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| | mshA_1 | D-inositol 3-phosphate glycosyltransferase. (412 aa) |
| | sbnA_1 | Putative siderophore biosynthesis protein SbnA. (403 aa) |
| | bioF1 | 8-amino-7-oxononanoate synthase 1. (390 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (423 aa) |
| | bioA | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (431 aa) |
| | bioD | ATP-dependent dethiobiotin synthetase BioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (240 aa) |
| | acsA_1 | Acetyl-coenzyme A synthetase. (670 aa) |
| | metK | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (402 aa) |
| | metH | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1174 aa) |
| | mshC | L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. (409 aa) |
| | tagE_1 | Putative poly(glycerol-phosphate) alpha-glucosyltransferase. (427 aa) |
| | AOT58264.1 | Glyoxalase-like domain protein. (134 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (271 aa) |
| | metF | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (304 aa) |
| | thiE | Thiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (247 aa) |
| | hcnC_2 | Hydrogen cyanide synthase subunit HcnC precursor. (383 aa) |
| | thiS | Sulfur carrier protein ThiS. (74 aa) |
| | thiG | Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (264 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (322 aa) |
| | AOT58723.1 | Putative sulfate transport protein CysZ. (278 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha. (448 aa) |
| | metZ | O-succinylhomoserine sulfhydrylase. (401 aa) |
| | metA | Homoserine O-succinyltransferase; Belongs to the MetA family. (312 aa) |
| | tagE_2 | Putative poly(glycerol-phosphate) alpha-glucosyltransferase. (762 aa) |
| | mfpsA | Mannosylfructose-phosphate synthase. (748 aa) |
| | AOT58850.1 | Hypothetical protein. (379 aa) |
| | asd_1 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (342 aa) |
| | cysM_1 | O-phosphoserine sulfhydrylase. (316 aa) |
| | cysO_1 | Sulfur carrier protein CysO. (92 aa) |
| | mec | CysO-cysteine peptidase. (140 aa) |
| | mtnA | Methylthioribose-1-phosphate isomerase; Belongs to the eIF-2B alpha/beta/delta subunits family. (353 aa) |
| | cbs | Putative cystathionine beta-synthase. (461 aa) |
| | mtnP | S-methyl-5'-thioadenosine phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. (278 aa) |
| | bioK_1 | L-Lysine-8-amino-7-oxononanoate aminotransferase. (904 aa) |
| | asd_2 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (370 aa) |
| | mqnB | Futalosine hydrolase; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). (252 aa) |
| | cysO_2 | Sulfur carrier protein CysO. (91 aa) |
| | mshA_4 | D-inositol 3-phosphate glycosyltransferase; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway. (448 aa) |
| | AOT59666.1 | Argininosuccinate lyase. (433 aa) |
| | mshD_3 | Mycothiol acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. (327 aa) |
| | bkdA_1 | 3-methyl-2-oxobutanoate dehydrogenase subunit alpha. (398 aa) |
| | bkdA_2 | 3-methyl-2-oxobutanoate dehydrogenase subunit alpha. (380 aa) |
| | metC | Cystathionine beta-lyase. (380 aa) |
| | thiC | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (591 aa) |
| | AOT59990.1 | Ferredoxin-nitrite reductase. (436 aa) |
| | acsA_2 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa) |
| | epsD | Putative glycosyltransferase EpsD. (386 aa) |
| | kanF | 2-deoxystreptamine glucosyltransferase. (370 aa) |
| | AOT60474.1 | GlcNAc-PI de-N-acetylase. (724 aa) |
| | folD_1 | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa) |
| | bacD_1 | Alanine-anticapsin ligase BacD. (474 aa) |
| | bacD_2 | Alanine-anticapsin ligase BacD. (511 aa) |
| | bacD_3 | Alanine-anticapsin ligase BacD. (417 aa) |
| | AOT60659.1 | Hypothetical protein. (313 aa) |
| | metB | Cystathionine gamma-synthase. (384 aa) |
| | mtnN | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. (387 aa) |
| | mshB | 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase; Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2- deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway. (296 aa) |
| | moeZ_3 | Putative adenylyltransferase/sulfurtransferase MoeZ. (392 aa) |
| | hom | Homoserine dehydrogenase. (447 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa) |
| | pta | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (696 aa) |
| | AOT61182.1 | Cobalamin-independent synthase, Catalytic domain. (337 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (331 aa) |
| | thiD | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. (296 aa) |
| | bioK_2 | L-Lysine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (462 aa) |
| | bioK_3 | L-Lysine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (445 aa) |
| | sbnA_2 | Putative siderophore biosynthesis protein SbnA. (346 aa) |
| | bioF | 8-amino-7-oxononanoate synthase. (1399 aa) |
| | AOT61590.1 | Glyoxalase-like domain protein. (143 aa) |
| | AOT61591.1 | Glyoxalase-like domain protein. (118 aa) |
| | AOT61600.1 | Argininosuccinate lyase. (441 aa) |
| | cysM_2 | Cysteine synthase. (388 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (654 aa) |
| | cysD | Sulfate adenylyltransferase subunit 2. (312 aa) |
| | sat/cysC | Putative bifunctional SAT/APS kinase; Catalyzes the synthesis of activated sulfate. (191 aa) |
| | acsA_3 | Acetyl-coenzyme A synthetase. (591 aa) |
| | ggt | Gamma-glutamyltranspeptidase precursor. (620 aa) |
| | kbl | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (397 aa) |
| | AOT62091.1 | Putative acetyltransferase. (145 aa) |
| | mmuM | Homocysteine S-methyltransferase. (336 aa) |
| | neoL | 2'-N-acetylparomamine deacetylase. (279 aa) |
| | egtD | Histidine-specific methyltransferase EgtD; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. (321 aa) |
| | egtC | Amidohydrolase EgtC; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. (271 aa) |
| | egtB | Iron(II)-dependent oxidoreductase EgtB; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family. (444 aa) |
| | gshA | Glutamate--cysteine ligase GshA; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. (511 aa) |
| | AOT62513.1 | Glyoxalase-like domain protein. (136 aa) |
| | folD_2 | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (290 aa) |
| | bacD_4 | Alanine-anticapsin ligase BacD. (454 aa) |
