(27 nodes) Common Pathway of Fibrin Clot Formation, and Regulation of fibrinolysis network (Cyprinodon variegatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	ENSCVAP00000002986	Coagulation factor VIIi. (452 aa)
	ENSCVAP00000002997	Coagulation factor X. (499 aa)
	LOC107099172	Coagulation factor X. (346 aa)
	LOC107086808	Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (430 aa)
	LOC107101324	Uncharacterized protein. (357 aa)
	LOC107100699	SERPIN domain-containing protein; Belongs to the serpin family. (487 aa)
	fgg	Fibrinogen gamma chain. (432 aa)
	LOC107084182	Coagulation factor IXb. (553 aa)
	cpb2	Carboxypeptidase B2 (plasma). (432 aa)
	plg	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (799 aa)
	proc	Uncharacterized protein. (436 aa)
	LOC107082275	Fib_alpha domain-containing protein. (380 aa)
	ENSCVAP00000017905	Fibrinogen C-terminal domain-containing protein. (258 aa)
	fgb	Fibrinogen beta chain. (495 aa)
	serpinc1	Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family. (458 aa)
	LOC107100367	SERPIN domain-containing protein; Belongs to the serpin family. (367 aa)
	LOC107099183	Coagulation factor VII. (447 aa)
	ENSCVAP00000023198	SERPIN domain-containing protein; Belongs to the serpin family. (152 aa)
	ENSCVAP00000024268	Uncharacterized protein. (266 aa)
	ahsg	Alpha-2-HS-glycoprotein 2. (368 aa)
	LOC107089261	Coagulation factor IXa. (512 aa)
	LOC107081198	SERPIN domain-containing protein; Belongs to the serpin family. (110 aa)
	LOC107101328	Uncharacterized protein. (363 aa)
	LOC107088694	Alpha-1-microglobulin/bikunin precursor. (354 aa)
	LOC107088697	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (226 aa)
	ENSCVAP00000026335	Uncharacterized protein. (119 aa)
	serpind1	Serpin peptidase inhibitor, clade D (heparin cofactor), member 1; Belongs to the serpin family. (505 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCVAP00000002986	ENSCVAP00000024268	ENSCVAP00000002986	ENSCVAP00000024268	Coagulation factor VIIi.	Uncharacterized protein.	0.483
ENSCVAP00000002986	ENSCVAP00000026335	ENSCVAP00000002986	ENSCVAP00000026335	Coagulation factor VIIi.	Uncharacterized protein.	0.585
ENSCVAP00000002986	cpb2	ENSCVAP00000002986	ENSCVAP00000012268	Coagulation factor VIIi.	Carboxypeptidase B2 (plasma).	0.500
ENSCVAP00000002986	fgg	ENSCVAP00000002986	ENSCVAP00000010675	Coagulation factor VIIi.	Fibrinogen gamma chain.	0.437
ENSCVAP00000002986	proc	ENSCVAP00000002986	ENSCVAP00000017692	Coagulation factor VIIi.	Uncharacterized protein.	0.510
ENSCVAP00000002986	serpinc1	ENSCVAP00000002986	ENSCVAP00000018372	Coagulation factor VIIi.	Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family.	0.681
ENSCVAP00000002986	serpind1	ENSCVAP00000002986	ENSCVAP00000030454	Coagulation factor VIIi.	Serpin peptidase inhibitor, clade D (heparin cofactor), member 1; Belongs to the serpin family.	0.499
ENSCVAP00000002997	ENSCVAP00000024268	ENSCVAP00000002997	ENSCVAP00000024268	Coagulation factor X.	Uncharacterized protein.	0.483
ENSCVAP00000002997	ENSCVAP00000026335	ENSCVAP00000002997	ENSCVAP00000026335	Coagulation factor X.	Uncharacterized protein.	0.585
ENSCVAP00000002997	cpb2	ENSCVAP00000002997	ENSCVAP00000012268	Coagulation factor X.	Carboxypeptidase B2 (plasma).	0.500
ENSCVAP00000002997	fgg	ENSCVAP00000002997	ENSCVAP00000010675	Coagulation factor X.	Fibrinogen gamma chain.	0.437
ENSCVAP00000002997	proc	ENSCVAP00000002997	ENSCVAP00000017692	Coagulation factor X.	Uncharacterized protein.	0.515
ENSCVAP00000002997	serpinc1	ENSCVAP00000002997	ENSCVAP00000018372	Coagulation factor X.	Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family.	0.681
ENSCVAP00000002997	serpind1	ENSCVAP00000002997	ENSCVAP00000030454	Coagulation factor X.	Serpin peptidase inhibitor, clade D (heparin cofactor), member 1; Belongs to the serpin family.	0.499
ENSCVAP00000017905	ENSCVAP00000023198	ENSCVAP00000017905	ENSCVAP00000023198	Fibrinogen C-terminal domain-containing protein.	SERPIN domain-containing protein; Belongs to the serpin family.	0.420
ENSCVAP00000017905	ENSCVAP00000024268	ENSCVAP00000017905	ENSCVAP00000024268	Fibrinogen C-terminal domain-containing protein.	Uncharacterized protein.	0.836
ENSCVAP00000017905	LOC107082275	ENSCVAP00000017905	ENSCVAP00000017887	Fibrinogen C-terminal domain-containing protein.	Fib_alpha domain-containing protein.	0.763
ENSCVAP00000017905	LOC107086808	ENSCVAP00000017905	ENSCVAP00000006594	Fibrinogen C-terminal domain-containing protein.	Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.	0.630
ENSCVAP00000017905	LOC107088694	ENSCVAP00000017905	ENSCVAP00000026193	Fibrinogen C-terminal domain-containing protein.	Alpha-1-microglobulin/bikunin precursor.	0.717
ENSCVAP00000017905	LOC107088697	ENSCVAP00000017905	ENSCVAP00000026196	Fibrinogen C-terminal domain-containing protein.	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family.	0.717