(21 nodes) IRAK2 mediated activation of TAK1 complex, and Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon network (Cyprinodon variegatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	tnfrsf1a	Tumor necrosis factor receptor superfamily, member 1a. (383 aa)
	tank	TRAF family member-associated NFKB activator. (335 aa)
	LOC107084970	TIR domain-containing protein; Belongs to the Toll-like receptor family. (949 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (763 aa)
	LOC107103870	TNF receptor-associated factor. (428 aa)
	ripk1	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like. (627 aa)
	traf3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (590 aa)
	tab1	TGF-beta activated kinase 1/MAP3K7 binding protein 1. (506 aa)
	LOC107093789	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (580 aa)
	ENSCVAP00000011893	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (305 aa)
	birc7	Baculoviral IAP repeat containing 7. (399 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
	ENSCVAP00000017074	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (64 aa)
	tab2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (752 aa)
	LOC107084938	TIR domain-containing protein. (950 aa)
	Ikbke	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (358 aa)
	tradd	Tnfrsf1a-associated via death domain. (292 aa)
	LOC107085741	Sterile alpha motif and leucine zipper containing kinase AZK. (793 aa)
	LOC107097523	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (484 aa)
	map3k20	Protein kinase domain-containing protein. (698 aa)
	tab3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (598 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	ENSCVAP00000011893	ENSCVAP00000001539	ENSCVAP00000011893	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.637
CHUK	ENSCVAP00000017074	ENSCVAP00000001539	ENSCVAP00000017074	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.822
CHUK	LOC107085741	ENSCVAP00000001539	ENSCVAP00000030213	Component of inhibitor of nuclear factor kappa B kinase complex.	Sterile alpha motif and leucine zipper containing kinase AZK.	0.637
CHUK	LOC107093789	ENSCVAP00000001539	ENSCVAP00000010683	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.987
CHUK	LOC107097523	ENSCVAP00000001539	ENSCVAP00000030943	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.962
CHUK	LOC107103870	ENSCVAP00000001539	ENSCVAP00000002344	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor.	0.579
CHUK	birc7	ENSCVAP00000001539	ENSCVAP00000012019	Component of inhibitor of nuclear factor kappa B kinase complex.	Baculoviral IAP repeat containing 7.	0.542
CHUK	map3k20	ENSCVAP00000001539	ENSCVAP00000031175	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein.	0.637
CHUK	ripk1	ENSCVAP00000001539	ENSCVAP00000004942	Component of inhibitor of nuclear factor kappa B kinase complex.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.693
CHUK	tab1	ENSCVAP00000001539	ENSCVAP00000009386	Component of inhibitor of nuclear factor kappa B kinase complex.	TGF-beta activated kinase 1/MAP3K7 binding protein 1.	0.963
CHUK	tab2	ENSCVAP00000001539	ENSCVAP00000020013	Component of inhibitor of nuclear factor kappa B kinase complex.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.972
CHUK	tab3	ENSCVAP00000001539	ENSCVAP00000031343	Component of inhibitor of nuclear factor kappa B kinase complex.	TGF-beta activated kinase 1 (MAP3K7) binding protein 3.	0.963
CHUK	tank	ENSCVAP00000001539	ENSCVAP00000001089	Component of inhibitor of nuclear factor kappa B kinase complex.	TRAF family member-associated NFKB activator.	0.521
CHUK	tnfrsf1a	ENSCVAP00000001539	ENSCVAP00000000255	Component of inhibitor of nuclear factor kappa B kinase complex.	Tumor necrosis factor receptor superfamily, member 1a.	0.535
CHUK	tradd	ENSCVAP00000001539	ENSCVAP00000022735	Component of inhibitor of nuclear factor kappa B kinase complex.	Tnfrsf1a-associated via death domain.	0.653
CHUK	traf3	ENSCVAP00000001539	ENSCVAP00000008442	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.764
CHUK	traf6	ENSCVAP00000001539	ENSCVAP00000013118	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.985
ENSCVAP00000011893	CHUK	ENSCVAP00000011893	ENSCVAP00000001539	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.637
ENSCVAP00000011893	ENSCVAP00000017074	ENSCVAP00000011893	ENSCVAP00000017074	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.938
ENSCVAP00000011893	LOC107084938	ENSCVAP00000011893	ENSCVAP00000020453	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	TIR domain-containing protein.	0.836