(121 nodes) Mixed, incl. DNA-binding transcription activator activity, RNA polymerase II-specific, and LIM domain network (Cyprinodon variegatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107093420	LIM homeobox transcription factor 1, alpha-like. (410 aa)
	LOC107100171	GATA binding protein 1a. (426 aa)
	msc	Musculin (activated B-cell factor-1). (145 aa)
	ldb2	LIM domain binding 2a. (313 aa)
	tcf21	Transcription factor 21. (182 aa)
	myb	V-myb avian myeloblastosis viral oncogene homolog. (594 aa)
	ENSCVAP00000000718	ETS domain-containing protein. (171 aa)
	nkx3-2	NK3 homeobox 2. (265 aa)
	LOC107098571	LIM homeobox transcription factor 1, alpha. (332 aa)
	barx1	BARX homeobox 1. (237 aa)
	msx1	Muscle segment homeobox 1a. (277 aa)
	LOC107098481	WT1 transcription factor a. (427 aa)
	ldb1	LIM domain binding 1a. (366 aa)
	LOC107095712	Inhibitor of DNA binding 4. (148 aa)
	ssbp3	Single stranded DNA binding protein 3b. (383 aa)
	ISL2	ISL LIM homeobox 2b. (374 aa)
	bhlha15	Basic helix-loop-helix family, member a15. (189 aa)
	LOC107102063	ETS transcription factor ELK4. (472 aa)
	ENSCVAP00000003849	Pax2_C domain-containing protein. (85 aa)
	LOC107097196	Paired box 10. (283 aa)
	LOC107095642	Transcription factor 12. (645 aa)
	LOC107097882	Fli-1 proto-oncogene, ETS transcription factor b. (492 aa)
	ID2	Inhibitor of DNA binding 2. (143 aa)
	scai	Suppressor of cancer cell invasion. (565 aa)
	LOC107096727	Cyclic nucleotide-binding domain-containing protein. (1166 aa)
	LOC107087002	Nescient helix loop helix 2. (124 aa)
	LOC107087010	Helix-loop-helix protein 2-like. (124 aa)
	ELK3	ETS transcription factor ELK3. (396 aa)
	gata1	Uncharacterized protein. (256 aa)
	pax1	Paired box 1a. (360 aa)
	LOC107100736	Uncharacterized protein. (75 aa)
	zfpm2	Zinc finger protein, FOG family member 2a. (1165 aa)
	ENSCVAP00000009728	ALX homeobox 4b. (311 aa)
	OTP	Orthopedia homeobox b. (316 aa)
	runx2	Runt-related transcription factor. (464 aa)
	LOC107098627	NK3 homeobox 3. (275 aa)
	LOC107091504	GATA binding protein 2a. (457 aa)
	ENSCVAP00000011115	NK2 homeobox 5. (186 aa)
	ENSCVAP00000011588	LIM domain binding 2a. (280 aa)
	lhx9	LIM homeobox 9. (431 aa)
	LOC107099472	Runt domain-containing protein. (302 aa)
	pax2	Paired box 2a. (391 aa)
	LOC107090877	LIM domain only 1. (155 aa)
	Zfpm1	Zinc finger protein, FOG family member 1. (1277 aa)
	LOC107102882	BHLH domain-containing protein. (245 aa)
	isl2	ISL LIM homeobox 2a. (359 aa)
	spi1	Spi-1 proto-oncogene b. (264 aa)
	myf6	Myogenic factor 6. (239 aa)
	myf5	Myogenic factor. (240 aa)
	LOC107098178	Runt-related transcription factor. (470 aa)
	shox2	Short stature homeobox 2. (312 aa)
	srf	MADS-box domain-containing protein. (596 aa)
	LHX3	LIM homeobox 3. (408 aa)
	LOC107101124	MADS-box domain-containing protein. (569 aa)
	runx3	Runt-related transcription factor. (422 aa)
	LOC107090769	LIM-domain binding 1b. (412 aa)
	LOC107091907	Uncharacterized protein. (2702 aa)
	LOC107093594	Myogenic factor. (275 aa)
	ets1	V-ets avian erythroblastosis virus E26 oncogene homolog 1. (485 aa)
	gata6	GATA binding protein 6. (490 aa)
	LOC107081559	Paired domain-containing protein. (136 aa)
	nav3	Neuron navigator 3. (2349 aa)
	lmo2	LIM domain only 2 (rhombotin-like 1). (160 aa)
	gata4	GATA binding protein 4. (395 aa)
	lhx4	LIM homeobox 4. (346 aa)
	tbx5	T-box transcription factor 5a. (524 aa)
	LOC107086212	Tensin 1b. (1764 aa)
	ENSCVAP00000019170	BHLH domain-containing protein. (230 aa)
	zbtb49	Zinc finger and BTB domain containing 49. (735 aa)
	nkx2-1	NK2 homeobox 1. (349 aa)
	mrtfa	Myocardin related transcription factor Ab. (1222 aa)
	ENSCVAP00000020672	Uncharacterized protein. (203 aa)
	MYOCD	Myocardin. (930 aa)
	mef2a	Myocyte enhancer factor 2aa. (528 aa)
	LOC107105223	Uncharacterized protein. (398 aa)
	LOC107096242	ETS domain-containing protein. (375 aa)
	heca	Hdc homolog, cell cycle regulator. (549 aa)
	LOC107095687	BHLH domain-containing protein. (453 aa)
	nr4a2	Nuclear receptor subfamily 4, group A, member 2b. (601 aa)
	LOC107085592	LIM domain only 1. (155 aa)
	ikzf1	IKAROS family zinc finger 1 (Ikaros). (567 aa)
	foxf2	Forkhead box F2b. (400 aa)
	alx4	Uncharacterized protein. (372 aa)
	GATA2	GATA binding protein 2. (460 aa)
	myog	Myogenin. (250 aa)
	LOC107090011	Interferon regulatory factor 4a. (461 aa)
	ENSCVAP00000023148	Si:dkey-34f9.3. (111 aa)
	LOC107083874	Myogenic factor. (263 aa)
	LOC107082632	MADS-box domain-containing protein. (489 aa)
	LOC107097873	Ets variant 2. (371 aa)
	vax1	Ventral anterior homeobox 1. (321 aa)
	Fev	FEV transcription factor, ETS family member. (232 aa)
	mef2b	Myocyte enhancer factor 2b. (387 aa)
	LOC107093887	Inhibitor of DNA binding 1, HLH protein. (163 aa)
	tbx1	T-box transcription factor 1. (497 aa)
	LOC107083754	T-cell acute lymphocytic leukemia 1. (434 aa)
	ENSCVAP00000025159	LIM zinc-binding domain-containing protein. (67 aa)
	LOC107083658	Uncharacterized protein. (529 aa)
	LOC107097264	T-box transcription factor 18. (516 aa)
	OTP-2	Orthopedia homeobox. (339 aa)
	LOC107092009	Uncharacterized protein; Belongs to the cytochrome P450 family. (390 aa)
	id3	Inhibitor of DNA binding 3. (116 aa)
	LOC107083040	Myocardin related transcription factor Bb. (909 aa)
	esm1	Endothelial cell-specific molecule 1. (225 aa)
	LOC107093035	LisH domain-containing protein. (429 aa)
	ssbp4	Single stranded DNA binding protein 4. (363 aa)
	hand2	Heart and neural crest derivatives expressed 2. (244 aa)
	cbfb	Core-binding factor subunit beta. (188 aa)
	LOC107104570	GATA binding protein 5. (393 aa)
	ENSCVAP00000030725	PET domain-containing protein. (151 aa)
	mef2d	Myocyte enhancer factor 2d. (580 aa)
	lmo3	LIM domain only 3. (241 aa)
	fli1	Fli-1 proto-oncogene, ETS transcription factor a. (467 aa)
	foxf1	Forkhead box F1. (380 aa)
	nkx6-3	NK6 homeobox 3. (260 aa)
	wtip	WT1 interacting protein. (706 aa)
	scrt2	Scratch family zinc finger 2. (319 aa)
	LOC107096961	Transcription factor 3a. (628 aa)
	LOC107098658	Si:dkey-90l8.3. (156 aa)
	LOC107086752	Neuronal differentiation 4. (356 aa)
	tbx3	T-box transcription factor 3a. (702 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ELK3	LOC107082632	ENSCVAP00000006744	ENSCVAP00000023494	ETS transcription factor ELK3.	MADS-box domain-containing protein.	0.595
ELK3	LOC107098178	ENSCVAP00000006744	ENSCVAP00000014056	ETS transcription factor ELK3.	Runt-related transcription factor.	0.410
ELK3	LOC107099472	ENSCVAP00000006744	ENSCVAP00000012351	ETS transcription factor ELK3.	Runt domain-containing protein.	0.410
ELK3	runx2	ENSCVAP00000006744	ENSCVAP00000010656	ETS transcription factor ELK3.	Runt-related transcription factor.	0.410
ELK3	runx3	ENSCVAP00000006744	ENSCVAP00000016509	ETS transcription factor ELK3.	Runt-related transcription factor.	0.410
ELK3	srf	ENSCVAP00000006744	ENSCVAP00000015112	ETS transcription factor ELK3.	MADS-box domain-containing protein.	0.595
ENSCVAP00000000718	ENSCVAP00000003849	ENSCVAP00000000718	ENSCVAP00000003849	ETS domain-containing protein.	Pax2_C domain-containing protein.	0.558
ENSCVAP00000000718	LOC107081559	ENSCVAP00000000718	ENSCVAP00000018035	ETS domain-containing protein.	Paired domain-containing protein.	0.737
ENSCVAP00000000718	LOC107093887	ENSCVAP00000000718	ENSCVAP00000024316	ETS domain-containing protein.	Inhibitor of DNA binding 1, HLH protein.	0.652
ENSCVAP00000000718	LOC107098178	ENSCVAP00000000718	ENSCVAP00000014056	ETS domain-containing protein.	Runt-related transcription factor.	0.704
ENSCVAP00000000718	LOC107099472	ENSCVAP00000000718	ENSCVAP00000012351	ETS domain-containing protein.	Runt domain-containing protein.	0.619
ENSCVAP00000000718	cbfb	ENSCVAP00000000718	ENSCVAP00000030542	ETS domain-containing protein.	Core-binding factor subunit beta.	0.448
ENSCVAP00000000718	pax2	ENSCVAP00000000718	ENSCVAP00000012581	ETS domain-containing protein.	Paired box 2a.	0.558
ENSCVAP00000000718	runx2	ENSCVAP00000000718	ENSCVAP00000010656	ETS domain-containing protein.	Runt-related transcription factor.	0.652
ENSCVAP00000000718	runx3	ENSCVAP00000000718	ENSCVAP00000016509	ETS domain-containing protein.	Runt-related transcription factor.	0.652
ENSCVAP00000003849	ENSCVAP00000000718	ENSCVAP00000003849	ENSCVAP00000000718	Pax2_C domain-containing protein.	ETS domain-containing protein.	0.558
ENSCVAP00000003849	LOC107097873	ENSCVAP00000003849	ENSCVAP00000023620	Pax2_C domain-containing protein.	Ets variant 2.	0.558
ENSCVAP00000003849	LOC107098178	ENSCVAP00000003849	ENSCVAP00000014056	Pax2_C domain-containing protein.	Runt-related transcription factor.	0.479
ENSCVAP00000003849	LOC107099472	ENSCVAP00000003849	ENSCVAP00000012351	Pax2_C domain-containing protein.	Runt domain-containing protein.	0.447
ENSCVAP00000003849	cbfb	ENSCVAP00000003849	ENSCVAP00000030542	Pax2_C domain-containing protein.	Core-binding factor subunit beta.	0.500