetical protein. (100 aa) |
| | AOT57884.1 | Hypothetical protein. (60 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (282 aa) |
| | hisE | Phosphoribosyl-ATP pyrophosphatase. (90 aa) |
| | carB | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1102 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (379 aa) |
| | AOT57933.1 | Hypothetical protein. (203 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (146 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (364 aa) |
| | aroK_1 | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (201 aa) |
| | aroC_1 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (394 aa) |
| | aroE | Shikimate dehydrogenase; Belongs to the shikimate dehydrogenase family. (282 aa) |
| | AOT57986.1 | Sporulation and cell division protein, SsgA. (140 aa) |
| | ilvE_1 | Branched-chain-amino-acid aminotransferase. (270 aa) |
| | argH | Argininosuccinate lyase. (476 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (397 aa) |
| | argR | Arginine repressor; Regulates arginine biosynthesis genes. (178 aa) |
| | argD_1 | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (400 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (309 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (383 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (342 aa) |
| | glnA2_1 | Putative glutamine synthetase 2. (458 aa) |
| | metH | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1174 aa) |
| | dapE_2 | Putative succinyl-diaminopimelate desuccinylase. (444 aa) |
| | qorA_1 | Quinone oxidoreductase 1. (310 aa) |
| | AOT58136.1 | Asparagine synthase. (575 aa) |
| | AOT58186.1 | Prephenate dehydrogenase. (361 aa) |
| | serB | Phosphoserine phosphatase. (402 aa) |
| | inhA | Enoyl-[acyl-carrier-protein] reductase [NADH]. (263 aa) |
| | ectA | L-2,4-diaminobutyric acid acetyltransferase; Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A. (178 aa) |
| | ectB | Diaminobutyrate--2-oxoglutarate transaminase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (450 aa) |
| | ectC | L-ectoine synthase; Catalyzes the circularization of gamma-N-acetyl-alpha,gamma- diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4- pyrimidine carboxylic acid), which is an excellent osmoprotectant. (132 aa) |
| | araC | L-arabonate dehydratase; Belongs to the IlvD/Edd family. (612 aa) |
| | dapA_2 | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (298 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (327 aa) |
| | gltB_1 | Glutamate synthase [NADPH] small chain. (486 aa) |
| | gltB_2 | Glutamate synthase [NADPH] large chain. (1520 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (271 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (427 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (269 aa) |
| | trpE_1 | Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (504 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (116 aa) |
| | hisF_1 | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (256 aa) |
| | priA_2 | Phosphoribosyl isomerase A; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. (241 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (216 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (197 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (370 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (445 aa) |
| | metF | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (304 aa) |
| | aroH_1 | Phospho-2-dehydro-3-deoxyheptonate aldolase; Belongs to the class-II DAHP synthase family. (451 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (354 aa) |
| | nadA | Quinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (392 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (322 aa) |
| | glnA | Glutamine synthetase. (469 aa) |
| | glnII | Glutamine synthetase 2. (343 aa) |
| | glnA2_2 | Putative glutamine synthetase 2. (453 aa) |
| | fabD | Malonyl CoA-acyl carrier protein transacylase. (307 aa) |
| | fabH_1 | 3-oxoacyl-[acyl-carrier-protein] synthase 3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (333 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (82 aa) |
| | fabF_1 | 3-oxoacyl-[acyl-carrier-protein] synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (420 aa) |
| | AOT58723.1 | Putative sulfate transport protein CysZ. (278 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha. (448 aa) |
| | AOT58736.1 | Hypothetical protein. (238 aa) |
| | metZ | O-succinylhomoserine sulfhydrylase. (401 aa) |
| | metA | Homoserine O-succinyltransferase; Belongs to the MetA family. (312 aa) |
| | leuA_1 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (589 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (433 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (371 aa) |
| | AOT58836.1 | CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase. (729 aa) |
| | asd_1 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (342 aa) |
| | AOT58965.1 | Hypothetical protein. (425 aa) |
| | AOT58968.1 | Hypothetical protein; RibD C-terminal domain. (215 aa) |
| | ilvB | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (562 aa) |
| | pqsD_2 | PQB biosynthetic 3-oxoacyl-[acyl-carrier-protein] synthase III. (342 aa) |
| | gbh | Guanidinobutyrase; Belongs to the arginase family. (325 aa) |
| | cysM_1 | O-phosphoserine sulfhydrylase. (316 aa) |
| | cysO_1 | Sulfur carrier protein CysO. (92 aa) |
| | mec | CysO-cysteine peptidase. (140 aa) |
| | AOT59145.1 | Bifunctional uroporphyrinogen-III synthetase/response regulator domain protein. (404 aa) |
| | mtnA | Methylthioribose-1-phosphate isomerase; Belongs to the eIF-2B alpha/beta/delta subunits family. (353 aa) |
| | ywqF | UDP-glucose 6-dehydrogenase YwqF. (447 aa) |
| | tagD | Glycerol-3-phosphate cytidylyltransferase. (157 aa) |
| | amaB | N-carbamoyl-L-amino acid hydrolase. (418 aa) |
| | lysA_1 | Diaminopimelate decarboxylase. (443 aa) |
| | cbs | Putative cystathionine beta-synthase. (461 aa) |
| | mtnP | S-methyl-5'-thioadenosine phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. (278 aa) |
| | bioK_1 | L-Lysine-8-amino-7-oxononanoate aminotransferase. (904 aa) |
| | psdht | Phenylserine dehydratase. (313 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (372 aa) |
| | lysC | Aspartokinase. (370 aa) |
| | asd_2 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (370 aa) |
| | mqnB | Futalosine hydrolase; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). (252 aa) |
| | cysO_2 | Sulfur carrier protein CysO. (91 aa) |
| | thrC_1 | Threonine synthase. (432 aa) |
| | qorA_2 | Quinone oxidoreductase 1. (332 aa) |
| | AOT59666.1 | Argininosuccinate lyase. (433 aa) |
| | AOT59744.1 | Asparagine synthase. (705 aa) |
| | AOT59822.1 | Homoserine kinase. (441 aa) |
| | ppsC | Phthiocerol synthesis polyketide synthase type I PpsC. (331 aa) |
| | AOT59904.1 | Alanine racemase. (343 aa) |
| | metC | Cystathionine beta-lyase. (380 aa) |
| | pat | Putative phenylalanine aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (361 aa) |
| | serS | Serine--tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (425 aa) |
| | pheA | Prephenate dehydratase. (312 aa) |
| | AOT59990.1 | Ferredoxin-nitrite reductase. (436 aa) |
| | kynU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (474 aa) |
| | AOT60105.1 | Zinc-type alcohol dehydrogenase-like protein. (321 aa) |
| | ask | Aspartokinase; Belongs to the aspartokinase family. (423 aa) |
| | AOT60162.1 | Haloacid dehalogenase-like hydrolase. (299 aa) |
| | folK | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. (199 aa) |
| | folB | Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (119 aa) |
| | folP1 | Dihydropteroate synthase 1; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (287 aa) |
| | panC | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (359 aa) |
| | argA | Amino-acid acetyltransferase; Belongs to the acetyltransferase family. (234 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (617 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (269 aa) |
| | AOT60298.1 | Haloacid dehalogenase-like hydrolase. (312 aa) |
| | AOT60432.1 | Bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Belongs to the UPF0336 family. (151 aa) |
| | acpS | Holo-[acyl-carrier-protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (122 aa) |
| | alr | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (394 aa) |
| | folD_1 | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa) |
| | rocD_1 | Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (415 aa) |
| | glyA_1 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (441 aa) |
| | bacD_1 | Alanine-anticapsin ligase BacD. (474 aa) |
| | bacD_2 | Alanine-anticapsin ligase BacD. (511 aa) |
| | bacD_3 | Alanine-anticapsin ligase BacD. (417 aa) |
| | AOT60659.1 | Hypothetical protein. (313 aa) |
| | yxeP_1 | Putative hydrolase YxeP. (407 aa) |
| | metB | Cystathionine gamma-synthase. (384 aa) |
| | tdcB | L-threonine dehydratase catabolic TdcB. (410 aa) |
| | mtnN | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. (387 aa) |
| | thrC_2 | Threonine synthase. (369 aa) |
| | dapE_3 | Succinyl-diaminopimelate desuccinylase. (367 aa) |
| | moeZ_3 | Putative adenylyltransferase/sulfurtransferase MoeZ. (392 aa) |
| | dapE_4 | Succinyl-diaminopimelate desuccinylase. (468 aa) |
| | hisN | Histidinol-phosphatase. (266 aa) |
| | aroA_1 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (448 aa) |
| | AOT60987.1 | Hypothetical protein; RibD C-terminal domain. (195 aa) |
| | adhT | Alcohol dehydrogenase. (322 aa) |
| | lysA_2 | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (463 aa) |
| | hom | Homoserine dehydrogenase. (447 aa) |
| | thrC_3 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (356 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (305 aa) |
| | glyA_2 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (453 aa) |
| | glyA2 | Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (419 aa) |
| | AOT61182.1 | Cobalamin-independent synthase, Catalytic domain. (337 aa) |
| | ilvB1 | Acetolactate synthase large subunit IlvB1. (617 aa) |
| | ilvH | Acetolactate synthase small subunit. (174 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa) |
| | serA | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (347 aa) |
| | ilvE_2 | Branched-chain-amino-acid aminotransferase. (363 aa) |
| | leuA_2 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (535 aa) |
| | leuC_1 | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (476 aa) |
| | leuD_1 | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa) |
| | bioK_2 | L-Lysine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (462 aa) |
| | fabF_2 | 3-oxoacyl-[acyl-carrier-protein] synthase 2; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (394 aa) |
| | fabH_2 | 3-oxoacyl-[acyl-carrier-protein] synthase 3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (327 aa) |
| | bioK_3 | L-Lysine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (445 aa) |
| | dapB | 4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (250 aa) |
| | dapA_4 | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (299 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (290 aa) |
| | AOT61461.1 | L-gulono-1,4-lactone dehydrogenase. (408 aa) |
| | argF_1 | Ornithine carbamoyltransferase. (308 aa) |
| | srfAA_1 | Surfactin synthase subunit 1; Belongs to the ATP-dependent AMP-binding enzyme family. (1089 aa) |
| | sbnA_2 | Putative siderophore biosynthesis protein SbnA. (346 aa) |
| | tycC_3 | Tyrocidine synthase 3. (2125 aa) |
| | lgrD_2 | Linear gramicidin synthase subunit D. (4618 aa) |
| | AOT61583.1 | Phenolphthiocerol synthesis polyketide synthase type I Pks15/1. (2148 aa) |
| | bioF | 8-amino-7-oxononanoate synthase. (1399 aa) |
| | AOT61600.1 | Argininosuccinate lyase. (441 aa) |
| | cysM_2 | Cysteine synthase. (388 aa) |
| | AOT61603.1 | Phenolphthiocerol synthesis polyketide synthase type I Pks15/1. (311 aa) |
| | yxeP_2 | Putative hydrolase YxeP. (447 aa) |
| | lgrD_4 | Linear gramicidin synthase subunit D. (315 aa) |
| | tycC_4 | Tyrocidine synthase 3. (803 aa) |
| | tdh_1 | L-threonine 3-dehydrogenase. (335 aa) |
| | hisF_2 | Imidazole glycerol phosphate synthase subunit HisF; Belongs to the HisA/HisF family. (266 aa) |
| | rocD_2 | Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (416 aa) |
| | argF_2 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (333 aa) |
| | lysA_3 | Diaminopimelate decarboxylase. (517 aa) |
| | poxB | Pyruvate dehydrogenase; Belongs to the TPP enzyme family. (670 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (227 aa) |
| | ppsD | Plipastatin synthase subunit D. (1277 aa) |
| | glsA | Thermolabile glutaminase; Belongs to the glutaminase family. (305 aa) |
| | dat | Diaminobutyrate--2-oxoglutarate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (446 aa) |
| | AOT61935.1 | Acetyltransferase (GNAT) family protein. (168 aa) |
| | AOT61950.1 | Hypothetical protein; RibD C-terminal domain. (206 aa) |
| | srfAB_2 | Surfactin synthase subunit 2. (86 aa) |
| | dhbF_1 | Dimodular nonribosomal peptide synthase. (2443 aa) |
| | ccr | Crotonyl-CoA reductase. (445 aa) |
| | dapE_5 | Putative succinyl-diaminopimelate desuccinylase. (462 aa) |
| | kbl | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (397 aa) |
| | fabH_3 | 3-oxoacyl-[acyl-carrier-protein] synthase 3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (314 aa) |
| | AOT62082.1 | Asparagine synthetase B. (565 aa) |
| | AOT62091.1 | Putative acetyltransferase. (145 aa) |
| | mmuM | Homocysteine S-methyltransferase. (336 aa) |
| | desA1 | Putative acyl-[acyl-carrier-protein] desaturase desA1. (324 aa) |
| | moaA1 | Cyclic pyranopterin monophosphate synthase 1. (340 aa) |
| | argD_3 | Acetylornithine/acetyl-lysine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (461 aa) |
| | AOT62228.1 | Radical SAM superfamily protein. (299 aa) |
| | kanC | 2-deoxy-scyllo-inosose synthase. (429 aa) |
| | AOT62245.1 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (342 aa) |
| | AOT62288.1 | Haloacid dehalogenase-like hydrolase. (310 aa) |
| | panD_2 | Aspartate 1-decarboxylase precursor; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (141 aa) |
| | egtD | Histidine-specific methyltransferase EgtD; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. (321 aa) |
| | egtC | Amidohydrolase EgtC; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. (271 aa) |
| | egtB | Iron(II)-dependent oxidoreductase EgtB; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family. (444 aa) |
| | gshA | Glutamate--cysteine ligase GshA; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. (511 aa) |
| | AOT62368.1 | Acetyltransferase (GNAT) family protein. (131 aa) |
| | asnO_2 | Asparagine synthetase [glutamine-hydrolyzing] 3. (608 aa) |
| | mas | Mycocerosic acid synthase. (353 aa) |
| | AOT62406.1 | Glycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (340 aa) |
| | AOT62439.1 | Iron-binding zinc finger CDGSH type. (72 aa) |
| | dapA_5 | 4-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (308 aa) |
| | aroK_2 | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (172 aa) |
| | aroC_2 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (394 aa) |
| | aroA_2 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (446 aa) |
| | aroH_2 | Phospho-2-dehydro-3-deoxyheptonate aldolase; Belongs to the class-II DAHP synthase family. (401 aa) |
| | AOT62526.1 | Hypothetical protein. (301 aa) |
| | folD_2 | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (290 aa) |
| | AOT62571.1 | 5-amino-6-(5-phosphoribosylamino)uracil reductase. (198 aa) |
| | AOT62576.1 | Putative oxidoreductase. (276 aa) |
| | AOT62602.1 | Acyl carrier protein. (78 aa) |
| | fabH_4 | 3-oxoacyl-[acyl-carrier-protein] synthase 3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (346 aa) |
| | AOT62605.1 | Hypothetical protein. (346 aa) |
| | bacD_4 | Alanine-anticapsin ligase BacD. (454 aa) |
| | leuC_2 | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (464 aa) |
| | leuD_2 | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (198 aa) |
