(23 nodes) Regulation of tumor necrosis factor-mediated signaling pathway network (Cyprinodon variegatus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSCVAP00000020558	Nuclear receptor domain-containing protein. (109 aa)
	LOC107093312	Cylindromatosis (turban tumor syndrome), like. (459 aa)
	tnfrsf1a	Tumor necrosis factor receptor superfamily, member 1a. (383 aa)
	traip	TRAF-interacting protein. (448 aa)
	ENSCVAP00000001057	Nuclear receptor domain-containing protein. (91 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (485 aa)
	Park2	RBR-type E3 ubiquitin transferase. (71 aa)
	ENSCVAP00000007456	Uncharacterized protein. (158 aa)
	gas6	Uncharacterized protein. (652 aa)
	LOC107093889	Cylindromatosis (turban tumor syndrome), b. (733 aa)
	spata2	Spermatogenesis associated 2. (564 aa)
	LOC107103662	Coiled-coil domain containing 3b. (282 aa)
	LOC107087577	ADAM metallopeptidase domain 17a. (871 aa)
	LOC107088242	Uncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
	trim32	Tripartite motif containing 32. (679 aa)
	cyld	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (949 aa)
	adam17	ADAM metallopeptidase domain 17b. (844 aa)
	ccdc3	Coiled-coil domain containing 3a. (291 aa)
	sharpin	SHANK-associated RH domain interacting protein. (435 aa)
	LOC107099084	Ubiquitin-conjugating enzyme E2Kb (UBC1 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
	otulin	OTU deubiquitinase with linear linkage specificity a. (686 aa)
	LOC107091977	Uncharacterized protein. (967 aa)
	LOC107104124	Uncharacterized protein. (187 aa)

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCVAP00000007456	LOC107088242	ENSCVAP00000007456	ENSCVAP00000009671	Uncharacterized protein.	Uncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family.	0.503
ENSCVAP00000007456	LOC107099084	ENSCVAP00000007456	ENSCVAP00000023618	Uncharacterized protein.	Ubiquitin-conjugating enzyme E2Kb (UBC1 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family.	0.503
LOC107087577	adam17	ENSCVAP00000009251	ENSCVAP00000018716	ADAM metallopeptidase domain 17a.	ADAM metallopeptidase domain 17b.	0.902
LOC107088242	ENSCVAP00000007456	ENSCVAP00000009671	ENSCVAP00000007456	Uncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family.	Uncharacterized protein.	0.503
LOC107088242	LOC107099084	ENSCVAP00000009671	ENSCVAP00000023618	Uncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-conjugating enzyme E2Kb (UBC1 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family.	0.900
LOC107088242	Park2	ENSCVAP00000009671	ENSCVAP00000007448	Uncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family.	RBR-type E3 ubiquitin transferase.	0.503
LOC107091977	LOC107093889	ENSCVAP00000028547	ENSCVAP00000007972	Uncharacterized protein.	Cylindromatosis (turban tumor syndrome), b.	0.907
LOC107091977	cyld	ENSCVAP00000028547	ENSCVAP00000017451	Uncharacterized protein.	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	0.905
LOC107091977	sharpin	ENSCVAP00000028547	ENSCVAP00000023328	Uncharacterized protein.	SHANK-associated RH domain interacting protein.	0.584
LOC107091977	spata2	ENSCVAP00000028547	ENSCVAP00000008522	Uncharacterized protein.	Spermatogenesis associated 2.	0.951
LOC107091977	tnfrsf1a	ENSCVAP00000028547	ENSCVAP00000000255	Uncharacterized protein.	Tumor necrosis factor receptor superfamily, member 1a.	0.881
LOC107093312	sharpin	ENSCVAP00000000157	ENSCVAP00000023328	Cylindromatosis (turban tumor syndrome), like.	SHANK-associated RH domain interacting protein.	0.617
LOC107093312	spata2	ENSCVAP00000000157	ENSCVAP00000008522	Cylindromatosis (turban tumor syndrome), like.	Spermatogenesis associated 2.	0.563
LOC107093312	tnfrsf1a	ENSCVAP00000000157	ENSCVAP00000000255	Cylindromatosis (turban tumor syndrome), like.	Tumor necrosis factor receptor superfamily, member 1a.	0.920
LOC107093889	LOC107091977	ENSCVAP00000007972	ENSCVAP00000028547	Cylindromatosis (turban tumor syndrome), b.	Uncharacterized protein.	0.907
LOC107093889	cyld	ENSCVAP00000007972	ENSCVAP00000017451	Cylindromatosis (turban tumor syndrome), b.	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	0.906
LOC107093889	sharpin	ENSCVAP00000007972	ENSCVAP00000023328	Cylindromatosis (turban tumor syndrome), b.	SHANK-associated RH domain interacting protein.	0.617
LOC107093889	spata2	ENSCVAP00000007972	ENSCVAP00000008522	Cylindromatosis (turban tumor syndrome), b.	Spermatogenesis associated 2.	0.954
LOC107093889	tnfrsf1a	ENSCVAP00000007972	ENSCVAP00000000255	Cylindromatosis (turban tumor syndrome), b.	Tumor necrosis factor receptor superfamily, member 1a.	0.920
LOC107099084	ENSCVAP00000007456	ENSCVAP00000023618	ENSCVAP00000007456	Ubiquitin-conjugating enzyme E2Kb (UBC1 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family.	Uncharacterized protein.	0.503