(46 nodes) Wnt signaling pathway network (Cyprinodon variegatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107082204	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
	LOC107094605	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
	ror1	Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (950 aa)
	LOC107094565	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	fzd3	Frizzled class receptor 3a; Belongs to the G-protein coupled receptor Fz/Smo family. (709 aa)
	ENSCVAP00000005841	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (399 aa)
	ENSCVAP00000006644	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (547 aa)
	FZD3	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (719 aa)
	LOC107087044	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	LOC107091405	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (386 aa)
	LOC107088152	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	wnt10b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (429 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
	porcn	Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (413 aa)
	Wls	Uncharacterized protein. (138 aa)
	LOC107091832	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (332 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	LOC107091926	Uncharacterized protein. (339 aa)
	fzd4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (532 aa)
	LOC107086320	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
	LOC107082387	Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (529 aa)
	ENSCVAP00000016777	FZ domain-containing protein. (117 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (341 aa)
	LOC107095691	DAN domain family, member 5. (261 aa)
	fzd10	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (598 aa)
	LOC107093197	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	ENSCVAP00000023340	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (571 aa)
	wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	Fzd8	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
	wnt2b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (339 aa)
	wnt16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	wnt2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	fzd6	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (684 aa)
	LOC107083190	Notum, palmitoleoyl-protein carboxylesterase a. (500 aa)
	ryk	Receptor like tyrosine kinase. (642 aa)
	bambi	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (254 aa)
	wnt9b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	sfrp5	Secreted frizzled-related protein 5. (318 aa)
	Fzd9	Frizzled class receptor 9b; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	Fzd5	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (560 aa)
	LOC107086319	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (377 aa)
	LOC107090768	Uncharacterized protein. (515 aa)
	ENSCVAP00000030951	FZ domain-containing protein. (106 aa)
	LOC107101621	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
	LOC107101620	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCVAP00000005841	ENSCVAP00000006644	ENSCVAP00000005841	ENSCVAP00000006644	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.783
ENSCVAP00000005841	ENSCVAP00000023340	ENSCVAP00000005841	ENSCVAP00000023340	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.771
ENSCVAP00000005841	ENSCVAP00000030951	ENSCVAP00000005841	ENSCVAP00000030951	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	FZ domain-containing protein.	0.406
ENSCVAP00000005841	FZD3	ENSCVAP00000005841	ENSCVAP00000006841	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.774
ENSCVAP00000005841	Fzd5	ENSCVAP00000005841	ENSCVAP00000030032	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.777
ENSCVAP00000005841	Fzd8	ENSCVAP00000005841	ENSCVAP00000024220	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family.	0.771
ENSCVAP00000005841	Fzd9	ENSCVAP00000005841	ENSCVAP00000029715	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled class receptor 9b; Belongs to the G-protein coupled receptor Fz/Smo family.	0.770
ENSCVAP00000005841	LOC107082204	ENSCVAP00000005841	ENSCVAP00000000231	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.470
ENSCVAP00000005841	LOC107083190	ENSCVAP00000005841	ENSCVAP00000026099	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Notum, palmitoleoyl-protein carboxylesterase a.	0.702
ENSCVAP00000005841	LOC107086319	ENSCVAP00000005841	ENSCVAP00000030367	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.487
ENSCVAP00000005841	LOC107086320	ENSCVAP00000005841	ENSCVAP00000015943	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.487
ENSCVAP00000005841	LOC107087044	ENSCVAP00000005841	ENSCVAP00000008168	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.451
ENSCVAP00000005841	LOC107088152	ENSCVAP00000005841	ENSCVAP00000010950	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.400
ENSCVAP00000005841	LOC107090768	ENSCVAP00000005841	ENSCVAP00000030927	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein.	0.702
ENSCVAP00000005841	LOC107091405	ENSCVAP00000005841	ENSCVAP00000010271	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.413
ENSCVAP00000005841	LOC107091832	ENSCVAP00000005841	ENSCVAP00000012636	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.531
ENSCVAP00000005841	LOC107091926	ENSCVAP00000005841	ENSCVAP00000014972	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein.	0.771
ENSCVAP00000005841	LOC107093197	ENSCVAP00000005841	ENSCVAP00000023025	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.482
ENSCVAP00000005841	LOC107094565	ENSCVAP00000005841	ENSCVAP00000002329	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.400
ENSCVAP00000005841	LOC107094605	ENSCVAP00000005841	ENSCVAP00000001484	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.451