46 items (Cyprinodon variegatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Chd8	Chromo domain-containing protein. (264 aa)
	LOC107090071	Uncharacterized protein. (1383 aa)
	psme3	Proteasome activator subunit 3. (256 aa)
	mdm2	MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family. (482 aa)
	armc10	Armadillo repeat containing 10. (339 aa)
	ENSCVAP00000023854	TP53 regulated inhibitor of apoptosis 1. (82 aa)
	ehmt1	Euchromatic histone-lysine N-methyltransferase 1b. (1279 aa)
	ep300	E1A binding protein p300 b. (2766 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (856 aa)
	usp10	Ubiquitin carboxyl-terminal hydrolase. (877 aa)
	rchy1	Ring finger and CHY zinc finger domain containing 1. (273 aa)
	mapkapk5	MAPK activated protein kinase 5. (471 aa)
	LOC107091261	Ring finger protein 34b. (408 aa)
	usp7	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1182 aa)
	ENSCVAP00000013077	SET domain-containing protein. (176 aa)
	tp63	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (669 aa)
	LOC107099910	BLM RecQ like helicase. (1091 aa)
	ENSCVAP00000015184	TROVE domain-containing protein. (1164 aa)
	cdk5	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	rfwd3	Ring finger and WD repeat domain 3. (529 aa)
	brd7	Bromodomain containing 7. (618 aa)
	rffl	Ring finger and FYVE-like domain containing E3 ubiquitin protein ligase. (343 aa)
	htt	Huntingtin. (2595 aa)
	taf3	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto. (939 aa)
	gata1	Uncharacterized protein. (256 aa)
	mul1	Mitochondrial E3 ubiquitin protein ligase 1b. (352 aa)
	prmt5	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (653 aa)
	nop53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (467 aa)
	sirt1	Sirtuin 1. (691 aa)
	mdm4	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family. (459 aa)
	ENSCVAP00000003720	Uncharacterized protein. (190 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (449 aa)
	LOC107092768	Ring finger protein 34a. (386 aa)
	LOC107086590	Muscle segment homeobox 3. (247 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1349 aa)
	crebbp	CREB binding protein b. (2380 aa)
	ehmt2	Euchromatic histone-lysine N-methyltransferase 2. (1130 aa)
	msx1	Muscle segment homeobox 1a. (277 aa)
	daxx	Death-domain associated protein. (673 aa)
	LOC107100171	GATA binding protein 1a. (426 aa)
	LOC107093412	Bromodomain containing 4. (1508 aa)
	LOC107098659	Euchromatic histone-lysine N-methyltransferase 1a. (770 aa)
	LOC107083428	CREB binding protein a. (2444 aa)
	LOC107092878	E1A binding protein p300 a. (2648 aa)
	tp73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (693 aa)
	cdkn2aip	CDKN2A interacting protein. (312 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Chd8	ENSCVAP00000015184	ENSCVAP00000022976	ENSCVAP00000015184	Chromo domain-containing protein.	TROVE domain-containing protein.	0.497
ENSCVAP00000013077	LOC107098659	ENSCVAP00000013077	ENSCVAP00000018720	SET domain-containing protein.	Euchromatic histone-lysine N-methyltransferase 1a.	0.895
ENSCVAP00000013077	kdm1a	ENSCVAP00000013077	ENSCVAP00000028102	SET domain-containing protein.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.507
ENSCVAP00000013077	sirt1	ENSCVAP00000013077	ENSCVAP00000004473	SET domain-containing protein.	Sirtuin 1.	0.403
ENSCVAP00000015184	Chd8	ENSCVAP00000015184	ENSCVAP00000022976	TROVE domain-containing protein.	Chromo domain-containing protein.	0.497
ENSCVAP00000015184	cdkn2aip	ENSCVAP00000015184	ENSCVAP00000021708	TROVE domain-containing protein.	CDKN2A interacting protein.	0.409
ENSCVAP00000015184	prmt5	ENSCVAP00000015184	ENSCVAP00000004970	TROVE domain-containing protein.	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily.	0.798
ENSCVAP00000015184	taf3	ENSCVAP00000015184	ENSCVAP00000007439	TROVE domain-containing protein.	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto.	0.639
LOC107083428	LOC107092878	ENSCVAP00000019004	ENSCVAP00000020689	CREB binding protein a.	E1A binding protein p300 a.	0.937
LOC107083428	LOC107100171	ENSCVAP00000019004	ENSCVAP00000000250	CREB binding protein a.	GATA binding protein 1a.	0.569
LOC107083428	brd7	ENSCVAP00000019004	ENSCVAP00000017571	CREB binding protein a.	Bromodomain containing 7.	0.557
LOC107083428	daxx	ENSCVAP00000019004	ENSCVAP00000000354	CREB binding protein a.	Death-domain associated protein.	0.458
LOC107083428	ep300	ENSCVAP00000019004	ENSCVAP00000025385	CREB binding protein a.	E1A binding protein p300 b.	0.937
LOC107083428	gata1	ENSCVAP00000019004	ENSCVAP00000007046	CREB binding protein a.	Uncharacterized protein.	0.569
LOC107083428	htt	ENSCVAP00000019004	ENSCVAP00000011739	CREB binding protein a.	Huntingtin.	0.765
LOC107083428	kdm1a	ENSCVAP00000019004	ENSCVAP00000028102	CREB binding protein a.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.570
LOC107083428	mdm2	ENSCVAP00000019004	ENSCVAP00000023426	CREB binding protein a.	MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family.	0.560
LOC107083428	mdm4	ENSCVAP00000019004	ENSCVAP00000004343	CREB binding protein a.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.424
LOC107083428	prmt5	ENSCVAP00000019004	ENSCVAP00000004970	CREB binding protein a.	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily.	0.467
LOC107083428	sirt1	ENSCVAP00000019004	ENSCVAP00000004473	CREB binding protein a.	Sirtuin 1.	0.590