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ptlI_1 ptlI_1 dapA_1 dapA_1 AOT57636.1 AOT57636.1 strE_1 strE_1 AOT57694.1 AOT57694.1 dapH dapH aroQ aroQ aroB aroB aroC_1 aroC_1 AOT58131.1 AOT58131.1 ectC ectC pel_2 pel_2 araC araC yagE yagE dapA_2 dapA_2 psuG_1 psuG_1 trpA trpA trpB trpB hisB hisB mtcA1 mtcA1 nei1 nei1 AOT58965.1 AOT58965.1 pelX pelX AOT59145.1 AOT59145.1 gmd gmd hutU hutU eno eno strE_2 strE_2 murQ murQ thrC_1 thrC_1 pheA pheA AOT59985.1 AOT59985.1 pdg pdg ilvD ilvD nasF_2 nasF_2 hemB hemB mqnA mqnA AOT60432.1 AOT60432.1 nnr nnr dapA_3 dapA_3 fumC fumC fumB fumB thrC_2 thrC_2 paaG paaG thrC_3 thrC_3 leuC_1 leuC_1 leuD_1 leuD_1 fpg1 fpg1 dapA_4 dapA_4 nei nei ptlI_2 ptlI_2 ptlI_3 ptlI_3 acnA acnA psuG_2 psuG_2 paaZ paaZ AOT62070.1 AOT62070.1 paaF_2 paaF_2 kanC kanC cynT cynT dapA_5 dapA_5 aroC_2 aroC_2 mtcA2 mtcA2 leuC_2 leuC_2 leuD_2 leuD_2 pel_1 pel_1 cyc2 cyc2 dapAL dapAL
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ptlI_1Pentalenene oxygenase; Belongs to the cytochrome P450 family. (447 aa)
dapA_14-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (325 aa)
AOT57636.1Hypothetical protein. (641 aa)
strE_1dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (339 aa)
AOT57694.1Hypothetical protein. (140 aa)
dapH2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase. (178 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (146 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (364 aa)
aroC_1Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (394 aa)
AOT58131.1Putative enoyl-CoA hydratase 1. (153 aa)
ectCL-ectoine synthase; Catalyzes the circularization of gamma-N-acetyl-alpha,gamma- diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4- pyrimidine carboxylic acid), which is an excellent osmoprotectant. (132 aa)
pel_2Pectate lyase precursor. (462 aa)
araCL-arabonate dehydratase; Belongs to the IlvD/Edd family. (612 aa)
yagEPutative 2-keto-3-deoxy-galactonate aldolase YagE; Belongs to the DapA family. (300 aa)
dapA_24-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (298 aa)
psuG_1Pseudouridine-5'-phosphate glycosidase; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. (387 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (271 aa)
trpBTryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (427 aa)
hisBImidazoleglycerol-phosphate dehydratase. (197 aa)
mtcA1Beta-carbonic anhydrase 1. (185 aa)
nei1Endonuclease 8 1; Belongs to the FPG family. (285 aa)
AOT58965.1Hypothetical protein. (425 aa)
pelXPectate disaccharide-lyase precursor. (530 aa)
AOT59145.1Bifunctional uroporphyrinogen-III synthetase/response regulator domain protein. (404 aa)
gmdGDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (337 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (552 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
strE_2dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (326 aa)
murQN-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (311 aa)
thrC_1Threonine synthase. (432 aa)
pheAPrephenate dehydratase. (312 aa)
AOT59985.1HhH-GPD superfamily base excision DNA repair protein. (201 aa)
pdgUltraviolet N-glycosylase/AP lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (296 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (617 aa)
nasF_2Uroporphyrinogen-III C-methyltransferase. (555 aa)
hemBDelta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (331 aa)
mqnAChorismate dehydratase; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (286 aa)
AOT60432.1Bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Belongs to the UPF0336 family. (151 aa)
nnrBifunctional NAD(P)H-hydrate repair enzyme Nnr; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to al [...] (493 aa)
dapA_34-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (305 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)
fumBFumarate hydratase class I, anaerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (555 aa)
thrC_2Threonine synthase. (369 aa)
paaG1,2-epoxyphenylacetyl-CoA isomerase; Belongs to the enoyl-CoA hydratase/isomerase family. (260 aa)
thrC_3Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (356 aa)
leuC_13-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (476 aa)
leuD_13-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa)
fpg1Formamidopyrimidine-DNA glycosylase 1; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (290 aa)
dapA_44-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (299 aa)
neiEndonuclease 8. (267 aa)
ptlI_2Pentalenene oxygenase; Belongs to the cytochrome P450 family. (517 aa)
ptlI_3Pentalenene oxygenase; Belongs to the cytochrome P450 family. (452 aa)
acnAAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (905 aa)
psuG_2Pseudouridine-5'-phosphate glycosidase; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. (310 aa)
paaZBifunctional protein PaaZ. (174 aa)
AOT62070.1Putative pterin-4-alpha-carbinolamine dehydratase. (101 aa)
paaF_22,3-dehydroadipyl-CoA hydratase. (247 aa)
kanC2-deoxy-scyllo-inosose synthase. (429 aa)
cynTCarbonic anhydrase 1; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (193 aa)
dapA_54-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (308 aa)
aroC_2Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (394 aa)
mtcA2Carbonic anhydrase 2. (263 aa)
leuC_23-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (464 aa)
leuD_23-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (198 aa)
pel_1Pectate trisaccharide-lyase precursor. (520 aa)
cyc2Germacradienol/geosmin synthase. (753 aa)
dapALPutative DapA-like lyase; Belongs to the DapA family. (298 aa)
Your Current Organism:
Streptomyces rubrolavendulae
NCBI taxonomy Id: 285473
Other names: S. rubrolavendulae
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