(106 nodes) Neurotransmitter secretion, and Norepinephrine Neurotransmitter Release Cycle network (Cyprinodon variegatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107093429	Syntaxin binding protein 2; Belongs to the STXBP/unc-18/SEC1 family. (585 aa)
	LOC107100485	Uncharacterized protein. (897 aa)
	ENSCVAP00000000394	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (231 aa)
	kcnc2	Potassium voltage-gated channel, Shaw-related subfamily, member 2; Belongs to the potassium channel family. (576 aa)
	ENSCVAP00000001661	Aa_trans domain-containing protein. (447 aa)
	ENSCVAP00000001965	Protein kinase domain-containing protein. (113 aa)
	LOC107095723	Uncharacterized protein. (1189 aa)
	ENSCVAP00000002273	Uncharacterized protein. (352 aa)
	LOC107086112	V-SNARE coiled-coil homology domain-containing protein. (119 aa)
	LOC107095688	Uncharacterized protein. (221 aa)
	LOC107081878	Syntaxin 1A (brain); Belongs to the syntaxin family. (287 aa)
	ENSCVAP00000003610	Uncharacterized protein. (73 aa)
	mpp2	Membrane protein, palmitoylated 2b (MAGUK p55 subfamily member 2); Belongs to the MAGUK family. (567 aa)
	LOC107098387	Uncharacterized protein. (1525 aa)
	ENSCVAP00000004593	Uncharacterized protein. (129 aa)
	LOC107095133	Solute carrier family 17 member 7b. (584 aa)
	SLC18A1	Solute carrier family 18 member A1. (743 aa)
	SYN3	Synapsin III. (538 aa)
	LOC107097210	Synaptotagmin Vb. (424 aa)
	LOC107091682	Ankyrin repeat domain 33Bb. (529 aa)
	cplx2	Complexin 2. (133 aa)
	LOC107098334	Syntaxin 11a; Belongs to the syntaxin family. (294 aa)
	LOC107089997	Solute carrier family 18 member A3. (518 aa)
	stxbp5	Syntaxin binding protein 5a (tomosyn). (1147 aa)
	LOC107085504	Uncharacterized protein. (1474 aa)
	LOC107102522	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (201 aa)
	syt11	Synaptotagmin XIb. (461 aa)
	stxbp1	Syntaxin binding protein 1a; Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
	RIMS2	Regulating synaptic membrane exocytosis 2. (1284 aa)
	LOC107091600	Syntaxin binding protein 5b (tomosyn). (1185 aa)
	STX19	Syntaxin 19. (302 aa)
	LOC107084378	Regulating synaptic membrane exocytosis 3. (324 aa)
	LOC107083726	Amyloid beta (A4) precursor protein-binding, family A, member 1b. (1122 aa)
	LOC107101860	t-SNARE coiled-coil homology domain-containing protein. (298 aa)
	ENSCVAP00000008755	t-SNARE coiled-coil homology domain-containing protein. (291 aa)
	ENSCVAP00000009295	C2 domain-containing protein. (158 aa)
	rab3c	RAB3C, member RAS oncogene family. (225 aa)
	URM1	Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically [...] (110 aa)
	LOC107093814	Syntaxin 4; Belongs to the syntaxin family. (297 aa)
	LOC107097655	Syntaxin 1B; Belongs to the syntaxin family. (303 aa)
	ENSCVAP00000010603	V-SNARE coiled-coil homology domain-containing protein. (81 aa)
	stx2	Syntaxin 2b; Belongs to the syntaxin family. (268 aa)
	LOC107094896	Synaptotagmin IXb. (525 aa)
	ENSCVAP00000012437	Solute carrier family 18 member 3a. (515 aa)
	ENSCVAP00000012541	Membrane protein, palmitoylated 4a (MAGUK p55 subfamily member 4); Belongs to the MAGUK family. (548 aa)
	ENSCVAP00000012588	Membrane protein, palmitoylated 4-like; Belongs to the MAGUK family. (523 aa)
	LOC107089162	Uncharacterized protein. (431 aa)
	UNC13C	Unc-13 homolog C. (2108 aa)
	ENSCVAP00000013083	Uncharacterized protein. (88 aa)
	LOC107087392	Amyloid beta (A4) precursor protein-binding, family A, member 2a. (837 aa)
	LOC107091323	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (202 aa)
	syt10	Synaptotagmin X. (551 aa)
	ppfia2	PTPRF interacting protein alpha 2. (1254 aa)
	APBA1	Amyloid beta precursor protein binding family A member 1. (832 aa)
	rims1	Regulating synaptic membrane exocytosis 1a. (970 aa)
	LOC107100514	RAB3B, member RAS oncogene family. (217 aa)
	LOC107084051	EF-hand domain-containing protein. (86 aa)
	LOC107091034	Amyloid beta (A4) precursor protein-binding, family A, member 2b. (944 aa)
	LOC107096970	Amyloid beta precursor protein binding family A member 3. (694 aa)
	LOC107083393	Complexin 2, like. (134 aa)
	cask	Calcium/calmodulin-dependent serine protein kinase b; Belongs to the MAGUK family. (955 aa)
	LOC107086759	Ankyrin repeat domain 33Aa. (424 aa)
	UNC13B	Unc-13 homolog B. (1438 aa)
	LOC107084483	Uncharacterized protein. (1327 aa)
	lenep	Lens epithelial protein. (64 aa)
	LOC107088412	S100 calcium binding protein A11. (86 aa)
	Vamp1	Zgc:92912. (125 aa)
	ENSCVAP00000021138	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (400 aa)
	ENSCVAP00000021350	C2 domain-containing protein. (382 aa)
	LOC107100323	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (217 aa)
	snap25	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (204 aa)
	ENSCVAP00000022246	Synaptotagmin VIIa. (462 aa)
	Vamp3	V-SNARE coiled-coil homology domain-containing protein. (109 aa)
	ENSCVAP00000022810	C2 domain-containing protein. (163 aa)
	slc17a8	Solute carrier family 17 member 8. (582 aa)
	ENSCVAP00000023666	t-SNARE coiled-coil homology domain-containing protein. (289 aa)
	slc18a2	Solute carrier family 18 member 2. (516 aa)
	syt7	Synaptotagmin VIIb. (563 aa)
	ENSCVAP00000024301	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (156 aa)
	ENSCVAP00000024317	Myb_DNA-bind_5 domain-containing protein. (373 aa)
	LOC107084380	Uncharacterized protein; Belongs to the MAGUK family. (575 aa)
	LOC107082578	Vesicle-associated membrane protein 2. (150 aa)
	LOC107095553	Regulating synaptic membrane exocytosis protein 2 isoform X1. (215 aa)
	LOC107083203	Uncharacterized protein. (433 aa)
	rab3a	RAB3A, member RAS oncogene family, b. (219 aa)
	LOC107082358	Membrane protein, palmitoylated 6a (MAGUK p55 subfamily member 6); Belongs to the MAGUK family. (555 aa)
	stxbp3	Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
	LOC107088169	Synapsin IIa. (467 aa)
	LOC107081823	RIMS binding protein 2. (1147 aa)
	LOC107101257	Synapsin I. (630 aa)
	tspoap1	Uncharacterized protein. (1989 aa)
	LOC107093748	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (233 aa)
	LOC107101223	Synaptotagmin-1-like. (424 aa)
	LOC107102333	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (285 aa)
	LOC107090842	Lin-7 homolog C (C. elegans). (184 aa)
	syt3	Synaptotagmin III. (549 aa)
	syt1	Synaptotagmin Ia. (422 aa)
	lin7a	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (217 aa)
	SLC17A6	Solute carrier family 17 member 6b. (580 aa)
	LOC107102274	Syntaxin binding protein 1b; Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
	ENSCVAP00000030142	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (159 aa)
	syt12	Synaptotagmin XII. (423 aa)
	LOC107084039	Synaptotagmin IXa. (563 aa)
	stx3	Syntaxin 3A; Belongs to the syntaxin family. (288 aa)
	LOC107089517	MFS domain-containing protein. (418 aa)
	LOC107083922	Synaptotagmin IIa. (431 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APBA1	ENSCVAP00000000394	ENSCVAP00000014206	ENSCVAP00000000394	Amyloid beta precursor protein binding family A member 1.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.455
APBA1	ENSCVAP00000001965	ENSCVAP00000014206	ENSCVAP00000001965	Amyloid beta precursor protein binding family A member 1.	Protein kinase domain-containing protein.	0.938
APBA1	ENSCVAP00000008755	ENSCVAP00000014206	ENSCVAP00000008755	Amyloid beta precursor protein binding family A member 1.	t-SNARE coiled-coil homology domain-containing protein.	0.456
APBA1	ENSCVAP00000012541	ENSCVAP00000014206	ENSCVAP00000012541	Amyloid beta precursor protein binding family A member 1.	Membrane protein, palmitoylated 4a (MAGUK p55 subfamily member 4); Belongs to the MAGUK family.	0.457
APBA1	ENSCVAP00000012588	ENSCVAP00000014206	ENSCVAP00000012588	Amyloid beta precursor protein binding family A member 1.	Membrane protein, palmitoylated 4-like; Belongs to the MAGUK family.	0.457
APBA1	ENSCVAP00000021138	ENSCVAP00000014206	ENSCVAP00000021138	Amyloid beta precursor protein binding family A member 1.	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	0.938
APBA1	ENSCVAP00000023666	ENSCVAP00000014206	ENSCVAP00000023666	Amyloid beta precursor protein binding family A member 1.	t-SNARE coiled-coil homology domain-containing protein.	0.456
APBA1	ENSCVAP00000024301	ENSCVAP00000014206	ENSCVAP00000024301	Amyloid beta precursor protein binding family A member 1.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.419
APBA1	ENSCVAP00000030142	ENSCVAP00000014206	ENSCVAP00000030142	Amyloid beta precursor protein binding family A member 1.	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family.	0.691
APBA1	LOC107081878	ENSCVAP00000014206	ENSCVAP00000003246	Amyloid beta precursor protein binding family A member 1.	Syntaxin 1A (brain); Belongs to the syntaxin family.	0.512
APBA1	LOC107082358	ENSCVAP00000014206	ENSCVAP00000026357	Amyloid beta precursor protein binding family A member 1.	Membrane protein, palmitoylated 6a (MAGUK p55 subfamily member 6); Belongs to the MAGUK family.	0.618
APBA1	LOC107084378	ENSCVAP00000014206	ENSCVAP00000008496	Amyloid beta precursor protein binding family A member 1.	Regulating synaptic membrane exocytosis 3.	0.487
APBA1	LOC107084380	ENSCVAP00000014206	ENSCVAP00000024619	Amyloid beta precursor protein binding family A member 1.	Uncharacterized protein; Belongs to the MAGUK family.	0.618
APBA1	LOC107084483	ENSCVAP00000014206	ENSCVAP00000019759	Amyloid beta precursor protein binding family A member 1.	Uncharacterized protein.	0.666
APBA1	LOC107085504	ENSCVAP00000014206	ENSCVAP00000006549	Amyloid beta precursor protein binding family A member 1.	Uncharacterized protein.	0.415
APBA1	LOC107086759	ENSCVAP00000014206	ENSCVAP00000018658	Amyloid beta precursor protein binding family A member 1.	Ankyrin repeat domain 33Aa.	0.457
APBA1	LOC107090842	ENSCVAP00000014206	ENSCVAP00000028713	Amyloid beta precursor protein binding family A member 1.	Lin-7 homolog C (C. elegans).	0.561
APBA1	LOC107091323	ENSCVAP00000014206	ENSCVAP00000013498	Amyloid beta precursor protein binding family A member 1.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.561
APBA1	LOC107091682	ENSCVAP00000014206	ENSCVAP00000004940	Amyloid beta precursor protein binding family A member 1.	Ankyrin repeat domain 33Bb.	0.457
APBA1	LOC107093429	ENSCVAP00000014206	ENSCVAP00000000098	Amyloid beta precursor protein binding family A member 1.	Syntaxin binding protein 2; Belongs to the STXBP/unc-18/SEC1 family.	0.691