(5 nodes) DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity, and Pentapeptide repeats (8 copies) network (Cyprinodon variegatus)

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Your Input:
	LOC107100266	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (752 aa)
	ENSCVAP00000003295	Uncharacterized protein. (209 aa)
	ENSCVAP00000007495	TOP4c domain-containing protein. (354 aa)
	ENSCVAP00000024849	HATPase_c domain-containing protein. (232 aa)
	ENSCVAP00000032577	annotation not available (354 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCVAP00000003295	ENSCVAP00000007495	ENSCVAP00000003295	ENSCVAP00000007495	Uncharacterized protein.	TOP4c domain-containing protein.	0.601
ENSCVAP00000003295	ENSCVAP00000024849	ENSCVAP00000003295	ENSCVAP00000024849	Uncharacterized protein.	HATPase_c domain-containing protein.	0.601
ENSCVAP00000003295	ENSCVAP00000032577	ENSCVAP00000003295	ENSCVAP00000032577	Uncharacterized protein.	annotation not available	0.601
ENSCVAP00000007495	ENSCVAP00000003295	ENSCVAP00000007495	ENSCVAP00000003295	TOP4c domain-containing protein.	Uncharacterized protein.	0.601
ENSCVAP00000007495	ENSCVAP00000024849	ENSCVAP00000007495	ENSCVAP00000024849	TOP4c domain-containing protein.	HATPase_c domain-containing protein.	0.899
ENSCVAP00000007495	LOC107100266	ENSCVAP00000007495	ENSCVAP00000000248	TOP4c domain-containing protein.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.671
ENSCVAP00000024849	ENSCVAP00000003295	ENSCVAP00000024849	ENSCVAP00000003295	HATPase_c domain-containing protein.	Uncharacterized protein.	0.601
ENSCVAP00000024849	ENSCVAP00000007495	ENSCVAP00000024849	ENSCVAP00000007495	HATPase_c domain-containing protein.	TOP4c domain-containing protein.	0.899
ENSCVAP00000024849	ENSCVAP00000032577	ENSCVAP00000024849	ENSCVAP00000032577	HATPase_c domain-containing protein.	annotation not available	0.899
ENSCVAP00000024849	LOC107100266	ENSCVAP00000024849	ENSCVAP00000000248	HATPase_c domain-containing protein.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.671
ENSCVAP00000032577	ENSCVAP00000003295	ENSCVAP00000032577	ENSCVAP00000003295	annotation not available	Uncharacterized protein.	0.601
ENSCVAP00000032577	ENSCVAP00000024849	ENSCVAP00000032577	ENSCVAP00000024849	annotation not available	HATPase_c domain-containing protein.	0.899
ENSCVAP00000032577	LOC107100266	ENSCVAP00000032577	ENSCVAP00000000248	annotation not available	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.671
LOC107100266	ENSCVAP00000007495	ENSCVAP00000000248	ENSCVAP00000007495	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	TOP4c domain-containing protein.	0.671
LOC107100266	ENSCVAP00000024849	ENSCVAP00000000248	ENSCVAP00000024849	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	HATPase_c domain-containing protein.	0.671
LOC107100266	ENSCVAP00000032577	ENSCVAP00000000248	ENSCVAP00000032577	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	annotation not available	0.671