(16 nodes) Acetylcholine regulates insulin secretion, and Phospholipase C-activating serotonin receptor signaling pathway network (Cyprinodon variegatus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107092874	5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a. (496 aa)
	LOC107097986	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1. (579 aa)
	LOC107100829	Guanine nucleotide binding protein (G protein), alpha 11b (Gq class). (359 aa)
	LOC107099623	Guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 4. (360 aa)
	LOC107097117	Guanine nucleotide binding protein (G protein), alpha 14a. (360 aa)
	LOC107098647	Phosphoinositide phospholipase C. (814 aa)
	tbxa2r	Thromboxane A2 receptor. (375 aa)
	PLCB4	Phosphoinositide phospholipase C. (971 aa)
	plcb3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1221 aa)
	adra1b	Adrenoceptor alpha 1Bb. (521 aa)
	LOC107088987	Uncharacterized protein. (357 aa)
	LOC107081969	Prostaglandin F receptor (FP). (364 aa)
	LOC107097118	Uncharacterized protein. (359 aa)
	htr2b	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (465 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
	LOC107088982	Uncharacterized protein. (354 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC107081969	LOC107088982	ENSCVAP00000021347	ENSCVAP00000032785	Prostaglandin F receptor (FP).	Uncharacterized protein.	0.700
LOC107081969	LOC107088987	ENSCVAP00000021347	ENSCVAP00000019743	Prostaglandin F receptor (FP).	Uncharacterized protein.	0.700
LOC107081969	LOC107097117	ENSCVAP00000021347	ENSCVAP00000007820	Prostaglandin F receptor (FP).	Guanine nucleotide binding protein (G protein), alpha 14a.	0.818
LOC107081969	LOC107097118	ENSCVAP00000021347	ENSCVAP00000025039	Prostaglandin F receptor (FP).	Uncharacterized protein.	0.818
LOC107081969	LOC107098647	ENSCVAP00000021347	ENSCVAP00000007985	Prostaglandin F receptor (FP).	Phosphoinositide phospholipase C.	0.403
LOC107081969	LOC107099623	ENSCVAP00000021347	ENSCVAP00000007613	Prostaglandin F receptor (FP).	Guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 4.	0.817
LOC107081969	LOC107100829	ENSCVAP00000021347	ENSCVAP00000005795	Prostaglandin F receptor (FP).	Guanine nucleotide binding protein (G protein), alpha 11b (Gq class).	0.818
LOC107081969	PLCB1	ENSCVAP00000021347	ENSCVAP00000027171	Prostaglandin F receptor (FP).	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.403
LOC107081969	PLCB4	ENSCVAP00000021347	ENSCVAP00000011166	Prostaglandin F receptor (FP).	Phosphoinositide phospholipase C.	0.406
LOC107081969	plcb3	ENSCVAP00000021347	ENSCVAP00000013729	Prostaglandin F receptor (FP).	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.403
LOC107088982	LOC107081969	ENSCVAP00000032785	ENSCVAP00000021347	Uncharacterized protein.	Prostaglandin F receptor (FP).	0.700
LOC107088982	LOC107088987	ENSCVAP00000032785	ENSCVAP00000019743	Uncharacterized protein.	Uncharacterized protein.	0.902
LOC107088982	LOC107092874	ENSCVAP00000032785	ENSCVAP00000001114	Uncharacterized protein.	5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a.	0.914
LOC107088982	LOC107097118	ENSCVAP00000032785	ENSCVAP00000025039	Uncharacterized protein.	Uncharacterized protein.	0.901
LOC107088982	LOC107097986	ENSCVAP00000032785	ENSCVAP00000002825	Uncharacterized protein.	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1.	0.914
LOC107088982	LOC107098647	ENSCVAP00000032785	ENSCVAP00000007985	Uncharacterized protein.	Phosphoinositide phospholipase C.	0.941
LOC107088982	PLCB1	ENSCVAP00000032785	ENSCVAP00000027171	Uncharacterized protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.941
LOC107088982	PLCB4	ENSCVAP00000032785	ENSCVAP00000011166	Uncharacterized protein.	Phosphoinositide phospholipase C.	0.440
LOC107088982	adra1b	ENSCVAP00000032785	ENSCVAP00000016401	Uncharacterized protein.	Adrenoceptor alpha 1Bb.	0.914
LOC107088982	htr2b	ENSCVAP00000032785	ENSCVAP00000026179	Uncharacterized protein.	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled.	0.914