(50 nodes) Mixed, incl. Insulin receptor signaling pathway, and AKT phosphorylates targets in the nucleus network (Cyprinodon variegatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107097451	IlGF domain-containing protein. (190 aa)
	SGK1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (431 aa)
	LOC107102671	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (422 aa)
	foxo3	Forkhead box O3b. (666 aa)
	igf1r	Tyrosine-protein kinase receptor. (1416 aa)
	LOC107100318	Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (439 aa)
	PIK3R5	Phosphoinositide-3-kinase regulatory subunit 5. (663 aa)
	LOC107088377	Tyrosine-protein phosphatase non-receptor type. (405 aa)
	LOC107087768	Si:ch73-335l21.1. (1267 aa)
	sirt1	Sirtuin 1. (691 aa)
	pik3r2	Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (724 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (410 aa)
	ENSCVAP00000008839	Uncharacterized protein. (261 aa)
	LOC107091522	Insulin receptor substrate 4a. (1343 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
	LOC107083639	Uncharacterized protein. (471 aa)
	sh2b1	SH2B adaptor protein 1. (937 aa)
	LOC107093735	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1b. (1452 aa)
	LOC107102306	Si:ch211-284e13.4. (1153 aa)
	LOC107103487	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1009 aa)
	LOC107099926	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	LOC107095350	Forkhead box O1 a. (666 aa)
	LOC107083482	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (470 aa)
	LOC107102230	Fork-head domain-containing protein. (613 aa)
	LOC107100834	Tyrosine-protein kinase receptor. (1366 aa)
	LOC107099244	Fork-head domain-containing protein. (633 aa)
	pdpk1	3-phosphoinositide dependent protein kinase 1b. (565 aa)
	stat3	Signal transducer and activator of transcription. (800 aa)
	LOC107097409	Tyrosine-protein kinase receptor. (1171 aa)
	sgk2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (361 aa)
	PIK3R5-2	Phosphoinositide-3-kinase regulatory subunit 5. (760 aa)
	GRB14	Growth factor receptor bound protein 14. (528 aa)
	pik3cb	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1009 aa)
	LOC107086777	Insulin receptor substrate 2a. (1061 aa)
	PIK3CA	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1038 aa)
	LOC107081636	Uncharacterized protein; Belongs to the protein kinase superfamily. (417 aa)
	ENSCVAP00000025336	PH domain-containing protein. (1058 aa)
	ins	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (140 aa)
	igf1	Insulin-like growth factor 1. (186 aa)
	irs2	Insulin receptor substrate 2b. (1114 aa)
	ENSCVAP00000029189	Forkhead box O6 b. (604 aa)
	ENSCVAP00000029198	V-akt murine thymoma viral oncogene homolog 3b. (181 aa)
	LOC107085131	Forkhead box O6 a. (719 aa)
	pik3cd	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (930 aa)
	insr	Tyrosine-protein kinase receptor. (1362 aa)
	foxo4	Forkhead box O4. (639 aa)
	ENSCVAP00000030679	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (48 aa)
	LOC107090730	Tyrosine-protein phosphatase non-receptor type. (434 aa)
	LOC107091852	Uncharacterized protein. (606 aa)
	LOC107094114	Growth factor receptor-bound protein 10b. (630 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCVAP00000008839	ENSCVAP00000029198	ENSCVAP00000008839	ENSCVAP00000029198	Uncharacterized protein.	V-akt murine thymoma viral oncogene homolog 3b.	0.492
ENSCVAP00000008839	GRB14	ENSCVAP00000008839	ENSCVAP00000020624	Uncharacterized protein.	Growth factor receptor bound protein 14.	0.467
ENSCVAP00000008839	LOC107083482	ENSCVAP00000008839	ENSCVAP00000015997	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.492
ENSCVAP00000008839	LOC107086777	ENSCVAP00000008839	ENSCVAP00000024084	Uncharacterized protein.	Insulin receptor substrate 2a.	0.621
ENSCVAP00000008839	LOC107087768	ENSCVAP00000008839	ENSCVAP00000004232	Uncharacterized protein.	Si:ch73-335l21.1.	0.621
ENSCVAP00000008839	LOC107091522	ENSCVAP00000008839	ENSCVAP00000011000	Uncharacterized protein.	Insulin receptor substrate 4a.	0.621
ENSCVAP00000008839	LOC107091852	ENSCVAP00000008839	ENSCVAP00000031840	Uncharacterized protein.	Uncharacterized protein.	0.467
ENSCVAP00000008839	LOC107094114	ENSCVAP00000008839	ENSCVAP00000032307	Uncharacterized protein.	Growth factor receptor-bound protein 10b.	0.467
ENSCVAP00000008839	LOC107097409	ENSCVAP00000008839	ENSCVAP00000020125	Uncharacterized protein.	Tyrosine-protein kinase receptor.	0.466
ENSCVAP00000008839	LOC107099926	ENSCVAP00000008839	ENSCVAP00000014231	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.492
ENSCVAP00000008839	LOC107100834	ENSCVAP00000008839	ENSCVAP00000018317	Uncharacterized protein.	Tyrosine-protein kinase receptor.	0.496
ENSCVAP00000008839	LOC107102306	ENSCVAP00000008839	ENSCVAP00000013030	Uncharacterized protein.	Si:ch211-284e13.4.	0.621
ENSCVAP00000008839	LOC107103487	ENSCVAP00000008839	ENSCVAP00000013241	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.641
ENSCVAP00000008839	PIK3CA	ENSCVAP00000008839	ENSCVAP00000024569	Uncharacterized protein.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family.	0.641
ENSCVAP00000008839	akt1	ENSCVAP00000008839	ENSCVAP00000011154	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.492
ENSCVAP00000008839	igf1r	ENSCVAP00000008839	ENSCVAP00000001583	Uncharacterized protein.	Tyrosine-protein kinase receptor.	0.496
ENSCVAP00000008839	insr	ENSCVAP00000008839	ENSCVAP00000030091	Uncharacterized protein.	Tyrosine-protein kinase receptor.	0.496
ENSCVAP00000008839	irs2	ENSCVAP00000008839	ENSCVAP00000029130	Uncharacterized protein.	Insulin receptor substrate 2b.	0.621
ENSCVAP00000008839	pdpk1	ENSCVAP00000008839	ENSCVAP00000019109	Uncharacterized protein.	3-phosphoinositide dependent protein kinase 1b.	0.607
ENSCVAP00000008839	pik3cb	ENSCVAP00000008839	ENSCVAP00000023194	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.641