(47 nodes) Norepinephrine Neurotransmitter Release Cycle, and Synaptic vesicle fusion to presynaptic active zone membrane network (Cyprinodon variegatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107093429	Syntaxin binding protein 2; Belongs to the STXBP/unc-18/SEC1 family. (585 aa)
	LOC107100485	Uncharacterized protein. (897 aa)
	ENSCVAP00000000394	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (231 aa)
	LOC107095723	Uncharacterized protein. (1189 aa)
	LOC107086112	V-SNARE coiled-coil homology domain-containing protein. (119 aa)
	LOC107095688	Uncharacterized protein. (221 aa)
	LOC107081878	Syntaxin 1A (brain); Belongs to the syntaxin family. (287 aa)
	LOC107098387	Uncharacterized protein. (1525 aa)
	SYN3	Synapsin III. (538 aa)
	LOC107097210	Synaptotagmin Vb. (424 aa)
	cplx2	Complexin 2. (133 aa)
	LOC107089997	Solute carrier family 18 member A3. (518 aa)
	LOC107102522	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (201 aa)
	syt11	Synaptotagmin XIb. (461 aa)
	stxbp1	Syntaxin binding protein 1a; Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
	RIMS2	Regulating synaptic membrane exocytosis 2. (1284 aa)
	ENSCVAP00000009295	C2 domain-containing protein. (158 aa)
	rab3c	RAB3C, member RAS oncogene family. (225 aa)
	LOC107093814	Syntaxin 4; Belongs to the syntaxin family. (297 aa)
	LOC107097655	Syntaxin 1B; Belongs to the syntaxin family. (303 aa)
	stx2	Syntaxin 2b; Belongs to the syntaxin family. (268 aa)
	LOC107089162	Uncharacterized protein. (431 aa)
	ENSCVAP00000013083	Uncharacterized protein. (88 aa)
	LOC107100514	RAB3B, member RAS oncogene family. (217 aa)
	LOC107083393	Complexin 2, like. (134 aa)
	UNC13B	Unc-13 homolog B. (1438 aa)
	LOC107084483	Uncharacterized protein. (1327 aa)
	Vamp1	Zgc:92912. (125 aa)
	ENSCVAP00000021350	C2 domain-containing protein. (382 aa)
	snap25	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (204 aa)
	Vamp3	V-SNARE coiled-coil homology domain-containing protein. (109 aa)
	ENSCVAP00000022810	C2 domain-containing protein. (163 aa)
	ENSCVAP00000023666	t-SNARE coiled-coil homology domain-containing protein. (289 aa)
	ENSCVAP00000024301	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (156 aa)
	LOC107082578	Vesicle-associated membrane protein 2. (150 aa)
	LOC107095553	Regulating synaptic membrane exocytosis protein 2 isoform X1. (215 aa)
	rab3a	RAB3A, member RAS oncogene family, b. (219 aa)
	stxbp3	Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
	LOC107081823	RIMS binding protein 2. (1147 aa)
	LOC107101257	Synapsin I. (630 aa)
	tspoap1	Uncharacterized protein. (1989 aa)
	LOC107093748	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (233 aa)
	LOC107102333	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (285 aa)
	syt1	Synaptotagmin Ia. (422 aa)
	ENSCVAP00000030142	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (159 aa)
	stx3	Syntaxin 3A; Belongs to the syntaxin family. (288 aa)
	LOC107083922	Synaptotagmin IIa. (431 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCVAP00000000394	ENSCVAP00000009295	ENSCVAP00000000394	ENSCVAP00000009295	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	C2 domain-containing protein.	0.737
ENSCVAP00000000394	ENSCVAP00000013083	ENSCVAP00000000394	ENSCVAP00000013083	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Uncharacterized protein.	0.401
ENSCVAP00000000394	ENSCVAP00000021350	ENSCVAP00000000394	ENSCVAP00000021350	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	C2 domain-containing protein.	0.501
ENSCVAP00000000394	ENSCVAP00000022810	ENSCVAP00000000394	ENSCVAP00000022810	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	C2 domain-containing protein.	0.737
ENSCVAP00000000394	ENSCVAP00000023666	ENSCVAP00000000394	ENSCVAP00000023666	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	t-SNARE coiled-coil homology domain-containing protein.	0.692
ENSCVAP00000000394	ENSCVAP00000030142	ENSCVAP00000000394	ENSCVAP00000030142	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family.	0.693
ENSCVAP00000000394	LOC107081823	ENSCVAP00000000394	ENSCVAP00000027011	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	RIMS binding protein 2.	0.426
ENSCVAP00000000394	LOC107081878	ENSCVAP00000000394	ENSCVAP00000003246	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Syntaxin 1A (brain); Belongs to the syntaxin family.	0.775
ENSCVAP00000000394	LOC107082578	ENSCVAP00000000394	ENSCVAP00000024795	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Vesicle-associated membrane protein 2.	0.806
ENSCVAP00000000394	LOC107083393	ENSCVAP00000000394	ENSCVAP00000016998	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Complexin 2, like.	0.585
ENSCVAP00000000394	LOC107083922	ENSCVAP00000000394	ENSCVAP00000032835	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Synaptotagmin IIa.	0.817
ENSCVAP00000000394	LOC107084483	ENSCVAP00000000394	ENSCVAP00000019759	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Uncharacterized protein.	0.697
ENSCVAP00000000394	LOC107086112	ENSCVAP00000000394	ENSCVAP00000002358	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	V-SNARE coiled-coil homology domain-containing protein.	0.806
ENSCVAP00000000394	LOC107089162	ENSCVAP00000000394	ENSCVAP00000012682	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Uncharacterized protein.	0.817
ENSCVAP00000000394	LOC107089997	ENSCVAP00000000394	ENSCVAP00000005909	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Solute carrier family 18 member A3.	0.496
ENSCVAP00000000394	LOC107093429	ENSCVAP00000000394	ENSCVAP00000000098	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Syntaxin binding protein 2; Belongs to the STXBP/unc-18/SEC1 family.	0.693
ENSCVAP00000000394	LOC107093814	ENSCVAP00000000394	ENSCVAP00000009964	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Syntaxin 4; Belongs to the syntaxin family.	0.736
ENSCVAP00000000394	LOC107095553	ENSCVAP00000000394	ENSCVAP00000024982	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Regulating synaptic membrane exocytosis protein 2 isoform X1.	0.695
ENSCVAP00000000394	LOC107095688	ENSCVAP00000000394	ENSCVAP00000002599	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Uncharacterized protein.	0.531
ENSCVAP00000000394	LOC107095723	ENSCVAP00000000394	ENSCVAP00000002263	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Uncharacterized protein.	0.501