(45 nodes) Regulation of epithelial to mesenchymal transition network (Cyprinodon variegatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Phldb1	PH domain-containing protein. (101 aa)
	glipr2	GLI pathogenesis-related 2, like; Belongs to the CRISP family. (152 aa)
	LOC107103699	Transforming growth factor beta; Belongs to the TGF-beta family. (349 aa)
	ENSCVAP00000009329	PH domain-containing protein. (101 aa)
	ENSCVAP00000009343	Uncharacterized protein. (400 aa)
	LOC107090395	Peptidase S72 domain-containing protein. (908 aa)
	LOC107099476	Interleukin-1. (247 aa)
	mcrip1	MAPK regulated corepressor interacting protein 1. (98 aa)
	pofut2	Protein O-fucosyltransferase 2. (445 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	LOC107102255	Dystroglycan 1. (905 aa)
	LOC107084078	Ephrin-A1a; Belongs to the ephrin family. (221 aa)
	LOC107091926	Uncharacterized protein. (339 aa)
	GREM1	Gremlin. (184 aa)
	LOC107088450	Mothers against decapentaplegic homolog. (503 aa)
	LOC107083120	Transforming growth factor beta; Belongs to the TGF-beta family. (407 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (542 aa)
	efna1	Ephrin-A1b; Belongs to the ephrin family. (231 aa)
	bmp4	Bone morphogenetic protein 4. (399 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2406 aa)
	LOC107081619	Uncharacterized protein. (334 aa)
	ENSCVAP00000021102	MH2 domain-containing protein. (204 aa)
	llgl2	LLGL scribble cell polarity complex component 2. (881 aa)
	LOC107094115	Pleckstrin homology-like domain, family B, member 2b. (1492 aa)
	trim62	Tripartite motif containing 62, tandem duplicate 1. (475 aa)
	ENSCVAP00000026913	PH domain-containing protein. (101 aa)
	ENSCVAP00000026914	Pleckstrin homology-like domain, family B, member 1a. (904 aa)
	bambi	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (254 aa)
	LOC107090307	Sprouty RTK signaling antagonist 2. (351 aa)
	pawr	PRKC, apoptosis, WT1, regulator. (346 aa)
	LOC107091872	Eph receptor A4b. (985 aa)
	dab2	DAB adaptor protein 2. (767 aa)
	gsc	Goosecoid. (237 aa)
	hpn	Hepsin; Belongs to the peptidase S1 family. (410 aa)
	tgfb3	Transforming growth factor beta; Belongs to the TGF-beta family. (400 aa)
	lef1	Lymphoid enhancer-binding factor 1. (378 aa)
	LOC107105022	Regulator of cell cycle. (126 aa)
	LOC107090663	Sprouty related EVH1 domain containing 3. (522 aa)
	LOC107092861	C2H2-type domain-containing protein. (590 aa)
	alx1	ALX homeobox 1. (321 aa)
	LOC107096868	Bone morphogenetic protein 16. (476 aa)
	usf3	Upstream transcription factor family member 3. (2179 aa)
	LOC107084459	Mothers against decapentaplegic homolog. (516 aa)
	tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
	znf750	Zinc finger protein 750. (600 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCVAP00000009329	ENSCVAP00000009343	ENSCVAP00000009329	ENSCVAP00000009343	PH domain-containing protein.	Uncharacterized protein.	0.516
ENSCVAP00000009343	ENSCVAP00000009329	ENSCVAP00000009343	ENSCVAP00000009329	Uncharacterized protein.	PH domain-containing protein.	0.516
ENSCVAP00000009343	ENSCVAP00000026913	ENSCVAP00000009343	ENSCVAP00000026913	Uncharacterized protein.	PH domain-containing protein.	0.464
ENSCVAP00000009343	Phldb1	ENSCVAP00000009343	ENSCVAP00000007915	Uncharacterized protein.	PH domain-containing protein.	0.469
ENSCVAP00000021102	LOC107096868	ENSCVAP00000021102	ENSCVAP00000003931	MH2 domain-containing protein.	Bone morphogenetic protein 16.	0.696
ENSCVAP00000021102	LOC107099476	ENSCVAP00000021102	ENSCVAP00000011289	MH2 domain-containing protein.	Interleukin-1.	0.457
ENSCVAP00000021102	LOC107103699	ENSCVAP00000021102	ENSCVAP00000008432	MH2 domain-containing protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.679
ENSCVAP00000021102	TGFBR2	ENSCVAP00000021102	ENSCVAP00000019474	MH2 domain-containing protein.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.705
ENSCVAP00000021102	bambi	ENSCVAP00000021102	ENSCVAP00000027179	MH2 domain-containing protein.	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	0.545
ENSCVAP00000021102	bmp4	ENSCVAP00000021102	ENSCVAP00000019784	MH2 domain-containing protein.	Bone morphogenetic protein 4.	0.696
ENSCVAP00000021102	lef1	ENSCVAP00000021102	ENSCVAP00000001276	MH2 domain-containing protein.	Lymphoid enhancer-binding factor 1.	0.493
ENSCVAP00000021102	tgfb2	ENSCVAP00000021102	ENSCVAP00000005342	MH2 domain-containing protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.485
ENSCVAP00000026913	ENSCVAP00000009343	ENSCVAP00000026913	ENSCVAP00000009343	PH domain-containing protein.	Uncharacterized protein.	0.464
GREM1	LOC107096868	ENSCVAP00000015951	ENSCVAP00000003931	Gremlin.	Bone morphogenetic protein 16.	0.717
GREM1	bmp4	ENSCVAP00000015951	ENSCVAP00000019784	Gremlin.	Bone morphogenetic protein 4.	0.717
LOC107083120	LOC107103699	ENSCVAP00000019380	ENSCVAP00000008432	Transforming growth factor beta; Belongs to the TGF-beta family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.667
LOC107083120	TGFBR2	ENSCVAP00000019380	ENSCVAP00000019474	Transforming growth factor beta; Belongs to the TGF-beta family.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.993
LOC107083120	tgfb2	ENSCVAP00000019380	ENSCVAP00000005342	Transforming growth factor beta; Belongs to the TGF-beta family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.965
LOC107083120	tgfb3	ENSCVAP00000019380	ENSCVAP00000032394	Transforming growth factor beta; Belongs to the TGF-beta family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.901
LOC107084078	LOC107091872	ENSCVAP00000014847	ENSCVAP00000030994	Ephrin-A1a; Belongs to the ephrin family.	Eph receptor A4b.	0.602