Your Input: | |
| | fancd2 | FA complementation group D2. (1437 aa) |
| | rpa3 | Replication protein A3. (122 aa) |
| | EME2 | ERCC4 domain-containing protein. (448 aa) |
| | ENSCVAP00000000721 | Uncharacterized protein. (212 aa) |
| | mcm7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa) |
| | dbf4 | DBF4 zinc finger. (606 aa) |
| | timeless | Timeless circadian clock. (1251 aa) |
| | ENSCVAP00000000885 | Rad51 domain-containing protein. (153 aa) |
| | ENSCVAP00000000928 | Piezo_RRas_bdg domain-containing protein. (310 aa) |
| | ENSCVAP00000000934 | Uncharacterized protein. (301 aa) |
| | bivm | Basic, immunoglobulin-like variable motif containing. (496 aa) |
| | mcm5 | DNA helicase; Belongs to the MCM family. (738 aa) |
| | ENSCVAP00000001347 | SCY domain-containing protein. (126 aa) |
| | dmc1 | DNA meiotic recombinase 1; Belongs to the RecA family. (261 aa) |
| | mcm10 | Minichromosome maintenance 10 replication initiation factor. (851 aa) |
| | chek1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (464 aa) |
| | LOC107091169 | ATPase family AAA domain containing 5a. (1526 aa) |
| | atrip | Uncharacterized protein. (773 aa) |
| | LOC107099756 | DBF4-type domain-containing protein. (786 aa) |
| | pole2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (529 aa) |
| | tp53bp1 | Tumor protein p53 binding protein, 1. (1349 aa) |
| | mcm3 | DNA helicase; Belongs to the MCM family. (814 aa) |
| | pcna | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa) |
| | msh3 | MutS homolog 3 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR). (929 aa) |
| | gins1 | GINS complex subunit 1 (Psf1 homolog). (189 aa) |
| | neil3 | Nei-like DNA glycosylase 3. (580 aa) |
| | fancf | FA complementation group F. (341 aa) |
| | rad51d | RAD51 paralog D. (350 aa) |
| | cdc7 | Cell division cycle 7 homolog (S. cerevisiae). (555 aa) |
| | mcmbp | Minichromosome maintenance complex binding protein. (630 aa) |
| | rpl10a | Ribosomal protein; Belongs to the universal ribosomal protein uL1 family. (216 aa) |
| | msh2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (937 aa) |
| | fanci | FA complementation group I. (1308 aa) |
| | wdhd1 | WD repeat and HMG-box DNA binding protein 1. (1064 aa) |
| | rmi1 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (643 aa) |
| | slf1 | SMC5-SMC6 complex localization factor 1. (877 aa) |
| | fbh1 | F-box DNA helicase 1. (882 aa) |
| | ENSCVAP00000005887 | XPGI domain-containing protein. (618 aa) |
| | ENSCVAP00000006422 | Tudor domain containing 3. (116 aa) |
| | LOC107103120 | SLX1 homolog B, structure-specific endonuclease subunit. (218 aa) |
| | msh5 | MutS homolog 5. (680 aa) |
| | rad54b | RAD54 homolog B. (871 aa) |
| | LOC107098698 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (428 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1026 aa) |
| | LOC107092444 | Polymerase (DNA-directed), delta 3, accessory subunit. (439 aa) |
| | lig1 | DNA ligase. (1004 aa) |
| | polk | Polymerase (DNA directed) kappa. (905 aa) |
| | cenpx | Centromere protein X. (114 aa) |
| | pole | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2017 aa) |
| | ENSCVAP00000009946 | MCM_OB domain-containing protein. (197 aa) |
| | Rbbp8 | SAE2 domain-containing protein. (75 aa) |
| | ENSCVAP00000010146 | Tower domain-containing protein. (2271 aa) |
| | spo11 | SPO11 initiator of meiotic double stranded breaks. (387 aa) |
| | orc1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (854 aa) |
| | LOC107088102 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (670 aa) |
| | PIEZO2 | Piezo type mechanosensitive ion channel component 2. (1161 aa) |
| | ENSCVAP00000011755 | TAN domain-containing protein. (119 aa) |
| | Atm | Uncharacterized protein. (145 aa) |
| | CDCA7L | zf-4CXXC_R1 domain-containing protein. (405 aa) |
| | pola1 | DNA polymerase. (1420 aa) |
| | eme1 | Essential meiotic structure-specific endonuclease 1. (522 aa) |
| | LOC107101209 | Ubiquitin-conjugating enzyme E2T (putative). (194 aa) |
| | poli | Polymerase (DNA directed) iota. (618 aa) |
| | LOC107082497 | Tudor domain containing 3. (759 aa) |
| | fancm | Uncharacterized protein. (1764 aa) |
| | orc2 | Origin recognition complex, subunit 2. (536 aa) |
| | prim1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (425 aa) |
| | chtf8 | CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (131 aa) |
| | bard1 | BRCA1 associated RING domain 1. (815 aa) |
| | fancb | FA complementation group B. (726 aa) |
| | rmi2 | RecQ mediated genome instability 2. (146 aa) |
| | Polh | Polymerase (DNA directed), eta. (298 aa) |
| | mad2l2 | Mitotic arrest deficient 2 like 2. (210 aa) |
| | rhno1 | Si:ch73-352p4.5. (287 aa) |
| | fancl | FA complementation group L. (371 aa) |
| | rad17 | RAD17 checkpoint clamp loader component. (493 aa) |
| | rpa2 | Replication protein A2. (278 aa) |
| | LOC107099910 | BLM RecQ like helicase. (1091 aa) |
| | CLSPN | Claspin. (1190 aa) |
| | DCLRE1B | DNA cross-link repair 1B. (460 aa) |
| | ENSCVAP00000014940 | Uncharacterized protein. (119 aa) |
| | Mcm9 | MCM domain-containing protein; Belongs to the MCM family. (263 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (680 aa) |
| | mus81 | MUS81 structure-specific endonuclease subunit. (608 aa) |
| | cdc45 | CDC45 cell division cycle 45 homolog (S. cerevisiae). (566 aa) |
| | XRCC3 | X-ray repair complementing defective repair in Chinese hamster cells 3. (454 aa) |
| | ENSCVAP00000015397 | Uncharacterized protein. (86 aa) |
| | rev1 | REV1 DNA directed polymerase. (1355 aa) |
| | cdca7 | Cell division cycle associated 7a. (394 aa) |
| | pms2 | PMS1 homolog 2, mismatch repair system component. (844 aa) |
| | pole4 | Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa) |
| | ENSCVAP00000016453 | BRCT domain-containing protein. (121 aa) |
| | mcph1 | Microcephalin 1. (702 aa) |
| | stn1 | STN1 subunit of CST complex. (350 aa) |
| | rad54l | RAD54 like. (564 aa) |
| | ercc1 | Excision repair cross-complementation group 1. (351 aa) |
| | dscc1 | DNA replication and sister chromatid cohesion 1. (390 aa) |
| | polq | Polymerase (DNA directed), theta. (2106 aa) |
| | gins3 | GINS complex subunit 3. (211 aa) |
| | rfc4 | Replication factor C (activator 1) 4. (357 aa) |
| | helq | Helicase, POLQ like. (897 aa) |
| | gins2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (186 aa) |
| | xpa | Xeroderma pigmentosum, complementation group A. (275 aa) |
| | prim2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (505 aa) |
| | ENSCVAP00000017542 | Fanconi_A_N domain-containing protein. (242 aa) |
| | gins4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (224 aa) |
| | pold4 | Si:dkey-28b4.7. (107 aa) |
| | Top3b | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (130 aa) |
| | msh4 | MutS homolog 4. (766 aa) |
| | apex2 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (572 aa) |
| | faap24 | FA core complex associated protein 24. (218 aa) |
| | Slx4 | BTB domain-containing protein. (1002 aa) |
| | ENSCVAP00000019055 | Uncharacterized protein. (256 aa) |
| | rfc2 | Replication factor C (activator 1) 2. (373 aa) |
| | mdc1 | Uncharacterized protein. (1864 aa) |
| | ENSCVAP00000019159 | Methionine sulfoxide reductase B1b. (252 aa) |
| | mlh3 | MutL homolog 3 (E. coli). (1087 aa) |
| | orc4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (447 aa) |
| | pole3 | Polymerase (DNA directed), epsilon 3 (p17 subunit). (146 aa) |
| | rev3l | REV3 like, DNA directed polymerase zeta catalytic subunit. (2776 aa) |
| | LOC107087852 | NTF2 domain-containing protein. (128 aa) |
| | LOC107089545 | Si:ch211-141o9.10. (326 aa) |
| | Gen1 | Chromo_2 domain-containing protein. (523 aa) |
| | nbn | Nibrin. (835 aa) |
| | nthl1 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (313 aa) |
| | fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (796 aa) |
| | Ankrd12 | ANK_REP_REGION domain-containing protein. (438 aa) |
| | pold2 | Polymerase (DNA directed), delta 2, regulatory subunit. (487 aa) |
| | mlh1 | MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (719 aa) |
| | cdt1 | Chromatin licensing and DNA replication factor 1. (459 aa) |
| | pold1 | DNA polymerase. (1105 aa) |
| | ercc4 | Excision repair cross-complementation group 4. (885 aa) |
| | MPHOSPH9 | M-phase phosphoprotein 9. (1240 aa) |
| | rfc1 | Replication factor C subunit 1. (1159 aa) |
| | rad52 | RAD52 homolog, DNA repair protein. (374 aa) |
| | msh6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1330 aa) |
| | recql4 | RecQ helicase-like 4. (942 aa) |
| | LOC107089962 | Zgc:110269. (342 aa) |
| | topbp1 | DNA topoisomerase II binding protein 1. (1503 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (285 aa) |
| | pms1 | PMS1 homolog 1, mismatch repair system component. (845 aa) |
| | dna2 | DNA replication helicase/nuclease 2. (1358 aa) |
| | ENSCVAP00000026260 | FA complementation group C. (427 aa) |
| | fancg | FA complementation group G. (522 aa) |
| | pola2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (604 aa) |
| | ENSCVAP00000027358 | Uncharacterized protein. (703 aa) |
| | tipin | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (507 aa) |
| | ercc5 | Excision repair cross-complementation group 5. (1006 aa) |
| | cdc6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (569 aa) |
| | rfc3 | Replication factor C (activator 1) 3. (356 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1274 aa) |
| | ten1 | TEN1 subunit of CST complex. (139 aa) |
| | recql5 | RecQ helicase-like 5. (1010 aa) |
| | LOC107087406 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (911 aa) |
| | chtf18 | AAA domain-containing protein. (920 aa) |
| | exd2 | Exonuclease 3'-5' domain containing 2. (671 aa) |
| | mcm4 | DNA helicase; Belongs to the MCM family. (853 aa) |
| | rad1 | RAD1 homolog (S. pombe). (279 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (692 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | Piezo1 | Piezo_RRas_bdg domain-containing protein. (408 aa) |
| | rfc5 | Replication factor C (activator 1) 5. (335 aa) |
| | palb2 | PALB2_WD40 domain-containing protein. (1325 aa) |
| | faap100 | Uncharacterized protein. (791 aa) |
| | mcm2 | DNA helicase; Belongs to the MCM family. (878 aa) |
| | atr | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2502 aa) |
| | orc5 | Origin recognition complex, subunit 5. (442 aa) |
| | mcm6 | DNA helicase; Belongs to the MCM family. (824 aa) |
| | orc3 | Origin recognition complex, subunit 3. (679 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (389 aa) |
| | dclre1a | DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae). (891 aa) |
| | brca1 | Uncharacterized protein. (1314 aa) |
| | apex1 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (310 aa) |
