(11 nodes) DHS-like NAD/FAD-binding domain superfamily, and NAD kinase network (Cyprinodon variegatus)

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	nampt	Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (491 aa)
	sirt3	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (344 aa)
	sirt6	Sirtuin 6. (349 aa)
	sirt4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (310 aa)
	sirt2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (383 aa)
	nnt	Nicotinamide nucleotide transhydrogenase. (1087 aa)
	LOC107094217	NAD kinase b. (491 aa)
	LOC107092410	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (304 aa)
	LOC107085358	Nicotinamide nucleotide transhydrogenase 2. (1071 aa)
	nadk	NAD kinase a. (430 aa)
	sirt7	Sirtuin 7. (409 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC107085358	LOC107092410	ENSCVAP00000025484	ENSCVAP00000018630	Nicotinamide nucleotide transhydrogenase 2.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.900
LOC107085358	LOC107094217	ENSCVAP00000025484	ENSCVAP00000015819	Nicotinamide nucleotide transhydrogenase 2.	NAD kinase b.	0.937
LOC107085358	nadk	ENSCVAP00000025484	ENSCVAP00000026593	Nicotinamide nucleotide transhydrogenase 2.	NAD kinase a.	0.937
LOC107085358	nnt	ENSCVAP00000025484	ENSCVAP00000012084	Nicotinamide nucleotide transhydrogenase 2.	Nicotinamide nucleotide transhydrogenase.	0.901
LOC107085358	sirt2	ENSCVAP00000025484	ENSCVAP00000008933	Nicotinamide nucleotide transhydrogenase 2.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.900
LOC107085358	sirt3	ENSCVAP00000025484	ENSCVAP00000002436	Nicotinamide nucleotide transhydrogenase 2.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.901
LOC107085358	sirt4	ENSCVAP00000025484	ENSCVAP00000006120	Nicotinamide nucleotide transhydrogenase 2.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.900
LOC107085358	sirt6	ENSCVAP00000025484	ENSCVAP00000004309	Nicotinamide nucleotide transhydrogenase 2.	Sirtuin 6.	0.900
LOC107085358	sirt7	ENSCVAP00000025484	ENSCVAP00000031002	Nicotinamide nucleotide transhydrogenase 2.	Sirtuin 7.	0.903
LOC107092410	LOC107085358	ENSCVAP00000018630	ENSCVAP00000025484	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Nicotinamide nucleotide transhydrogenase 2.	0.900
LOC107092410	LOC107094217	ENSCVAP00000018630	ENSCVAP00000015819	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	NAD kinase b.	0.924
LOC107092410	nadk	ENSCVAP00000018630	ENSCVAP00000026593	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	NAD kinase a.	0.924
LOC107092410	nampt	ENSCVAP00000018630	ENSCVAP00000000184	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family.	0.919
LOC107092410	nnt	ENSCVAP00000018630	ENSCVAP00000012084	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Nicotinamide nucleotide transhydrogenase.	0.900
LOC107092410	sirt2	ENSCVAP00000018630	ENSCVAP00000008933	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.613
LOC107092410	sirt3	ENSCVAP00000018630	ENSCVAP00000002436	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.544
LOC107092410	sirt4	ENSCVAP00000018630	ENSCVAP00000006120	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.485
LOC107092410	sirt6	ENSCVAP00000018630	ENSCVAP00000004309	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Sirtuin 6.	0.610
LOC107092410	sirt7	ENSCVAP00000018630	ENSCVAP00000031002	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Sirtuin 7.	0.553
LOC107094217	LOC107085358	ENSCVAP00000015819	ENSCVAP00000025484	NAD kinase b.	Nicotinamide nucleotide transhydrogenase 2.	0.937